Navigation Links
Individual differences in a clock gene predict decline of performance during sleep deprivation

People are known to differ markedly in their response to sleep deprivation, but the biological underpinnings of these differences have remained difficult to identify. Researchers have now found that a genetic difference in a so-called clock gene, PERIOD3, makes some people particularly sensitive to the effects of sleep deprivation. The findings, reported by Antoine Viola, Derk-Jan Dijk, and colleagues at the University of Surrey's Sleep Research Center, appear online this week in the journal Current Biology, published by Cell Press.

There are two variants of the PERIOD3 gene found in the human population, encoding either long or short versions of the corresponding protein. Each individual will possess two copies of the gene, either of which might be the long or short form. Previous work had indicated that the different forms of the gene appear to influence characteristic morning and evening activity levels—for example, "owl" versus "lark" tendencies.

In the new work, a multidisciplinary research team consisting of biological scientists and psychologists compared how individuals possessing only the longer gene variant and those possessing only the shorter one coped with being kept awake for two days, including the intervening night. The researchers found that although some participants struggled to stay awake, others experienced no problems with the task.

The results were most pronounced during the early hours of the morning (between 4 and 8 a.m.), during which individuals with the longer variant of the gene performed very poorly on tests for attention and working memory.

The authors point out that this early-morning period corresponds to stretches of time when shift workers struggle to stay awake, during which many accidents related to sleepiness occur. But the scientists also emphasize that the new research was conducted in the laboratory, and whether forms of the PERIOD3 gene also predict individual differences in the tolerance
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
2. Team Invents Device For Weighing Individual Molecules
3. Individuals and populations differ in gene activity levels, not just genes
4. Variation in womens X chromosomes may explain differences among individuals, between sexes
5. Big differences in duplicated DNA distinguish chimp and human genomes
6. Identical twins may have more differences than meet the eye
7. Study outlines genetic differences between potential pandemic influenza strains
8. Brain differences could explain why males and females experience pain relief differently
9. Most human-chimp differences due to gene regulation ?not genes
10. Albatross study shows regional differences in ocean contamination
11. Viral genetic differences are possible key to HIV dementia
Post Your Comments:
(Date:5/8/2015)... May 8, 2015 Synaptics Inc. (NASDAQ: SYNA ... that members of the executive management team will present at ... Technology, Media and Telecom Conference Date: May 18, 2015 ... Boston, MA Cowen and Company ... 2:45pm ET Location: The New York Palace Hotel, ...
(Date:5/5/2015)... , May 5, 2015, NXT-ID, Inc. (NASDAQ: ... focused on the growing mobile commerce market, reminds investors and ... Technology Officer, is presenting  at CARTES SECURE CONNEXIONS AMERICA 2015, ... 2015. The three-day conference is organized into ... speaking in is themed Global Fraud: Where is the ...
(Date:4/27/2015)... , Apr. 27, 2015 Profile Solutions, ... control and security systems is pleased to announce that ... as a consultant and member of its scientific advisory ... widely known as a thought leader in technology-enhanced learning ... Technology Group, and has published studies and books focused ...
Breaking Biology News(10 mins):Synaptics to Present at Upcoming Investor Conferences 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... available in Spanish . Studies by ... presence of Escherichia coli pathogens in surface waters ... in underwater sediments. Most E. coli strains ... water quality managers to estimate fecal contamination. These findings, ...
... of years ago, humans discovered flammable gas could be produced ... anaerobic digestion. Today, EU laws are pushing governments to use ... to enrich soil or biogas for energy. Our environment would ... dumped in diminishing landfill sites. However, while the scientific ...
... have filled an important gap in the study of tunicate ... gelatinous, free-swimming types of tunicates. Their study was featured on ... of Plankton Research . Tunicates are a phylum of ... covering called a tunic, from which the name derives. ...
Cached Biology News:E. coli can survive in streambed sediments for months 2Time to make more out of waste 2Time to make more out of waste 3Woods Hole Oceanographic Institution study sheds light on tunicate evolution 2
(Date:5/22/2015)... According to a new market ... Gel Electrophoresis, Agarose & Polyacrylamide Gel, Capillary Electrophoresis, Isoelectric ... & by End User - Global Forecast to 2020", ... reach around $1.98 Billion by 2020 with a CAGR ... Browse 226 ma rket data ...
(Date:5/22/2015)... Knowledgent , the data and analytics firm, ... of big data analytics in the life sciences and ... life sciences and healthcare organizations understand the ways in ... insights. , The life sciences and healthcare industries historically ... profiling, compliance and regulatory requirements, and scientific research. These ...
(Date:5/21/2015)... 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the ... develops and commercializes proprietary technologies and products for advanced ... for the second fiscal quarter ended March 31, 2015. ... to advance business with our existing customers and to ... and CEO of SQI. "The delivery of a fully ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Specialty ... audit and been admitted to BPA Worldwide as ... Worldwide will track audience data for Specialty Pharmacy ... , “By becoming a member of BPA ... to providing our clients with the most reliable, ...
Breaking Biology Technology:Electrophoresis Market Worth $1.98 Billion by 2020 2Electrophoresis Market Worth $1.98 Billion by 2020 3Electrophoresis Market Worth $1.98 Billion by 2020 4New White Paper Explores the Potential of Big Data Analytics in Life Sciences and Healthcare 2SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8Specialty Pharmacy Times Joins BPA Worldwide 2
... Data presented today at the 19th Congress of ... demonstrated that the HeartWare MVAD ® Pump ... biocompatibility in Good Laboratory Practice (GLP) animal studies, ... clinical studies. (Photo:   http://photos.prnewswire.com/prnh/20110909/LA65433 ...
... (NSF) has awarded Northwestern University a six-year, $16.2 million ... Engineering Center (MRSEC), one of the oldest interdisciplinary research ... integrates educational activities with a scientific research program, is ... in the nation to successfully renew support from the ...
... 8, 2011 HUYA Bioscience International, ... announced a strategic partnership with the Zhejiang Chinese ... will accelerate the global drug development of China,s ... partnership is expected to bring productive synergy between ...
Cached Biology Technology:HeartWare Completes GLP Studies of Next Generation MVAD® Pump; Data Presented Today at ISRBP Congress 2HeartWare Completes GLP Studies of Next Generation MVAD® Pump; Data Presented Today at ISRBP Congress 3HeartWare Completes GLP Studies of Next Generation MVAD® Pump; Data Presented Today at ISRBP Congress 4Collaborative science and engineering 2HUYA Bioscience International Forms Alliance With Zhejiang Chinese Medical University Life Science College 2HUYA Bioscience International Forms Alliance With Zhejiang Chinese Medical University Life Science College 3