Navigation Links
Mechanism for neurodenegerative diseases linked to transport proteins

Hampering the transport of proteins within cells may underlie several adult-onset neurodegenerative diseases, such as Huntington's, ALS and Kennedy disease. Understanding how this cell transport is blocked in these diseases may offer targets for future therapy.

In a new study published online June 4 in Nature Neuroscience, researchers from the University of Illinois at Chicago College of Medicine showed how a chemical pathway that is obstructed in Kennedy disease interferes with a cellular distribution system called "fast axonal transport" that moves proteins from where they are synthesized to where they are needed in the cell.

This transport system is critical in neurons because these cells can be as much as three feet long, says Dr. Scott Brady, professor and head of anatomy and cell biology at UIC.

"A breakdown in fast axonal transport would selectively kill neurons because neurons are especially dependent on the transport system," Brady said.

Kennedy disease is also known as spinal and bulbar muscular atrophy, or SBMA. Like the better-known ALS and Huntington's, it is a rare but devastating disease, affecting one in 40,000 people, usually between the ages of 30 and 50. Huntington's strikes about four times as many.

Neurodegenerative diseases like SBMA are caused by the lengthening of part of a gene that encodes repetitions of the amino acid glutamine in the protein. Although different genes are affected, all of the polyglutamine-expansion or "polyQ" diseases are characterized by symptoms that begin in middle age and by the loss of certain types of neurons through a pattern in which the neuron's terminals die before the cell body. PolyQ genes are expressed in many types of cells, but only neurons are affected.

Earlier studies had linked specific neurodegenerative diseases to mutations in proteins involved in intracellular transport. This led researchers to wonder if the deranged polyQ proteins inhibit fast axonal tr
'"/>

Source:University of Illinois at Chicago


Page: 1 2

Related biology news :

1. Mechanism for the captation of nutrients in plants- unknown to date
2. Mechanism regulating tooth shape formulation found
3. Mechanism for Epstein-Barr virus proteins role in blood cancers discovered
4. Mechanism for memory revealed in neurons of electric fish
5. Mechanism identified for promising neurological drug
6. Mechanisms involved with tumor relapse identified
7. Mechanism of nicotines learning effects explored
8. Ecological destruction fuels emerging diseases
9. Molecular machine may lead to new drugs to combat human diseases
10. Female sex hormones play a vital role in defense against sexually transmitted diseases
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
(Date:5/8/2015)... , May 8, 2015 Synaptics Inc. (NASDAQ: ... announced that members of the executive management team will present ... Annual Technology, Media and Telecom Conference Date: May 18, ... Boston, MA Cowen and ... Time: 2:45pm ET Location: The New York Palace Hotel, ...
(Date:5/5/2015)... May 5, 2015, NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, reminds investors and media ... Officer, is presenting  at CARTES SECURE CONNEXIONS AMERICA 2015, held ... The three-day conference is organized into a ... in is themed Global Fraud: Where is the Trust ...
(Date:4/27/2015)... LAUDERDALE, Fla. , Apr. 27, 2015 ... of access control and security systems is pleased to ... the company as a consultant and member of its ... is widely known as a thought leader in ... Distance Learning Technology Group, and has published studies and ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... D.C.Recent climate modeling has shown that reducing the ... give the Earth a wetter climate in the ... scientists Long Cao and Ken Caldeira offers a ... atmospheric carbon dioxide (CO2) concentrations are decreasing. Their ...
... Scientists at the European Molecular Biology Laboratory (EMBL) in ... researchers to label any protein of their choice with ... in living cells, by introducing a single reactive artificial ... technique enables researchers to label even rare proteins very ...
... Biomechanics researchers Timothy Higham of Clemson University and Andrew ... in a forward, firm-footed stance across a slippery surface is ... move slowly. Approaching a slippery surface slowly hinders the necessary ... contact is made. The researchers studied helmeted guinea fowl ...
Cached Biology News:Cutting carbon dioxide helps prevent drying 2Don't shuffle on slippery surfaces, Clemson University, Charleston researchers say 2
(Date:5/28/2015)... , May 27, 2015 Research and ... Jain PharmaBiotech,s new report "Cell Therapy - ... This report describes and evaluates cell ... to play an important role in the practice ... the old fashioned bone marrow transplants. Role of ...
(Date:5/28/2015)... SAN CARLOS, Calif. , May 28, 2015 ... genetic testing, today announced a study published in ... that the Panorama single-nucleotide polymorphism (SNP)-based non-invasive prenatal ... in the first trimester. A ... indicates that complete molar pregnancies occur in about ...
(Date:5/28/2015)... May 28, 2015 RXi Pharmaceuticals Corporation (NASDAQ: ... and developing innovative therapeutics, primarily in the areas of ... public offering of 26 million units at a price ... proceeds of approximately $10.4 million. Each unit consists of ... overallotment purchase right to purchase 0.50 of a share ...
(Date:5/28/2015)... May 28, 2015 The Fertility Centers ... own Dr. Danielle Vitiello has taken on a new ... Dr. Vitiello will provide guidance, leadership, oversight and quality ... count Dr. Vitiello among our team of experienced reproductive ... CEO, Joseph A. Hill, M.D. “Her expertise and compassionate, ...
Breaking Biology Technology:Global Cell Therapy Market 2015-2020 - Technologies, Markets and Companies 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 3RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3Danielle Vitiello, MD of Fertility Centers of New England, Named New Medical Director 2
... /Xinhua-PRNewswire/ -- Simcere Pharmaceutical,Group (NYSE: SCR ), ... and innovative anti-cancer pharmaceuticals in the rapidly,growing China ... its 2008,third quarter results on Thursday, November 6, ... Simcere,s chief executive officer, Jinsheng,Ren, and chief financial ...
... 2008 The most advanced and powerful electron microscope ... the new Canadian Centre for Electron Microscopy at McMaster ... world with a microscope of such a high calibre," ... Electron Microscopy, professor of Materials Science and Engineering, ...
... ANGELES, Oct. 20 Humanitarian, Dr. Gary Michelson,is ... animals,",says Aimee Gilbreath, Executive Director of Found Animals ... 501(c)3., Found Animals and its strategic partner ... announced the launch of The Michelson Prize in,Reproductive ...
Cached Biology Technology:Simcere Pharmaceutical Group to Announce Third Quarter 2008 Earnings on Thursday, November 6, 2008 2McMaster University unveils world's most advanced microscope 2Humanitarian Offers $75 Million for Single Dose Sterilization of Cats and Dogs 2Humanitarian Offers $75 Million for Single Dose Sterilization of Cats and Dogs 3Humanitarian Offers $75 Million for Single Dose Sterilization of Cats and Dogs 4