Navigation Links
Protein discovery could unlock the secret to better TB treatment

UCL scientists have found a protein that could unlock the secret to quicker, more effective treatment of TB by waking TB bacteria in the body. Once the TB bacteria are active again, the disease becomes treatable using common drugs like antibiotics. Scientists believe that uncovering the molecular structure of this protein will lead the way to designing drugs which enable treatment of dormant and multidrug resistant TB.

In England and Wales around 400 people die each year from the disease. The top challenge for TB control in the European region is multidrug-resistant TB (MDR-TB). Eight per cent of the bacteria causing TB in patients are resistant to one or more drugs and one per cent show multidrug resistance. Left untreated, a person with infectious TB of the lungs infects around 10 to 15 people every year.

In a study published on 1st March 2005 in Nature Structural & Molecular Biology, a combined team discovered the structure of a protein known as resuscitation promoting factor (Rpf). Five versions of the Rpf protein exist in TB bacteria. The paper's unveiling of the molecular structure of Rpf could be crucial to the treatment of TB in the future.

Dr John Ward, Dept of Biochemistry and Molecular Biology at UCL, said: "The discovery of Rpf in the TB bacteria could allow the development of methods to 'wake-up' all dormant bacteria in a patient allowing antibiotics to kill the bacteria and cure the disease."

The team includes Prof Brian Henderson at the UCL Eastman Dental Institute, Nicholas Keep from Birkbeck, University of London, and John Ward at UCL as well as researchers from INSERM Montpellier.


'"/>

Source:University College London


Page: 1

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Researchers Uncover Key Step In Manufacture of Memory Protein
3. An HIV Protein Plays a Surprising Role in Gene Activation
4. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
5. New SARS Protein Linked To Important Cell Doorway
6. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
7. PANTHER Protein Classification System Database 5.0
8. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
9. Newly Discovered Compound Blocks Known Cancer-Causing Protein
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. Protein offers way to stop microscopic parasites in their tracks
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein discovery could unlock the secret better treatment

(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
(Date:10/17/2014)... German . To ... treating overdoses, doctors are often limited to supportive therapy such ... a combination of drugs involved. So what can be done ... pills? ETH professor Jean-Christophe Leroux from the Institute of Pharmaceutical ... this question. "The task was to develop an agent that ...
(Date:10/16/2014)... efficiently, they are anything but sustainable: environmental damage ... is becoming increasingly evident. Despite their disadvantages, however, ... regarded as the sole possibility of achieving higher ... Bernhard Schmid, an ecology professor at the University ... agriculture and forestry. After all, a new study ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... a person with allergies or asthma, breathing in pollen ... inhalation by someone sensitive to their effects, these tiny ... producing uncontrollable sneezing, coughing, or extreme shortness of breath ... allergy and asthma attacks. , Scientists have long assumed ...
... of the effect of male circumcision on HIV infection, ... published in PLoS Medicine on October 25. ... new infections among heterosexual men in South Africa by ... are generally lower among African groups where circumcision is ...
... Nuclear Medicine uses PET, radiotracer to track enzyme in ... enzyme in the lungs, possibly contributing to some of ... in the September issue of the Journal of Nuclear ... the enzyme, also shows that smokers had a lower ...
Cached Biology News:New factor implicated in allergy and asthma attacks 2New factor implicated in allergy and asthma attacks 3PLoS Medicine publishes first trial of effect of male circumcision on HIV infection 2PLoS Medicine publishes first trial of effect of male circumcision on HIV infection 3Smoking damages key regulatory enzyme in the lung 2Smoking damages key regulatory enzyme in the lung 3
(Date:10/20/2014)... OR (PRWEB) October 20, 2014 Local ... participate in an investigational study of donor stem cells ... in stem cell therapy and has performed clinical stem ... this study is to determine if a single injection ... affected joints can help reduce pain and inflammation in ...
(Date:10/19/2014)... 19, 2014 The Asia-Pacific Bromine ... in Asia-Pacific with analysis and forecast of revenue. ... Pacific Bromine Market report, to get an idea ... a glimpse of the segmentation in the Asia-Pacific ... and figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , ...
(Date:10/19/2014)... Orthopedic braces and support systems report defines and segments the ... The Orthopedic braces and support systems market in Asia is ... a developing CAGR of 4.4% from 2013 to 2018. , ... support systems market, to get an idea of the in-depth ... of orthopedic braces and support systems market in the same ...
(Date:10/18/2014)... October 18, 2014 The Asia-Pacific ... and segments the bio-based advanced phase change material ... revenue. , Browse through the TOC of the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bio-based advanced phase change ...
Breaking Biology Technology:Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 4
... 5 Schering-Plough Corporation (NYSE: SGP ) ... by David Nicholson, Ph.D., senior vice president, Global Project ... Barclays Capital Global Healthcare Conference in Miami on Tuesday, ... is expected to talk about the company,s R&D pipeline ...
... rosacea-specific study also slated for presentation at American Academy ... NAPA, Calif., March 5 Senetek PLC (OTC Bulletin ... development of technologies that target the science of healthy ... at the American Academy of Dermatology,s 67th Annual Meeting ...
... SAN FRANCISCO, Calif., March 5 Poniard Pharmaceuticals, ... company focused on innovative oncology therapies, today announced ... discuss the Company,s fourth quarter and year-end financial ... development activities for picoplatin, the Company,s lead product ...
Cached Biology Technology:Pyratine XR(TM) Launches at 67th AAD Meeting, Offering Hope to 14 Million Rosacea Sufferers 2Pyratine XR(TM) Launches at 67th AAD Meeting, Offering Hope to 14 Million Rosacea Sufferers 3Poniard Pharmaceuticals to Host Fourth Quarter and Year-End 2008 Financial Results Conference Call on March 12 2
Although each Beacon 2000 System includes one preinstalled sample chamber (size specified at time of order), optional chambers are available and easily retrofit by the user....
Whole blood is collected from healthy guinea pigs of either sex from US source which are free of visible diseases at time of blood collection. Hemolytic titer: CH50 = 435 units...
...
... serial preparation of four ... cytosol/particulate/cytoskeleton/nuclear fractions from one ... can directly be used ... as 2-D gel/Western blot/gel-shift/translocation/enzyme ...
Biology Products: