Navigation Links
Key gene controlling kidney development found

A gene called Six2 plays a critical role in the development of the kidney by keeping a population of "parent" stem cells constantly available to produce the differentiated cells that give rise to specialized parts of the organ, according to investigators at St. Jude Children's Research Hospital. Differentiation is the process by which a progenitor (unspecialized) cell develops characteristics specific to its job in the body.

The kidney stem cells, called mesenchymal blastemal cells, are the source of cells triggered by chemical signals to differentiate into nephrons--the structures in the kidney that cleanse the blood of waste. The nephrons later become attached to ducts--tubes that collect the filtered blood as urine and direct it to the bladder. The St. Jude team showed that Six2 works by preventing some of the precursor cells from responding to these signals. This ensures there will be a continual source of undifferentiated stem cells available to maintain the growth of the kidney.

"Our work shows that Six2 is critical to preventing the developing kidney from running out of stem cells and collapsing into a mass of underdeveloped tissue," said Guillermo Oliver, Ph.D., a member of the St. Jude Genetics and Tumor Cell Biology Department. Oliver is senior author of a report on this finding that appears in the online issue of The EMBO Journal.

"Our discovery of Six2's role in the developing kidney suggests that a similar mechanism exists in other developing organs," said Michelle Self, the doctoral student in Oliver's laboratory who did most of the work on this project.

The St. Jude team showed that the kidneys in developing mice lacking the Six2 gene were remarkably smaller than normal mice and were non-functional at birth. In addition, they produced an abnormal excess in the number of nephrons that in turn produced a useless mass of tissue. Furthermore, the remaining precursor cells underwent apoptosis (cell suicide), further depl
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2

Related biology news :

1. Scientists find that protein controls aging by controlling insulin
2. Gene controlling circadian rhythms linked to drug addiction
3. Enzyme affects hypertension by controlling salt levels in body
4. Liquid crystals show promise in controlling embryonic stem cells
5. Important gene controlling tree growth and development found
6. Key gene controlling eye lens development identified
7. Electronic chip, interacting with the brain, modifies pathways for controlling movement
8. Edge density key to controlling gypsy moth spread
9. Bioartificial kidney under study at MCG
10. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
11. NASA links nanobacteria to kidney stones and other diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Key gene controlling kidney development found

(Date:9/17/2014)... EC-FP5 four-year project, delivering its first release in 2004. ... in several EC projects, as a part of the ... BON), to increase the general awareness of the work ... dissemination of the Fauna Europaea results, the ... e-Publishing tools to prepare data papers for all 56 ...
(Date:9/17/2014)... very cleverly, some lessons on how to create the ... Shaw, director of the Optical Technology Center at Montana ... the nanoscale, we,ll discover them." , Some of those ... a conference called "The Nature of Light: Light in ... University of Arizona College of Optical Sciences. The conference ...
(Date:9/17/2014)... research from the Copenhagen Centre for Social Evolution and ... theory that birth weight and -length can partially predict ... such as autism and schizophrenia later in life. The ... and subsequent hospital diagnoses for up to 30 years, ... The study is published today in the Proceedings ...
Breaking Biology News(10 mins):Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3
... Ants, wasps and humans live in highly complex societies. Our ... trying to find the balance between cooperation and conflict. Understanding ... us key insights into the evolution of sociality in animals. ... biologist Floria Mora-Kepfer Uy, looks at colonies of social wasps ...
... , Press conference announcement: Three years after Fukushima: ... dial-in information, Press room information, Attention PIOs: Sending ... information, Press registration information, Hotel information, U.S. visa ... information about the Ocean Sciences Meeting, please see ...
... powered by methanol or hydrogen have been well studied, ... biomass as a fuel because of the lack of ... researchers at the Georgia Institute of Technology have developed ... converts biomass to electricity with assistance from a catalyst ...
Cached Biology News:What cooperation and conflict in an insect's society can teach us about social acceptance 22014 Ocean Sciences Meeting: Press conference announcement; sending press kits; press registration 22014 Ocean Sciences Meeting: Press conference announcement; sending press kits; press registration 32014 Ocean Sciences Meeting: Press conference announcement; sending press kits; press registration 42014 Ocean Sciences Meeting: Press conference announcement; sending press kits; press registration 5Solar-induced hybrid fuel cell produces electricity directly from biomass 2Solar-induced hybrid fuel cell produces electricity directly from biomass 3
(Date:9/17/2014)... Sept. 17, 2014 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: ... and commercializes proprietary technologies and products for advanced microarray ... approved for trading in the United States ... expected to commence on September 17, 2014 on the ... to trade on the TSX Venture Exchange under its ...
(Date:9/17/2014)... 17 de septiembre de 2014  Cryoport, ... proveedor mundial de soluciones logísticas avanzadas criogénicas ... la vida, anunció hoy la contratación de ... con sede en Rótterdam, Países Bajos, para ... Europa en rápido crecimiento. Según los términos ...
(Date:9/17/2014)... , September 17, 2014 ... mode of action from a truly novel ... MGB Biopharma, a biopharmaceutical company ... announces today that it has secured £4.0m ... lead antibacterial, MGB-BP-3, against a range of ...
(Date:9/17/2014)... Cambridge, MA (PRWEB) September 17, 2014 ... and Safety (ACRES) , a multi-stakeholder non-profit collaborative ... and efficiency in clinical research, today announced Phase ... (SASI). , Amir H. Kalali, ... Quintiles and Arti Bajpai, President, Compliance and Quality ...
Breaking Biology Technology:SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 2MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 3MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 4MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 6MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 7Global Standards Initiative for Clinical Research Sites Advances 2Global Standards Initiative for Clinical Research Sites Advances 3Global Standards Initiative for Clinical Research Sites Advances 4
... April 30 Dendreon Corporation,(Nasdaq: DNDN ) today announced ... Deutsche Bank 33rd Annual Health Care Conference ... ET, Bank of America Health Care Conference Four ... 11:00 a.m. ET, Rodman & Renshaw 5th Annual Global ...
... 3rd Among US For-Profit Healthcare Companies, EL ... provider of kidney care services, announced it has ... Magazine as one of the Top 125,ranking companies ... awarded to organizations that demonstrate a deep,commitment to ...
... Molecular Quantitative Viral Load Assay, ORANGE COUNTY, ... BEC ) announced today that it has ... virus (HCV) from Siemens Healthcare,Diagnostics. Under the agreement, ... viral load HCV blood test for use on ...
Cached Biology Technology:DaVita Honored for 4th Year as Training Top 125 Recipient 2Beckman Coulter Acquires Rights to Hepatitis C Virus 2
One bottle containing 30 ml of protein solution and 0.1% sodium azide....
...
Sheep polyclonal to Quinolone ( Abpromise for all tested applications). Antigen: Norfloxacin(N)conjugated to BSA...
Certified U.S. origin. Bovine Serum:, *Certified U.S. origin. Available raw, nonsterile filtered, or sterile filtered. , , *Sterility tested , , *Low Hemoglobin levels , , *Mycoplasma testing upon...
Biology Products: