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Math model predicts cancer behavior

apy approaches which create a harsh microenvironment in the tumor may leave behind the most aggressive and invasive tumor cells.

"In the immediate term we may be diminishing tumor burden, but the long term effect is to have a much nastier tumor than there was to begin with," Quaranta said. There is anecdotal evidence, he added, to support the idea that changes to the microenvironment result in a tumor with more or less invasive potential. Such manipulations of the microenvironment could offer new directions for cancer treatment, he said.

Next up for the group are in vitro and in vivo experiments designed to test, validate and refine the mathematical model.
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Source:Vanderbilt University Medical Center


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