Navigation Links
Key gene controlling kidney development found

A gene called Six2 plays a critical role in the development of the kidney by keeping a population of "parent" stem cells constantly available to produce the differentiated cells that give rise to specialized parts of the organ, according to investigators at St. Jude Children's Research Hospital. Differentiation is the process by which a progenitor (unspecialized) cell develops characteristics specific to its job in the body.

The kidney stem cells, called mesenchymal blastemal cells, are the source of cells triggered by chemical signals to differentiate into nephrons--the structures in the kidney that cleanse the blood of waste. The nephrons later become attached to ducts--tubes that collect the filtered blood as urine and direct it to the bladder. The St. Jude team showed that Six2 works by preventing some of the precursor cells from responding to these signals. This ensures there will be a continual source of undifferentiated stem cells available to maintain the growth of the kidney.

"Our work shows that Six2 is critical to preventing the developing kidney from running out of stem cells and collapsing into a mass of underdeveloped tissue," said Guillermo Oliver, Ph.D., a member of the St. Jude Genetics and Tumor Cell Biology Department. Oliver is senior author of a report on this finding that appears in the online issue of The EMBO Journal.

"Our discovery of Six2's role in the developing kidney suggests that a similar mechanism exists in other developing organs," said Michelle Self, the doctoral student in Oliver's laboratory who did most of the work on this project.

The St. Jude team showed that the kidneys in developing mice lacking the Six2 gene were remarkably smaller than normal mice and were non-functional at birth. In addition, they produced an abnormal excess in the number of nephrons that in turn produced a useless mass of tissue. Furthermore, the remaining precursor cells underwent apoptosis (cell suicide), further depl
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2

Related biology news :

1. Scientists find that protein controls aging by controlling insulin
2. Gene controlling circadian rhythms linked to drug addiction
3. Enzyme affects hypertension by controlling salt levels in body
4. Liquid crystals show promise in controlling embryonic stem cells
5. Important gene controlling tree growth and development found
6. Key gene controlling eye lens development identified
7. Electronic chip, interacting with the brain, modifies pathways for controlling movement
8. Edge density key to controlling gypsy moth spread
9. Bioartificial kidney under study at MCG
10. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
11. NASA links nanobacteria to kidney stones and other diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Key gene controlling kidney development found

(Date:10/15/2014)... the 44th Rosenstiel Award for Distinguished Work in Biomedical ... the mechanisms of genomic instability and its implications for ... second alumnus to win the Rosenstiel Award; the first, ... Alt is the Charles A. Janeway Professor of Pediatrics ... an investigator at the Howard Hughes Medical Institute at ...
(Date:10/14/2014)... new study published in Cancer Research shows ... and colon cancers—can promote the development of skin cancers ... and survival of sun-damaged skin cells. , Previously considered ... proteins called sirtuins that help regulate genomic stability and ... SIRT6 helps repair DNA damage, which can lead to ...
(Date:10/14/2014)... how to produce enough food to feed the world ... Organization of the United Nations predicts that food production ... feed a growing global population, and plants are one ... Plants—grains, cereals, fruits, vegetables, and more—feed humans directly ... tap into our knowledge of how plants work to ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... linked a chemical that plays an essential role in ... infertility, the 22nd annual conference of the European Society ... Amiri, embryology laboratory director at the IVF Centre, Fatemieh ... (NO) has been recognised as a molecule that plays ...
... at the Case Western Reserve University School of ... the brain's immune cells triggers a cascade of ... eventually leads to the neural cell death found ... findings in the Journal of Biological Chemistry article, ...
... live or die depends on whether they can muscle their ... Salk Institute for Biological Studies pin-pointed the molecular survival gear ... fray and hook up with other cells. , In ... in the lab of Fred H. Gage, Ph.D., a professor ...
Cached Biology News:Study links high levels of nitric oxide to infertility and sperm DNA damage 2Case Western Reserve University researchers find protein associated with brain cell death 2Life and death in the hippocampus: what young neurons need to survive 2Life and death in the hippocampus: what young neurons need to survive 3
(Date:10/22/2014)... 2014   Synthetic Biologics, Inc. (NYSE MKT: ... serious infections and diseases, announced today that the U.S. ... Allowance for a composition of matter patent application that ... program, SYN-004. This is Synthetic Biologics, first allowed patent ... adds to the Company,s extensive C. difficile ...
(Date:10/22/2014)... 22, 2014 Nuvilex, Inc. (OTCQB: NVLX) – ... people worldwide are living with diabetes, with  that number ... The global market for diabetes treatments is approximately $500 ... worldwide died from pancreatic cancer.  Pancreatic cancer is the ... in the United States , and ...
(Date:10/22/2014)... and HONG KONG , Oct. ... disease therapeutics enterprise, announced today that rare disease expert ... as vice president, research. Dr. McKew brings more than ... leadership positions at the National Institutes of Health, Wyeth ... by Wyeth). Dr. McKew will lead aTyr,s efforts to expand ...
(Date:10/20/2014)... 20, 2014 Mapp Biopharmaceutical,s valiant effort ... therapeutic to fight the Ebola outbreak will make ... the production of pharmaceuticals can be, according to ... that while some may be taken aback by ... with industry knowledge are well aware of the ...
Breaking Biology Technology:Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3
... PLC, a,subsidiary of MGT Capital Investments, Inc. (Amex: ... development of Computer-Aided Detection (CAD) and image,analysis software ... welcomes,the initiative by Barbara Cubin, Republican Representative for ... Computed Tomography,Colonography (CTC). CTC is the innovative screening ...
... Ill., Dec. 21 Abbott (NYSE: ABT ),will ... on Monday,Jan. 7, 2008. Thomas C. Freyman, executive vice ... presentation on the company at,11:00 a.m. Central time., ... accessible through,Abbott,s Investor Relations Web site at http://www.abbottinvestor.com ...
... Inc.,("Solstice") announced the appointment of Dennis L. Smith ... continue to serve as Chairman to its,Board of ... industry experience,and expertise to Solstice that will be ... as the company continues to broaden,its product portfolio ...
Cached Biology Technology:Medicsight Welcomes U.S. Initiative to Reimburse CT Colonography for Early Detection of Colorectal Cancer 2Medicsight Welcomes U.S. Initiative to Reimburse CT Colonography for Early Detection of Colorectal Cancer 3Medicsight Welcomes U.S. Initiative to Reimburse CT Colonography for Early Detection of Colorectal Cancer 4Medicsight Welcomes U.S. Initiative to Reimburse CT Colonography for Early Detection of Colorectal Cancer 5Dennis L. Smith Appointed President and Chief Executive Officer of Solstice Neurosciences, Inc. 2
QPRT Antibody...
This antibody is specific for human J-chain as defined by ELISA assay using purified human immunoglobulin fragments as solid phase target antigen....
Agarose, Biotechnology grade, 500g...
... covering tissue sections and cell preparations immunohistochemically stained ... end products. UltraMount Plus can be ... AEC that require an aqueous mounting medium, or ... heating is required prior to use. This product ...
Biology Products: