Navigation Links
Math model predicts cancer behavior

Vito Quaranta clicks on a small black dot on his computer screen. The dot ?which represents about a thousand cancer cells ?begins to "grow," morphing into a mass with finger-like projections that looks like an invasive tumor.

The Vanderbilt professor of cancer biology envisions a future when computer simulations like this will be used to predict a tumor's clinical progression and formulate individualized treatment plans. For the last two years, he has headed a major effort to develop the kind of mathematical model for cancer invasion powerful enough for this purpose. The result was published as an entirely theoretical paper in the journal Cell and, if he is right, it represents a "sea change" in how biology is done.

The new approach is not so different from forecasting the weather.

"Today we can know pretty well that for the next few days we're going to expect good weather or that there's a storm on the way," Quaranta said. "That's the kind of predictive power we want to generate with our model for cancer invasion."

Quaranta and colleagues at Vanderbilt University and the University of Dundee in Scotland developed a computational model for cancer invasion and described the model in the Dec. 1 issue of Cell. The model ?a series of mathematical equations that drive computer simulations of tumor growth ?suggests that the microenvironment around tumor cells determines the tumor's ultimate cellular makeup and invasive potential.

The investigators have focused on the events of invasion and metastasis (movement of a tumor to distant sites), Quaranta said, because these events mark "the critical transition of a tumor that in the end will be lethal for the patient." A tumor that does not penetrate the surrounding tissue can often be surgically removed with curative success.

"When a patient comes in with a tumor, we'd like to understand for that particular tumor, what are the chances that metastasis is going to occur," Quara
'"/>

Source:Vanderbilt University Medical Center


Page: 1 2 3 4

Related biology news :

1. Scientists identify new model Of NK cell development
2. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
3. Molecular models advance the fight against malaria
4. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
5. Genetic therapy reverses nervous system damage in animal model of inherited human disease
6. Disease progression model of pancreatic cancer developed by Penn researchers
7. A new way to share models of biological systems
8. Understanding biases in epidemic models important when making public health predictions
9. Climate model links higher temperatures to prehistoric extinction
10. Gene therapy advance treats hemophilia in mouse models
11. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Math model predicts cancer behavior

(Date:7/23/2014)... NY -- The potential for clinical use of ... therapeutic strategies has previously been hindered by the ... of tumors. The ability to use etoposide treatment ... treatment of heart disease, specifically acute myocardial infarction, ... Cells and Development , a peer-reviewed journal from ...
(Date:7/23/2014)... WELLESLEY, Massachusetts , July 23, 2014 ... reveals in its new report, GLOBAL MARKETS AND ... and related technologies is expected to grow to nearly ... growth rate (CAGR) of 10.1%. The image, flow, and ... CAGR.      (Logo: http://photos.prnewswire.com/prnh/20140723/694805 ) , ...
(Date:7/23/2014)... This news release is available in German . ... use varying sensory modalities for orientation, some of which ... for example take the polarization pattern produced by sunlight ... researchers from the Max Planck Institute for Ornithology in ... colleagues from Israel that a night active mammal, the ...
Breaking Biology News(10 mins):Global Market for Sensors to Reach Nearly $154.4 Billion in 2020; Image Sensors Moving at 11.7% 2Global Market for Sensors to Reach Nearly $154.4 Billion in 2020; Image Sensors Moving at 11.7% 3Bats use the evening sky's polarization pattern for orientation 2
... Building Components (UHGBC), a program in the Gerald D. ... Expo. This event showcases the work of faculty-led research ... and sustainable technologies for the built environment. The ... the College of Architecture,s atrium. The event is free ...
... If Guinness World Records had a category for the largest ... just claimed it. They have designed and successfully ... manufacture the essential amino acid histidine. It is more than ... created by researchers at the University of Washington in 2003. ...
... study conducted by researchers at the Johns Hopkins Malaria ... of drug resistance in malaria-causing parasites taken from both ... human blood samples showed a high prevalence for pyrimethamine-resistance, ... used to treat malaria in the region. However, parasites ...
Cached Biology News:UH Green Building Components Expo showcasing eco-friendly projects 2Creation of the largest human-designed protein boosts protein engineering efforts 2Creation of the largest human-designed protein boosts protein engineering efforts 3Contrasting patterns of malaria drug resistance found between humans and mosquitoes 2
(Date:7/23/2014)... (MIPT and Russian Quantum Center at Skolkovo) and ... and the Institute of Physics in Bratislava, Slovakia) ... of particles passing through an amplifier and, conversely, ... are provided in an article published in the ... , Quantum entangled particles are considered to be ...
(Date:7/23/2014)... 2014 Last year, Formedix ... leading global provider of data management solutions for clinical ... leading-edge system for electronic data capture (EDC) and clinical ... and study execution tools added TrialMaster to its Transform ... version of Transform for TrialMaster, is being released this ...
(Date:7/23/2014)... July 23, 2014 DuPont Pioneer announced ... as vice president of Agricultural Biotechnology (ABT), effective July ... he served most recently as president, chief executive officer ... business leadership in the seed and crop protection industry ... Paul E. Schickler , president of DuPont Pioneer. “I ...
(Date:7/23/2014)... , July 23, 2014  Sofinnova Ventures, a ... announced the closing of Sofinnova Venture Partners IX, L.P. ... excess of the initial fund target of $425 million. ... successful biotechnology companies. Consistent with recent funds, SVP IX ... stage clinical programs, along with select investments in earlier ...
Breaking Biology Technology:Scientists find way to maintain quantum entanglement in amplified signals 2Scientists find way to maintain quantum entanglement in amplified signals 3Scientists find way to maintain quantum entanglement in amplified signals 4Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Sofinnova Raises $500 Million Biotech Venture Fund 2
... WOBURN, Mass., April 7, 2011 The Center for Business ... to the American Red Cross in support of the relief ... employees made personal contributions to the fund while the organization ... the compassion and generosity CBI employees have displayed to help ...
... Fla. April 5, 2011 A new drug is ... an inherited predisposition to the disease. These patients with ... which can become locally invasive or metastatic, according to a ... at the 102nd annual meeting of the American Association for ...
... (Nasdaq: CEPH ) has scheduled its regular quarterly ... p.m. EDT on Tuesday, May 3, 2011. May 3, ... be distributed by PRNewswire4:50 p.m. EDT , To participate in ... 67208985:00 p.m. EDT , Conference call begins promptly. Simultaneous ...
Cached Biology Technology:The Center for Business Intelligence Donates to the American Red Cross, Matching Employee Contributions for Disaster Relief in Japan 2New drug is effective against the most common form of skin cancer 2
Request Info...
... blotted protein on PVDF membrane or with ... N-terminal sequence of proteins (5-20 residues) can ... HPLC or mono-and bidimensional SDS-PAGE, followed by ... the well known EDMAN degradation method. Pre-treatment ...
Recombinant Ovine (Sheep) Growth Hormone, Ultra Pure...
ELF® 97 Immunohistochemistry Kit...
Biology Products: