Navigation Links
Mobile DNA part of evolution's toolbox

. The coelacanth is a descendant of the ancient marine organism that gave rise to the terrestrial vertebrates more than 360 million years ago. Humans are therefore separated from the coelacanth by hundreds of millions of years of evolution, yet the two organisms still share critical DNA sequences.

In the coelacanth, the ultraconserved segments were produced by a retroposon known as a short interspersed repetitive element, or SINE, which is a piece of DNA that can make copies of itself and insert those copies elsewhere in an organism's genome. Haussler and his colleagues called this SINE the LF-SINE, where LF stands for lobe-finned fishes--the group of fishes that gave rise to both the coelacanth and terrestrial vertebrates.

The LF-SINE was very active in the evolutionary lineage leading to the terrestrial vertebrates, but much less active after animals moved onto land. Humans have 245 recognizable copies of the LF-SINE, most or all of which probably were in place before the origins of the mammals. But in the lineage leading to the coelacanth, the LF-SINE remained active, so that the coelacanth genome is now estimated to contain hundreds of thousands of copies of the sequence.

The close copies of the ultraconserved element scattered around vertebrate genomes have changed less than would be expected over evolutionary time, indicating that they are functionally important. But relatively few of the copies contain parts that code for proteins, which suggests they instead are helping to regulate when genes are turned on and off. Furthermore, when Bejerano analyzed the locations of the copies, he found that they tended to be near genes that control the development of the brain.

Haussler and his colleagues then looked at a particular example -- a copy of the ultraconserved element that is near a gene called Islet 1 (ISL1). ISL1 produces a protein that helps control the growth and differentiation of motor neurons. In the laboratory
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Mobile phone use not linked to increased risk of glioma brain tumours
2. On a flys wing, scientists tally evolutions winners and losses
3. Taking evolutions temperature: Researchers pinpoint the energy it takes to make a species
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mobile DNA part evolution toolbox

(Date:4/17/2014)... West Orange, NJ. April 16, 2014. Kessler Foundation ... for $1.8 million from the Department of Defense ... PhD, is principal investigator for the randomized, double-blinded, ... to improve bone and muscle strength after spinal ... Human Performance & Engineering Research at Kessler Foundation. ...
(Date:4/17/2014)... per eight hundred births, Down syndrome - or trisomy ... intellectual disability. It results from a chromosomal abnormality where ... chromosome 21 (1% of the human genome). A study ... Department of Genetic Medicine and Development at the University ... Nature , shed light on how the extra chromosome ...
(Date:4/17/2014)... One day about eight years ago, Katia Silvera , ... her father were on a field trip in a mountainous ... they had never seen before. , Unable to identify it, ... The orchid turned out to be an unnamed species. So ... . , "Lophiaris" is the genus name, comprising about 40 ...
Breaking Biology News(10 mins):Kessler Foundation awarded Department of Defense grant for spinal cord injury research 2Trisomy 21: How an extra little chromosome throws the entire genome off balance 2Trisomy 21: How an extra little chromosome throws the entire genome off balance 3Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3
... emission of greenhouse gases over the next several decades ... a study by UC Merced marine biologist Michael Beman. ... the burning of fossil fuels and other human activities ... study shows that the increased acidity will fundamentally alter ...
... 2010)The New York Stem Cell Foundation (NYSCF) extends congratulations to ... NYSCF-Robertson Investigators, who was named one of Time Magazine,s 2010 ... the Year Issue. Dr. Rossi, an Assistant Professor of ... of an innovative method for reprogramming skin cells back into ...
... State University professor is part of a national research ... times more greenhouse gas emissions than estimated by the ... on the Konza Prairie Biological Station and other local ... demonstrate that nitrous oxide emissions from rivers and streams ...
Cached Biology News:Rising greenhouse gases profoundly impact microscopic marine life 2Time Magazine names Derrick Rossi to 2010 list of 'People Who Mattered' 2Dodds contributes to new national study on nitrogen water pollution 2
(Date:1/15/2014)... Calif. (PRWEB) January 15, 2014 Cynvenio, ... and management through the genomic analysis of tumor cells ... Therapy Finder™, a web-based cancer decision support application powered ... option with Cynvenio’s ClearID™ genomic test, Therapy Finder will ...
(Date:1/15/2014)... , January 15, 2014 A study has ... on the Formula 1 track could help to tackle the ... Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) and ... provider Simplyhealth. Telemetry technology, which is inspired by ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased to ... Science organizations who need document translations. Clients will now ... documents in advance with a selection of nearly 50 life ... a critical factor in clinical and scientific fields, and decrease ...
(Date:1/15/2014)... Biotechnology Company, Limited ("TaiGen") today announced that they have ... pharmaceutical company, to develop and commercialize nemonoxacin (Taigexyn ® ... Turkey and other members of ... for the treatment of bacterial infections including those caused ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... Antwerp, Belgium October 8, 2010 VIB researchers at ... an important role in the development of Hereditary Sensory and ... rare genetic disorder of the peripheral nervous system. Identification of ... the disease in patients as well as improved genetic counseling ...
... taken the first step to building a computer capable of ... sunny side of the planet Mercury. Te-Hao Lee, Swarup Bhunia ... of circuits - that can take twice the heat that ... Science last month. The engineers took their cue from ...
... Biocept, Inc. ("Biocept"), an emerging leader in biotechnology, announced today ... "We are pleased to welcome Bruce to our Board. ... into our next stage of development," said Stephen M. Coutts, ... practicing Certified Public Accountant since 1986.  He is also a ...
Cached Biology Technology:HSAN 1: Identification of new mutations, more accurate diagnosis and improved genetic counseling 2New computer switches handle heat that renders transistors useless 2
... Biochem/physiol Actions: Glutathione-S-transferases (GSTs) are a group ... many xenobiotics in mammals. The enzymes ... thiol group of the glutathione to electrophilic ... mutagenic, carcinogenic, and toxic effects of the ...
... Anti-GSTM1 Monoclonal Antibody Epitope: ... [Schistosoma japonicum]. Recommended Storage: ... Aliquot contents and freeze at -20 C ... of freezing and thawing. Centrifuge product if ...
... National Instruments PCIe-1429 is the industrys first ... PCIe-1429, you now can acquire images at ... available for Camera Link cameras to perform ... and image acquisition, fault analysis, and advanced ...
Amodiaquine...
Biology Products: