Navigation Links
Key gene controlling kidney development found

A gene called Six2 plays a critical role in the development of the kidney by keeping a population of "parent" stem cells constantly available to produce the differentiated cells that give rise to specialized parts of the organ, according to investigators at St. Jude Children's Research Hospital. Differentiation is the process by which a progenitor (unspecialized) cell develops characteristics specific to its job in the body.

The kidney stem cells, called mesenchymal blastemal cells, are the source of cells triggered by chemical signals to differentiate into nephrons--the structures in the kidney that cleanse the blood of waste. The nephrons later become attached to ducts--tubes that collect the filtered blood as urine and direct it to the bladder. The St. Jude team showed that Six2 works by preventing some of the precursor cells from responding to these signals. This ensures there will be a continual source of undifferentiated stem cells available to maintain the growth of the kidney.

"Our work shows that Six2 is critical to preventing the developing kidney from running out of stem cells and collapsing into a mass of underdeveloped tissue," said Guillermo Oliver, Ph.D., a member of the St. Jude Genetics and Tumor Cell Biology Department. Oliver is senior author of a report on this finding that appears in the online issue of The EMBO Journal.

"Our discovery of Six2's role in the developing kidney suggests that a similar mechanism exists in other developing organs," said Michelle Self, the doctoral student in Oliver's laboratory who did most of the work on this project.

The St. Jude team showed that the kidneys in developing mice lacking the Six2 gene were remarkably smaller than normal mice and were non-functional at birth. In addition, they produced an abnormal excess in the number of nephrons that in turn produced a useless mass of tissue. Furthermore, the remaining precursor cells underwent apoptosis (cell suicide), further depl
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2

Related biology news :

1. Scientists find that protein controls aging by controlling insulin
2. Gene controlling circadian rhythms linked to drug addiction
3. Enzyme affects hypertension by controlling salt levels in body
4. Liquid crystals show promise in controlling embryonic stem cells
5. Important gene controlling tree growth and development found
6. Key gene controlling eye lens development identified
7. Electronic chip, interacting with the brain, modifies pathways for controlling movement
8. Edge density key to controlling gypsy moth spread
9. Bioartificial kidney under study at MCG
10. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
11. NASA links nanobacteria to kidney stones and other diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Key gene controlling kidney development found

(Date:6/26/2015)... 26, 2015 ATL Technology, LLC, a top provider ... in single use solutions, headquartered in Springville, Utah ... California corporation with locations in ... Jose, Costa Rica ). This acquisition will ... with ATL Technology,s existing facility in Costa ...
(Date:6/25/2015)... 2015  TAKE Solutions Ltd., a global business technology ... States Patent and Trademark Office (USPTO) for its "Method ... Solutions, Clinical Accelerators to reduce the time taken to ... standardization without the accelerators), thus reducing time to market. ... At the heart of the patented Clinical Data Standardization ...
(Date:6/24/2015)... , June 24, 2015  Synaptics Inc. ... human interface solutions, today announced that Sharp has ... provide secure authentication for its latest flagship smartphone ... more than 200 million shipments of its fingerprint ... reinforces Synaptics, strength, scalability and leadership in the ...
Breaking Biology News(10 mins):ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2TAKE Solutions Awarded Patent By USPTO 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2
... Center have identified a variation in a particular gene ... years, scientists have known that the devastating, early-onset form ... about the gene(s) responsible until now. The results are ... Genetics . In a previous study, a region ...
... BioScience includes the following research articles: ... Advancing Understanding. Heather L. Sanders and Sarah ... genes and epigenetic phenomena that regulate the development ... that are becoming available for the study of ...
... complex genetic signature associated with Alzheimer,s disease, the ... the elderly. The research, published by Cell Press ... Journal of Human Genetics , uses a powerful, ... this devastating neurodegenerative disorder. Previous research ...
Cached Biology News:Genetic variation may lead to early cardiovascular disease 2BioScience tip sheet, January 2009 2Scientists make strides toward defining genetic signature of Alzheimer's disease 2
(Date:7/1/2015)... AURORA, Colo. and BANGALORE, India ... a global genomic profiling company that uses next generation ... appointment of Scott A. Storrer as chief ... and CEO, he will be responsible for all strategy, ... Vijay Chandru , who has served as Strand,s chairman ...
(Date:7/1/2015)... InferMed , s ... will augment Elsevier ... olutions suite   Elsevier , a world-leading ... announced today the acquisition of  InferMed , a ... InferMed,s Arezzo technology supports clinicians in choosing the most ...
(Date:6/30/2015)... ... 2015 , ... Students and faculty from Beijing City University ... “Integrative Biotechnology,” an applied biotechnology course team-taught by faculty members from both institutions. ... from both universities and is taught on both continents. , “Our alliance with ...
(Date:6/30/2015)... , June 30, 2015  Today, Americord Registry, one of ... Andrew Horne , a partner at Kirkland & Ellis ... Logo - http://photos.prnewswire.com/prnh/20150630/226958LOGO   "We ... Advisory Board," says Martin Smithmyer , CEO of Americord. ... legal career that will assist Americord,s growth and vision." ...
Breaking Biology Technology:Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2Americord Registry Announces Andrew Horne as Advisory Board Member 2
... Ltd. (Amex:,SVA), a vaccine-focused biotech company in China, ... two upcoming investor conferences, including the,Oppenheimer 19th Annual ... Suisse Asian Healthcare Conference in Beijing, China., ... to present on,Tuesday, November 4, 2008 at 3:20 ...
... 29 Osteotech, Inc.,(Nasdaq: OSTE ), a ... for,regenerative healing, announced today that it has received ... Administration ("FDA") for its next,generation grafting material. Osteotech ... graft substitute, and as a bone void filler, ...
... Oct. 29 Genomic Health,Inc. (Nasdaq: GHDX ) ... and webcast on Wednesday, November 5, 2008 at 4:30 ... results. The call and webcast,will follow the release of ... Call Details, To access the live conference call ...
Cached Biology Technology:Sinovac to Participate in Two Upcoming Investor Conferences 2Osteotech Receives FDA Clearance for its Next Generation Grafting Material 2Genomic Health to Announce Third Quarter 2008 Financial Results and Host Conference Call on Wednesday, November 5, 2008 2
UGT1A6 (D-20)...
...
... The T2-02 diaphragm pump features T Squareds ... achieves remarkable performance and efficiency. With the ... range, T2-02 is ideal for use in ... ultra-compact size, long life, and high efficiency. ...
Normal Hamster Serum...
Biology Products: