Navigation Links
Math model predicts cancer behavior

Vito Quaranta clicks on a small black dot on his computer screen. The dot ?which represents about a thousand cancer cells ?begins to "grow," morphing into a mass with finger-like projections that looks like an invasive tumor.

The Vanderbilt professor of cancer biology envisions a future when computer simulations like this will be used to predict a tumor's clinical progression and formulate individualized treatment plans. For the last two years, he has headed a major effort to develop the kind of mathematical model for cancer invasion powerful enough for this purpose. The result was published as an entirely theoretical paper in the journal Cell and, if he is right, it represents a "sea change" in how biology is done.

The new approach is not so different from forecasting the weather.

"Today we can know pretty well that for the next few days we're going to expect good weather or that there's a storm on the way," Quaranta said. "That's the kind of predictive power we want to generate with our model for cancer invasion."

Quaranta and colleagues at Vanderbilt University and the University of Dundee in Scotland developed a computational model for cancer invasion and described the model in the Dec. 1 issue of Cell. The model ?a series of mathematical equations that drive computer simulations of tumor growth ?suggests that the microenvironment around tumor cells determines the tumor's ultimate cellular makeup and invasive potential.

The investigators have focused on the events of invasion and metastasis (movement of a tumor to distant sites), Quaranta said, because these events mark "the critical transition of a tumor that in the end will be lethal for the patient." A tumor that does not penetrate the surrounding tissue can often be surgically removed with curative success.

"When a patient comes in with a tumor, we'd like to understand for that particular tumor, what are the chances that metastasis is going to occur," Quara
'"/>

Source:Vanderbilt University Medical Center


Page: 1 2 3 4

Related biology news :

1. Scientists identify new model Of NK cell development
2. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
3. Molecular models advance the fight against malaria
4. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
5. Genetic therapy reverses nervous system damage in animal model of inherited human disease
6. Disease progression model of pancreatic cancer developed by Penn researchers
7. A new way to share models of biological systems
8. Understanding biases in epidemic models important when making public health predictions
9. Climate model links higher temperatures to prehistoric extinction
10. Gene therapy advance treats hemophilia in mouse models
11. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Math model predicts cancer behavior

(Date:4/24/2014)... (LMU) in Munich have identified the structural features ... between viral and endogenous RNAs in living cells. ... of cellular metabolism and hijack cellular resources for ... dependent on viral RNA molecules that are delivered ... and/or newly synthesized in the host cell, and ...
(Date:4/24/2014)... with new insights into the make-up of tropical forests, ... Basin have revealed unprecedented detail of the size, age ... satellite maps with hundreds of field plots. , ... the amount of carbon each tree can store. This ... which trees are given a cash value according to ...
(Date:4/24/2014)... a welcome mat to bacteria seeking to invade, and scientists ... this week in the Proceedings of the National Academy ... microbe and host that researchers can exploit to protect plants. ... Arabidopsis puts out a molecular signal that invites ... army were unknowingly passing by a castle, and the sentry ...
Breaking Biology News(10 mins):Viral infections: Identifying the tell-tale patterns 2Viral infections: Identifying the tell-tale patterns 3Amazon rainforest survey could improve carbon offset schemes 2How a plant beckons the bacteria that will do it harm 2How a plant beckons the bacteria that will do it harm 3
... the womb? Previously, researchers assumed that consumption of "bad" ... growth and that "good" omega-3 fatty acids prevent expansive ... Universitt Mnchen showed no evidence to support this "perinatal ... epidemic with more and more younger children affected by ...
... Anatomists, 2012 Basmajian Award will be presented on April ... of cell biology, neurobiology and anatomy at the Medical ... at the AAA Annual Meeting at EB 2012 (Tuesday, ... Diego, CA)., This award recognizes health science faculty who ...
... PhytoKeys known for applying cutting ... is pioneering an electronic-only publishing workflow in a series ... of January 2012 (see related press release ). ... took effect to the way plant scientists name new plants, ...
Cached Biology News:Fish oil during pregnancy does not protect against excessive adipose tissue development 2Todd Hoagland honored by Anatomy Society for excellence in teaching, research & scholarship 2Early land plants: Early adopters! 2Early land plants: Early adopters! 3
(Date:1/15/2014)... 15, 2014 Freeslate, Inc ., ... announced that Lupin Limited, one of India’s top five ... Protégé PharmD System for high throughput solid form ... focused on a wide range of quality, affordable generic ...
(Date:1/14/2014)... 2014 Carahsoft and CDS Federal Services ... 2014 at 2pm EST (11am PST), “Natural Language Processing: ... on how technology can turn raw, heterogeneous data into ... agencies. The online webinar will last approximately one hour. ...
(Date:1/14/2014)... 2014 EquitiesIQ, a leading informational research ... Alliqua is an emerging biomedical company acquiring, developing, manufacturing, ... market. , Free report download: http://equitiesiq.com/reports/alliqua/ , ... management team and Board, which launched the company’s new ...
(Date:1/14/2014)... In recent years, growing suspicion about the pharmaceutical ... and promotion has led to unprecedented levels of public ... about the insidious impact of commercialization of research, has ... the world’s biggest pharmas for illegal marketing activities, allegations ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... Kansas Day of,Innovation featuring the fifth annual Great ... Thursday, September 4th, 2008 at the Wichita,Marriott, 9100 ... providing early stage, high-growth companies in Kansas with ... "This has grown to,be a dynamic event that ...
... 18 /Xinhua-PRNewswire/ --,Synutra International, Inc. (Nasdaq: SYUT, "Synutra"), ... producer, marketer and seller of,nutritional products for infants, ... its proposed public offering of its common stock,indefinitely., ... board has determined it is,in the best interest ...
... July 18 /PRNewswire/ - Norgen Biotek Corp., an ... for RNA, DNA and protein purifications, today announced ... new kits geared towards the,isolation of RNA and ... diagnostic,applications. In response to customer demands and emerging ...
Cached Biology Technology:2008 Kansas Day of Innovation Featuring the Fifth Annual Great Plains Capital Conference Scheduled for September 2Synutra Announces Postponement of Proposed Offering 2Norgen Biotek Corp. Launches Four New Kits for the Purification of RNA and DNA from Plants and Fungi 2
... Situ Assay Kit is a fluorescent-based assay ... undergoing apoptosis. The kit is for research ... or therapeutic procedures. CHEMICON®s CaspaTag™ Pan-Caspase In ... to detect active caspases. The methodology is ...
... is a fluorescein-conjugated jetSI-ENDO ... at 520 nm), the powerful ... are used to determine the ... intracellular delivery and trafficking of ...
... Cellular uptake of long double stranded ... RNA interference in a diverse group of ... culture. RNA interference leads to the inhibition ... destruction of the target messenger RNA (mRNA). ...
... and reduced space requirements of the ... DNA analysis technology affordable .The benchtop ... of SEQUENOM's applications and assays, including: ... , Gene Expression Analysis (QGE) , ...
Biology Products: