Navigation Links
Life-extending protein keeps blood sugar in check

A protein that extends lifespan in yeast, worms, and flies keeps blood sugar under control in mice, reports a new study in the August Cell Metabolism. The findings suggest therapeutic interventions for the prevention and treatment of metabolic disorders, such as type 2 diabetes, which frequently arise with age, the researchers said.

The team found that mice with an excess of the protein Sirt1 in cells of the pancreas have improved glucose tolerance and enhanced insulin secretion in response to glucose. Glucose is the principal circulating sugar in the blood and the major energy source of the body.

"Mice with an increased amount of Sirt1 show a better response to high blood glucose levels that regularly occur after eating sweets, such as cookies or cakes," said Shin-ichiro Imai of Washington University School of Medicine. "The mice respond fast to high glucose by raising insulin levels, clearing the blood of the circulating sugar."

"Under normal feeding conditions, when glucose levels are lower, the mice with elevated Sirt1 appear normal," Imai added. "This is good news, suggesting that therapies designed to manipulate the amount of Sirt1 might improve insulin response in those with type 2 diabetes without causing other problems."

Pancreatic b cells have a highly coordinated mechanism that senses rises in blood glucose and converts that information into signals that increase the secretion of insulin, Imai explained. Insulin produced by the pancreas allows cells to take up glucose from the bloodstream and burn it for energy. A failure to make or respond to insulin in people with diabetes causes blood sugar levels to rise.

The researchers found that Sirt1 is present in pancreas cells that secrete insulin hormone. Mice genetically modified to have an excess of Sirt1 in b cells of the pancreas had improved glucose tolerance and enhanced insulin secretion in response to glucose.

The altered mice maintained their improved b ce ll function with age, they reported. Further analyses found that Sirt1 regulates genes involved in insulin secretion by b cells.

"Together, these results establish that an increase dosage of Sirt1 has beneficial effects on mammalian physiology," Imai said. "Our findings also provide new insight into the physiological and molecular functions of Sirt1 in glucose metabolism and suggest therapeutic interventions for the prevention and treatment of diabetes and other age-associated metabolic disorders."


Source:Cell Press

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:

(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... ... 23, 2016 , ... In a new case report published today in STEM ... who developed lymphedema after being treated for breast cancer benefitted from an injection of ... dealing with this debilitating, frequent side effect of cancer treatment. , Lymphedema ...
(Date:6/23/2016)... , June 23, 2016 ... Hematology Review, 2016;12(1):22-8 ... , the peer-reviewed journal from touchONCOLOGY, Andrew ... escalating cost of cancer care is placing an ... result of expensive biologic therapies. With the patents ...
Breaking Biology Technology: