Navigation Links
Mutant mouse provides insights into breast cancer

By discovering a mutant mouse that is highly susceptible to mammary tumors, Cornell researchers have found a novel potential link between genetic defects in DNA replication (copying) and breast cancer.

The mouse contains a mutation in a gene essential for replicating DNA in both humans and mice that increases the rate of flawed copies of genetic material, leading to mouse breast cancers.

In a paper published in Nature Genetics online (and upcoming in the Dec. 27 print issue), the Cornell geneticists report that by extensively testing hundreds of mice pedigrees, they found a mutant line of mice called Chaos3 that had a 20-fold increase in a hallmark for cancer called genomic instability -- a blanket term for an elevation in the number of mutations, chromosomal aberrations or loss of integrity of genetic information that occur when DNA replicates. While the Chaos3 mice appear normal in every way, the females are highly predisposed to mammary tumors.

"It's known that most cancers, by the time you look at them, have genomic instability in some form or another," said John Schimenti, a genetics professor in Cornell's Departments of Biomedical Sciences, and Molecular Biology and Genetics and the paper's senior author. "Our research demonstrated that genomic instability is probably leading to these cancers."

Schimenti and colleagues found that in the Chaos3 mice, the DNA codings in a gene called Mcm4 were partially impaired. The Mcm4 gene is one of six related Mcm genes that play essential roles in replication and were originally discovered at Cornell in baker's yeast (S. cerevisiae). The genes have remained largely unchanged throughout evolution and are evident in archaebacteria, yeast, mammals and more. It is unknown why the impaired Mcm4 genes in the Chaos3 mice led exclusively to breast cancer, Schimenti said.

Mcm4 is essential for DNA replication and thus cell growth, according to Schimenti. Partially impaired Mcm4 gene
'"/>

Source:Cornell University News Service


Page: 1 2

Related biology news :

1. Mutant mice show key autism traits
2. Mutant gene causes severe kidney disease in infants
3. Man and mouse share genome structures
4. Genome-wide mouse study yields link to human leukemia
5. Report that delayed motherhood decreases life expectancy of mouse offspring
6. Agilent Technologies introduces advanced zebrafish, mouse microarrays for stem cell and developmental biology research
7. Stem cells in bone marrow replenish mouse ovaries
8. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
9. Researchers extend mouse lifespan by protecting against free radicals
10. Gene therapy advance treats hemophilia in mouse models
11. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mutant mouse provides insights into breast cancer

(Date:10/2/2014)... CARTES SECURE CONNEXIONS 2014 Conference: A Step Ahead ... SECURE CONNEXIONS 2014 is being held at Paris Nord ... This 29 th  international meeting for the digital security ... together the global community of a constantly evolving sector. ... will set the pace for the event.   ...
(Date:10/1/2014)... discovered a new form of non-genetic inheritance, showing for ... previous sexual partner in flies at least., This ... Greek times, but was discredited in the early 20th ... out, UNSW Australia scientists Dr Angela Crean, Professor Russell ... male flies and studied their offspring., They found that ...
(Date:10/1/2014)... , Finnland, October 1, 2014 /PRNewswire/ ... Durchbruch im Bereich der Biowissenschaften   ... ein Kommen und Gehen zahlreicher Detektionstechnologien. Einige ... zum goldenen Standard. Die Photonen-Upconversion ist eine ... letzten Jahren mit Begeisterung aufgenommen wurde. Jetzt ...
Breaking Biology News(10 mins):CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 2CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 3CARTES SECURE CONNEXIONS - Conferences & Speakers 2014 4Semen secrets: How a previous sexual partner can influence another male's offspring 2Innovative Verwendungslösung für die Photonen-Upconversion 2Innovative Verwendungslösung für die Photonen-Upconversion 3
... ease the antibiotic drought, scientists in Massachusetts are describing ... in efforts to discover badly needed new antibiotics. Their ... monthly journal. Frederick Ausubel and colleagues note ... germ-fighting drugs involve adding the potential drug to cultures ...
... Pa., Aug. 4 ComCam International, Inc. (Pink Sheets: CMCJ), ... and services, today announced that it has been selected by ... integration for a Maritime Domain Awareness and Seaport security project. ... stated, "Our two companies have worked informally for about a ...
... paint has been restricted in the United States since ... in major countries from three continents there is still ... to sell consumer paints that contain dangerous levels of ... PhD, and his team have found that approximately 73 ...
Cached Biology News:ComCam Selected by ePortation on New Maritime Domain Awareness Project 2Lead-based consumer paint remains a global public health threat 2Lead-based consumer paint remains a global public health threat 3
(Date:10/2/2014)... (PRWEB) October 02, 2014 ... throughput research solutions for biopharmaceutical development, today announced ... - 24, 2014 at GlaxoSmithKline (GSK) in Ware, ... discussions of best practices in high throughput research ... R&D leaders gathered together to discuss the challenges ...
(Date:10/2/2014)... 02, 2014 At a time when many ... has introduced a new kind of squeeze aimed at ... the Scienceware® Squeeze Rite™ Wash Bottle , catalog no. ... within the bottle reduces the waste of reagents, solutions and ... liquids. , “Easier to squeeze when compared to standard 500ml ...
(Date:10/2/2014)... 2, 2014 SIRO Clinpharm, an ... at the prestigious Annual Conference of the Society for ... Vegas , where they were invited to speak ... like ,data analytics to support fraud detection, ,clinical data ... ,benefits of working together as virtual and integrated teams,. ...
(Date:10/1/2014)... Switzerland (PRWEB) October 01, 2014 ... the quality of the final product. However, while ... regulated, regulatory frameworks such as Good Manufacturing Practices ... the responsibility of the manufacturer to interpret these ... consistent weighing performance quality. METTLER TOLEDO experts have ...
Breaking Biology Technology:Freeslate European Summit Highlights Best Practices in High Throughput Research and Data Management 2New Wash Bottle Reduces Waste of Reagents, Solutions, and Other Liquids 2SIRO Clinpharm Showcases Biometrics Capabilities at the SCDM 2014 Annual Conference in Las Vegas 2Comply with Weighing-Related Regulations in Pharma Manufacturing 2
... Senesco Technologies , Inc. ("Senesco" or the "Company") (NYSE ... 2009, the Company entered into a definitive purchase agreement with Partlet ... 1,111,111 shares of its common stock (the "Shares") at a price ... up to 1,000,000 shares of common stock, which warrants are exercisable ...
... its discovery just a few years ago, graphene has ... super-materials poised to transform the electronics and nanotechnology landscape. ... of Arizona State University explains, this two dimensional honeycomb ... Its unusual properties make it ideal for applications that ...
... , KENILWORTH, N.J., July 9 Schering-Plough Corporation ... Schering-Plough K.K., the company,s country operation in Japan, ... mg Tablets for the treatment of major depressive ... Seika Kabushiki Kaisha, Ltd. Schering-Plough and Meiji Seika ...
Cached Biology Technology:Senesco Technologies Enters Into Agreement For Up To $1.0 Million In Financing 2Senesco Technologies Enters Into Agreement For Up To $1.0 Million In Financing 3Senesco Technologies Enters Into Agreement For Up To $1.0 Million In Financing 4Material world: Graphene's versatility promises new applications 2Material world: Graphene's versatility promises new applications 3Material world: Graphene's versatility promises new applications 4REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 2REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 3REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 4REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients 5
... of Class II Biological Safety Cabinets ... to the world's highest safety standards. ... cabinets cannot be adjusted out of ... noise and arm rest ensure safety ...
... The Holten MaxiSafe 2010 Class II ... ergonomical working condition of comfort while ... efficiency and performance.,Refined operator, environment and ... both exhausted and recirculated air.,Bottom filters ...
... is designed for paramagnetic bead precipitation from ... PCR plates with no additional accessories. The ... a standard SBS 96-well microplate footprint. The ... guarantees easy and fast (as little as ...
... Minidizer is a personal desktop unit ideal for ... requirements. , Rotation speed set at 12 ... 80o C , Bottle capacity of four ... 15 ml conical ,plastic bottles , Consistent, ...
Biology Products: