Navigation Links
Newly identified protein complex sheds light on axon growth mechanism

New research sheds light on the molecular mechanisms underlying axon growth and synapse formation in the nematode worm C.elegans. In a study published today in the open access journal Journal of Biology, researchers have characterised a new protein, UNC-69, required for proper locomotion . They show that UNC-69 interacts with UNC-76 in a protein complex likely to be involved in the trafficking of vesicles along axons - a process that drives axon growth and helps synapse formation. The research also shows that UNC-69 is directly involved in the formation of new synapses.

A group led by Michael Hengartner, from the University of Zurich in Switzerland, cloned and characterised UNC-69, a previously known protein that had never been characterised. By studying mutants lacking unc-69 they show that the protein is widely expressed in the C.elegans nervous system and is required for normal axon development.

Hengartner and colleagues then show that UNC-69 physically interacts with another protein expressed in the nervous system, UNC-76. Through experiments on double mutant combinations, the authors show that the two proteins cooperate to regulate axon development. The authors also show that UNC-69 is needed for the formation or maintenance of new synapses.

It is known that UNC-76 binds to molecular 'motor' proteins called kinesins that transport vesicles along growing axons. Hengartner and colleagues propose that the UNC-69/UNC-76 complex may be implicated in vesicle trafficking, a process that is necessary for axon growth and new synapse formation.

The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans
Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce Wightman, Mona Spector, David Meili, Nancy Tsung, Christa Rhiner, Dimitris Bourikas, Esther Stoeckli, Gian Garriga, H Robert Horvitz and Michael O Hengartner
Journal of Biolog y 2006, 5:9 (25 May 2006)


'"/>

Source:BioMed Central


Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Newly Discovered Compound Blocks Known Cancer-Causing Protein
4. Newly discovered pathway might help in design of cancer drugs
5. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
6. Newly discovered protein an important tool for sleeping sickness research
7. Newly discovered genetic disease sheds light on bodys water balance
8. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
9. Newly recognized gene mutation may reduce seeds, resurrect plants
10. Newly discovered birdlike dinosaur is oldest raptor ever found in South America
11. Fitting in: Newly evolved genes adopt a variety of strategies to remain in the gene pool
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... 2, 2016   The Weather Company , an IBM ... an industry-first capability in which consumers will be able to ... ask questions via voice or text and receive relevant information ... Marketers have long sought an advertising solution that ... be personal, relevant and valuable; and can scale across millions ...
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
(Date:6/23/2016)...  The Biodesign Challenge (BDC), a university competition that ... living systems and biotechnology, announced its winning teams at ... New York City . The teams, ... at MoMA,s Celeste Bartos Theater during the daylong summit. ... curator of architecture and design, and Suzanne Lee ...
(Date:6/23/2016)... 23, 2016 Apellis Pharmaceuticals, Inc. today ... trials of its complement C3 inhibitor, APL-2. The ... ascending dose studies designed to assess the safety, ... injection in healthy adult volunteers. Forty ... a single dose (ranging from 45 to 1,440mg) ...
(Date:6/23/2016)... Pleasant Prairie, WI (PRWEB) , ... June 23, ... ... sciences consultancy focused on quality, regulatory and technical consulting, provides a free ... webinar is presented on July 13, 2016 at 12pm CT at no charge. ...
Breaking Biology Technology: