Navigation Links
Microarray technology for tailoring breast cancer therapy

Microarray technology could be used to tailor therapy according to the individual, and prevent breast cancer patients from having to undergo painful unsuccessful therapies. In a study published in the journal Breast Cancer Research, researchers analysed tumour tissue samples and identified a group of64 genes that can be used to predict a patient's response in the five years after adjuvant therapy for breast cancer. Identifying patients whose breast tumours express these genes could potentially be used to predict which patients would not benefit from adjuvant therapy, and avoid patients being given therapies with the potential of causing more harm than good.

A team of researchers led by Jonas Bergh from the Karolinska Institutet in Stockholm, Sweden, analysed the gene expression profiles of 159 breast cancer patients using DNA microarray analysis. From these samples they identified the genetic signatures shown by 38 patients who had a poor prognosis - defined as relapse or death from any cause within 5 years. The remaining 121 patients were defined as the 'good prognosis' group. The researchers also used gene expression profiling to separate patients who did well with and without adjuvant therapy, and those whose tumours failed to respond to treatment.

An analysis of the genes expressed in the tumours of all 159 patients showed that 64 genes were used to separate the patients with good and poor prognoses.The researchers then tested the predictive value of the group of 64 genes compared with three currently used clinical markers. Using the expression patterns of the 64 genes identified by the researchers gave significantly better(P=0.007) prediction rates than histological grading, tumour stage and age - which are all accepted prognostic markers for breast cancer.

The present lack of criteria to help tailor breast cancer treatment to individual patients indicates a need to develop new techniques for better prediction of how patients will respond
'"/>

Source:Karolinska Institutet


Page: 1 2

Related biology news :

1. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
2. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
3. Breakthrough Microarray-based Technology for the Study of Cancer
4. Nanogen Issued Patent for Electronic Microarray With Memory
5. Characterizing Skin Cancer by Microarrays
6. Microarrays as phenotype
7. $6.5 Million Grant for Microarray Center at Yale School of Medicine
8. Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research
9. Genomatix Microarray Analysis Pipeline achieves Affymetrix GeneChip compatible?status
10. Novel technology detects human DNA mutations
11. Novel antiviral technology inhibits RSV infection in mice
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Microarray technology for tailoring breast cancer therapy

(Date:3/17/2015)... , March 17, 2015  MecklerMedia Corporation (OTCQX: ... exhibition for service robots ever held in ... place on May 11-13, 2015 at the Javits ... for the event include: Acorn Product Development; Axis ... Infranor; Kinova Robotics; Littler; NewBotic Corporation; Neya Systems ...
(Date:3/12/2015)... , March 12, 2015 IriTech, a ... a member of the Texas Instruments Design Network, announced ... has demonstrated its IriShield USB MK2120U device during ... facility for pension distribution. The iris ... to be marketed in India ...
(Date:3/12/2015)... , March 12, 2015 ... standardized identity and access management (IAM) solution for ... schedule. With Beta System,s new IAM package, customers ... practices gleaned from multiple IAM implementations across different ... software as well as any necessary services and ...
Breaking Biology News(10 mins):MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2
... (Aug. 8, 2013) Female mice who were growth restricted in ... less active and prone to obesity as adults, said researchers from ... Nutrition Research Center (CNRC) at BCM and Texas Children,s ... International Journal of Obesity . "Given that ...
... In a world full of hungry predators, prey animals ... face a particular challenge when it comes to defending themselves. ... interesting is that they can,t run away," says John Orrock, ... run, you can,t necessarily hide, so what can you do? ...
... recovery efforts following the devastating effects of the 2011 tsunami ... within the reactor,s core. A study in the journal ... Alamos National Laboratory (LANL) shows that muon imaging may offer ... and locating the melted fuel. Muon imaging, which utilizes ...
Cached Biology News:Kids born small should get moving 2Eavesdropping plants prepare to be attacked 2Getting to the core of Fukushima 2
(Date:3/25/2015)... Hills, IL (PRWEB) March 25, 2015 ... Cole-Parmer® Symmetry® Top-Loading Balances and Analytical Balances to ... The expanded line of weighing balances from the ... Precision Toploading Balances increase your efficiency by ... a variety of samples. Weighing modes include parts ...
(Date:3/25/2015)... (PRWEB) March 25, 2015 Data ... Novel Mechanism of Action in Neuromuscular Diseases ... – Cytokinetics, Incorporated (Nasdaq: CYTK) announced the publication ... muscle troponin activator tirasemtiv in the journal Neurotherapeutics. ... IIa “Evidence of Effect” or hypothesis-generating clinical trial ...
(Date:3/25/2015)... - The Gairdner Foundation is pleased to announce ... some of the most significant medical discoveries from ... world,s most esteemed medical research prizes, the awards ... prize to each scientist for their work. The Canada Gairdner ... innovation across the country, inspiring the next generation ...
(Date:3/25/2015)... , March 25, 2015   Demy-Colton Life Science ... investor and business development conferences exclusively for the biopharmaceutical ... launching the Biotech CEO Summit. The ... that brings together biotech industry leaders who are united ... innovation while reaping the rewards of biotech,s new golden ...
Breaking Biology Technology:New Economical Top-Loading and Analytical Symmetry Balances from Cole-Parmer 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 3Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 4Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 5Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 62015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 22015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 42015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 52015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 62015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 72015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 8Biotech CEO Summit to Bring Key Biotech Leaders Together in Industry Brain Trust 2
... got turned on its head again last week, as British ... aircraft. For the vast majority of U.S. travelers, new regulations ... have toothpaste and shampoo when they arrive at their destinations ... at airport arrivals terminals). For the sake of security, well ...
... according to schedule, the newest multimillion-dollar research institution at ... sometime after 2010. , ,But even as architects design ... leaders are busy forging its identity. , ,Marsha Seltzer, ... as interim director of WID, a $375 million multidisciplinary ...
... After months of speculation, North Prairie Productions, LLC , ... site for a biodiesel plant that will produce 45 million ... construction on the $42 million facility next spring on about ... it will relocate its Waterloo offices. , ,The site ...
Cached Biology Technology:Opportunities rise from travel chaos 2Waisman director leading early stages of the Wisconsin Institutes for Discovery 2Waisman director leading early stages of the Wisconsin Institutes for Discovery 3Evansville site chosen for biodiesel plant 2
... shaker flask clips, purpose-designed to firmly retain ... clips are equipped with a top retainer ... a bottom retainer spring, and silicon tubing ... glassware. Clips include the required mounting ...
RABBIT ANTI HUMAN ALPHA-2-ANTIPLASMIN...
... Bullseye Red Taq DNA Polymerase ... exhibits very high activity in primer extension ... contains a red dye which provides easy ... enzyme was added and allows confirmation of ...
RNA oligomers from 10 to 50 bases purified by PAGE and MS-checked. RNAs are supplied dried and fully deprotected....
Biology Products: