Navigation Links
NYU study reveals how brain's immune system fights viral encephalitis

New York University biologists have uncovered how the innate immune system in mice's brains fights viral infection of neurons. The findings, published as the cover study in the latest issue of Virology, show that proteins in neurons fight the virus at multiple stages--by preventing the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brain.

"There is no magic bullet in fighting viral infections in neurons," said NYU Biology Professor Carol Shoshkes Reiss, the study's senior author. "However, these findings show the redundancy of the immune system--when one response fails to fight infection, others step in."

The study was also conducted at NYU, by a post-doctoral fellow, Mark Trottier, Jr., PhD, now at Michigan State, and Beth Palian, currently a doctoral student at the University of Southern California.

Recently, the West Nile virus has been responsible for a viral encephalitis outbreak in the northeast. The NYU researchers set out to determine how the body can fight viral encephalitis. Specifically, they examined how type I interferons--proteins made by the body that are released in response to stimuli, notably infection--work in neurons and to determine if nerve cells' response to interferons is similar to that of other cells.

Examining the effect of the virus in mice and in cell culture, the researchers found that neurons are sensitive to the protective effect of interferons, inducing pathways to fight the virus' spread. However, their findings showed that interferons fight the virus at different stages of the virus' life cycle. First, they inhibit viral RNA and protein synthesis. If this fails, interferons block the virus from forming particles which can be released and infect other neurons. This is critical, since the immune system does not kill infected precious neurons the way it does other cells, which can be replaced.

The researchers attributed the spread of vi
'"/>

Source:New York University


Page: 1 2

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: NYU study reveals how brain immune system fights viral encephalitis

(Date:5/17/2013)... for Experimental Biology (FASEB) released a new analysis ... highlighting the devastating impact of sequestration on the nation,s ... a May 15th Senate Appropriations Committee hearing featuring NIH ... $1.6 billion cut the agency sustained in FY 2013 ... the scientific community." , According to data from ...
(Date:5/16/2013)... HOUSTON African-American adults living closer to a fast ... than those who lived further away from fast food, ... Anderson Cancer Center, and this association was particularly strong ... new study published online in the American Journal ... residential proximity to a fast food restaurant, and among ...
(Date:5/16/2013)... May 16, 2013 The relationship between the ... has not been clear. Schizophrenia is commonly associated ... There are clues that reduced IQ may be ... example, reduced cognitive ability may precede the onset ... present in healthy relatives of people diagnosed with ...
Breaking Biology News(10 mins):Body mass index of low income African-Americans linked to proximity of fast food restaurants 2Body mass index of low income African-Americans linked to proximity of fast food restaurants 3Genetic risk for schizophrenia is connected to reduced IQ 2
... groundbreaking environmental study to be published in a prestigious ... end up in fish in as little as three ... Canada, played a key role in designing and carrying ... mercury emissions from coal-fired power plants and other industrial ...
... WEST LAFAYETTE, Ind. -- Biologists have determined the three-dimensional ... in the assembly of new viruses. The Paramecium ... transferring its DNA into host cells. Once inside the ... which is needed to produce structural proteins that are ...
... mining evidence from the classic films made by Mitchell ... suffered something of a setback in Victorian England, at ... times, lefties, numbers quickly rose again, the researchers report ... of Cell Press. , "Left-handedness is important because ...
Cached Biology News:Scientists learn structure of enzyme in unusual virus 2Films of Mitchell and Kenyon illuminate lefties' decline in Victorian England 2
(Date:5/17/2013)... MIAMI , May 17, 2013  Insero Health, ... medical needs in epilepsy and related neurological disorders, is ... of its lead compound INS001 in patients with drug-resistant ... Drug and Device Trials (AED) Xll meeting by Dr. ... epileptologist and Chairman of Insero,s Scientific Advisory Board.  In ...
(Date:5/17/2013)... May 17, 2013 Rust removal is one ... non-metal home items could be damaged. To help rust contractors ... of its no-scrubbing rust remover it called Rusterizer. ... available with 10% discount. , My Cleaning Products explained that ... them or by staining them. The first one, it ...
(Date:5/16/2013)... 2013 ISPE announced ... CAE, to the newly created position of Vice ... Myers will be responsible for stimulating ISPE’s revenue ... advancing the Society’s Member-led and staff-driven business model, ... refine organizational, membership and product marketing. , “Barbara ...
(Date:5/16/2013)... (PRWEB) May 16, 2013 Cambridge Healthtech ... from August 19-23, 2013 at the Renaissance Waterfront Hotel ... Summit provide a close-up look at the current strategies ... ensuring bottom-line quality. Leaders in the field will ... to produce biopharmaceuticals with greater specificity and efficiency. , ...
Breaking Biology Technology:Insero Health Reports Positive Data on Phase I Trial of Novel Therapy for Drug-resistant Epilepsy 2Organic-Based Rust Remover Cuts Down Price by 10%, My Cleaning Products Details Mechanics How to Get the Discount 2ISPE Names Barbara A. Myers, CAE, as Vice President of Professional Development 2The 2013 Bioprocessing Summit to Bring Together International Leaders to Discuss Today's Bioprocess Issues From Cell Line Selection to Manufacturing in Boston, MA 2
... as 1 cell , Karen Dolter Jeff ... microprep kit provides a,convenient method for isolating total RNA ... bound to a solid support, which eliminates the,need for ... quality, with no detectable DNA contamination and is suitable ...
... transduction pathway of your choice , ... Cloning Systems, Inc. , The PathDetect in ... for assessing the in vivo activation of ... a unique fusion trans-activator,plasmid that expresses pathway-specific ...
... , Eagle Eye Optical Filter Optimized for ... A new optical filter has been developed for the Eagle ... increases contrast and sensitivity when imaging,silver-stained protein gels. , The ... currently sold with an optical filter optimized for imaging nucleic ...
Cached Biology Technology:Fast Isolation of Total RNA from Small Numbers of Cells 2Fast Isolation of Total RNA from Small Numbers of Cells 3Fast Isolation of Total RNA from Small Numbers of Cells 4Fast Isolation of Total RNA from Small Numbers of Cells 5Fast Isolation of Total RNA from Small Numbers of Cells 6New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 2New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 3New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 4New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 5New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 6Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 2Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 3
SHEEP ANTI HUMAN CATHEPSIN G...
...
Human Aminopeptidase P1/XPNPEP1 Affinity Purified PAb Protein Family: Aminopeptidases, Metalloproteases...
streptavidin, Alexa Fluor® 750–allophycocyanin conjugate (Alexa Fluor® 750–allophycocyanin streptavidin) *1 mg/mL*...
Biology Products: