Navigation Links
Jumping gene helps explain immune system's abilities

e system's 'a la carte' process happens is still murky," says Craig. But the a la carte approach provides great diversity from a limited number of choices, whether in the immune system or in a cafeteria. For example, at a cafeteria, one diner could have a meal of mashed potatoes, broccoli and a pork chop, and another French fries, salad and a hamburger, and so on through all the possible combinations of offerings. While the choices aren't as tasty, immune cells select sections of certain genetic instructions in order to make instructions for a protein that will recognize a particular antigen. Machinery snips out unwanted genetic sections and reconnects the leftover ones, creating a unique gene (the cellular equivalent of the diner's meal). Snipping out different sections will lead to a different gene, carrying instructions for a different protein that will recognize a different antigen, and on and on. This a la carte process, known as V(D)J recombination, is similar to the excision of jumping genes, but none had matched one of its characteristic oddities: As the unwanted DNA is being removed, the remaining DNA forms a tiny loop. Unexpectedly, when Hermes is being cut out of the DNA, the leftover DNA also forms a hairpin loop, temporarily doubling back on itself, postdoctoral fellows Liqin Zhou, Ph.D., and Rupak Mitra, Ph.D., discovered in experiments in test tubes and with E. coli bacteria. Although this loop distances Hermes from its well-studied cousins, the Hermes protein still has an important family trait, the researchers report. Colleagues at the National Institutes of Health found that a few key building blocks in the protein's DNA-snipping crevice are identical to those in other jumping genes' proteins, even though the overall sequence is quite different. "Because of its similarities both to V(D)J recombination and to other families of jumping genes, Hermes is the first real link between the two processes," says Craig. "It also is likely to be a good model t
'"/>

Source:John Hopkins Medecine


Page: 1 2 3

Related biology news :

1. Jumping genes contribute to the uniqueness of individual brains
2. Jumping gene could provide non-viral alternative for gene therapy
3. Protein helps regulate the genes of embryonic stem cells
4. Scientists reveal the shape of a protein that helps retroviruses break into cells
5. Thai spice helps cut blood sugar swings
6. Chemists synthesize molecule that helps body battle cancers, malaria
7. Ancient DNA helps clarify the origins of two extinct New World horse species
8. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
9. Study: Well-known protein helps stem cells become secretory cells
10. Beyond genes: Lipid helps cell wall protein fold into proper shape
11. Simple sea sponge helps scientists understand tissue rejection
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Jumping gene helps explain immune system abilities

(Date:2/24/2015)... NEW YORK , Feb. 24, 2015 This report ... Thousands by the following Segments: Face Biometrics, and Voice Biometrics. The ... , Japan , Europe ... & Africa , and Latin ... period 2013 through 2020. Also, a seven-year historic analysis is provided ...
(Date:2/19/2015)... , Feb .19, 2015 Research and ... the addition of the "Military Electro-Optical / ... Sensor Technology, by Platform - Forecast to 2020" ... The military electro-optical/infrared systems market is expected to ... CAGR of 7.71%. This report segments ...
(Date:2/12/2015)... Minn. , Feb. 12, 2015   ... company specializing in clinical study management systems, has ... Program , further distinguishing iMedNet ... Clinical Research Organizations (CROs) and healthcare consultants.  Building ... support, prospective customer referrals and numerous co-marketing opportunities), ...
Breaking Biology News(10 mins):World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3MedNet Solutions Announces Key Enhancements To Its iMedNet Partner Program 2
... of their limb movements by moving a joint with ... of the almost perfect elastic substance called resilin. This ... high-speed video footage, published in the open access journal ... mouthparts of crabs and crayfish. Malcolm Burrows ...
... deadly disease that prevents the body from using stored sugar ... gene therapy at the University of Florida putting scientists ... in children. Called glycogen storage disease type 1A, the ... store and use sugar between meals. In order to survive, ...
... San Francisco, and collaborators at Harvard Medical School have ... process that clears glucose out of the bloodstream, shedding ... on a cellular level. Establishing the ... in mice, has broad implications for both the future ...
Cached Biology News:Resilin springs simplify the control of crustacean limb movements 2UF makes gene therapy advance in severe genetic disorder 2UF makes gene therapy advance in severe genetic disorder 3UCSF discovers new glucose-regulating protein linked with diabetes 2
(Date:2/26/2015)... 26, 2015 According to a new ... Market For Transgenic Crops (Corn, Soybean, Cotton and Others), ... Size, Share, Growth, Trends and Forecast, 2013 – 2019,”the ... million in 2012 and is expected to reach USD ... 9.5% from 2013 to 2019. , Demand for ...
(Date:2/26/2015)... Regis Technologies announced new potent ... drug substances. , Regis Technologies is proud to announce ... Compound Suite (PCS) for 2015. , Regis is a ... facility in Morton Grove, Illinois. The PCS addition will ... up to about one kilogram per batch. , ...
(Date:2/26/2015)... , Feb. 26, 2015 Tauriga Sciences, Inc. ... company with interests in the natural wellness sector and ... today that its products will be featured at the ... Partners, 27 th Annual Growth Stock Conference on ... at 1 Ritz Carlton Drive, Dana Point ...
(Date:2/26/2015)... , Feb. 26, 2015   Lexicon Pharmaceuticals, Inc. ... will present at the Cowen 35 th Annual Health ... EST in Boston .  Lexicon management will ... A webcast of the presentation will be available ... of the presentation will be available at www.lexpharma.com ...
Breaking Biology Technology:Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 2Global Agricultural Biotechnology Market is Expected to Reach USD 28,694.1 Million in 2019 : Transparency Market Research 3Regis Extends cGMP Services to Oncology Market 2SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 2SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 3SEC Compliance Featuring Products From Tauriga Sciences, Inc. at ROTH Capital Conference 4Lexicon To Present At The Cowen 35th Annual Health Care Conference 2
... of Wisconsin-Madison spinoff working on hydrogen energy sources, has received ... continued research. , ,The company is trying to generate hydrogen ... as part of a cars engine or an electrical generator. ... a highly explosive gas. , ,The companys previous research ...
... two weeks to go before the presidential election, the polls ... over claims made by Republican George W. Bush and Democrat ... one attempt to cut through the hype and the clutter ... the economy : Kerry says 1.6 million jobs have been ...
... Automation, Inc. , a Milwaukee-headquartered maker of automation and ... a new line of embedded processors from Intel and ... design. , ,Intels IXP processor line runs in a ... adapted to the demands of manufacturing environments, a Rockwell ...
Cached Biology Technology:Presidential candidates stretch necks and facts 2Presidential candidates stretch necks and facts 3
... The Dodeca silver stain kits ... staining devices including Bio-Rad Dodeca stainers. ... nanogram quantities of proteins in polyacrylamide ... The kit includes sensitizer concentrate, silver ...
PTC-100 cycler with gold/silver block with Hot Bonnet heated lid, holds one 96-well V-plate or96x0.2ml tubes...
... The DTX Series Multimode Detectors provide ... variety of application and automation needs. ... absorbance measurements on the same instrument, ... standalone instruments or can be integrated ...
... is available in a ready-to-use format. ... for dewaxing paraffin-embedded tissue sections prior ... or other analytical methods. The conventional ... dipping the slides in a series ...
Biology Products: