Navigation Links
Life-extending protein keeps blood sugar in check

A protein that extends lifespan in yeast, worms, and flies keeps blood sugar under control in mice, reports a new study in the August Cell Metabolism. The findings suggest therapeutic interventions for the prevention and treatment of metabolic disorders, such as type 2 diabetes, which frequently arise with age, the researchers said.

The team found that mice with an excess of the protein Sirt1 in cells of the pancreas have improved glucose tolerance and enhanced insulin secretion in response to glucose. Glucose is the principal circulating sugar in the blood and the major energy source of the body.

"Mice with an increased amount of Sirt1 show a better response to high blood glucose levels that regularly occur after eating sweets, such as cookies or cakes," said Shin-ichiro Imai of Washington University School of Medicine. "The mice respond fast to high glucose by raising insulin levels, clearing the blood of the circulating sugar."

"Under normal feeding conditions, when glucose levels are lower, the mice with elevated Sirt1 appear normal," Imai added. "This is good news, suggesting that therapies designed to manipulate the amount of Sirt1 might improve insulin response in those with type 2 diabetes without causing other problems."

Pancreatic b cells have a highly coordinated mechanism that senses rises in blood glucose and converts that information into signals that increase the secretion of insulin, Imai explained. Insulin produced by the pancreas allows cells to take up glucose from the bloodstream and burn it for energy. A failure to make or respond to insulin in people with diabetes causes blood sugar levels to rise.

The researchers found that Sirt1 is present in pancreas cells that secrete insulin hormone. Mice genetically modified to have an excess of Sirt1 in b cells of the pancreas had improved glucose tolerance and enhanced insulin secretion in response to glucose.

The altered mice maintained their improved b ce
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Life extending protein keeps blood sugar check

(Date:10/29/2014)... both genetic and environmental, have been blamed for ... Some, such as a family history of schizophrenia, ... Toxoplasma gondii , a parasite transmitted by ... viewed with skepticism. , A new study by ... at the University of Pennsylvania,s School of Veterinary ...
(Date:10/29/2014)... household and industrial products are in the environment – ... of them, scientists have yet to determine whether they ... toward doing that by estimating which substances people are ... in the ACS journal Environmental Science & Technology ... the risks to human health of any given substance ...
(Date:10/29/2014)... held in New York City on September 19, 2014, ... Cancer Society Professor of Genome Sciences and Medicine at ... Doctor of Philosophy of Tel Aviv University, was awarded ... , In addition to her honorary degree from TAU, ... TAU School of Medicine, and for the past 18 ...
Breaking Biology News(10 mins):Penn vet professor investigates parasite-schizophrenia connection 2Penn vet professor investigates parasite-schizophrenia connection 3Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2
... and U.S. Department of Agriculture should jointly establish a ... the effectiveness of actions meant to improve water quality ... Gulf of Mexico, says a new report from the ... to move forward on the larger process of allocating ...
... Throughout history, human beings have used the whistle for everything ... orangutan,s spontaneous whistling is providing scientists at Great Ape Trust ... learning. In a paper published this month in Primates ... on all aspects of primates in relation to humans and ...
... could lead to a radical re-thinking about how the ... "Six of the adult females that we followed in ... out on the Arctic sea ice," said Universit Laval ... Gilles Gauthier as part of an International Polar Year ...
Cached Biology News:EPA and USDA should create new initiative to better monitor nutrients 2EPA and USDA should create new initiative to better monitor nutrients 3EPA and USDA should create new initiative to better monitor nutrients 4Orangutan's spontaneous whistling opens new chapter in study of evolution of speech 2Orangutan's spontaneous whistling opens new chapter in study of evolution of speech 3Snowy owl -- a marine species? 2
(Date:10/31/2014)... York, NY (PRWEB) October 31, 2014 ... such as healthcare, construction, finance and consumer electronics ... For this reason, industry research firm IBISWorld has ... industry to its growing industry report collection. , ... develop software for biometric technologies such as fingerprint, ...
(Date:10/30/2014)...  Ardelyx, Inc. (NASDAQ: ARDX ), ... and metabolic diseases, today announced that it will ... November 6, 2014. Following the announcement, the Ardelyx ... and webcast at 4:30pm ET to review the ... The live webcast can be accessed ...
(Date:10/30/2014)... CA (PRWEB) October 30, 2014 ... today that they have manually curated public data source ... non profit customers. the data is now available ... curates and unifies public and internal data sources for ... and knowledge out of the data that becomes more ...
(Date:10/30/2014)... Grace Century portfolio project, Provia Laboratories , ... the Board, to the National Stem Cell Ethics Committee ... by the Ministry of Health on behalf of the Government ... More than a year after Bahamian Parliament passed the ... Christie said the government has completed the accompanying regulations and ...
Breaking Biology Technology:Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2Rancho BioSciences Manually Curated TCGA Data Sets Available 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3
... done and now they,ve done it. What,s more, they did ... U.S. Department of Energy (DOE),s Lawrence Berkeley National Laboratory (Berkeley ... the first experimental demonstration of GRIN for gradient index ... a wide range of exotic optics, including superfast computers based ...
... 2011 Amgen (Nasdaq: AMGN ) and ... into a definitive acquisition agreement under which Amgen has ... venture-funded,  biotechnology company headquartered in Woburn, Mass. BioVex is ... Phase 3 clinical development, that may represent a new ...
... (Nasdaq: CEPH ) will hold a public memorial service ... and CEO on February 1, 2011, at 6:00 p.m. at The ... Dr. Baldino founded Cephalon in 1987 and led the ... ten biotechnology companies in the world. He was a recognized pioneer ...
Cached Biology Technology:GRIN plasmonics 2GRIN plasmonics 3GRIN plasmonics 4Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 2Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 3Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 4Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 5Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 6Amgen to Acquire BioVex, a Privately Held Biotechnology Company Headquartered in Woburn, Mass 7Cephalon to Hold Public Memorial Service to Celebrate the Life of Company Founder, Frank Baldino, Jr., Ph.D. 2
... Formula variant: With the ... described by Hoagland and ... Equivalency: Formulated to contain ... powder per liter of ...
... separation and fractionation of nucleic-acid ... nuclei from cytosolic proteins A ... greatly facilitating study of low-abundance ... acid binding proteins (e.g., transcription ...
... Eagle's medium have been developed ... most widely used modification is ... a modification of Minimum Essential ... a higher concentration of vitamins ...
... EpiTect Bisulfite Kit enables complete conversion ... less than 6 hours. The highly ... against DNA degradation and a spin-column-based ... fast and reliable results for all ...
Biology Products: