Navigation Links
Newly identified protein complex sheds light on axon growth mechanism

New research sheds light on the molecular mechanisms underlying axon growth and synapse formation in the nematode worm C.elegans. In a study published today in the open access journal Journal of Biology, researchers have characterised a new protein, UNC-69, required for proper locomotion . They show that UNC-69 interacts with UNC-76 in a protein complex likely to be involved in the trafficking of vesicles along axons - a process that drives axon growth and helps synapse formation. The research also shows that UNC-69 is directly involved in the formation of new synapses.

A group led by Michael Hengartner, from the University of Zurich in Switzerland, cloned and characterised UNC-69, a previously known protein that had never been characterised. By studying mutants lacking unc-69 they show that the protein is widely expressed in the C.elegans nervous system and is required for normal axon development.

Hengartner and colleagues then show that UNC-69 physically interacts with another protein expressed in the nervous system, UNC-76. Through experiments on double mutant combinations, the authors show that the two proteins cooperate to regulate axon development. The authors also show that UNC-69 is needed for the formation or maintenance of new synapses.

It is known that UNC-76 binds to molecular 'motor' proteins called kinesins that transport vesicles along growing axons. Hengartner and colleagues propose that the UNC-69/UNC-76 complex may be implicated in vesicle trafficking, a process that is necessary for axon growth and new synapse formation.

The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans
Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce Wightman, Mona Spector, David Meili, Nancy Tsung, Christa Rhiner, Dimitris Bourikas, Esther Stoeckli, Gian Garriga, H Robert Horvitz and Michael O Hengartner
Journal of Biolog
'"/>

Source:BioMed Central


Page: 1 2

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Newly Discovered Compound Blocks Known Cancer-Causing Protein
4. Newly discovered pathway might help in design of cancer drugs
5. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
6. Newly discovered protein an important tool for sleeping sickness research
7. Newly discovered genetic disease sheds light on bodys water balance
8. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
9. Newly recognized gene mutation may reduce seeds, resurrect plants
10. Newly discovered birdlike dinosaur is oldest raptor ever found in South America
11. Fitting in: Newly evolved genes adopt a variety of strategies to remain in the gene pool
Post Your Comments:
(Date:10/30/2014)... 2014 Biological membranes are mainly composed of lipid ... solution ions onto lipid membranes helps clarify functional ... provides a quantitative description of the equilibria between ... and Zbigniew Figaszewski from the University of Bialystok, ... these findings, just published in EPJ E ...
(Date:10/29/2014)... to date, researchers have used DNA sequencing to uncover ... Joseph Buxbaum, Ph.D., Icahn School of Medicine at Mount ... of Harvard and MIT, and their colleagues examined more ... unrelated people. They identified changes in 107 genes that ... spectrum disorder (ASD) – a jump from the nine ...
(Date:10/29/2014)... to make their food, but they also need protection from ... a group of molecules in plants that shields them from ... of the American Chemical Society , one team reports on ... Timothy Zwier and colleagues at Purdue University note that the ... serious damage to plant DNA and, as a result, hinder ...
Breaking Biology News(10 mins):Ion adsorption matter in biology 2
... model suggests that inhospitable hydrodgen-sulphide rich waters could have ... oceans. The research, published online this week in the ... the oceans 550-700 million years ago and shows that ... of complex life, were controlled by the biological availability ...
... hybrid nanomaterials, i.e. combinations of synthetic polymers and inorganic (gold, ... at the University of Helsinki in April. Part of ... a billionth of a metre, matter and materials behave in ... known what types of effects the nano version of the ...
... 200-plus research universities that make up ScienceWorksForU.S. today again ... across-the-board cuts to discretionary spending that will result in ... The consequences to the U.S. economy of reduced R&D ... reduction in U.S. GDP over the next nine years ...
Cached Biology News:Toxic oceans may have delayed spread of complex life 2Is nanosilver toxic? 2Is nanosilver toxic? 3Sequester will have a devastating impact on america's research enterprise 2Sequester will have a devastating impact on america's research enterprise 3
(Date:10/27/2014)... 27, 2014 New Q4-2014 incentives ... , an industry leading unified communication and collaboration ... agents to deliver cloud-based audio and web/video conferencing ... , With SoundConnect’s Q4 incentive partners ... and/or web conferencing licenses sold, now through December ...
(Date:10/27/2014)... EASTON, Mass. , Oct. 27, 2014 /PRNewswire/ ... the "Company"), a worldwide leader in the development ... to the life sciences research market, today announced ... team presented a novel, accurate, highly reproducible, and ... time – routine high-throughput protein analysis on small ...
(Date:10/26/2014)... The report "Data Center Networking ... Equipment, WAN Optimization Appliances]: Global Advancements, Worldwide Forecasts ... center networking market into various segments with an ... also identifies the factors driving this market, various ... with the future roadmaps. , Browse 106 market ...
(Date:10/25/2014)... October 23, 2014 ViaDerma, ... pharmaceutical company devoted to bringing new products to ... 2015. , ViaDerma has developed an innovative, patent-pending ... rapid mass transfer of pharmaceutical active ingredients to ... provide immediate localized therapy. The transdermal delivery method ...
Breaking Biology Technology:SoundConnect Unveils Q4 Partner Incentives 2Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 2Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 3Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 4Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 5Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3
... Aug. 1 Medivation, Inc.,(Nasdaq: MDVN ) today ... will present at the BMO Capital Markets 2008 Focus ... Eastern Time at,the Millennium Broadway Hotel in New York., ... and its clinical,development programs for Dimebon for Alzheimer,s and ...
... LITTLE FALLS, N.J., Aug. 1 CANTEL MEDICAL,CORP. ... its Crosstex,International, Inc. subsidiary, effective today. As planned, ... Crosstex, retired effective today,after over 50 years with ... company. Gary Steinberg and Mitchell Steinberg, also,former owners ...
... ROCKVILLE, Md., Aug. 1 Novavax, Inc. (Nasdaq:,NVAX) ... announced,registered direct equity financing of $18 million by ... existing shelf registration statement.,The Company sold 6,686,650 units ... affiliates of the Company. Each unit was comprised,of ...
Cached Biology Technology:Medivation Announces Presentation at the BMO Capital Markets 2008 Focus on Healthcare Conference on August 5 2Cantel Medical Announces Management Succession at Crosstex Healthcare Disposables Subsidiary 2Novavax Announces Closing of $18 Million Registered Direct Offering 2Novavax Announces Closing of $18 Million Registered Direct Offering 3
Polyclonal Antibody to Coronin / CORO1C This antibody was developed against synthetic peptides corresponding to amino acids 407-420 of human CORO1C....
... Tyrosine Hydroxylase (Ser40) Polyclonal Antibody ... against synthetic phosphopeptide corresponding to ... phospho-Ser40 of rat Tyrosine Hydroxylase ... by sequential chromatography on phospho- ...
Monoclonal Antibody to GLP Immunogen: Ni-NTA purified truncated recombinant GLP expressed in E. Coli strain BL21 (DE3)...
Biotin anti-human CD164...
Biology Products: