Navigation Links
New insight into regulation of blood stem cells

Scientists have made a significant advance toward understanding the regulation of blood stem cells and the complex, lifelong process of blood cell formation. A research study published in the February issue of Developmental Cell expands on previous studies by using adult animals to examine the role of a key gene known to be required for blood cell formation. Information gained from this research will be useful for future studies aimed at directing stem cell differentiation in a variety of potential therapeutic contexts.

Blood cell formation, known as hematopoiesis, begins with a hematopoietic stem cell (HSC), which can either "self-renew" and make more copies of itself or differentiate into either red blood cells, various types of white blood cells, or platelets. The genes that control proliferation and differentiation have been difficult to study using traditional gene disruption methods because loss of genes thought to be critical for this process often results in embryonic death, making it impossible to study the role of the gene of interest in mature animals.

Dr. Michael P. Cooke and colleagues from the Genomics Institute of the Novartis Research Foundation in San Diego found a way around this problem. The researchers used random mutagenesis and screening to find animals with hematopoiesis defects, and they used genetics to identify the causative gene. One line mapped to a mutation in the gene c-Myb, which has a known role in regulation of blood formation.

Interestingly, they found that c-Myb is not required for every step of hematopoiesis or for every type of blood cell. Instead, c-Myb is critical for very distinct steps in the formation of specific types of blood cells. Most surprisingly, the c-Myb mutants also had a dramatic increase in the total number of HSCs, suggesting that part of the normal function of c-Myb is to hold HSC multiplication in check.

These data suggest that c-Myb is a key regulator of hematopoiesis and acts a
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. New insight into people who see colors in letters and numbers
2. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
3. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
4. New insights into how Huntingtons disease attacks the brain
5. Gambling monkeys give insight into neural machinery of risk
6. Structures of marine toxins provide insight into their effectiveness as cancer drugs
7. Flies on speed offer insight into the roles of dopamine in sleep and arousal
8. Grasshopper love songs give insight into sensory tuning
9. Studies on human genome variation provide insight into disease
10. Study provides insight into cellular defenses against genetic mutation
11. New insights into the software of life
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New insight into regulation blood stem cells

(Date:10/29/2014)... their types and numbers of bugs and bacteria ... the difference between a closed case and an ... a more than $866,000 U.S. Department of Justice ... changing populations. The microbial communities may provide crucial ... race, socioeconomic relations and more, said Eric Benbow, ...
(Date:10/29/2014)... as ,facultative, form part—together with other cells—of tissues and ... from the others. However, they have a very special ... cells again. This phenomenon is something that happens in ... tissue growth, thus allowing the regeneration of the organ ... the underlying mechanism that allows these cells to retain ...
(Date:10/29/2014)... October 27, 2014 — Cambridge, MA and Hebei, China ... the complete, high quality sequencing of the Jujube genome. ... Rhamnaceae family, and the Jujube genome is particularly difficult ... other complicating factors. It is the first time that ... sequenced. This study has been recently published in ...
Breaking Biology News(10 mins):MSU partners with Detroit to investigate death scenes 2A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2BGI Tech and Hebei Agricultural University complete the genome sequencing of the jujube tree 2
... [Brown University] In India most people who are HIV ... cheap and available. It would therefore meet international standards of ... to test every person in the billion-plus population every five ... PLoS One . The findings are based on ...
... meet June 16-19, 2013 at the Best Western Ramkota Rapid ... as the Entomological Society of America,s North Central Branch holds ... , Forests pests, such as the mountain pine ... pests such as the western corn rootworm, the soybean aphid, ...
... genome consortium, consisted of scientists from China Agricultural University, ... the genome sequencing and analysis of the duck ( ... A viruses, which caused a new epidemic in China ... and provides an invaluable resource for unraveling the interactive ...
Cached Biology News:Cost-effective: Universal HIV testing in India 2Cost-effective: Universal HIV testing in India 3Cost-effective: Universal HIV testing in India 4The duck genome provides new insight into fighting bird flu 2
(Date:10/27/2014)... October 27, 2014 The report ... Intelligent Traffic Management, Communication, Monitoring), and by Display ... to 2019” segments the global market into various ... It also identifies the drivers and restraints for ... challenges. , Browse 75 market tables and 37 ...
(Date:10/27/2014)... Pa. , Oct. 27, 2014 ... Foundation of America (CCFA) announced today the launch ... , an educational campaign designed to ... diseases (IBD) on the paired role of nutrition ... To view the multimedia assets associated with this ...
(Date:10/26/2014)... (PRWEB) October 26, 2014 The ... Routers, ADC, Network Security Equipment, WAN Optimization Appliances]: ... and segments the data center networking market into ... of revenues. The report also identifies the factors ... opportunities impacting it along with the future roadmaps. ...
(Date:10/25/2014)... 25, 2014 The report “Adipic ... by Geography - Global Trends & Forecast to ... respect to market drivers, opportunities, and trends in ... and 27 figures spread through 217 slides and ... Trends & Forecast to 2019”., http://www.marketsandmarkets.com/Market-Reports/adipic-acid-269.html , ...
Breaking Biology Technology:Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 2Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 3Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 4
... March 5 AcroMetrix, a global leader ... and serological,diagnostics, announced today that it has ... for the development and supply of molecular ... AcroMetrix provides In Vitro Diagnostic manufacturers and ...
... NeoStem, Inc. (Amex: NBS ),which is pioneering ... cells for future medical need, today announced that,Denis Rodgerson, ... The University of Nevada Las Vegas campus this evening. ... of adult stem,cell collection centers into Las Vegas, the ...
... industry insiders respectively serve, pressing industry needs to ... ... WASHINGTON, March 5 Logos Press announces two new ... education. These new books respectively serve,pressing needs to empower ...
Cached Biology Technology:AcroMetrix Signs Development and Supply Agreement With Beckman Coulter Inc. for Molecular Quality Control Standards 2NeoStem's Denis Rodgerson, Ph.D. to Lecture on Stem Cells and Regenerative Medicine at University of Nevada Las Vegas Campus 2NeoStem's Denis Rodgerson, Ph.D. to Lecture on Stem Cells and Regenerative Medicine at University of Nevada Las Vegas Campus 3New Books on Best Practices in Biotechnology Business Development and Biotechnology Education 2
...
Jak3 Antibody Ship: Hot Store: -20 C...
WASF2 Immunogen: WASF2 (NP_008921, 73 a.a. ~ 173 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Applications: Western blotting Stability: Room temperature, indefinitely ...
Biology Products: