Navigation Links
Missing Receptor Molecule Causes Tumor Growth

ng receptor and not the missing signal can contribute significantly to tumor growth.

Silenced Genes
Further tests proved why there was such a small number of receptors. Prof. Krainer: "There can be two reasons for the loss of a receptor molecule like DR4. Firstly, the responsible gene could have been lost or damaged. Secondly, this gene could have been modified in a way which would prevent it from functioning." It was exactly the latter. Prof. Krainer and his team ascertained that in 75% of the specimens which contained only a few DR4 receptors the responsible gene was modified. Some components of this gene were modified by attaching methyl groups. Methylation is indeed a common way in which cells silence genes, but in the affected tumor cells, it obviously happens at the wrong time.

To conclude their research, Prof. Krainer and his colleagues retested their findings: Their results were confirmed by testing 36 different tumor tissues taken directly from patients. In comparison, these cells represent the real causes of disease much better than cell cultures commonly used for experimental research. It was determined that in 20% of the tissues examined the gene responsible for DR4 was methylated to a higher degree and DR4 was missing.

This research supported by funding from the Austrian Science Fund, FWF, paves the way for future therapy through the important discovery that the methylation of the gene for DR4 can contribute to the formation of tumors. These therapies could manipulate the malfunctioning signal transfer system, DR4-TRAIL, to make cancer cells return to the originally programmed cell death.

Image and text will be available online from Wednesday, 15th June 2005, 09.00 a.m. MEZ onwards: http://www.fwf.ac.at/en/press/receptor.html


'"/>

Source:Medical University of Vienna


Page: 1 2

Related biology news :

1. Found: Missing sequence of the human Y chromosome
2. Missing fossil link Dallasaurus found
3. DNA Molecules Used To Assemble Nanoparticles
4. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
5. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
6. Successful Test Of Single Molecule Switch Opens The Door To Biomolecular Electronics
7. Touching Molecules With Your Bare Hands
8. Team Invents Device For Weighing Individual Molecules
9. Molecule by molecule, new assay shows real-time gene activity
10. Molecule does more than slice and dice RNA
11. Molecules in blood foretell development of preeclampsia
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Missing Receptor Molecule Causes Tumor Growth

(Date:8/20/2015)... Aug. 20, 2015   Sensory, Inc ., ... the user experience and security of consumer electronics ... announced that its TrulySecure™ is the ... to be FIDO Certified™. The FIDO ... with the FIDO UAF (Universal Authentication Framework) 1.0 ...
(Date:8/19/2015)... HAUPPAUGE, N.Y. , Aug. 19, 2015 /PRNewswire/ ... announced that it has entered into a Definitive ... intellectual property, of iris authentication market leader EyeLock ... transaction, VOXX will have a controlling interest in ... is subject to completion of due diligence.  Expanding ...
(Date:8/18/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/9dmm6l/global_biometric ... "Global Biometric Authentication & Identification Market: Focus On ... 2015-2020" report to their offering. ... market is expected to grow at an estimated ... generate over $25 billion (approximately) by 2020 as ...
Breaking Biology News(10 mins):TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2
... never reach the tumors they,re intended to treat, ... the blood vessels feeding the tumors are abnormal"leaky ... Judah Folkman, MD, founder of the Vascular Biology ... researchers have discovered an explanation for these abnormalities ...
... 75% of fertilizers and fertilizer technology used around the ... to 1970s by scientists and engineers at the Tennessee ... Shields, a former TVA official. Shields is now Interim ... and Agricultural Development, based in Muscle Shoals, Alabama. ...
... A group of Yale undergraduates have discovered dozens of ... the Amazon rain forest, including several so genetically distinct ... taxonomical genera. The analysis of 135 endophytes - ... of plants - by members of the Rain Forest ...
Cached Biology News:Normalizing tumor vessels to improve cancer therapy 2Normalizing tumor vessels to improve cancer therapy 3TVA fertilizer technology used worldwide -- but few new products since 1970s 2TVA fertilizer technology used worldwide -- but few new products since 1970s 3TVA fertilizer technology used worldwide -- but few new products since 1970s 4Yale undergrads' Amazon trip yields a treasure trove of diversity 2
(Date:9/2/2015)... , September 2, 2015 Biovista ... winners of the 2015 BeHEARD science challenge, a global ... rare disease researchers, access to the latest life science ... drug repositioning and pathway analytics capability to support ... Foundation in the study of Niemann-Pick Disease Type A ...
(Date:9/2/2015)... FRANCISCO, Calif. , Sept. 2, 2015 ... Bonnie H. Anderson , president and chief executive ... Conference on Wednesday, September 16, 2015 at 10:30 a.m. ... The live audio webcast and subsequent ... . The webcast will be available shortly after conclusion ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... members will be attending Pharma Ed Resources upcoming educational seminar and training ... industry leading speakers, this timely conference will provide Updates & Case Studies on ...
(Date:9/1/2015)... ... ... Spirax Sarco , the leader in products and services for steam ... This platform, offering unique online ordering capabilities, is only available to Spirax Sarco distributors. ... Spirax Sarco Anytime and within minutes you can be making your purchase. Distributors ...
Breaking Biology Technology:Biovista Sponsors Wylder Nation Foundation's Research on Acid Sphingomyelinase Deficiency 2Veracyte to Present at Morgan Stanley Global Healthcare Conference 2Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 2Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 3Spirax Sarco Announces New Features to Anytime Platform 2
... Profitability for Brazilian Farmers , ... Brasilia, Brazil (PRWEB) ... Dow AgroSciences LLC , a wholly owned subsidiary of The ... granted by the Brazilian National Commission on Biosafety, CTNBio, for cultivation ...
... 11 Neogen Corporation,(Nasdaq: NEOG ) announced today ... program to purchase up to 500,000 shares of the company,s,common ... stock,repurchase program first approved in 1999. , ... open market or in negotiated,transactions, depending on market conditions and ...
... Dec. 11 WellCentive ( http://www.wellcentive.com ),today announced ... technology (HIT),solutions designed to efficiently, securely and cost-effectively ... providers. WellCentive Gateway allows,providers, such as physicians, ... of,outside HIT systems. WellCentive Connect is a ...
Cached Biology Technology:Herculex Receives Regulatory Approval in Brazil 2Herculex Receives Regulatory Approval in Brazil 3Neogen Announces New Share Repurchase Program 2WellCentive Launches New Health Information Exchange Platforms 2WellCentive Launches New Health Information Exchange Platforms 3
Mouse monoclonal [3G131] to Desmoglein 1 ( Abpromise for all tested applications). entrezGeneID: 1828 SwissProtID: Q02413...
TCP-1 alpha (H-110)...
Synphilin 1 Immunogen: Synthetic peptide corresponding to residues S(829) L E L N G E K D K D K G R T L Q R T(847) of human Synphilin 1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
COMING SOON: Anti-Mouse C5/C5b, Clone BB5.1. Monoclonal Antibody...
Biology Products: