Navigation Links
Outsmarting the smartie bug

New tools in the fight against pneumococci ?the bugs targeted by vaccines recently announced by the Department of Health ?are described by a team led by scientists from the Wellcome Trust Sanger Institute. They have put together a complete description of the targets of the vaccine that will help monitor the disease and provide new tools for rapid diagnosis.

Pneumococci (formal name Streptococcus pneumoniae) are widespread, causing non-invasive disease, such as ear and sinus infections, and rarer, invasive disease, such as pneumonia and meningitis. About one in three children each year has an ear infection, of which about one-third will be due to the pneumococcus. More significantly, invasive disease is a major cause of death: around 1 million people, mostly young children in developing countries, die each year.

The research, published online today in PLoS Genetics, shows how the target of the vaccines, called the polysaccharide capsule, has evolved and allows the researchers to determine functions of the genes involved. The polysaccharide capsule forms a sugary coat around the bacterium and changing the structure of the capsule can help it to fool our immune defence systems ?like a Smartie changing its colour.

"The bug has a polysaccharide coat which can take any one of 90 different forms, known as serotypes," said Stephen Bentley, leader of the project at the Wellcome Trust Sanger Institute. "The coat is essential for its ability to cause disease and its interaction with our immune system and some serotypes are more likely to be associated with disease."

"The current vaccines provide excellent protection against pneumococcal disease, but only that caused by some of the 90 serotypes, and it is important that we keep a watch on the development of this organism. Our work in describing all known variants will help in that surveillance"

Two vaccines are available. The first, PCV, recognizes seven forms of the capsule and protec
'"/>

Source:Public Library of Science


Page: 1 2 3

Related biology news :

1. New insight into people who see colors in letters and numbers
2. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
3. New insight into regulation of blood stem cells
4. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
5. New insights into how Huntingtons disease attacks the brain
6. Gambling monkeys give insight into neural machinery of risk
7. Structures of marine toxins provide insight into their effectiveness as cancer drugs
8. Flies on speed offer insight into the roles of dopamine in sleep and arousal
9. Grasshopper love songs give insight into sensory tuning
10. Studies on human genome variation provide insight into disease
11. Study provides insight into cellular defenses against genetic mutation
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Outsmarting the smartie bug

(Date:11/4/2014)... of Medicine announced today that it is a ... the Bill & Melinda Gates Foundation. Laura ... Reproductive Sciences; and Vice Chair of Research and ... will pursue an innovative global health and development ... Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) funds individuals ...
(Date:11/4/2014)... VILNIUS, Lithuania , Nov. 4, 2014 /PRNewswire/ ... identification technologies, today announced that the latest version ... place in the Ongoing MINEX evaluation ... interoperability of fingerprint algorithms using the INCITS 378 ... a mandatory requirement in public tenders in ...
(Date:11/2/2014)... month,s issue of Physics World , James Dacey ... "valley of death" to take their innovations from the ... the gruelling challenge facing all start-up companies as they ... physicists because of two main factors: physics-based inventions are ... often turn out to be a lot more complicated ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3The 'valley of death' facing physics start-ups 2
... that some biological structures, like the brain or the ... explain. Biologists have proposed various ways that so-called ,irreducibly ... bit. But a new study proposes an alternative route. ... becoming more intricate, say authors Dan McShea and Wim ...
... Ohio American adults who prepare their own meals and ... on one of those activities at the expense of the ... a 10-minute increase in food preparation time was associated with ... for both men and women. The finding applied to single ...
... helpers (nannies) in a cichlid fish allow the dominant male ... and territory, according to new research published today in ... 30 days which corresponds to one breeding cycle in ... and the University of Bern (Switzerland) studied the investment strategies ...
Cached Biology News:Study proposes alternative way to explain life's complexity 2Study proposes alternative way to explain life's complexity 3Exercise or make dinner? Study finds adults trade one healthy act for another 2Exercise or make dinner? Study finds adults trade one healthy act for another 3
(Date:11/26/2014)...  Roka Bioscience, Inc. (NASDAQ: ROKA ), a ... the detection of foodborne pathogens, today announced that Paul ... th Annual Healthcare Conference on December 2, 2014 at ... York Palace in New York, NY . ... Company, its operations, strategies and prospects may be discussed. To ...
(Date:11/24/2014)... Belgium , Nov. 24, 2014 ... focused on developing diagnostic tests for cancer and other conditions, ... will be presented at the Science for Business BioWin Day ... Belgium . The data come from VolitionRx,s lung cancer ... Pneumology department of the Centre Hospitalier Universitaire (CHU) de Liege ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 Continental ... patient populations into clinical trials at its mid-Atlantic ... , “Continental was created with the idea of ... a fundamental role in medical advances," said Continental's ... syphilis experiment to the immortal cell line of ...
(Date:11/24/2014)... 2014 Senior Vice President, General ... leadership skills, business acumen Elsevier , ... products and services, congratulates Diane Bartoli , Senior ... Workflow, Elsevier Clinical Solutions, for being recognized in the ... Awards issue of Profiles in Diversity Journal ...
Breaking Biology Technology:Roka Bioscience to Present at the Piper Jaffray Healthcare Conference 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3
... and Families, EMERYVILLE, Calif., April 15 ... two new health care areas designed to,soothe patients ... to offer health resources. The Carol Ann,Read Breast ... procedures, all in one location, for the quickest ...
... Able to Detect a Single Cancer Cell Through In Vivo ... ... Caliper Life,Sciences, Inc. (Nasdaq: CALP ) today introduced Bioware(R) Ultra cell ... in vivo imaging applications. Bioware Ultra cell lines are,10 to 100 times ...
... Pittsburgh-based Foundation,Radiology Group (FRG), a full-service ... diagnostic images for hospitals,announced today that James ... the,position of Chief Medical Officer. The appointment ... nationwide network of radiology physician groups to,provide ...
Cached Biology Technology:Alta Bates Summit Medical Center Opens Two Warm, Supportive Patient Centers: Carol Ann Read Breast Health Center and Family Resource Center 2Alta Bates Summit Medical Center Opens Two Warm, Supportive Patient Centers: Carol Ann Read Breast Health Center and Family Resource Center 3Increased Light Leads to Early Detection: Caliper Life Sciences Introduces Bioware(R) Ultra Cancer Cell Lines 2Increased Light Leads to Early Detection: Caliper Life Sciences Introduces Bioware(R) Ultra Cancer Cell Lines 3James W. Backstrom, M.D., Named Chief Medical Officer of Foundation Radiology Group 2James W. Backstrom, M.D., Named Chief Medical Officer of Foundation Radiology Group 3
IHC detection kit for PCNA in cells and tissues...
... Immunogen: Synthetic peptide derived from the ... protein. Specificity: Reacts with the ... Reactivity: Human Mouse (positive controls: WNT1-transfected ... lysates and mouse Mouse-1 cell lysates). ...
The pYES2 vector is designed for native expression of your protein of interest in S. cerevisiae. It contains the URA3 gene for selection in yeast and 2 origin for high-copy maintenance....
... cAMP - [125I] Direct SPA ... SPA.Includes lysis reagents that eliminate lengthy ... cAMP measurement (optional use).Range: 1.32-84.28 ng/ml ... pmol/ml).Overnight protocol.Store at 2-8 C. Category: ...
Biology Products: