Navigation Links
MRSA vaccine shows promise in mouse study

enabled the team to compile a list of cell-surface antigens from diverse strains of the bacteria, many of them new targets. From that list, Schneewind and colleagues selected 19 potential vaccine targets taken from eight different strains of S. aureus.

By injecting each of the 19 target proteins into mice and measuring the immune response, they identified the four proteins that generated the strongest immune response. Two of those proteins, IsdA and IsdB, help the microbe acquire needed iron from the host's red blood cells. The other two, SdrD and SdrE, are thought to be involved in bacterial adhesion to host tissues.

When tested alone as a vaccine, each of the four proteins provided only partial or no protection. Fifty to 70 percent of mice vaccinated with one of these proteins and injected with a dose of a laboratory strain of the bacteria calculated to kill 50 percent of the mice, were still alive one week later.

When they vaccinated the mice using the combined vaccine, however, all of the mice survived. Although unvaccinated mice had clear evidence of kidney infections, the "bacterial load" in vaccinated mice was reduced "to a level below detection."

The next step was to test the vaccine's ability to protect mice from multiple bacterial strains isolated from humans. The researchers vaccinated 50 mice. Three weeks later, they injected groups of 10 with potentially lethal doses of one of five different clinical isolates.

The vaccine completely protected mice against two strains--including the virulent community-associated strain--and offered significant protection, resulting in 60- to 90-percent survival, against three other strains. All unprotected mice injected with the USA100 strain died within 36 hours, for example, but 60 percent of vaccinated mice survived injection with that strain.

"Further testing," said first author of the study Yukiko K. Stranger-Jones, a graduate student in the Schneewind
'"/>

Source:University of Chicago Medical Center


Page: 1 2 3

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Gene vaccine for Alzheimers disease shows promising results
5. Influenza vaccine uses insect cells to speed development
6. Norovirus, AIDS vaccine and Hepatitis Virus
7. HIV vaccine trial breaks ground for future research
8. Live vaccines more effective against horse herpes virus
9. NIAID begins clinical trial of West Nile virus vaccine
10. Designing vaccines by computer
11. Wake Forest scientists find new combination vaccine effective against plague
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MRSA vaccine shows promise mouse study

(Date:3/24/2015)... DUBLIN , Mar. 24, 2015 Research and Markets ... "Face and Voice Biometrics - Global Strategic Business Report" report ... for Face and Voice Biometrics in US$ Thousands by the following ... analytics for the US, Canada , ... , Middle East & ...
(Date:3/24/2015)... March 24, 2015   Crossmatch ™, a ... announced that its U.are.U ® 4500 Fingerprint ... Goorin Bros . to achieve PCI compliance for ... access to the POS terminal, protecting the retailer ... data breaches. With one-third of ...
(Date:3/23/2015)...   HOYOS Labs , a leading global authentication ... the Company will demonstrate multiple biometrics-based technologies under its ... Connect:ID on March 23 through 25, 2015, in ... the IEEE Biometric Open Protocol Standard; free biometrics-based consumer ... control system. BOPS was invented by HOYOS Labs and ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... of Education and Human Development,s Department of Health and Kinesiology, ... Texas Chapter of the American College of Sports Medicine (ACSM),s ... will deliver lectures at a series of Texas educational institutions ... big honor for both Bill and our department," said Wan ...
... a previously unknown structure in between a liquid and ... long oily chains, according to Purdue University researchers. However, ... Water plays a huge role in biological processes, from ... that this transformation is useful in a way not ...
... LLC, creator of the Selman Surgical Rehearsal Platform (SRP), ... to University Hospitals (UH) Case Medical Center in Cleveland, ... Physicians at the medical center have been instrumental in ... that the institution becomes the first to own the ...
Cached Biology News:UTSA physiologist William Cooke named 2013 Lecture Series Speaker by Texas Sports Medicine Chapter 2Oil and water: An icy interaction when oil chains are short, but steamy when chains are long 2Oil and water: An icy interaction when oil chains are short, but steamy when chains are long 3Surgical Theater, LLC sells first Surgical Rehearsal Platform to UH Case Medical Center 2Surgical Theater, LLC sells first Surgical Rehearsal Platform to UH Case Medical Center 3
(Date:4/23/2015)... , April 23, 2015 BioTE Medical ... his book "Age Healthier Live Happier - Avoiding Over-Medication ... the Age Management Medicine Group Conference at JW Marriott ... 2015. ",Age Healthier Live Happier, is a ... avoid over-medication and searching for a higher quality of ...
(Date:4/23/2015)... 23, 2015 Follow us ... a series of genetic tests that determine individual ... Gehrig's disease, Huntington's disease, and Alzheimer's disease. Predictive ... composition and interaction in diseased tissue/cells to understand ... as the response to treatment, such as in ...
(Date:4/23/2015)... 23, 2015 Glemser Technologies ... first EMC® Enterprise Content Division (ECD) Certified Solution ... EMC Documentum® for Life Sciences Solution Suite . ... and capabilities to provide life sciences companies of ... , The EMC Documentum Solution Suite offers four ...
(Date:4/23/2015)... 23, 2015 /PRNewswire/ - Crystal Research Associates, LLC announced ... ® (EIO) on Aeterna Zentaris Inc. (NASDAQ: ... on Crystal Research Associates, website at www.crystalra.com ... at www.aezsinc.com . Aeterna Zentaris ("Aeterna" ... company in oncology, endocrinology, and women,s health. With a ...
Breaking Biology Technology:Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 3Glemser Earns Accreditation for Life Sciences Solution Suite 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 3
... Mass., Aug. 3, 2011 ... medicine, was awarded the American Association of Neuromuscular & ... Accreditation with Exemplary Status. EMG Laboratory has provided ... in and around Merrimack Valley and Cape Cod since ...
... Neuralstem, Inc. (NYSE Amex: CUR ) ... contract to develop its human neural stem cell technology ... contract, entitled "Research to Treat Cancerous Brain Tumors with ... with Principal Investigator John Zhang, MD, PhD, Professor of ...
... 2, 2011 Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ... financial results on Monday, August 8, 2011, after the U.S. ... call and webcast on Monday, August 8, 2011, at 5:00 ... financial results and highlights.  A live webcast of the call ...
Cached Biology Technology:EMG Laboratory Attains Prestigious National Accreditation for Clinical Excellence in Neuromuscular Diagnosis 2EMG Laboratory Attains Prestigious National Accreditation for Clinical Excellence in Neuromuscular Diagnosis 3Neuralstem Awarded Department of Defense Contract for Brain Cancer Research 2Neuralstem Awarded Department of Defense Contract for Brain Cancer Research 3Anadys Pharmaceuticals to Report Second Quarter 2011 Financial Results 2
MBS 384 well satellite block unit with height adjusting heated lid, 384 well block holds 1 x 0.04 ml 384 well plate...
Multidrop DW is a high-speed automated dispenser for Deep Well plates, 1.1 ml test tubes and 96-well plates. Designed for accuracy and precision, the Multidrop DW dispenses up to eight different reag...
ma. plate stack height 70mm...
... MBS Satellite Thermal Cycler (MBS) ... solution for medium to high ... combines the latest in satellite ... and PC control, resulting in ...
Biology Products: