Navigation Links
Rescuing injured hearts by enhancing regeneration

Using a two-drug approach, researchers at Children's Hospital Boston have demonstrated that it may be possible to rescue heart function after a heart attack and protect the heart from scarring. Working with rats, they combined an agent that overcomes a natural inhibitor of cell division with a naturally occurring growth factor that encourages blood vessel growth (angiogenesis). Together, these two agents enabled heart-muscle cells to multiply and the heart to regain its function after a simulated myocardial infarction. The study will appear in the October 17 issue of the Proceedings of the National Academy of Sciences (posted online during the week of October 9).

Normally, after a heart attack, the damaged heart muscle cannot grow back and is instead replaced by scar tissue. Excessive scarring can impair the heart's pumping capacity and can lead to life-threatening arrhythmias. Heart-muscle cells (cardiomyocytes) normally cannot replicate in mammals, a major obstacle to regeneration. However, in a paper last year, Felix Engel, PhD, and Mark Keating, MD, in the Department of Cardiology at Children's Hospital Boston, showed that they could coax cardiomyocytes to multiply in a petri dish by inhibiting an enzyme known as p38 MAP kinase, which normally suppresses cardiomyocyte replication. [See: www.childrenshospital.org/newsroom/Site1339/mainpageS1339P1sublevel139.html]

Engel and Keating (Keating is now at the Novartis Institute for BioMedical Research) now build on this finding. They studied 120 rats, some with simulated heart attacks. After the injury, the animals were randomly assigned to receive injections with a p38 MAP kinase inhibitor alone, the angiogenesis stimulator FGF1 alone, both agents together, or saline (placebo) for four weeks. Three months later, rats that had received both FGF1 and the p38 MAP kinase inhibitor had markedly improved heart
'"/>

Source:Children's Hospital Boston


Page: 1 2 3

Related biology news :

1. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
2. NASA technology helping injured US troops
3. Bone marrow stem cells may heal hearts even years after heart attacks
4. Mice with glowing hearts shed light on how hearts develop
5. Free-radical busting antioxidants might not promote healthy hearts
6. UT Southwestern researchers find gene mutation that leads to broken hearts
7. Adult stem cell research at UB targets damaged hearts
8. Newts which regrow their hearts
9. Mechanical artificial hearts can remove need for heart transplant by returning heart to normal
10. Mutation improves memory, may lead to memory-enhancing pill
11. Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Rescuing injured hearts enhancing regeneration

(Date:10/16/2014)... have challenged conventional thinking on how the bowel lining ... for how bowel cancer starts. , The researchers produced ... regenerating the ,crypts, that are a feature of the ... in bowel cancer development, a controversial finding as scientists ... Using 3D imaging technologies, Dr Chin Wee Tan and ...
(Date:10/16/2014)... Northridge, Calif. (October 16, 2014) – Post-menopausal women ... effect on hormone levels or genital bleeding, after ... of an investigational fermented soy germ-based nutritional supplement ... according to a new peer-reviewed pilot study reported ... Society (NAMS) annual scientific meeting. , "These ...
(Date:10/15/2014)... risk from strains of influenza virus increases with the ... become complacent that the most substantial threats have been ... pandemics arise when a new virus strain – against ... spreads in the human population. There have been five ... of which – the 1918 Spanish Flu – cost ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2
... identified the first common gene variants associated with an ... for heart attack, stroke and kidney failure. The report ... Genetics identifies variants in genes for proteins involved ... influence blood pressure levels, an association previously seen in ...
... disease, red tides and other marine environmental issues ... a source for pharmaceuticals. These chemicals function as ... be usable in human health care. ... The Medical University of South Carolina and North ...
... one-sixth of the world,s population -- nearly one billion people, ... basis? If you happen to be one of 15 ... your sleeves and design a $5, hand-held device to sanitize ... began as a class project, it has since become a ...
Cached Biology News:Common gene variants increase risk of hypertension, may lead to new therapies 2Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs 2Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs 3Iowa student engineers develop hand-held water sanitizer for a thirsty world 2
(Date:10/20/2014)... MENLO PARK, Calif. , Oct. 20, 2014 ... announced today that the Company has signed a ... Institute of Regenerative Medicine (CIRM), effective October 1, ... of Clinical Development payments and the release of ... $14.3 million CIRM grant award for clinical development ...
(Date:10/20/2014)... 20, 2014 PureTech , a science ... healthcare problems, announced today the closing of a ... from Invesco Perpetual, a $120 Billion group of ... PureTech,s existing pipeline forward and to advance new ... scientific creativity to really go for the big ...
(Date:10/19/2014)... 2014 The Latin American hardware encryption ... Latin America with analysis and forecast of revenue. This ... is expected to reach $2,366.8 million by 2018, at ... Browse through the TOC of the Latin American hardware ... in-depth analysis provided. It also provides a glimpse of ...
(Date:10/19/2014)... 2014 The Asian Automatic patient billing ... analysis and forecast of revenue. The Automatic patient billing ... $463.9 million by 2018, at a developing CAGR of ... TOC of the Asian Automatic patient billing market, to ... also provides a glimpse of the segmentation of this ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... past few years, many companies have been downsizing their ... name speculation market had cooled. There has not been, ... saw a 20% increase in the number of domain ... , ,The domain name market has been reinvigorated due ...
... Committee voted unanimously to authorize an audit of troubled ... 6-0 vote came after several hours of testimony on ... state has lost millions of dollars that cannot be ... been plagued by varying problems, including delays in implementation, ...
... upon us as I write these words! This year's theme, ... in the Midwest from medical devices to diagnostics to drugs ... ,Although all kinds of records are being broken in terms ... on the final attendance number, but the pre-registration number floating ...
Cached Biology Technology:Renew your domain name! 2Renew your domain name! 3Renew your domain name! 4Audit of multi-million dollar state IT spending will proceed 2Let the olympics of biotechnology in the Midwest begin! 2Let the olympics of biotechnology in the Midwest begin! 3Let the olympics of biotechnology in the Midwest begin! 4
The Mu-End™ Protein Truncation Kit provides a convenient method for generating a library of N-terminal and C-terminal protein deletions that can be expressed in E. coli....
... SearchLight® IR Mouse Cytokine Array is a ... the quantitative measurement of 12 cytokines in ... culture supernatants. Each well of the microplate ... specific cytokines in standards and samples added ...
... difficult to achieve in many bacterial strains ... more restriction and modification (R-M) systems that ... "foreign". TypeOne™ Restriction Inhibitor provides a powerful ... strains with type I R-M systems. ...
... AMPure is a magnetic bead-based ... no sample transfer, centrifugation or ... small and large PCR extension ... microplates. Agencourt AMPure can easily ...
Biology Products: