Navigation Links
Molecule by molecule, new assay shows real-time gene activity

Editor: Have a look at the videos: 1 & 2

Chemists at Harvard University have developed the first technique providing a real-time, molecule-by-molecule "movie" of protein production in live cells. Their direct observation of fluorescently tagged molecules in single cells -- providing striking real-time footage of the birth of individual new protein molecules inside -- greatly increases scientists' precision in probing genetic activity.

Using the new assay, described this week in the journal Science, researchers led by Harvard's X. Sunney Xie counted, one by one, protein molecules generated in small bursts within cells as multiple ribosomes bound to single copies of mRNA complete the process by which DNA, an organism's long-term genetic repository, yields its crop of proteins. These random, or stochastic, bursts of protein expression are described in detail in a separate paper Xie and colleagues present this week in Nature.

"Although central to life processes, the expression of many important genes takes place at very low levels, making it difficult or impossible to observe using current technologies," says Xie, professor of chemistry and chemical biology in Harvard's Faculty of Arts and Sciences. "Our experiments provide the most sensitive means to date of observing real-time activity of single molecules inside cells. This new technique could provide us with unprecedented insights into gene expression and many other fundamental biological processes in living cells." The central dogma of molecular biology holds that DNA is transcribed into mRNA, which is then translated into proteins. But several technical hurdles have hampered study of these key processes. Researchers' current understanding of this two-step pathway is built upon their averaging of genetic and biochemical activity across large populations of ce
'"/>

Source:Harvard University


Page: 1 2 3

Related biology news :

1. DNA Molecules Used To Assemble Nanoparticles
2. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
3. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
4. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
5. Touching Molecules With Your Bare Hands
6. Team Invents Device For Weighing Individual Molecules
7. Missing Receptor Molecule Causes Tumor Growth
8. Molecule does more than slice and dice RNA
9. Molecules in blood foretell development of preeclampsia
10. Molecule that destroys bone also protects it, new research shows
11. PCRM develops worlds first cruelty-free insulin assay
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Molecule molecule new assay shows real time gene activity

(Date:8/4/2015)... , Aug. 04, 2015 ... http://www.researchandmarkets.com/research/nvh7k2/digital_forensics ) has announced the addition of ... (Hardware, Software, and Service), Sub-Segment (Computer Forensics, ... Forensics), Tool Types, Service, Vertical and Region ... to their offering. By Component ...
(Date:7/31/2015)... , Kina, 31. juli 2015 Den ... bliver afholdt af BGI fra den 22. - 25. oktober ... Konferencen fejrer sin 10-års fødselsdag i år. Siden ... mest indflydelsesrige årlige møder på ,omik,-feltet, og er en ... ICG-10 fokuserer på nylige gennembrud og ...
(Date:7/31/2015)... 31 juillet 2015 La 10e Conférence ... sera organisée par le BGI du 22 au ... en Chine. La conférence célèbre ... en 2006, l,ICG est devenue l,une des réunions ... des « omiques » et c,est aussi la plus dynamique, ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3
... may be associated with more advanced physical disability and ... by neurologists at the University at Buffalo have shown. ... Neurology meeting, held earlier this month, indicated that:, ... insufficient vitamin D levels. , Clinical evaluation and ...
... N.Y. Changing the hue of hospital gowns and bed ... a physician,s ability to detect cyanosis and other health-related skin ... Institute. "If a doctor sees a patient, and then ... or no idea whether the patient,s skin has changed color," ...
... Forget what you know about how diseases are diagnosednew ... FASEB Journal ( http://www.fasebj.org ) details a noninvasive ... stages before symptoms can be seen using traditional methods. Even ... early that they may be reversed before any permanent damage ...
Cached Biology News:Low vitamin D levels are related to ms brain atrophy, cognitive function, studies show 2Nude-colored hospital gowns could help doctors better detect hard-to-see symptoms 2New tool helps scientists 'see' molecular signals of eye disease before symptoms arise 2
(Date:8/28/2015)... ... August 28, 2015 , ... ... presented two studies at the International Spine Intervention Society’ s 23rd ... through to August 1st, 2015. With a focus on evidence-based research and clinical ...
(Date:8/28/2015)... ... , ... Since the initial launch of FireflySci Inc. (FFS) in early 2015, the company continues ... Images such as the Fonz in a lab coat and Large Marge have been posted ... field. , FireflySci is proud to be the only cuvette manufacturer is the ...
(Date:8/27/2015)... /PRNewswire/ - Portage Biotech Inc. ("Portage") (OTC Market: ... Holding Company Limited (Biohaven), announced today that dosing ... BHV-0223, a glutamate modulating agent. Biohaven filed an ... obtained clearance from the U.S. Food and Drug ... holds 54% equity interest in Biohaven, a private ...
(Date:8/27/2015)... Aug. 27, 2015 HUYA Bioscience International (HUYA) today ... the Japan Society of HTLV-1, held this week at ... purpose of the Society is to promote research on ... of medical technology and research related to these fields ... "HUYA is proud to support this prestigious conference," ...
Breaking Biology Technology:Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4
... that it intends to release the results of its ... approximately 4:00 p.m. Eastern,Time (ET). Following the release, at ... discuss the results of its first quarter of fiscal ... one hour in,duration. The conference call will also be ...
... JobLoft.com, a leading online job,board that lists ... on,geographic proximity, announced today the expansion of ... acquisition of RegionalHelpWanted.com by,its parent company, onTargetjobs. ... 350 geographically focused,Internet job boards, JobLoft.com now ...
... - Company Establishes U.S. subsidiary in Philadelphia Area ... a leader in in,vivo cellular imaging, announced today ... Inc. is the U.S. subsidiary of Paris-based Mauna,Kea ... new,endoscopic imaging approach which improves patient care by ...
Cached Biology Technology:Martek to Announce First Quarter 2008 Results on March 5, 2008 2JobLoft.com Strengthens Local Market Candidate Reach Through RegionalHelpWanted.com Acquisition 2Chris Tihansky Appointed President of In Vivo Cellular Imaging Leader Cellvizio Inc. 2