Navigation Links
New RNAi tools enable systematic studies of gene function

An international public-private research team led by scientists at the Broad Institute of MIT and Harvard announced today the construction and availability of an extensive library of molecular reagents to silence most human and mouse genes.

As described in the March 24 issue of Cell, this library consists of small RNA molecules that can switch off genes individually, allowing the user to dissect the genetic underpinnings of normal biology and disease. These RNA-interference (RNAi)-based gene inhibitors are packaged in lentiviruses, enabling their use in virtually all types of human and mouse cells. This work springs from the RNAi Consortium (TRC), a unique collaboration among academic research institutions and leading life science companies with the mission to build comprehensive RNAi libraries and make them available to scientists worldwide.

"Switching off a single gene through RNAi reveals how that gene functions in a particular biological process. When RNAi's potential is applied to thousands of genes ?as it has been in fruit flies and nematodes ?it can provide a more complete picture of that process," said David Root, a senior author of the Cell paper and the director of TRC and the RNAi platform at the Broad Institute. "Thanks to this unique public-private effort, we now have new tools to enable the entire research community to realize the potential of RNAi in the two most important species in biomedicine."

"The RNAi library developed by TRC is a rich resource for biological discovery," said Nir Hacohen, assistant professor at Massachusetts General Hospital and Harvard Medical School, associate member of the Broad Institute and a senior author. "Ongoing studies in my own laboratory to understand how the immune system senses pathogens and appropriately targets its response will be accelerated using these tools."

RNAi gives scientists the ability to turn off an individual gene. Its workhorses are small RNA molecules, each of which i
'"/>

Source:Broad Institute of MIT and Harvard


Page: 1 2 3

Related biology news :

1. Improved statistical tools reveal many linked loci
2. Virginia Tech group adds tools to DNA-targeted anti-cancer drugs
3. New tools used to control foodborne hepatitis A outbreaks related to green onions
4. MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools
5. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
6. Discovery of new molecular tools for biosynthesis could lead to advances in use of pectin
7. Recycled paper and compost could both be key tools to control plant disease
8. Nanotech tools yield DNA transcription breakthrough
9. Molecular tools make the cut
10. Chimpanzees found to use tools to hunt mammalian prey
11. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New RNAi tools enable systematic studies gene function

(Date:4/15/2014)... nanoparticle form could help reduce side effects by targeting ... scientists have developed nanoparticles that deliver one or two ... design particles that can carry any more than that ... devised a new way to build such nanoparticles, making ... drugs. In a paper published in the Journal ...
(Date:4/15/2014)... in the Congo Basin to increase by 0.7 ... greenhouse gases by half, according to a study ... , Explosive population growth and inefficient agricultural practices ... Central Africa. A team of researchers from the ... affect longer-term temperatures in the region. Using a ...
(Date:4/15/2014)... systems soon could be powering the forklifts used in ... with faster refueling times than ever before, courtesy of ... Carriers (HHC). , The goal of the project is ... refuel at low pressure four to five times faster ... hydrogen a competitive advantage over batteries for a big ...
Breaking Biology News(10 mins):Targeting cancer with a triple threat 2Targeting cancer with a triple threat 3Study: Deforestation could intensify climate change in Congo Basin by half 2Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 2Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 3Low-cost, hydrogen-powered forklifts with rapid refueling, zero emissions coming soon 4
... may have more in common than previously thought. At ... Bejan and Penn State biologist James Marden. What they ... systems from animal locomotion to the formation of river ... Flows evolve to reduce friction or other forms of resistance, ...
... dismaying reports that a promising antitumor drug could, in theory, ... Japanese team of researchers that suggests a potentially better option. ... Journal of Experimental Medicine (online April 27). ... new blood vessels that feed growing tumors. Agents that block ...
... Each year, the Entomological Society of America (ESA) features ... are a lively question-and-answer, college bowl-style competition on ... an important and entertaining component of the ESA Annual ... five regional Branches will compete in the national competition ...
Cached Biology News:Unifying the animate and the inanimate designs of nature 2A longer lasting tumor blocker 2Entomological Society of America's Linnaean Games teams selected 2
(Date:1/15/2014)... More than 5 million Americans are ... 3 seniors will die with Alzheimer’s or another dementia, ... have shocked many Americans into looking for ways to ... tragic age-related cognitive disorders. Jonathan Weisman, president of Biohack ... others achieve true cognitive enhancement. Now, he is sharing ...
(Date:1/15/2014)... CA (PRWEB) January 15, 2014 ... high throughput research solutions, today announced that Lupin ... has received delivery of Freeslate’s CM Protégé ... screening. , Lupin, headquartered in Mumbai, India, ... affordable generic and branded formulations and Active Pharmaceutical ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine ... cells grown under simulated embryonic conditions, today announced ... agreement with Suneva Medical, Inc. for physician-dispensed aesthetic ... (CCM). , This agreement is an ... Suneva Medical, through which Suneva has exclusively licensed ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014 ... together with two institutes from the National Institutes ... reliable tools for bringing safer, more effective treatments ... collaborating with the National Center for Advancing Translational ... to develop better and more clinically predictive tissue ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... nanotubes as the critical component of a robust terahertz ... and communication devices, sensors and non-invasive medical imaging systems ... systems. The polarizer developed by the Rice lab ... engineering and of physics and astronomy, is the most ...
... (OTCBB: SNGX) (Soligenix or the Company), a development stage ... Amendment to its Amended and Restated Certificate of Incorporation ... stock which will take effect tomorrow morning. ... an opportune time to effect a reverse stock split," ...
...  bioTheranostics, Inc., a bioMerieux company that develops innovative ... introduced a new product line of high medical ... called PRECIS Precision Medicine by bioTheranostics(SM). Precision medicine, ... diagnosis of primary tumor site and predictive biomarkers ...
Cached Biology Technology:Research at Rice University leads to nanotube-based device for communication, security, sensing 2Research at Rice University leads to nanotube-based device for communication, security, sensing 3Soligenix Announces 1 for 20 Reverse-Split of its Common Stock 2Soligenix Announces 1 for 20 Reverse-Split of its Common Stock 3Soligenix Announces 1 for 20 Reverse-Split of its Common Stock 4bioTheranostics Launches Precision Medicine Biomarkers for Tumor Pathway Interrogation 2bioTheranostics Launches Precision Medicine Biomarkers for Tumor Pathway Interrogation 3
... Fluoroskan Ascent FL ... fluorometric and luminometric measurement ... long list of advanced ... and Luminoskan Ascent. Fluoroskan ...
Mouse monoclonal [AZ24] to Polo like kinase ( Abpromise for all tested applications)....
... Roche Applied Science, which pioneered the blending ... High Fidelity and Expand Long Template PCR ... PCR System the first product of ... This new blend combines Taq DNA Polymerase ...
... 13 5'G AATTC3' 3'CTTAA G5' Inactivation Conditions: Heat ... precipitation. Storage Conditions: 10mM Tris-HCl (pH 7.5), 100mM ... 0.01% BSA, 50% glycerol. Shipping and Storage: Shipped ... One unit is defined as the amount of ...
Biology Products: