Navigation Links
Newly Discovered Compound Blocks Known Cancer-Causing Protein

Duke Comprehensive Cancer Center scientists have discovered a potential new drug that inhibits destructive cell signals that drive the growth of one-third of all cancers. The scientists showed they could block the growth of cultured colon cancer cells using this new compound, called cysmethynil.

Their finding, reported in the March 22, 2005, issue of Proceedings of the National Academy of Sciences, is the first step toward developing a new class of anti-cancer drugs that block the Icmt protein from activating uncontrolled cell growth, a hallmark of cancer, according to Patrick Casey, Ph.D. Casey is the study's senior investigator and Duke pharmacologist and cancer biologist.

Moreover, said Casey, their discovery is the first to emerge from the Duke Small Molecule Screening Facility, which houses a library of more than 13,000 compounds available for screening promising drugs with potential to fight cancer and other diseases. Using automated robotics, the facility provides the kind of drug discovery capability usually available only to pharmaceutical company scientists.

Duke's new facility is a finalist for one of six $9 million National Institutes of Health (NIH) grants that will create a national network of publicly accessible small molecule facilities and make them available to researchers nationwide.

Duke University has filed a patent application for cysmethynil, Casey said, and intends to shepherd it through the first steps of drug development by testing the compound in animal models of cancer.

The research was supported by grant from the NIH and a Howard Hughes Medical Institute predoctoral fellowship to Casey graduate student Ann M. Winter-Vann, the first author of the study.

"This is the first selective small molecule inhibitor of Icmt, a protein that has been shown to be an important player in keeping a cancer-causing gene called 'Ras' turned on inside cells," said Casey.

Ras is a normal genetic component
'"/>

Source:DukeMedNews


Page: 1 2 3

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Newly discovered pathway might help in design of cancer drugs
4. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
5. Newly discovered protein an important tool for sleeping sickness research
6. Newly discovered genetic disease sheds light on bodys water balance
7. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
8. Newly recognized gene mutation may reduce seeds, resurrect plants
9. Newly discovered birdlike dinosaur is oldest raptor ever found in South America
10. Fitting in: Newly evolved genes adopt a variety of strategies to remain in the gene pool
11. Newly identified mechanism helps explain why people of African descent are more vulnerable to TB
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Newly Discovered Compound Blocks Known Cancer Causing Protein

(Date:5/6/2015)... 6, 2015 LifeBEAM, a developer of bio-sensing ... announced today that they will expand their partnership in ... bio-sensing cycling helmet and the first joint project between ... colors in order to give cyclists more style choices ... LifeBEAM and Lazer announced their plan to release a ...
(Date:4/27/2015)... , Apr. 27, 2015 Profile Solutions, Inc. ... and security systems is pleased to announce that Dr ... a consultant and member of its scientific advisory board. ... known as a thought leader in technology-enhanced learning models. ... Group, and has published studies and books focused on ...
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... The European eel is on the way to disappearing for ... scientific arguments for suspending all fishing. Despite this situation, Swedish ... management plan by the Swedish Institute for the Marine Environment ... the target that has been set for silver eels capable ...
... the German government to phase out nuclear power by 2022 ... than Germany or Japan, which is still coming to terms ... issue, published by the SETAC journal Environmental Toxicology and ... effects of radiation, using research from the Chernobyl disaster. ...
... a critical part of a human cell,s control system that is ... sensor known as the "gating ring" can open a channel that ... membrane similar to the way a subway turnstile allows people ... in the regulation of crucial bodily activities like blood pressure, insulin ...
Cached Biology News:Will the eel survive its management? 2UCLA scientists identify how major biological sensor in the body works 2UCLA scientists identify how major biological sensor in the body works 3
(Date:5/29/2015)... , May 28, 2015 Research ... addition of Jain PharmaBiotech,s new report "Cytogenetics ... offering. This report deals with cytogenetics ... use mainly to describe the chromosome structure and ... of molecular biology, it is also referred to ...
(Date:5/28/2015)... , May 28, 2015 ... announced the addition of Jain PharmaBiotech,s new ... and Companies"  to their offering.  ... remains a challenge in management. With nearly ... the seven major markets of the world ...
(Date:5/28/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/l9dqwt/animal_genetics ) has announced the ... by Testing services - Global Forecast to 2020" ... genetics market is estimated to be worth around $2.5 ... 8-9% during the forecast period of 2014 to 2020 ... animal protein consumption, increasing adoption of advanced genetic technologies ...
(Date:5/28/2015)... 2015 Natera, Inc., a leader in ... in Ultrasound in Obstetrics & Gynecology ... prenatal test (NIPT) can identify a complete molar ... A study based upon data collected in the ... about 1 in 1,000 pregnancies, although other studies ...
Breaking Biology Technology:Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 2Global Cytogenetics Market Report 2015-2024 - Technologies, Markets and Companies 3Global Alzheimer Disease Report 2015-2024 - New Drugs, Markets and Companies 2Global Alzheimer Disease Report 2015-2024 - New Drugs, Markets and Companies 3Global Animal Genetics (Canine, Equine, Poultry, Porcine, Bovine, and Genetic Material) Market 2015 - Global Forecast to 2020 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 3
... HOUSTON, Feb. 5 In a paper published in the ... Norman L. Sussman, Brendan M. McGuire and James H. Kelly ... device. "There are currently three times as many patients on ... available and few ways to stabilize them if they enter ...
... Feb. 4 /PRNewswire-Asia-FirstCall/ -- BMP Sunstone,Corporation (Nasdaq: BJGP ... will attend the 2009 UBS Global Healthcare Services,Conference, which will ... to 11th. , Management is currently ... 2009, and hold one-on-one meetings the same day. , ...
... U.S. with New Facility and Personnel Additions to Better ... - As part of an ongoing initiative to expand ... has significantly bolstered its data management resources with the ... larger office space, which will be directed by new ...
Cached Biology Technology:Stem Cell Innovations' PluriCells(TM) to Form the Basis of a Liver Assist Device to Support Patients Waiting for Transplant. 2Stem Cell Innovations' PluriCells(TM) to Form the Basis of a Liver Assist Device to Support Patients Waiting for Transplant. 3BMP Sunstone to Present at UBS Global Healthcare Services Conference 2New General Manager, Transition to New Raleigh Offices Highlight Datatrial's Expansion of North American Operations 2
Yeast tRNA 50 l...
...
... Low volume pipetting is increasingly ... volumes in DNA sequencing and other ... with performance and precision unparalleled in ... documented confirmation of all aspirated,and dispensed ...
... allow for the rapid isolation of DNA from ... slice in the spin filter, centrifuge for 3 ... recovered. There is no need to melt agarose ... can also be used for buffer exchange, primer ...
Biology Products: