Navigation Links
MicroRNA gene that regulates lifespan found by Yale scientists

Genes that control the timing of organ formation during development also control timing of aging and death, and provide evidence of a biological timing mechanism for aging, Yale researchers report in the journal Science.

"Although there is a large variation in lifespan from species to species, there are genetic aspects to the processes of development and aging," said Frank Slack, associate professor of Molecular, Cellular and Developmental Biology and senior author of the paper. "We used the simple, but genetically well-studied, C. elegans worm and found genes that are directly involved in determination of lifespan. Humans have genes that are nearly identical."

A microRNA and the developmental-timing gene it controls, lin-4 and lin-14, affect patterns of cellular development at very specific stages. Slack's group found that mutations in these genes alter both the timing of the worm development stages-- and the worm lifespan.

C. elegans has been the premier model organism for studying the genetics of aging, and an excellent predictor of genes that also control mammalian aging.

To test their functions, they made mutants in both of these genes. Animals with a loss-of-function mutation in lin-4 had a lifespan that was significantly shorter than normal, suggesting that lin-4 prevents premature death. Conversely, over-expressing lin-4 led to a longer lifespan. They also found that a loss–of-function mutation in lin-14, the target of lin-4, caused the opposite effect -- a 31 percent longer lifespan.

According to Slack, their results are strong evidence of an "intrinsic biological clock" that runs for aging as well as for normal organ development. Included results showed the developmental programs that these genes regulate are modulated through insulin signaling, demonstrating the connection between insulin-driven metabolism and aging.

"This mic
'"/>

Source:Yale University


Page: 1 2

Related biology news :

1. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
2. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
3. MicroRNAs play a big part in gene regulation - and evolution
4. MicroRNA tweaks protein that controls early heart development
5. MicroRNAs have shaped the evolution of the majority of mammalian genes
6. MicroRNA may have fail-safe role in limb development
7. MicroRNAs can be tumor suppressors
8. MicroRNA helps prevent tumors
9. MicroRNAs as tumor suppressors
10. Multi-purpose protein regulates new protein synthesis and immune cell development
11. Scientists identify molecule that regulates well-known tumor suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MicroRNA gene that regulates lifespan found Yale scientists

(Date:12/3/2014)... Dec. 2, 2014 As part of our ... Technologies is pleased to announce the release of a ... to collect the workforce data that they need. ... been left by existing readers. Many such devices have ... and modern technology. Older models force users to navigate ...
(Date:11/21/2014)... 2014   Atmel® Corporation (NASDAQ: ... touch technology solutions, today launched the industry,s first family ... widest V cc range from 1.7V to 5.5V. ... I 2 C bus communication speeds, and are available ... them ideal for consumer, industrial, computer, and medical applications. ...
(Date:11/15/2014)... 13, 2014  While we may still be a few ... in "Star Trek" to gain instant access to all that ... with smartphones and tablets for monitoring and measuring our health ... This may seem a tad Orwellian to some, but a ... of these technological opportunities into their healthcare regime. ...
Breaking Biology News(10 mins):Inception Technologies to Release New Biometric Reader 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
... Education for All) argues that the education of children ... and nutrition, which have reduced major diseases in poor ... Matthew Jukes, one of the books authors says: ... in schools, wed go a long way to enabling ...
... M2SYS Fingerprint Technology to ... Accurately Verify Check Casher Identity, ATLANTA, Sept. ... development firm, announced today its partnership,with TeraCorp Enterprises, a ... the M2SYS Bio-Plugin(TM) fingerprint,solution into TeraCash, a cutting-edge check ...
... the latest horticulture research on high tunnels, ... The American Society for Horticultural Science (ASHS) ... horticulture presentations from the 2007 ASHS Annual ... broad selection of horticulture presentations by world-class ...
Cached Biology News:Leading experts cite poor health and nutrition as major barrier to education in developing world 2M2SYS Technology Partners with TeraCorp Enterprises to Provide Added Security Within Check Cashing Solution 2HortTalks, a valuable scientific resource 2
(Date:12/19/2014)... 18, 2014 Relmada Therapeutics, Inc. (OTCQB: RLMD), ... of chronic pain, announced the results of its annual ... was a transformational year in Relmada,s history and it ... company," said Sergio Traversa , chief executive officer ... on key financial, human resource and clinical development objectives ...
(Date:12/17/2014)... Houston, TX (PRWEB) December 17, 2014 ... marketing and administration for Stoller Group. In this position, ... Stoller Group, on administrative matters, develop marketing strategy and ... and services. , “Achim has tremendous knowledge and ... president of Stoller Group. “His experience and innovative thinking ...
(Date:12/17/2014)... Xeno Diagnostics has again received an ... COLA inspection. Xeno has met all criteria for ... organization. Accreditation is earned only by laboratories that ... demonstrate continued accuracy in the performance of proficiency ... , While the Laboratory Excellence award ...
(Date:12/17/2014)... Md. , Dec. 17, 2014  United Therapeutics ... senior executive promotions as well as changes to ... Senior Executive Promotions United Therapeutics announced ... President and Co-Chief Executive Officer and David Zaccardelli ... Officer.  In connection with these promotions, Dr. Rothblatt,s title ...
Breaking Biology Technology:Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4
... Engineering Technology to Bring New Choices, More Options to Global ... ... and RESEARCH TRIANGLE PARK, N.C., Feb. 11,/PRNewswire- FirstCall/ -- DuPont (NYSE: ... to bring higher-yielding,agricultural products to the market faster. Terms of the ...
... 11 On February 8, Michael F. Brigham,President ... ) (http://www.immucell.com ),updated the investment community in ... in the interview include an overview of the,company, ... for,which investors should watch., To hear the ...
... to gently clean and help heal ... ... today,announced that it has launched the Qoustic Wound Therapy System(TM), which,advances ... a safe, cost-effective alternative to painful sharps,debridement and other surgical modalities. ...
Cached Biology Technology:DuPont and Precision BioSciences Collaborate to Accelerate Crop Product Development 2WallSt.net Updates Investment Community Through All-New Interview With ImmuCell 2Arobella Medical, LLC Launches Qoustic Wound Therapy System(TM) 2Arobella Medical, LLC Launches Qoustic Wound Therapy System(TM) 3
... tool provides the firm pressure necessary ... in tubes or plates. The multifunctional ... that firmly holds thin-wall 0.5 ml ... opening or closing. A side slot ...
... USP is a highly nutritious versatile medium ... Due to the inclusion of both Tryptone ... growth of many fastidious organisms without the ... to United States Pharmacopeia standards for use ...
...
... B-Bridge's siSolutions RNAi Services offer ... for your siRNA studies. B-Bridges advanced ... and technical expertise ensure that you ... experiments. siSolutions siRNA Design Service utilizes ...
Biology Products: