Navigation Links
Jumping gene helps explain immune system's abilities

e system's 'a la carte' process happens is still murky," says Craig. But the a la carte approach provides great diversity from a limited number of choices, whether in the immune system or in a cafeteria. For example, at a cafeteria, one diner could have a meal of mashed potatoes, broccoli and a pork chop, and another French fries, salad and a hamburger, and so on through all the possible combinations of offerings. While the choices aren't as tasty, immune cells select sections of certain genetic instructions in order to make instructions for a protein that will recognize a particular antigen. Machinery snips out unwanted genetic sections and reconnects the leftover ones, creating a unique gene (the cellular equivalent of the diner's meal). Snipping out different sections will lead to a different gene, carrying instructions for a different protein that will recognize a different antigen, and on and on. This a la carte process, known as V(D)J recombination, is similar to the excision of jumping genes, but none had matched one of its characteristic oddities: As the unwanted DNA is being removed, the remaining DNA forms a tiny loop. Unexpectedly, when Hermes is being cut out of the DNA, the leftover DNA also forms a hairpin loop, temporarily doubling back on itself, postdoctoral fellows Liqin Zhou, Ph.D., and Rupak Mitra, Ph.D., discovered in experiments in test tubes and with E. coli bacteria. Although this loop distances Hermes from its well-studied cousins, the Hermes protein still has an important family trait, the researchers report. Colleagues at the National Institutes of Health found that a few key building blocks in the protein's DNA-snipping crevice are identical to those in other jumping genes' proteins, even though the overall sequence is quite different. "Because of its similarities both to V(D)J recombination and to other families of jumping genes, Hermes is the first real link between the two processes," says Craig. "It also is likely to be a good model t
'"/>

Source:John Hopkins Medecine


Page: 1 2 3

Related biology news :

1. Jumping genes contribute to the uniqueness of individual brains
2. Jumping gene could provide non-viral alternative for gene therapy
3. Protein helps regulate the genes of embryonic stem cells
4. Scientists reveal the shape of a protein that helps retroviruses break into cells
5. Thai spice helps cut blood sugar swings
6. Chemists synthesize molecule that helps body battle cancers, malaria
7. Ancient DNA helps clarify the origins of two extinct New World horse species
8. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
9. Study: Well-known protein helps stem cells become secretory cells
10. Beyond genes: Lipid helps cell wall protein fold into proper shape
11. Simple sea sponge helps scientists understand tissue rejection
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Jumping gene helps explain immune system abilities

(Date:9/1/2014)... animals, bats are perfectly adapted to a life without light. ... reflected echoes to measure distance to obstacles or prey. In ... delays. A study carried out by researchers at Technische Universitt ... map dynamically adapts to external factors. , Closer ... in too close to an object, the number of activated ...
(Date:8/31/2014)... bacteria C. diff , that causes diarrhoea, temperature ... at the University of Leicester. , Using a mass ... possible to identify the unique ,smell, of C. ... the condition., What is more, the Leicester team say ... the disease simply from their smell a chemical ...
(Date:8/31/2014)... today in Nature Climate Change , suggests that ... if not exceed, the global targets for total greenhouse gas ... we should all think carefully about the food we choose ... the world is just one of a number of actions ... and ensure there is enough food for all. , ...
Breaking Biology News(10 mins):Zooming in for a safe flight 2Scientists develop 'electronic nose' for rapid detection of C. diff infection 2Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4
... they grow older, but autopsy data from a long-range study ... that the brains of a third of those who had ... the type of small, cumulative injury that can come from ... presented the study results at Experimental Biology 2008 in San ...
... what makes some people stand head and shoulders above the ... first common version of a gene influencing height has now ... can make a height difference of up to 6cm. ... today in the journal Nature Genetics, mean that scientists now ...
... or biological rhythm, controls many metabolic functions and is ... 24-hour cycle that is important in determining sleeping and ... mammals. The newly discovered rhythm, like the circadian ... brain that functions as the main control center for ...
Cached Biology News:1/3 of risk for dementia attributable to small vessel disease, autopsy study shows 2A tall story: New research adds to growing body of knowledge of genetics of height 2NYU dental professor discovers biological clock linking tooth growth to other metabolic processes 2
(Date:8/31/2014)... 2014 Available spectra is similar ... research and cultivation of a wide range of ... LEDs with proven patented and pending wide spectrum ... uniformity in critical applications in contrast to growth ... “Our customers have a large variety of differently ...
(Date:8/29/2014)... Electronic circuits are based on electrons, but one of ... photonic circuits, i.e. circuits based on light (photons) instead ... to create a stream of single photons and control ... sorts of attempts to achieve this control, but now ... creating a steady stream of photons emitted one at ...
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and ... candidates to participate in an investigational study of donor ... goal of this study is to determine if a ... two arthritically affected joints can help reduce pain and ... the current investigational study must be older than nine ...
(Date:8/28/2014)... SAN DIEGO, California, USA (PRWEB) August 28, 2014 ... at the Department of Physics and Optical Science and ... at the University of North Carolina at Charlotte, and ... has been elected to serve as the 2015 Vice ... photonics. , SPIE 2014 President Philip Stahl announced recent ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... has been named the,Singapore Entrepreneurial Company of the ... that have pushed the boundaries of excellence in ... 2008.,Mr David Picard, CEO of Moleac, received the ... Award for Singapore Entrepreneurial Company,of the Year at ...
... April 21 GenVault, a leading provider of ... the release today of GenConnect 3.2, the newest ... Highlights of the release include a strategic ... seamlessly into third-party informatics offerings, as well as ...
... Inc. (Nasdaq: ITMN ) announced today that it ... 30, 2009 at 4:00 p.m. Eastern time. A live ... 4:30 p.m. Eastern time that same day. , ... 973-200-3372 (international), conference ID# 95970767. To access the webcast, ...
Cached Biology Technology:Moleac Named Singapore Entrepreneurial Company of the Year at the Frost & Sullivan Excellence in Healthcare Awards 2Moleac Named Singapore Entrepreneurial Company of the Year at the Frost & Sullivan Excellence in Healthcare Awards 3GenVault Corporation Launches its Latest Centralized and Standardized Software Solution for Biobanking and Biological Sample Management, GenConnect 3.2 2GenVault Corporation Launches its Latest Centralized and Standardized Software Solution for Biobanking and Biological Sample Management, GenConnect 3.2 3InterMune to Release First Quarter Financial Results on April 30 2
UltraPure DNase/RNase-Free Distilled Water is designed for use in all molecular biology applications. It is 0.1-m membrane-filtered and tested for DNase and RNase activity....
... DEPC-treated Water is suitable ... is prepared by incubating with ... autoclaved to remove the DEPC.DNase/RNase-Free ... for use in all molecular ...
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
The Hybrid Hunter Yeast Two-Hybrid System uses the activation of reporter genes to indicate positive protein-protein interactions. Two reporters are used an auxotrophic marker and lacZ....
Biology Products: