Navigation Links
Living view in animals shows how cells decide to make proteins

Scientists at Duke University Medical Center have visualized in a living animal how cells use a critical biological process to dice and splice genetic material to create unique and varied proteins.

The scientists say the findings, made in mice, help explain a key wonder of human biology: how the same genes found in every cell of an individual’s body can produce different proteins in different tissues and organs. These varied proteins, in turn, dictate the function of each tissue or organ.

The findings also may offer insight into a number of diseases, including cancer, in which the genetic process -- called alternative splicing -- goes awry and produces the wrong proteins, the scientists said.

The scientists published the findings in the Dec. 1, 2006, issue of the journal RNA. The study was funded by the National Institutes of Health.

Scientists previously have examined alternative splicing in cells and tissues in test tubes, but this study marks its first successful visualization in a living mammal, said senior investigator Mariano Garcia-Blanco, M.D., Ph.D., a professor of molecular genetics and microbiology.

"We were able to watch alternative splicing as it occurred in different tissues," he said. "It’s an excellent example of how experiments in living organisms provide a much more complete picture of how genes and proteins behave than do experiments using cells in culture."

Until 20 years ago, scientists believed that a single gene made a single protein. With the discovery of alternative splicing, it became clear that one gene can produce multiple proteins.

In alternative splicing, microscopic "scissors" in a gene chop the genetic material RNA into bits called "exons" and then reassemble the bits in a different order to form a new RNA molecule. In the process, some of the exons are retained while others are excluded. The exons that are retained in the final RNA determine which proteins the RNA pr
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
2. Living with salt
3. Living anti-HIV gel shows early promise
4. Living taste cells produced outside the body
5. Living laboratory found on shoreline statues
6. Study: Living coral reefs provide better protection from tsunami waves
7. Living with water scarcity -- world must act now
8. Plants, animals share molecular growth mechanisms
9. Elephants imitate truck noises, other animals
10. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
11. Gene therapy for Parkinsons disease moves forward in animals
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Living view animals shows how cells decide make proteins

(Date:2/24/2015)... This report analyzes the worldwide markets for Face and ... and Voice Biometrics. The report provides separate comprehensive analytics for the ... Europe , Asia-Pacific , ... and Latin America . Annual estimates and forecasts ... historic analysis is provided for these markets. Market data and analytics ...
(Date:2/18/2015)... , Feb. 18, 2015  Cepheid (NASDAQ: CPHD ... the following conferences, and invited investors to participate via webcast. ... Boston, MA Tuesday, March 3, 2015 at 11.20 ... Orlando, FL Wednesday, March 4, 2015 ... To access the live webcasts for these events, please visit ...
(Date:2/11/2015)... DALLAS , February 11, 2015 /PRNewswire/ ... market research report "Access Control Market by Product ... (Commercial, Residential, Military and Defense, Government, Industrial, Healthcare, ... , published by MarketsandMarkets, the Access Control ... by 2020, growing at a CAGR of ...
Breaking Biology News(10 mins):World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16Cepheid to Webcast Upcoming Financial Presentations 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4
... -- The strength of a lemur couple,s bond is reflected ... "It,s like singing a duet, but with smells ... who supervised the study. Duke researchers sampled and ... living at the Duke Lemur Center in Durham, NC. The ...
... TEMPE, Ariz. Lawrence Krauss, an Arizona State University ... Exploration and the Department of Physics, has been elected ... Academy, which includes Nobel Laureates James Watson and Steven ... as members, is limited to 80 persons. It was ...
... MIAMI (Jan. 29, 2014) A new study ... Abess Center for Ecosystem Science and Policy and the ... several species of coastal sharks respond to stress from ... shark species responded differently. Hammerhead sharks were by far ...
Cached Biology News:Lemur lovers sync their scents 2Lemur lovers sync their scents 3ASU professor Lawrence Krauss is elected to the International Academy of Humanists 2New study examines the effects of catch-and-release fishing on sharks 2
(Date:2/26/2015)... --  Synageva BioPharma Corp. (NASDAQ: ... for rare disorders, today reported 2014 full year ... objectives, and financial guidance.  Synageva,s management team will ... EST to review the financial results and provide ... call by telephone, please dial (877) 445-4603 for ...
(Date:2/26/2015)... 26, 2015 Protiviti ( www.protiviti.com ), a ... the Governance Portal , designed to increase the ... (GRC) tasks across multiple business units and projects. The ... customers better align their controls with the COSO ( ... requirements. In response to client feedback, Protiviti has also ...
(Date:2/26/2015)... (PRWEB) February 26, 2015 The Movement ... demonstration to support life extension technologies and awareness. The ... Universal Coordinated Time, on March 21st 2015, in a ... , Eric Schulke, Founder of MILE, says, “Our ... with urgency. The Movement for Indefinite Life Extension is ...
(Date:2/26/2015)... Feb. 26, 2015  NuGene International, Inc. ("NuGene") ... for skin and hair rejuvenation, has announced that ... of record for investor relations and strategic communications. ... distribution, sales and diversification strategies – and we ... prospective shareholders," stated Ali Kharazmi CEO of NuGene ...
Breaking Biology Technology:Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 2Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 3Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 2NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 3
... 2011 Life Technologies Corporation (NASDAQ: ... Baird,s 2011 Growth Stock Conference on Tuesday, May 10 ... Chief Executive Officer, will present on behalf of the ... be available for three weeks following the conference on ...
... 2011 Click Here, Inc., and Richards Partners ... Lifeline Skin Care™, a wholly owned subsidiary of ... biotechnology company focused on therapeutic and research products. ... using its proprietary stem cell technology.  Based in ...
... its promise of superfast computers and ultrapowerful optical ... one of the hottest fields in high-technology. However, ... nanostructures that feature interfaces between noble metals and ... Energy (DOE),s Lawrence Berkeley National Laboratory (Berkeley Lab) ...
Cached Biology Technology:Life Technologies to Present at Baird's 2011 Growth Stock Conference 2Lifeline Skin Care™ Selects Click Here, Inc., Richards Partners 2Lifeline Skin Care™ Selects Click Here, Inc., Richards Partners 3New kid on the plasmonic block 2New kid on the plasmonic block 3New kid on the plasmonic block 4New kid on the plasmonic block 5
Roll of Mesh 5m x 25cm...
... Beacon 2000 Fluorescence Polarization System is ... and assay development. Standard Beacon 2000 ... System uses a quartz-halogen lamp that ... 360-700 nm. It accommodates all applications ...
Preparation Note: Prepared essentially by method of Singer, T.P., J. Biol. Chem., 174, 11 (1948). Quality Clarifier: Contains lipase Unit Definition: One unit will hydrolyze 1.0 μmole of p-ni...
... Tris buffer, pH 10.2 give activity approx. ... Assays in diethanolamine buffer, pH 9.8 give ... buffer system. Protein determined by Biuret Physical ... Preparation Unit Definition: One unit will hydrolyze ...
Biology Products: