Navigation Links
Patterns in genome organization may partially explain how microbial cells work

The location of a piece of real estate may be its most important feature to many Realtors, and bioengineering researchers at the University of California, San Diego (UCSD) and the University of Virginia have reported that the location of genes and other features distributed along the chromosomes of bacteria and simpler organisms also is fundamentally important to how microbial cells operate.

In a paper published Jan. 13 online in PLoS Computational Biology, the researchers reported large- and small-scale organizational patterns in the genomes of 135 bacteria ranging from those that cause typhoid fever and various other human infections to organisms that enrich the nitrogen content of soil. In addition, 16 more primitive microorganisms, including one that thrives in boiling hot springs, also exhibit patterns in their genomes that are highly nonrandom.

"This high degree of organization of prokaryotic genomes is a complete surprise, and this finding carried many implications that biologists might not have considered before," said Bernhard Palsson, a professor of bioengineering at UCSD's Jacobs School of Engineering and adjunct professor of medicine and co-author of the analysis. "These findings show that evolution of prokaryotes [organisms that lack nuclei] is constrained not just by variations in the content of genes, but also by the intricate ways in which those genes are arranged on chromosomes."

A bacterial cell usually operates with one copy of its genome. Until 2002, there had been no way to determine if a particular gene or area of the chromosome was segregated in any particular way inside the cell. New techniques that attach fluorescent "reporter" markers to predetermined spots on chromosomes have indicated that many bacterial genes tend to be found at specific cellular locations. Patterns are not obvious in the sequences of prokaryotic genomes, which led the team led by Palsson to use signal-processing methods to identify long-range spat
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. Man and mouse share genome structures
2. Whole genome fine map of rice completed
3. Study finds more than one-third of human genome regulated by RNA
4. A bacterial genome reveals new targets to combat infectious disease
5. Scientists decipher genome of fungus that can cause life-threatening infections
6. Highly adaptable genome in gut bacterium key to intestinal health
7. Fleshing out the genome
8. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
9. wFleaBase: the Daphnia genome database
10. NHGRI targets 12 more organisms for genome sequencing
11. Chimp genome reveals a retroviral invasion
Post Your Comments:
(Date:7/23/2014)... alongside decades of in-depth monitoring, has provided unique ... a population of top-predators. Published in Nature ... seals have significantly altered in accordance with changes ... conditions. Despite a shift in the population towards ... through generations, leaving the population in decline. ...
(Date:7/23/2014)... a high health risk warning for Yellowknife and surrounding ... to forest fires. In the image taken by ... normal wind patterns. Fire is an obvious health ... not quite so obvious and its effects are insidious. ... (forest, brush, crop, structure, tires, waste or wood burning) ...
(Date:7/23/2014)... 780 million people around the world have no access ... Organization (WHO), 3.4 million people die from water-related diseases ... goal of making a contribution to solving this problem. ... Stark, head of the Functional Materials Laboratory, the 23-year-old ... a prototype. , "What makes our DrinkPure filter unique ...
Breaking Biology News(10 mins):Genetic study shows major impact of climate change on Antarctic fur seals 2Genetic study shows major impact of climate change on Antarctic fur seals 3ETH student develops filter for clean water around the world 2
... University of California, San Diego NanoEngineers won a ... develop the tools to manufacture biodegradable frames around which ... grow. Developing methods for growing tissues that mimic nature,s ... efforts to grow replacement cardiac tissues for people who ...
... University of Illinois researchers are using a new kind of ... the relationship between cell mass and growth rate. ... professor Rashid Bashir, published its results in the online early ... Sciences . "It,s merging micro-scale engineering and cell biology," ...
... Nov. 15, 2010 Tiny molecules called microRNAs ... labor, raising the prospect that RNA-based drugs might be ... Medical Center have discovered in a preclinical study. ... controls labor, so with future research we might have ...
Cached Biology News:Nanoengineers aim to grow tissues with functional blood vessels 2Nanoengineers aim to grow tissues with functional blood vessels 3Microsensors offer first look at whether cell mass affects growth rate 2Tiny RNA molecules control labor, may be key to blocking premature birth 2
(Date:7/23/2014)... , 23 de julio de 2014 /PRNewswire/ ... o la Compañía) ha anunciado hoy una asociación ... (ABIA o el Instituto), para el ... un dispositivo de terapia de señal bioeléctrica (el ... El Instituto, que tiene una importante experiencia ...
(Date:7/23/2014)... , July 23, 2014 regulated information ... research and development pipeline with positive topline results ... brivaracetam . This study was designed to evaluate the ... and 200 mg/day, without titration) compared to placebo, ... with partial-onset seizures, not fully controlled despite treatment ...
(Date:7/23/2014)... California (PRWEB) July 23, 2014 With the ... in HD resolution for more than 15 minutes, Fastec Imaging ... the world of high speed imaging. “Finally, a high speed ... camera we use in our everyday lives.” proclaims Matt Kearney, ... Fastec has always been to demystify and simplify the traditionally ...
(Date:7/22/2014)... (PR Web) July 21, 2014 (PRWEB) July 23, ... for Biomaterials, at Rutgers University. , The ... and ideas across the full spectrum of scientists ... selected research and development topics that represent the ... have been programmed to:,     Provide ...
Breaking Biology Technology:ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 2ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 3ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 4ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 5ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7Fastec Imaging Introduces the First High Speed Camcorder 2Fastec Imaging Introduces the First High Speed Camcorder 3The 2014 NJ Symposium on Biomaterials Science Earns Society for Biomaterials Endorsement 2
... March 4 SGX Pharmaceuticals,(Nasdaq: SGXP ) ... and,full year 2007 on Wednesday, March 12, 2008. ... call and webcast at 8:00 a.m. Pacific Time.,Mike ... Myers, Chief,Financial Officer, will host the conference call ...
... PHILADELPHIA - For centuries, engineers have bent and torn ... scientists at the University of Pennsylvania School of Engineering ... at nanoscale sizes in the form of wires a ... has enable Penn engineers to construct a theoretical model ...
... Achieves 2007 Net Income of $13.1 Million, DUBLIN, ... a pharmaceutical company dedicated to the discovery, rapid,development and ... reported financial results for the fourth,quarter and year ended ... for the 2007 fourth quarter of $5.1,million, or $0.09 ...
Cached Biology Technology:SGX Pharmaceuticals Schedules Teleconference and Webcast for Fourth Quarter and Full Year 2007 Results 2Surface dislocation nucleation: Strength is but skin deep at the nanoscale, Penn engineers discover 2SuperGen Reports 2007 Fourth Quarter and Annual Financial Results 2SuperGen Reports 2007 Fourth Quarter and Annual Financial Results 3SuperGen Reports 2007 Fourth Quarter and Annual Financial Results 4SuperGen Reports 2007 Fourth Quarter and Annual Financial Results 5SuperGen Reports 2007 Fourth Quarter and Annual Financial Results 6SuperGen Reports 2007 Fourth Quarter and Annual Financial Results 7SuperGen Reports 2007 Fourth Quarter and Annual Financial Results 8SuperGen Reports 2007 Fourth Quarter and Annual Financial Results 9SuperGen Reports 2007 Fourth Quarter and Annual Financial Results 10SuperGen Reports 2007 Fourth Quarter and Annual Financial Results 11SuperGen Reports 2007 Fourth Quarter and Annual Financial Results 12
... Expansion Kit - Neurosphere is a system designed ... expansion as neurospheres in a serum free environment. ... Media Supplement, which has been optimized for neural ... . (1996) Genes & Development 10 :3129). ...
Request Info...
... RQ1 RNase-Free DNase is a ... single-stranded or double-stranded DNA to produce ... for use in applications where maintaining ... RQ1 DNase is qualified for use ...
... Polymerase I catalyzes the template-directed polymerization of ... direction. DNA Polymerase I possesses a 3?5 ... the error rate during DNA replication, and ... enables the enzyme to replace nucleotides in ...
Biology Products: