Navigation Links
Mobile DNA part of evolution's toolbox

. The coelacanth is a descendant of the ancient marine organism that gave rise to the terrestrial vertebrates more than 360 million years ago. Humans are therefore separated from the coelacanth by hundreds of millions of years of evolution, yet the two organisms still share critical DNA sequences.

In the coelacanth, the ultraconserved segments were produced by a retroposon known as a short interspersed repetitive element, or SINE, which is a piece of DNA that can make copies of itself and insert those copies elsewhere in an organism's genome. Haussler and his colleagues called this SINE the LF-SINE, where LF stands for lobe-finned fishes--the group of fishes that gave rise to both the coelacanth and terrestrial vertebrates.

The LF-SINE was very active in the evolutionary lineage leading to the terrestrial vertebrates, but much less active after animals moved onto land. Humans have 245 recognizable copies of the LF-SINE, most or all of which probably were in place before the origins of the mammals. But in the lineage leading to the coelacanth, the LF-SINE remained active, so that the coelacanth genome is now estimated to contain hundreds of thousands of copies of the sequence.

The close copies of the ultraconserved element scattered around vertebrate genomes have changed less than would be expected over evolutionary time, indicating that they are functionally important. But relatively few of the copies contain parts that code for proteins, which suggests they instead are helping to regulate when genes are turned on and off. Furthermore, when Bejerano analyzed the locations of the copies, he found that they tended to be near genes that control the development of the brain.

Haussler and his colleagues then looked at a particular example -- a copy of the ultraconserved element that is near a gene called Islet 1 (ISL1). ISL1 produces a protein that helps control the growth and differentiation of motor neurons. In the laboratory
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Mobile phone use not linked to increased risk of glioma brain tumours
2. On a flys wing, scientists tally evolutions winners and losses
3. Taking evolutions temperature: Researchers pinpoint the energy it takes to make a species
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mobile DNA part evolution toolbox

(Date:10/17/2014)... Copenhagen have shown for the first time how bacteria ... patients, giving them the opportunity to get tremendous insights ... The study also discovered the bacterial growth in chronic ... or slowed down by the immune cells. The researchers ... helped "suffocate" the bacteria, forcing the bacteria to switch ...
(Date:10/16/2014)... Melbourne researchers have challenged conventional thinking on how the ... new mechanism for how bowel cancer starts. , The ... maintaining and regenerating the ,crypts, that are a feature ... are involved in bowel cancer development, a controversial finding ... existence. , Using 3D imaging technologies, Dr Chin Wee ...
(Date:10/15/2014)... WASHINGTON, N.Y. , Oct. 15, 2014 /PRNewswire/ ... technology solutions for home and community-based care, today ... benefits of implementing Sandata,s Santrax® Electronic Visit Verification™ ... Care Services is a home health company founded ... Texas . The ...
Breaking Biology News(10 mins):Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2Cryptic clues drive new theory of bowel cancer development 2Sandata Announces Case Study with Quality Care Services, Inc. 2
... cells grow fast. That,s an essential characteristic of what makes ... and are continuously growing and dividing, far outstripping our normal ... metabolism. CSHL Professor Adrian Krainer and his team ... process and in the process specifically kill cancer cells. ...
... at the University of Liverpool have found that, like ... that describes multiple health issues that occur in the ... condition occurs when a number of health problems, such ... together, with the potential to increase the risk of ...
... The UK Government has recently imposed a ban on importing ... fungal disease Chalara, which kills the trees and has entered ... researchers argue that the nursery trade, horticultural stakeholders and the ... risks to tree health posed by imported plant pathogens. They ...
Cached Biology News:Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells 2Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells 3Obese dogs at risk of health condition experienced by humans 2Action needed to prevent more devastating tree diseases entering the UK 2
(Date:10/20/2014)... The report “Pharmacy Automation Systems Market ... Labeling Systems, Table-top Counters) by End-user (Inpatient Pharmacy ... Trends to 2019” analyzes and studies the major ... Europe, Asia-Pacific, and the Rest of the World ... figures spread through 300 pages and in-depth TOC ...
(Date:10/20/2014)... , October 20, 2014 , ... (GI) disorders and the delivery of care has revealed ... and worrying inequalities in the provision of healthcare services ... was commissioned by United European Gastroenterology (UEG), have been ... and public awareness of the burden of GI disorders ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Local veterinary ... in an investigational study of donor stem cells for ... stem cell therapy and has performed clinical stem cell ... study is to determine if a single injection of ... joints can help reduce pain and inflammation in the ...
(Date:10/19/2014)... The Asian Automatic patient billing report ... and forecast of revenue. The Automatic patient billing market ... million by 2018, at a developing CAGR of 7.2% ... of the Asian Automatic patient billing market, to get ... provides a glimpse of the segmentation of this market ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... ... of surrogacy. West Coast Surrogacy, Inc. founder/director Amy Kaplan, an expert in reproductive ... carrier. , ... December 29, 2009 -- Children – they’re everywhere, especially during the holidays. A chubby ...
... , , , , , , , ... provider of biopharmaceutical products in China, announced today,that it has filed ... a human clinical trial for its vaccine,against human enterovirus 71 (EV ... first clinical trial application for HFMD vaccine,submitted in China. , ...
... , TSX symbol: SBS , CALGARY, ... an update today on its progress on plant-produced Apo ... between Pfizer Inc. and The Medicines Company, of Parsippany, ... exclusive rights to Pfizer,s Apo AI(Milano) program is a ...
Cached Biology Technology:Is Your New Year's Resolution to Overcome Infertility and Create a Family? A Reputable Surrogacy Agency Can Make 2010 Your Year 2Is Your New Year's Resolution to Overcome Infertility and Create a Family? A Reputable Surrogacy Agency Can Make 2010 Your Year 3Is Your New Year's Resolution to Overcome Infertility and Create a Family? A Reputable Surrogacy Agency Can Make 2010 Your Year 4Is Your New Year's Resolution to Overcome Infertility and Create a Family? A Reputable Surrogacy Agency Can Make 2010 Your Year 5Sinovac Files Clinical Trial Application with SFDA for Vaccine Against Hand, Foot, and Mouth Disease 2Sinovac Files Clinical Trial Application with SFDA for Vaccine Against Hand, Foot, and Mouth Disease 3Sinovac Files Clinical Trial Application with SFDA for Vaccine Against Hand, Foot, and Mouth Disease 4SemBioSys updates progress on Apo AI(Milano) 2SemBioSys updates progress on Apo AI(Milano) 3
... Immunogen: Synthetic peptide derived from the ... 36 protein This peptide sequence is ... another Zymed polyclonal Connexin 36 antibody Cat. ... Connexin 36. Reactivity: Mouse (positive control: ...
Invitrogen's Calcium Phosphate Transfection Kit provides high-quality reagents to enable the introduction of DNA into tissue culture cells via calcium phosphate co-precipitation....
...
...
Biology Products: