Navigation Links
NYU biologists map out early stages of embryo formation

A team of genomic researchers headed by biologists at New York University's Center for Comparative Functional Genomics, in collaboration with researchers at Harvard University, the Max Planck Institute, and Cenix Biosciences, has mapped out a preliminary molecular diagram of the early stages of embryo formation, offering for the first time a global look at how a single cell begins its path into a multi-cellular organism. The findings are reported in the August 11 issue of the journal Nature.

The team is studying the function of the genome of Caenorhabditis elegans (C. elegans), the first animal species whose genome was completely sequenced and a model organism to study how embryos develop.

With the complete genome sequence of C. elegans, the researchers sought to comprehend how the parts encoded by the genome are used to build complex dynamical biological systems--in this case, an engineering diagram for embryo formation. Using a new way to combine results from different functional genomic approaches including RNA interference (RNAi), a method for studying the function of genes in vivo, the researchers were able to develop a first-draft diagram for the early embryo at the molecular level, describing how its components fit together both physically and logically.

"These results point to a high level of coordination among a relatively small number of molecular machines required for proper early embryonic development in C. elegans," said Fabio Piano, an assistant professor in NYU's Department of Biology, who headed the research team. "This may also be the case for human embryogenesis. The diagrams linking all these genes reveal discrete patterns of interconnections, allowing us to begin to visualize the molecular network underlying a complex process like early embryogenesis as a whole."

These analyses suggest that out of the almost 20,000 genes in C. elegans, the embryo requires a core set of less than 1,000 genes to coordinate the early e vents that guide the development of the animal. The results further suggest specific roles for new genes that had not been studied before, and functional tests of a subset of these supported the predictions.

Describing how embryos function at the molecular level may help understand how human embryos develop, and may also provide new insights for cancer research since genes acting in early embryogenesis are often erroneously reactivated in cancer cells.

The research is the latest in a series of studies conducted at NYU's Center for Comparative Functional Genomics in collaboration with researchers at Harvard and Yale Universities, which set the stage for these most recent findings. An essential aspect of these studies was the coordination between experts in cell and molecular biology and those with computational and mathematical backgrounds.


'"/>

Source:New York University


Related biology news :

1. Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
2. GeneNotes - A novel information management software for biologists
3. FSU biologists describe key role of signal-transcribing gene during cell cycle
4. High-tech tags on marine animals yield valuable data for biologists and oceanographers
5. UCSD biologists find new evidence for one-way evolution
6. UC San Diego biologists solve plant growth hormone enigma
7. FSU biologists uncover mechanisms that shape cells for better or worse
8. NYU biologists identify gene that coordinates two cellular processes
9. MIT biologists solve vitamin puzzle
10. Yale biologists trick viruses into extinction
11. Brown cancer biologists identify major player in cell growth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... 27, 2016 Research and ... Biometrics Market 2016-2020"  report to their offering.  , ... The analysts forecast the global multimodal biometrics ... during the period 2016-2020.  Multimodal biometrics ... such as the healthcare, BFSI, transportation, automotive, and ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... 2016 , ... A compact PET scanner called NuPET™ has ... Resonance Imaging) in existing third-party MRI systems. PET and MRI are complementary imaging ... Simultaneous PET/MRI imaging offers a solution to many challenges that face researchers who ...
(Date:4/27/2016)... , April 27, 2016 MedDay, ... disorders, today announces the appointment of Catherine Moukheibir as Chairman ... MedDay,s previous Chairman, Jean Jacques Garaud , who contributed ... change is effective immediately. Catherine started her career ... and London .  She held ...
(Date:4/26/2016)... ... April 26, 2016 , ... BaseHealth , the comprehensive ... company as Chief Business Officer. Arianpour, a genomics pioneer and visionary commercial leader ... most recently Chief Commercial Officer of Pathway Genomics. He has held senior executive ...
(Date:4/26/2016)... ... April 26, 2016 , ... Mr. Palmer created the ... signing the first multi-million dollar, multi-year managed services contract in the U.S. intelligence community ... join our leadership team,” said John Younger, founder of Accolo. “We are growing ...
Breaking Biology Technology: