Navigation Links
Jefferson researchers find nanoparticle shows promise in reducing radiation side effects

A gene responsible for the production of a protein called vasostatin may prove a promising new way of treating pancreatic cancer, suggests research published ahead of print in Gut.

Pancreatic cancer is the fifth leading cause of cancer deaths in the developed world, and is extremely difficult to treat. Only 3% of affected patients are still alive five years after diagnosis, a survival rate that has remained static for the past three decades.

Currently, the only viable treatment is surgery. Radiotherapy and chemotherapy have little impact on the disease.

The research team investigated the potential of the protein vasostatin to suppress the development of new blood vessels and pancreatic tumour cells both in test tubes and in mice with pancreatic cancer.

'Solid' tumours, such as pancreatic cancer, are heavily dependent on a rich blood supply to enable them to grow rapidly and spread throughout the body. This process is known as angiogenesis.

The protein gene was incorporated into a virus (adenovirus), so that it would be able to penetrate the cells, acting as a vector.

The test tube experiments showed that 72 hours after infection with the genetically modified virus, vasostatin was clearly active in the tissue. Tumour growth in the mice was also curbed, and when compared with mice which had not been infected with the virus, the difference between the two groups was highly significant.

The researchers then looked more closely at the pancreatic cells and the cell linings of the blood vessels (vascular endothelial cells).

They found that although vasostatin seemed to have little impact on the pancreatic cells, it blocked the formation of new blood vessels, effectively cutting off the supply of nutrients to the malignant cells. This effect was seen in both the test tube and animal experiments.

This type of gene therapy "may be a potent strategy to treat many malignant tumours, including pancreatic can
'"/>

Source:Thomas Jefferson University


Page: 1 2

Related biology news :

1. Jefferson Virologists Coax HIV Out of Hiding
2. Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
3. Jefferson scientists identify gene defect leading to abnormal skin development and cancer
4. Jefferson researchers building a better rabies vaccine
5. Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
6. Immune cell communication key to hunting viruses, Jefferson immunologists show
7. Jefferson researchers uncover new way nature turns genes on and off
8. Jefferson scientists find aging gene also protects against prostate cancer development
9. Jefferson scientists find high glucose before surgery raises risk of dangerous complications
10. Jefferson researchers discovery may change thinking on how viruses invade the brain
11. Elderly spinal cord injuries increase five-fold in 30 years, Jefferson neurosurgeons find
Post Your Comments:
(Date:3/24/2015)... PALM BEACH GARDENS, Fla. , March 24, ... of biometric identity management solutions, today announced that ... enabling premium clothing accessory retailer Goorin Bros ... login. The Crossmatch biometrics-based solution secures access to ... customers from the increased risk of data breaches. ...
(Date:3/23/2015)... , March 23, 2015   HOYOS Labs ... management company, today announced that the Company will demonstrate ... both enterprise and consumers at Connect:ID on March 23 ... HOYOS Labs will highlight the IEEE Biometric Open ... ; and enterprise access control system. BOPS was ...
(Date:3/23/2015)... OXFORD, Conn. , Mar. 23, 2015 NXT-ID, Inc. ... authentication company focused on the growing mobile commerce market, announces ... a new advertising campaign on CNBC television starting March 30 ... ads will commence airing in New York ... Executive Officer said: "We are excited about our new ad ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... much as one-third of global energy consumption. However, unconventional ... CO2 emissions. ETH Zurich Professor for Sociology, Dirk Helbing, ... that could improve vehicular traffic flow by up to ... the ETH Zurich Chair of Sociology, a specialist in ...
... in girls has been found to negatively affect these ... abuse, adolescent pregnancy, and cancers of the reproductive system. ... certain adolescents are at increased risk for early puberty ... strategies for high-risk youths., New research shows that greater ...
... U.S. Department of Homeland,Security (DHS) announced today that in ... a success and accomplished its intended,goals. In its first ... prosecuted 90 of those migrants, and helped reduce the ... waters between Puerto Rico,and the Dominican Republic. "The ...
Cached Biology News:Traffic control systems 2Traffic control systems 3Traffic control systems 4Family conditions may affect when girls experience puberty 2Biometrics Help Identify, Apprehend and Deter Illegal Migrants 2
(Date:4/30/2015)... DIEGO , April 30, 2015  Pfenex ... engaged in the development of biosimilar therapeutics including ... announced the closing of its previously announced underwritten ... stock at a public offering price of $15.50 ... by the underwriters of their option to purchase ...
(Date:4/30/2015)... FRANCE (PRWEB) April 30, 2015 ... and at http://www.lespausa.com , Fleur’s ... multi-action product combining the benefits of makeup, skin ... This subtly tinted cream is designed with specific ... for an even complexion and a healthy glow. ...
(Date:4/30/2015)... Kent, WA (PRWEB) April 30, 2015 ... recently developed ultrafiltration membranes, the PX, PY, ... test coupons, sheets, and disks. Designed to ... applications, these new membranes can fill critical process ... effluent hinder downstream processes. , “New regulations on ...
(Date:4/29/2015)... --  Doximity , the leading online medical network with ... announced a new, instant method for physicians to apply ... click, all US physicians can quickly submit their verified ... open job opportunity, and a recruiter will reach out ... of physicians are open to new jobs, and yet ...
Breaking Biology Technology:Pfenex Inc. Announces Closing of Public Offering of Common Stock and Full Exercise of Underwriters' Option to Purchase Additional Shares 2Fleur’s Introduces CC CRÈME Perfect Skin Solution 2Fleur’s Introduces CC CRÈME Perfect Skin Solution 3Sterlitech Offers New Ultrafiltration Membranes 2Doximity Offering Hospitals Easy, Efficient Physician Application Tool 2
... Wis . - Did the state of Wisconsin improperly apply ... by Menasha Corp. ? , ,The Wisconsin Supreme ... to hear the case, and there is an estimated $350 ... Menasha Corp. , ,At issue is the definition of modified ...
... . - For reasons that may be as innocent as ... that would trade Wisconsin's city-by-city regulation of the cable television ... jobs, help many consumers and speed new technologies to the ... earlier this spring. Since then, however, it has been gathering ...
... Accounting Oversight Board (PCAOB) will place a greater ... numerous studies, including our own, that show IT change ... the investment to fix your change management process because ... compliance program. , ,PCAOB Release number 2006-007, a ...
Cached Biology Technology:In a fast-paced economy, lawmakers must pick up speed 2In a fast-paced economy, lawmakers must pick up speed 3Why IT change management is more important than ever 2Why IT change management is more important than ever 3Why IT change management is more important than ever 4
Human Cystatin A MAb (Clone 224705)...
...
Microlite 2+ Plate, round bottom; an irradiated, high binding surface with enhanced dynamic range, extra high reflectivity and minimal cross talk for low signal luminescent reactions....
... HERAfreeze ultra low temperature freezers ... for safe storage of biological samples ... plus five separate inner doors ensure ... energy costs. ,Application oriented accessories ...
Biology Products: