Navigation Links
Rescuing injured hearts by enhancing regeneration

Using a two-drug approach, researchers at Children's Hospital Boston have demonstrated that it may be possible to rescue heart function after a heart attack and protect the heart from scarring. Working with rats, they combined an agent that overcomes a natural inhibitor of cell division with a naturally occurring growth factor that encourages blood vessel growth (angiogenesis). Together, these two agents enabled heart-muscle cells to multiply and the heart to regain its function after a simulated myocardial infarction. The study will appear in the October 17 issue of the Proceedings of the National Academy of Sciences (posted online during the week of October 9).

Normally, after a heart attack, the damaged heart muscle cannot grow back and is instead replaced by scar tissue. Excessive scarring can impair the heart's pumping capacity and can lead to life-threatening arrhythmias. Heart-muscle cells (cardiomyocytes) normally cannot replicate in mammals, a major obstacle to regeneration. However, in a paper last year, Felix Engel, PhD, and Mark Keating, MD, in the Department of Cardiology at Children's Hospital Boston, showed that they could coax cardiomyocytes to multiply in a petri dish by inhibiting an enzyme known as p38 MAP kinase, which normally suppresses cardiomyocyte replication. [See: www.childrenshospital.org/newsroom/Site1339/mainpageS1339P1sublevel139.html]

Engel and Keating (Keating is now at the Novartis Institute for BioMedical Research) now build on this finding. They studied 120 rats, some with simulated heart attacks. After the injury, the animals were randomly assigned to receive injections with a p38 MAP kinase inhibitor alone, the angiogenesis stimulator FGF1 alone, both agents together, or saline (placebo) for four weeks. Three months later, rats that had received both FGF1 and the p38 MAP kinase inhibitor had markedly improved heart
'"/>

Source:Children's Hospital Boston


Page: 1 2 3

Related biology news :

1. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
2. NASA technology helping injured US troops
3. Bone marrow stem cells may heal hearts even years after heart attacks
4. Mice with glowing hearts shed light on how hearts develop
5. Free-radical busting antioxidants might not promote healthy hearts
6. UT Southwestern researchers find gene mutation that leads to broken hearts
7. Adult stem cell research at UB targets damaged hearts
8. Newts which regrow their hearts
9. Mechanical artificial hearts can remove need for heart transplant by returning heart to normal
10. Mutation improves memory, may lead to memory-enhancing pill
11. Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Rescuing injured hearts enhancing regeneration

(Date:8/18/2015)... , Aug. 18, 2015  Navitas today ... contributor to the Submission Content Management webinar ... a non-profit forum. Dedicated to the Implementation of ... neutral platform for industry, vendors, health authorities, ... and work towards a standard method of ...
(Date:8/12/2015)... CORAL SPRINGS, Florida , August 12, 2015 /PRNewswire/ ... globally, the pace of mobile payment innovation and advanced ... continues to replace the way consumers rely on using ... forges ahead with reinventing the future for payment services ... Inc. (NASDAQ: NXTD ), :  Google, Inc. (NASDAQ: ...
(Date:8/10/2015)... , August 10, 2015 ... Eye Tracking Technology for more than two decades, announces ... for integration into all consumer display formats. The SMI ... integration of eye tracking into consumer tablets, laptops, desktop ... smart glasses. Omnivision,s leading sensor technology contributes to the ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3
... edition of Environmental Health Perspectives reports that during the past ... year in the U.S. and Japan. In a review of ... found significantly fewer boys being born relative to girls in ... fetuses that die are male. They note that the decline ...
... forests of Cambodia, conservationists from the Wildlife Conservation Society ... colony of slender-billed vultures, one of the world's ... forested country just east of the Mekong River in ... of the only known slender-billed vulture nesting areas in ...
... they had already eaten -- in this case, leftover chicken-wing ... no such environmental cues, finds a new Cornell study. , ... a table where leftover bones accumulated compared with those whose ... women. , "The results suggest that people restrict their ...
Cached Biology News:Pitt study notes decline in male births in the US and Japan 2Cambodian vulture nests offer hope for species 2
(Date:8/31/2015)... ... August 31, 2015 , ... The Global ... chain risk management and resiliency practitioners with luminaries and thought leaders to advance ... be recognized for their innovations and performance excellence. At that time its principle ...
(Date:8/31/2015)... ... August 31, 2015 , ... In recent years, biodegradable ... as low carbon footprints and compostability. These properties can help in limiting the ... the basis of applications, the market for biodegradable plastics can be broadly segmented ...
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ( ... "Argentina Biomedical Sensors Market - Growth, Trends & Forecasts ... The Argentina Biomedical Sensors market is estimated at $0.17 ... the period 2014-2020 The near future will ... formulation of each individual. These sensors can be set ...
(Date:8/31/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/53wxp3/israel_biomedical ) ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Biomedical Sensors market is estimated at $0.19 billion by ... 2014-2020 The near future will bring biomedical ... each individual. These sensors can be set to trigger ...
Breaking Biology Technology:Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 2Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Argentina Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts 2014-2020 2Israel Biomedical Sensors Market 2015 - Growth, Trends & Forecasts to 2020 2
... tech-savvy workers and managers for Wisconsins knowledge-based economy ... will require partnerships between business, education and government ... K-through-gray learning spectrum. , ,The latest example of ... UW-Stout to streamline transfer of credits for technical ...
... HR executives in London, UK. The participants were managers ... multinational firms. The subject of discussion was agile resourcing ... the workforce more flexible. The goal of agile resourcing ... the right people, with the right skills, in the ...
... Wingra Technologies announced Tuesday its release ... of software tools that automates the migration of server ... , ,Earlier versions of GroupWise Migrator for Exchange ... and personal distribution lists from GroupWise to Exchange. The ...
Cached Biology Technology:Higher ed cooperation will produce more skilled workers for Wisconsin 2Higher ed cooperation will produce more skilled workers for Wisconsin 3Stuck in Talent Gridlock 2Stuck in Talent Gridlock 3Wingra Technologies releases new e-mail-message migration software 2
Abgene's ALTO-8 is the first automated decapper/capper for Abgene Twist-Lock tubes....
Request Info...
... bank refrigerators: ,Each upright model provides ... 4C temperature uniformity for refrigerated blood. The ... Surveillance Module for complete blood storage monitoring. ... equipped with the HemaPro 101 alarm/monitor. All ...
... BR4i refrigerated multifunction centrifuges are equally capable of ... low sound level with a large range of ... rotor exchange system without tools ensures that the ... Instant rotor exchange (5 sec.) ...
Biology Products: