Navigation Links
More evidence mammals, fruit flies share make-up on function of biological clocks

A study by researchers at New York University and the University of London offers additional evidence that mammals and fruit flies share a common genetic makeup that determines the function of their internal biological clocks.

The research team consisted of post-doctoral researcher Ben Collins, Esteban Mazzoni, a graduate student, and Assistant Professor Justin Blau of NYU's Department of Biology and Professor Ralf Stanewsky of the University of London.

Drosophila fruit flies are commonly used for research on biological, or circadian, clocks because of the relative ease of finding mutants with non-24-hour rhythms and then identifying the genes underlying the altered behavior. These studies in fruit flies have allowed the identification of similar "clock genes" in mammals, which function in a similar manner in mammals as they do in a fly's clock. However, prior to this study, biologists had concluded that the role of one protein--Cryptochrome (Cry)--was quite different between flies and mammals. In fruit flies, Cry is a circadian photoreceptor, which helps light reset the biological clock with changing seasons, or in jet lag-style experiments (in which light is manipulated to mimic the experience of traveling over multiple time zones) in the lab. In mammals, however, Cry assists in the 24-hour rhythmic expression of clock genes and has nothing to do with re-setting the clock.

The researchers sought to determine additional roles for Cry in fruit flies by testing the rhythmic expression of clock genes in flies with either a mutant version of Cry, or with Cry produced at artificially high levels. In both cases, they found that the clock had stopped ?with high levels of clock gene expression when Cry was mutated, and low levels when Cry was over-produced. These results indicated that Cry normally inhibits clock gene expression in many clock cells ?just as it does in the mammalian clock.

"In addition to finding a new function for Cryptoc
'"/>

Source:New York University


Page: 1 2

Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. Light therapy may combat fungal infections, new evidence suggests
3. Researchers find first evidence of venom system in extinct mammal
4. Scientists find evidence of catastrophic sand avalanches, sea level changes in Gulf of Mexico
5. Oldest dated evidence of cattle in southern Africa found
6. SLU researchers uncover direct evidence on how HIV invades healthy cells
7. Same-sex mating by fungi spawned infection outbreak, evidence suggests
8. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
9. Why we give: New study finds evidence of generosity among our early human ancestors
10. New evidence supports century-old theory of cancer spread
11. New evidence questions the simple link between prion proteins and madcow disease
Post Your Comments:
(Date:7/31/2015)... de 2015 A 10 a. Conferência ... pela BGI de 22-25 de outubro de 2015, em ... conferência está celebrando seu 10 o. aniversário este ano. ... uma das reuniões mais influentes do mundo no ramo ... entusiastas e prazerosos. A ICG-10 se ...
(Date:7/31/2015)... , 31. Juli 2015 Die 10. internationale Konferenz ... BGI veranstaltet und findet vom 22. bis 25. ... , statt. Die Konferenz feiert ... Start 2006 ist die ICG weltweit zu einem ... Sie ist eines der dynamischsten, enthusiastischsten und angenehmsten ...
(Date:7/30/2015)... Calif. , July 30, 2015 ... services for gene function analysis and biomarker discovery, ... RNA (sgRNA) Knockout Library targeting all human protein ... and permanently "knock out" a gene,s function. Cellecta,s ... a high throughput screening tool so that researchers ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2
... been introducing exotic species into natural environments in ... meet less indispensable purposes such as horticulture, fishing ... always adapted for hosting new arrivals. Past introduction ... Australia or brown fario trout into Southern hemisphere ...
... a major reproduction site for leatherback turtles. This sea ... activity: it ingests plastics, get accidentally caught in fishing ... hunted illegally for their meat and their eggs. Female ... three years to lay their eggs. What happens in ...
... subtext of a novel, the human genome sequence harbors ... A, C, T and G. Since DNA is a ... sequences among individuals also holds clues to ancestry. ... variations to diseases are very common nowadays. But a ...
Cached Biology News:Conservation of freshwater fish biodiversity: a challenge for the countries of the South 2Conservation of freshwater fish biodiversity: a challenge for the countries of the South 3Isotope analysis reveals foraging area dichotomy for Atlantic leatherback turtles 2Multi-institutional study identifies new form of inherited risk of cancer 2
(Date:8/26/2015)... , Aug. 26, 2015  Platform therapeutic company ... has received a $1.5M Phase II SBIR grant ... further develop its therapeutic agent to reduce arteriovenous ... in end stage renal disease (ESRD) patients undergoing ... Institute of Diabetes and Digestive and Kidney Diseases ...
(Date:8/26/2015)... England , August 26, 2015 ... Ltd against Europlasma NV relating to P2i United ... have resolved their dispute in the United States ... liability on the part of either party. As a result ... Central District of California dismissed the ...
(Date:8/25/2015)...   WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... company serving the pharmaceutical, biotechnology, and medical device industries, ... Exchange Stock Code: 0950), a research-based biopharmaceutical company headquartered ... years of operations in China , ... agreement whereby WuXi,s Laboratory Testing Division (LTD) will be ...
(Date:8/25/2015)... ... August 25, 2015 , ... One of the world’s foremost authorities ... Corp., Bindiya Vakil, has been on a mission for the past two weeks. She’s ... chain operations - from the two massive explosions that occurred on August 12 at ...
Breaking Biology Technology:Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 2Symic Biomedical Awarded $1.5MM NIH Phase II SBIR Grant to Develop its Proteoglycan Mimetic Therapeutics to Reduce Vascular Access Failures in ESRD 3P2i Settles United States Litigation 2WuXi PharmaTech to Be Exclusive Supplier of Laboratory Testing Services to Lee's Pharm 2WuXi PharmaTech to Be Exclusive Supplier of Laboratory Testing Services to Lee's Pharm 3Resilinc Supply Chain Expert Warns: Impact of Tianjin Chemical Explosions Will be Far Worse than Reported 2Resilinc Supply Chain Expert Warns: Impact of Tianjin Chemical Explosions Will be Far Worse than Reported 3Resilinc Supply Chain Expert Warns: Impact of Tianjin Chemical Explosions Will be Far Worse than Reported 4
... today can recount the extraordinary struggles that Drs. Patrick Steptoe ... for Medicine or Physiology, confronted when they defied much of ... the 1970s. Now, Dr. Joseph D. Schulman, the only American ... the development of IVF, has written a new book, " ...
... The American Society for Cell Biology, in collaboration with ... today announce the launch of The Cell: An Image ... Society for Cell Biology. In 2009 the ASCB was ... of Health,s (NIH) Grand Opportunities program to build a ...
... December 9, 2010 Scientists from Pacific Biosciences ... have successfully employed single molecule, real-time (SMRT) DNA sequencing ... recent deadly cholera epidemic in Haiti. Published Thursday ... the results provide the first whole genome sequence analysis ...
Cached Biology Technology:Nobel Prize Winner Robert Edwards: A Personal Memoir by the Only American Physician to Participate in Developing IVF 2ASCB Launches The Cell: An Image Library(TM) to Inspire Discovery and Improve Human Health 2ASCB Launches The Cell: An Image Library(TM) to Inspire Discovery and Improve Human Health 3Pacific Biosciences and Harvard scientists decode genome of Haitian cholera pathogen 2Pacific Biosciences and Harvard scientists decode genome of Haitian cholera pathogen 3
... monoclonal [E12] to MAP1 Light Chain MAP1A ... physical interactions between microtubules and components of the ... heavy chain subunit and multiple light chain subunits. ... of the light chain subunits and can associate ...
Image Acquisition and documentation system for fluorescent and non-fluorescent gels, membranes, blots, film, plates and assays...
PC based system for advanced chemifluorescent, chemiluminescent, fluorescent and colorimetric, microarray and microscope imaging and analysis....
... features a 4.1 mega pixel digital color ... TLC color images., The cabinet features ... longwave UV tubes positioned on two sides ... fluorescence studies , Interior overhead white ...
Biology Products: