Navigation Links
Life-extending protein keeps blood sugar in check

A protein that extends lifespan in yeast, worms, and flies keeps blood sugar under control in mice, reports a new study in the August Cell Metabolism. The findings suggest therapeutic interventions for the prevention and treatment of metabolic disorders, such as type 2 diabetes, which frequently arise with age, the researchers said.

The team found that mice with an excess of the protein Sirt1 in cells of the pancreas have improved glucose tolerance and enhanced insulin secretion in response to glucose. Glucose is the principal circulating sugar in the blood and the major energy source of the body.

"Mice with an increased amount of Sirt1 show a better response to high blood glucose levels that regularly occur after eating sweets, such as cookies or cakes," said Shin-ichiro Imai of Washington University School of Medicine. "The mice respond fast to high glucose by raising insulin levels, clearing the blood of the circulating sugar."

"Under normal feeding conditions, when glucose levels are lower, the mice with elevated Sirt1 appear normal," Imai added. "This is good news, suggesting that therapies designed to manipulate the amount of Sirt1 might improve insulin response in those with type 2 diabetes without causing other problems."

Pancreatic b cells have a highly coordinated mechanism that senses rises in blood glucose and converts that information into signals that increase the secretion of insulin, Imai explained. Insulin produced by the pancreas allows cells to take up glucose from the bloodstream and burn it for energy. A failure to make or respond to insulin in people with diabetes causes blood sugar levels to rise.

The researchers found that Sirt1 is present in pancreas cells that secrete insulin hormone. Mice genetically modified to have an excess of Sirt1 in b cells of the pancreas had improved glucose tolerance and enhanced insulin secretion in response to glucose.

The altered mice maintained their improved b ce
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Life extending protein keeps blood sugar check

(Date:10/15/2014)... 2014   Neurotechnology , a provider of ... of the VeriLook Surveillance 3.0 software development ... biometric face identification using live video streams from ... new version not only identifies faces in a ... while they are moving through the video frame. ...
(Date:10/14/2014)... sequenced the house fly genome for the first time, ... an insect that thrives in pathogen-rich dung piles and ... the journal Genome Biology , will increase understanding ... flies quickly adapt to resist insecticides, which could lead ... domestica) carry and transmit more than 100 human and ...
(Date:10/14/2014)... – Scientists from The Scripps Research Institute (TSRI) have ... Health (NIH) to lead an investigation of Lassa fever ... Africa. The study aims to understand how Lassa fever ... others survive the inflection. , "The ultimate goal ... how Lassa fever virus causes disease and develop new ...
Breaking Biology News(10 mins):VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
... , , , , ... AUDIO: Falon Tilley and Michael W. Beets discuss the successful implementation of ... Click here for more information. , , ... , , , , , ...
... by Jonathan Waxman is a collection of short stories that ... a doctor,s life before the dawn of management. Written in ... from the author,s decades of clinical experience. Chutney Wars, The ... a few of the chapters in this engagingly written book. ...
... have been awarded fellowships from the Alfred P. ... NYU,s Center for Neural Science, and Nicholas Stavropoulos, ... NYU Langone Medical Center and its Neuroscience Institute. ... and scholars "whose achievements and potential identify them ...
Cached Biology News:Healthy Lunchbox Challenge helps influence healthy eating habits in children 2Healthy Lunchbox Challenge helps influence healthy eating habits in children 3Healthy Lunchbox Challenge helps influence healthy eating habits in children 4Two NYU faculty win Sloan Foundation research fellowships 2
(Date:10/22/2014)... Ras Al Khaimah, UAE (PRWEB) October 22, 2014 ... in game-changing life science and healthcare projects, announces the ... MBBS MRCGP DRCOG DCH to its advisory team. Dr. ... research advisory team. , A graduate of ... Dr. Siddiqui was subsequently degreed in medicine in 2001. ...
(Date:10/22/2014)... 2014 Nuvilex, Inc. (OTCQB: NVLX) – According ... worldwide are living with diabetes, with  that number expected ... global market for diabetes treatments is approximately $500 billion.  ... died from pancreatic cancer.  Pancreatic cancer is the fourth ... the United States , and according ...
(Date:10/20/2014)... 20, 2014 Convey Computer , ... team from Iowa State University won first place in ... a Convey HC-2ex, the team’s solution achieved the highest ... than the second place finisher. , Experts from all ... the month long challenge, using a variety of design ...
(Date:10/20/2014)... BOSTON , Oct. 20, 2014 ... commercialization company tackling big healthcare problems, announced today ... investment round, with participation from Invesco Perpetual, a ... be used to drive PureTech,s existing pipeline forward ... technologies. "PureTech has the scientific creativity to really ...
Breaking Biology Technology:Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6
... 2011 Bacterin International Holdings, Inc. ... development of revolutionary bone graft material and anti-infective coatings for ... The record month reflects both greater capacity and efficiency in ... new hires and a management reorganization completed during the month. ...
... 5, 2011   Medical devices ... underlying sales growth of 5%. In an interview ... talks Q2 results and introduces his plans for a new ... focus on emerging markets.  Bohuon also announced plans ...
... can make graphene out of just about anything with carbon -- ... University lab of chemist James Tour proved it when they invited ... them how it,s done. The work is part of a ... described how graphene -- a single-atom-thick sheet of the same material ...
Cached Biology Technology:Bacterin Reports New Hires and Management Reorganization, Driving Most Active Processing Month in July 2Bacterin Reports New Hires and Management Reorganization, Driving Most Active Processing Month in July 3Bacterin Reports New Hires and Management Reorganization, Driving Most Active Processing Month in July 4Bacterin Reports New Hires and Management Reorganization, Driving Most Active Processing Month in July 5Bacterin Reports New Hires and Management Reorganization, Driving Most Active Processing Month in July 6One box of Girl Scout Cookies worth $15 billion 2
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... 100-120 and 220-240 V, is a microfluidics-based ... gel-based electrophoresis, including some data analysis, in ... for protein analysis (it does not include ... The system includes the electrophoresis station, priming ...
...
... Grace's medium was originally formulated to ... the Australian emperor gum moth,Antherea eucalypti. The ... to more closely resembleAnthereahemolymph. The cell lines ... the first continuous lines developed. The basal ...
Biology Products: