Navigation Links
Key gene controlling kidney development found

A gene called Six2 plays a critical role in the development of the kidney by keeping a population of "parent" stem cells constantly available to produce the differentiated cells that give rise to specialized parts of the organ, according to investigators at St. Jude Children's Research Hospital. Differentiation is the process by which a progenitor (unspecialized) cell develops characteristics specific to its job in the body.

The kidney stem cells, called mesenchymal blastemal cells, are the source of cells triggered by chemical signals to differentiate into nephrons--the structures in the kidney that cleanse the blood of waste. The nephrons later become attached to ducts--tubes that collect the filtered blood as urine and direct it to the bladder. The St. Jude team showed that Six2 works by preventing some of the precursor cells from responding to these signals. This ensures there will be a continual source of undifferentiated stem cells available to maintain the growth of the kidney.

"Our work shows that Six2 is critical to preventing the developing kidney from running out of stem cells and collapsing into a mass of underdeveloped tissue," said Guillermo Oliver, Ph.D., a member of the St. Jude Genetics and Tumor Cell Biology Department. Oliver is senior author of a report on this finding that appears in the online issue of The EMBO Journal.

"Our discovery of Six2's role in the developing kidney suggests that a similar mechanism exists in other developing organs," said Michelle Self, the doctoral student in Oliver's laboratory who did most of the work on this project.

The St. Jude team showed that the kidneys in developing mice lacking the Six2 gene were remarkably smaller than normal mice and were non-functional at birth. In addition, they produced an abnormal excess in the number of nephrons that in turn produced a useless mass of tissue. Furthermore, the remaining precursor cells underwent apoptosis (cell suicide), further depl
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2

Related biology news :

1. Scientists find that protein controls aging by controlling insulin
2. Gene controlling circadian rhythms linked to drug addiction
3. Enzyme affects hypertension by controlling salt levels in body
4. Liquid crystals show promise in controlling embryonic stem cells
5. Important gene controlling tree growth and development found
6. Key gene controlling eye lens development identified
7. Electronic chip, interacting with the brain, modifies pathways for controlling movement
8. Edge density key to controlling gypsy moth spread
9. Bioartificial kidney under study at MCG
10. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
11. NASA links nanobacteria to kidney stones and other diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Key gene controlling kidney development found

(Date:7/28/2014)... Norwegian explorer Roald Amundsen reached the South Pole in ... arrived long before any human. , Using data from ... the Antarctic continent, including the South Pole, a group ... (DRI) in Reno, Nevada, created the most accurate and ... southernmost continent. The new record, described in an article ...
(Date:7/28/2014)... Yale School of Medicine have pinpointed a mechanism in part ... in the blood, linking it to both type 1 and ... 28 issue of Proceedings of the National Academies of ... enzyme located in a part of the hypothalamus known ... in motion that control glucose levels in the blood," said ...
(Date:7/28/2014)... findings of a new study suggest two ways to effectively ... as well in obese women, compared to women of a ... one-size-fits-all method, researchers say, but as the population has increased ... works for obese women. Studies have consistently found that obesity ... which may in turn affect how well the pill prevents ...
Breaking Biology News(10 mins):Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Glucose 'control switch' in the brain key to both types of diabetes 2Strategies identified to improve oral contraceptive success with obese women 2
... developed a clever method to purify parasitic organisms from ... proteomic studies and a deeper insight into the biology ... each year. Many infectious pathogens, like those ... have a complex life cycle alternating between free-living creature ...
... carbon dioxide from burning of fossil fuels might be kept below ... next few decades, say researchers. They say that less plentiful oil ... greater supplies of coal mean that it must be the main ... Biogeochemical Cycles . , ...
... addition to social factors when selecting a mate. In ... PLoS Genetics, scientists in China, France, and the ... be involved in mate choice in some human populations. ... Major Histocompatibility Complex (MHC), a large genomic region involved in ...
Cached Biology News:Curbing coal emissions alone might avert climate danger, say researchers 2Curbing coal emissions alone might avert climate danger, say researchers 3
(Date:7/28/2014)... July 28, 2014 Proove Biosciences ... will be exhibiting data and research conducted through their ... Spine Intervention Society’s (ISIS) 22nd Annual Scientific Meeting. ... the Hyatt Regency, in Orlando, Florida. , ... clinical competence of physicians who care for patients suffering ...
(Date:7/28/2014)... , July 28, 2014  David Hardison, Ph.D., ... by Deloitte , has been elected chairman of ... Consortium, a non-profit working to establish common protocols ... as it relates to electronic health records. ... mission of collaborating with organizations across the research ...
(Date:7/28/2014)... July 28, 2014 It’s a hard truth: ... benefits to further their post-secondary education are failing to obtain ... released this year. And according to an analysis by ... is veteran students’ uninformed choice of college majors, which leads ... of the study: Some 51.7 percent of post-9/11 veterans using ...
(Date:7/28/2014)... 28, 2014 Research and Markets has ... Market 2014-2018" report to their offering. ... is a technique used to determine the size of a ... is crucial to analyze the size of particles as it ... analysis is performed to determine the behavior and nature of ...
Breaking Biology Technology:Proove Biosciences Exhibits Industry Leading Data and Research at International Spine Intervention Society’s 22nd Annual Scientific Meeting 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 2Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 4Global Particle Size Analysis Market 2014-2018 2
... 2012 Oxford BioTherapeutics (OBT) today announces that ... advisor and non-executive director.  Dr Begley, who was the Vice ... Amgen, will take on a key role in helping shape ... its pipeline of oncology antibody-based drugs into clinical development. ...
... Advanstar Communications, is pleased to announce the agenda for ... held April 26 - 27, 2012 at the Loews ... share their strategies for improving patient outcomes and product ... Conference highlights include: , The ...
... Jan. 11, 2012  goBalto, developer of new generation ... completed a FDA 21 CFR Part 11 compliance ... trials application. Tracker,s successful audit will help both ... running clinical trials comply with FDA rules and ...
Cached Biology Technology:Oxford BioTherapeutics Appoints C. Glenn Begley as a Senior Clinical Advisor and Non-executive Director 2Oxford BioTherapeutics Appoints C. Glenn Begley as a Senior Clinical Advisor and Non-executive Director 3Complete Agenda Announced for 11th Annual Patient Adherence Forum 2goBalto Completes a Successful FDA 21 CFR Part 11 Compliance Audit 2
See product name for description....
RAT ANTI MOUSE TCR V BETA 7:RPE Immunogen: T-cell lymphoma TK1...
... Serum • Rhesus serum is collected from ... years of age. Available Anticoagulants: ... (Na) N-06: K2EDTA N-08: ... N-03: Alsevers N-05: ACD ...
Porcine Serum US Origin 6 Months or Older...
Biology Products: