Navigation Links
Rescuing injured hearts by enhancing regeneration

function, as measured on echocardiograms: their hearts pumped almost as well as the hearts of uninjured rats. They also had reduced thinning of the cardiac wall and the least amount of scarring.

Rats receiving only the p38 MAP kinase inhibitor had increased proliferation of cardiomyocytes, but no longer had improved heart function at three months. Those receiving only FGF1 maintained their functional improvement, but did not show as much cell proliferation as those receiving the p38 MAP kinase inhibitor. Rats receiving both agents had the greatest improvements in both cell proliferation and heart function.

The findings suggest that getting cardiomyocytes to replicate is not enough to rescue heart function, but that angiogenesis is also needed, Engel says.

"Regeneration is not just making more cardiomyocytes," he says. "Cardiomyocytes need a blood supply and oxygen to survive. FGF1 did not have a great effect on cell proliferation, but we found it was providing a new blood supply. If you just inhibit p38 MAP kinase, you don't get blood vessels."

Two important steps are needed to turn these findings into a treatment, Engel says. First is to show that the treatment works when not given immediately after the heart attack, since many people sustain progressive damage to their hearts from repeated minor infarctions. In this study, rats were treated soon after injury.

Second is the need to develop a safe delivery method. Because FGF1 stimulates angiogenesis, it has the potential for serious side effects if it goes to places other than the heart, possibly promoting tumor growth, for example. And the p38 MAP kinase inhibitor has been shown to damage the liver.

"Every treatment trying to induce proliferation of cardiomyocytes also carries a risk of inducing tumor growth, and thus you have to limit the time and location of treatment," Engel adds.

One possibility is to inject smaller doses of the agen
'"/>

Source:Children's Hospital Boston


Page: 1 2 3

Related biology news :

1. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
2. NASA technology helping injured US troops
3. Bone marrow stem cells may heal hearts even years after heart attacks
4. Mice with glowing hearts shed light on how hearts develop
5. Free-radical busting antioxidants might not promote healthy hearts
6. UT Southwestern researchers find gene mutation that leads to broken hearts
7. Adult stem cell research at UB targets damaged hearts
8. Newts which regrow their hearts
9. Mechanical artificial hearts can remove need for heart transplant by returning heart to normal
10. Mutation improves memory, may lead to memory-enhancing pill
11. Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Rescuing injured hearts enhancing regeneration

(Date:3/19/2015)... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... market, announces its biometric payment technology, the Wocket® smart wallet ... on Washington DC,s Fox 5 News ... Next Great Thing", host Laura Evans calls the ... really big breakthrough in mobile payment.,  Award-winning ...
(Date:3/16/2015)... , March 16, 2015 ... GmbH will present groundbreaking innovations in biometric identification ... Germany .      (Photo: ... biometric innovation is well at the forefront: the ... e-gate made in Germany . ...
(Date:3/11/2015)... , Mar. 11, 2015 Research and Markets ... the "Access Control Market by Product, Application & ... report to their offering. , This ... to reach $10.4 billion by 2020, with an estimated ... report covers the products types such as contact cards ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2
... in the treatment of cocaine overdoses and a new defense ... the groundbreaking research that will be unveiled at the American ... conference takes place Sunday, May 16 -Thursday, May 20 at ... A Possible Treatment for Cocaine Addiction ...
... from Mahidol University have developed a rapid, high-throughput screening ... related report by Munkongdee et al, "Rapid diagnosis of ... 2010 issue of The Journal of Molecular Diagnostics ... a genetic defect in the production of a component ...
... 11, 2010) -- Cell-cell junctions are multi-molecular complexes ... act as barriers to permeability, and allow intercellular transport. ... Cold Spring Harbor Laboratory Press, surveys current research on ... Rockefeller University) and W. James Nelson (Stanford University), both ...
Cached Biology News:Biotherapeutic Innovations on Display at AAPS National Biotechnology Conference 2
(Date:3/29/2015)... NJ (PRWEB) March 29, 2015 As ... deadlines often required by our pharmaceutical manufacturing clients, Whitehouse ... its sponsorship of the Berkenstock Race Team for the ... requires not only speed, but a strong sense of ... principles that lead to success in the quality control ...
(Date:3/27/2015)... 27, 2015   SurePure, Inc . (OTCQB: ... today that the Company has completed the verification ... of SurePure ("SURP") securities on OTCQB, an electronic ... and development stage companies. On March ... eligibility requirements designed to improve marketplace integrity and ...
(Date:3/27/2015)... Governor Andrew M. Cuomo today announced ... - the world’s largest business idea competition with $5 ... $1 million, six $500,000 awards and four $250,000 awards. ... compete for prizes that will turn ideas with high ... York region. , "Last year's successful 43North competition ...
(Date:3/26/2015)... 2015  BioNano Genomics, Inc., the leader in genome ... as chief commercial officer. Salyer has more than 20 ... in life sciences. At BioNano, Salyer will oversee the ... platform to assemble a comprehensive view of complex genomes ... 32 institutions located in the United States ...
Breaking Biology Technology:Whitehouse Laboratories Reaffirms Commitment to Speedy Results – Renews Sponsorship of Berkenstock Racing Team 2SurePure Completes Verification and Approved for Trading on the OTCQB Marketplace 2Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 2Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 4Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 5BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3
... Qi Lu, former EVP of,Yahoo!, continues to dedicate his passion ... HYSTA, USA. HYSTA is greatly,honored to have Qi,s on-going commitment ... August, he had served more than 10,years, which was a ... that has not changed is his dedication to serve the ...
... RainDance Technologies,Inc., a provider of innovative droplet-based ... today dedicated its new headquarters and,operations building ... Keynoting the event was Sir Richard ... medicine and Founder and Chief Scientific Officer ...
... for NDA Resubmission ... Planned For First Quarter 2009, LEXINGTON, Mass., Sept. 26 ... has reached,agreement with the U.S. Food and Drug Administration (FDA) with ... to,re-submission (complete response) of the New Drug Application (NDA) for,NEBIDO(R) in ...
Cached Biology Technology:Update: HYSTA Announces Dr. Qi Lu to Continue on as President of HYSTA, USA 2RainDance Dedicates New Headquarters, Manufacturing Facility 2RainDance Dedicates New Headquarters, Manufacturing Facility 3Indevus and FDA Agree on Path Forward for NEBIDO(R) 2Indevus and FDA Agree on Path Forward for NEBIDO(R) 3Indevus and FDA Agree on Path Forward for NEBIDO(R) 4
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
... Dinitro-5,5'-dithiodibenzoic acid , DTNB , Ellman's reagent ... , *CAS-No.: 69-78-3 *Storage: ... with a reactive grouping not present in the ... reagent which will react directly with the product ...
96 Well Base Plate...
... that has been shown to help maintain the ... by reverse transcription, in vitro RNA transcription, and ... tightly binds RNases in a 1:1 ratio. It ... as RNase A, RNase B, RNase C, and ...
Biology Products: