Navigation Links
Math model predicts cancer behavior

"The beauty of our model is that it really represents the cancer cells very well," Quaranta said. "Sandy (Anderson) was able to capture the random behavior of cells."

In the model, when cells divide they randomly choose from a set of 100 different "phenotypes" ?behaviors that result from distinct genetic characteristics. For example, a cell might choose characteristics that allow it to divide more quickly or to detach from its neighbors. The investigators set the environmental conditions: these include the oxygen and nutrient concentrations and the landscape of connective tissue that surrounds the cells. They were surprised to find that the microenvironment around the tumor determines both the tumor's shape and its composition.

"What we get is a picture of cells that are evolving and growing within a microenvironment," Quaranta said. "The nice thing about computer simulations is you can create ‘what if' scenarios: what if we make the oxygen very high, what if we turn oxygen off in the middle of tumor growth, what if we change the landscape of connective tissue"

"By doing this we discovered new things that we didn't know before. And that is the hallmark of a good mathematical model: it's not just a repository of data that is put together; it actually tells you which variables are the important ones and gives outcomes that you wouldn't have otherwise predicted."

The current model predicts that in mild environmental conditions ?imagine a lush rainforest, Quaranta said ?many cell types co-exist and the tumor shape is round with smooth edges, characteristic of a non-invasive tumor. Under harsh environmental conditions ?imagine a desert ?the most aggressive cell types dominate and the tumor shape has fingering, invasive projections.

By changing a single condition ?oxygen concentration ?the investigators can modulate the tumor's degree of invasiveness, Quaranta said.

The findings suggest that current chemother
'"/>

Source:Vanderbilt University Medical Center


Page: 1 2 3 4

Related biology news :

1. Scientists identify new model Of NK cell development
2. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
3. Molecular models advance the fight against malaria
4. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
5. Genetic therapy reverses nervous system damage in animal model of inherited human disease
6. Disease progression model of pancreatic cancer developed by Penn researchers
7. A new way to share models of biological systems
8. Understanding biases in epidemic models important when making public health predictions
9. Climate model links higher temperatures to prehistoric extinction
10. Gene therapy advance treats hemophilia in mouse models
11. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Math model predicts cancer behavior

(Date:7/24/2014)... York, NY - July 24, 2014 -- Keryx Biopharmaceuticals, ... from the long-term, randomized, active control Phase 3 study ... iron-based phosphate binder, for the treatment of hyperphosphatemia in ... PERFECTED study (PhosphatE binding and iRon delivery with FErric ... Journal of the American Society of Nephrology ...
(Date:7/24/2014)... Bushmeat, the use of native animal species for food ... be a significant factor in the decline of many ... new study indicates that more than half of the ... raptors and hornbills., "By surveying not only the meat ... being eaten inside the forest by hunters and brought ...
(Date:7/24/2014)... study has identified two factors that characterize sustainable ... production of highly qualified physics teachers. Specifically, one ... physics teacher education in combination with institutional motivation ... viable. Science, Technology, Engineering and Math (STEM) teacher ... study points the way for institutions seeking to ...
Breaking Biology News(10 mins):Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4Creating sustainable STEM teacher preparation programs 2
... noses and Microsoft Windows, infamous blue screen of death ... being made by a new research report appearing online ... Specifically, scientists now know exactly why we sneeze, what ... not work properly. Much like a temperamental computer, our ...
... Olympic athletes may be the best trained and physically ... susceptible to back pain. BackPainRelief.net is releasing an infographic ... injuries can be avoided. (Photo: ... for a number of injuries, and back pain is ...
... (July 30, 2012) When the longest cells in the body ... is no easy task. This is in part because these ... one meter in adult humans which is a lot ... order to reach the "command center" of the cell,s nucleus. ...
Cached Biology News:Allergies? Your sneeze is a biological response to the nose's 'blue screen of death' 2Backpainrelief.net Tackles Sports Injuries with Infographic 2Long-distance distress signal from periphery of injured nerve cells begins with locally made protein 2Long-distance distress signal from periphery of injured nerve cells begins with locally made protein 3
(Date:7/24/2014)... rely on sophisticated equipment, trained personnel, and detection ... against terrorist attacks. A revolutionary new electronic chip ... their job much easier. , The groundbreaking nanotechnology-inspired ... Aviv University ,s School of Chemistry and Center ... Herzliya company Tracense, picks up the scent of ...
(Date:7/24/2014)... synthetic processes prefer to settle into equilibriuma state ... within the realm of non-equilibrium conditions where new ... energy and phases, such as temperature fluctuations, freezing ... to regulate their body temperature, airplanes to fly, ... , But even though these conditions exist ...
(Date:7/24/2014)... 2014 SRI International has been awarded a ... of Allergy and Infectious Diseases (NIAID), part of the ... potential therapies for HIV infection and AIDS. The contract ... AIDS and the complications and opportunistic infections associated with ... transmission of HIV. According to the ...
(Date:7/24/2014)... , July 24, 2014  Neogen Corporation (Nasdaq: ... future forecasts of its potential revenue from new rodenticide ... to investors and analysts on July 22, 2014, Neogen,s ... analysts regarding this research. "It was my ... about the potential of a new type of rodenticide, ...
Breaking Biology Technology:Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3Neogen comments on SenesTech 2
... Reaches severance agreement with unionsSEATTLE, May 15 Cell ... that, as previously discussed in a press release on ... operations and has reached agreement with the employee union ... a reduction of CTI,s total headcount in Italy by ...
... (TSX:ONC, NASDAQ: ONCY ) announced today that data from ... at the 2009 American Society of Clinical Oncology (ASCO) Annual ... 29-June 2, 2009. The abstracts are available on the ASCO ... poster presentations, - Dr. Monica ...
... May 14 /PRNewswire-FirstCall/ - Spectral Diagnostics Inc., (TSX: SDI), ... and a therapeutic targeting severe sepsis, today announced its ... 2009. , "This quarter, we achieved an important milestone ... Toraymyxin(TM) for the US market after thorough due diligence ...
Cached Biology Technology:Cell Therapeutics Closes Italian Facility, Reduces Headcount and Expects to Cut $14 Million in Operating Expenses 2Oncolytics Biotech(R) Inc.'s Research Collaborators to Present Data on REOLYSIN(R) Clinical Trials at ASCO Conference 2Spectral announces first quarter 2009 results 2Spectral announces first quarter 2009 results 3Spectral announces first quarter 2009 results 4Spectral announces first quarter 2009 results 5Spectral announces first quarter 2009 results 6Spectral announces first quarter 2009 results 7
... IndicationIncludes all the features of Tracker, plus software ... for a user defined period of time in ... a family of instruments all built around a ... and that can track two fields at once ...
... all features of Tracker, plus software to note ... and provide a food reward.The Spatial Behavior line ... a video camera, frame grabber, and feature extraction ... once and up to 6 moving animals. ...
... Place AvoidanceIncludes all features of Tracker, plus ... a user defined subsection of the arena, and ... family of instruments all built around a video ... that can track two fields at once and ...
tracking dye in electrophoresis; free acid, C 19 H 10 BrO 5 S; MW: 669.96...
Biology Products: