Navigation Links
New insight into regulation of blood stem cells

Scientists have made a significant advance toward understanding the regulation of blood stem cells and the complex, lifelong process of blood cell formation. A research study published in the February issue of Developmental Cell expands on previous studies by using adult animals to examine the role of a key gene known to be required for blood cell formation. Information gained from this research will be useful for future studies aimed at directing stem cell differentiation in a variety of potential therapeutic contexts.

Blood cell formation, known as hematopoiesis, begins with a hematopoietic stem cell (HSC), which can either "self-renew" and make more copies of itself or differentiate into either red blood cells, various types of white blood cells, or platelets. The genes that control proliferation and differentiation have been difficult to study using traditional gene disruption methods because loss of genes thought to be critical for this process often results in embryonic death, making it impossible to study the role of the gene of interest in mature animals.

Dr. Michael P. Cooke and colleagues from the Genomics Institute of the Novartis Research Foundation in San Diego found a way around this problem. The researchers used random mutagenesis and screening to find animals with hematopoiesis defects, and they used genetics to identify the causative gene. One line mapped to a mutation in the gene c-Myb, which has a known role in regulation of blood formation.

Interestingly, they found that c-Myb is not required for every step of hematopoiesis or for every type of blood cell. Instead, c-Myb is critical for very distinct steps in the formation of specific types of blood cells. Most surprisingly, the c-Myb mutants also had a dramatic increase in the total number of HSCs, suggesting that part of the normal function of c-Myb is to hold HSC multiplication in check.

These data suggest that c-Myb is a key regulator of hematopoiesis and acts a
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. New insight into people who see colors in letters and numbers
2. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
3. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
4. New insights into how Huntingtons disease attacks the brain
5. Gambling monkeys give insight into neural machinery of risk
6. Structures of marine toxins provide insight into their effectiveness as cancer drugs
7. Flies on speed offer insight into the roles of dopamine in sleep and arousal
8. Grasshopper love songs give insight into sensory tuning
9. Studies on human genome variation provide insight into disease
10. Study provides insight into cellular defenses against genetic mutation
11. New insights into the software of life
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New insight into regulation blood stem cells

(Date:8/24/2015)... 2015 The consulting company Frost & ... manufacturer DERMALOG and its customized solutions and products for ... of the Year Award". DERMALOG is particularly successful with a ... -Cross reference: Picture is available at AP Images ... On Thursday evening, in South Africa,s ...
(Date:8/20/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market and creator of the ... Card Alliance and the EMV Migration Forum.  ... Card Alliance Latin America (SCALA) Chapter provides NXT-ID, Inc. ... leaders promoting adoption of smart card technology. ...
(Date:8/17/2015)... OXFORD, Conn. , Aug. 17, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... announces its new sales campaign for Q4 2015. The ... winning marketing team consisting of Amplitude Marketing Group ( ... Amplitude Marketing Group is a leader in retail driven ...
Breaking Biology News(10 mins):Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3
... fond of talking about it as are politicians, economists ... The problem is that the term sustainability can refer ... at the Technische Universitaet Muenchen have shed light on ... science they have managed to give the term "sustainability" ...
... School of Medicine found that women may have a slightly higher ... acute coronary syndrome (ACS), but that these differences appear to be ... study, published in the August 26, 2009 issue of the ... however that overall there was no significant difference in mortality observed ...
... use wireless sensors, which can monitor chemical processes or ... wireless network. Still, many facilities that could benefit ... use a wired network instead, because the reliability, speed ... do not meet their needs. The U.S. ...
Cached Biology News:New tools for sustainable farming 2New tools for sustainable farming 3Study finds women slightly more likely to die than men in the 30 days following a heart attack 2SRNL, automakers to develop high-performance wireless sensors networks 2SRNL, automakers to develop high-performance wireless sensors networks 3
(Date:8/26/2015)... 26, 2015  Platform therapeutic company Symic Biomedical, ... a $1.5M Phase II SBIR grant from the ... its therapeutic agent to reduce arteriovenous fistula (AVF) ... stage renal disease (ESRD) patients undergoing hemodialysis. The ... Diabetes and Digestive and Kidney Diseases (NIDDK), will ...
(Date:8/26/2015)... BEIJING , August 26, 2015 Israel ... DiaCardio wins 1 st place  Wayerz comes ... in Israel by venture capital fund JVP, ... including the US, China , Israel ... America .  Impressive achievement for the Israeli representatives ...
(Date:8/26/2015)... 26, 2015 After litigating and negotiating ... relating to P2i United States patent ... in the United States without any ... of either party. As a result of the parties, settlement, ... California dismissed the case without prejudice. ...
(Date:8/26/2015)... ... August 26, 2015 , ... PRC Clinical, a Clinical Trial ... with local sponsors in southern California. The Clinical Trial Management Expert CRO seeks to ... regulatory pathways., , Stem Cell Meeting on the Mesa ...
Breaking Biology Technology:Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 2Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 5Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 6P2i Settles United States Litigation 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3
... In an address to,shareholders at the company,s ... ) Chairman and CEO David B. Snow Jr. ... designed to deliver strong,continuing earnings growth through 2008 ... specialty pharmacy to retaining and winning,customers, and advanced ...
... May 22 /PRNewswire-FirstCall/ - In accordance with the,terms ... Inc.,"Atrium" (TSX: ATB) today announced that it has ... Chemicals division for total proceeds of,US$166.4 million in ... is now a health and nutrition pure-play and ...
... CT Injection System Technology Detects Extravasations during CT ... ... MEDRAD, INC., announced today,that its XDS(TM) Extravasation Detector has ... a technology that aids in the,detection of leaking intravenous contrast ...
Cached Biology Technology:Medco CEO to Shareholders: Delivering Results, Driving Shareholder Value 2Medco CEO to Shareholders: Delivering Results, Driving Shareholder Value 3Medco CEO to Shareholders: Delivering Results, Driving Shareholder Value 4MEDRAD(R) XDS(TM) Extravasation Detector Wins Medical Design Excellence Award 2MEDRAD(R) XDS(TM) Extravasation Detector Wins Medical Design Excellence Award 3
...
2ndGen Predilute antibody for staining tissue sections. Optimized for use with Zymeds Histostain-PLUS, NBA, HistoST5050, and Cap-Plus IHC Kits.Labeling: ASR...
... degradation of single-stranded DNA and RNA endonucleolytically ... nuclease prefers ssDNA over dsDNA by 30,000-fold, ... double-stranded DNA from both ends (1,2). Mung ... mapping studies (3,4), for flushing staggered ends ...
Endomorphin-2. Cross reactivity: Endomorphin-1 3%, Met-enkephalin <0.03%, Leu-enkephalin <0.01% and beta-Endorphin <0.01%....
Biology Products: