Navigation Links
Newly identified protein complex sheds light on axon growth mechanism

New research sheds light on the molecular mechanisms underlying axon growth and synapse formation in the nematode worm C.elegans. In a study published today in the open access journal Journal of Biology, researchers have characterised a new protein, UNC-69, required for proper locomotion . They show that UNC-69 interacts with UNC-76 in a protein complex likely to be involved in the trafficking of vesicles along axons - a process that drives axon growth and helps synapse formation. The research also shows that UNC-69 is directly involved in the formation of new synapses.

A group led by Michael Hengartner, from the University of Zurich in Switzerland, cloned and characterised UNC-69, a previously known protein that had never been characterised. By studying mutants lacking unc-69 they show that the protein is widely expressed in the C.elegans nervous system and is required for normal axon development.

Hengartner and colleagues then show that UNC-69 physically interacts with another protein expressed in the nervous system, UNC-76. Through experiments on double mutant combinations, the authors show that the two proteins cooperate to regulate axon development. The authors also show that UNC-69 is needed for the formation or maintenance of new synapses.

It is known that UNC-76 binds to molecular 'motor' proteins called kinesins that transport vesicles along growing axons. Hengartner and colleagues propose that the UNC-69/UNC-76 complex may be implicated in vesicle trafficking, a process that is necessary for axon growth and new synapse formation.

The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans
Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce Wightman, Mona Spector, David Meili, Nancy Tsung, Christa Rhiner, Dimitris Bourikas, Esther Stoeckli, Gian Garriga, H Robert Horvitz and Michael O Hengartner
Journal of Biolog y 2006, 5:9 (25 May 2006)


'"/>

Source:BioMed Central


Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Newly Discovered Compound Blocks Known Cancer-Causing Protein
4. Newly discovered pathway might help in design of cancer drugs
5. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
6. Newly discovered protein an important tool for sleeping sickness research
7. Newly discovered genetic disease sheds light on bodys water balance
8. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
9. Newly recognized gene mutation may reduce seeds, resurrect plants
10. Newly discovered birdlike dinosaur is oldest raptor ever found in South America
11. Fitting in: Newly evolved genes adopt a variety of strategies to remain in the gene pool
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... 30, 2017  On April 6-7, 2017, Sequencing.com will ... hackathon at Microsoft,s headquarters in ... focus on developing health and wellness apps that provide ... the Genome is the first hackathon for personal ... largest companies in the genomics, tech and health industries ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
Breaking Biology News(10 mins):
(Date:6/27/2017)... ... 2017 , ... The recent vote by the American Medication Association to align ... to patients and hopefully sheds new light on the way health insurers, governments and ... and founding partner of Texas Fertility Center . , “This designation is ...
(Date:6/27/2017)... ... 27, 2017 , ... According to a recent report from ... not have negative short- or long-term effects on benthic communities. , The ... located at the Puget Sound Naval Shipyard & Intermediate Maintenance Facility in Bremerton, ...
(Date:6/26/2017)... ... June 26, 2017 , ... NDA Partners Chairman Carl ... Product Development R&D at Allergan and CMC expert with more than twenty-five years ... biopharma companies, has joined the firm as an Expert Consultant. , ...
(Date:6/26/2017)... ... June 26, 2017 , ... Two new members were elected to ... June 9, 2017: Jeremy Nowak, President, J Nowak Strategy and Michele Masucci, Ph.D., Vice ... election of Glen N. Gaulton and Kenneth L. Kring, and re-election of David P. ...
Breaking Biology Technology: