Navigation Links
Individual differences in a clock gene predict decline of performance during sleep deprivation

People are known to differ markedly in their response to sleep deprivation, but the biological underpinnings of these differences have remained difficult to identify. Researchers have now found that a genetic difference in a so-called clock gene, PERIOD3, makes some people particularly sensitive to the effects of sleep deprivation. The findings, reported by Antoine Viola, Derk-Jan Dijk, and colleagues at the University of Surrey's Sleep Research Center, appear online this week in the journal Current Biology, published by Cell Press.

There are two variants of the PERIOD3 gene found in the human population, encoding either long or short versions of the corresponding protein. Each individual will possess two copies of the gene, either of which might be the long or short form. Previous work had indicated that the different forms of the gene appear to influence characteristic morning and evening activity levels—for example, "owl" versus "lark" tendencies.

In the new work, a multidisciplinary research team consisting of biological scientists and psychologists compared how individuals possessing only the longer gene variant and those possessing only the shorter one coped with being kept awake for two days, including the intervening night. The researchers found that although some participants struggled to stay awake, others experienced no problems with the task.

The results were most pronounced during the early hours of the morning (between 4 and 8 a.m.), during which individuals with the longer variant of the gene performed very poorly on tests for attention and working memory.

The authors point out that this early-morning period corresponds to stretches of time when shift workers struggle to stay awake, during which many accidents related to sleepiness occur. But the scientists also emphasize that the new research was conducted in the laboratory, and whether forms of the PERIOD3 gene also predict individual differences in the tolerance
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
2. Team Invents Device For Weighing Individual Molecules
3. Individuals and populations differ in gene activity levels, not just genes
4. Variation in womens X chromosomes may explain differences among individuals, between sexes
5. Big differences in duplicated DNA distinguish chimp and human genomes
6. Identical twins may have more differences than meet the eye
7. Study outlines genetic differences between potential pandemic influenza strains
8. Brain differences could explain why males and females experience pain relief differently
9. Most human-chimp differences due to gene regulation ?not genes
10. Albatross study shows regional differences in ocean contamination
11. Viral genetic differences are possible key to HIV dementia
Post Your Comments:
(Date:4/13/2015)... April 13, 2015 According ... "Global Biometrics Market Forecast & Opportunities, 2020", the global ... of around 14% till 2020. The biometrics market ... scale implementation and review of biometric management systems. ... new products with greater efficiency, are resulting in ...
(Date:4/8/2015)... 8, 2015  Infinisource, a leading provider of SaaS-based ... Morpho, a leading supplier of biometric identification and ... market,s most advanced biometrically-enabled time clock, the companies ... clock is setting a bold, new standard for ... the small and mid-size employer. When connected to ...
(Date:4/2/2015)... , April 2, 2015 ... Q1 2015 attributed to somewhat higher than 125 MSEK. ... the year-end report 2014 that revenues for Q1 2015 ... the company reported for Q4 2014. The operating result ... be negative. The complete interim report will as previously ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Revises Revenues for Q1 2015 2
... are small fat capsules, often added to beauty products. ... of transporting active ingredients deep into the skin and ... the skins structure by rejuvenating and smoothing the skin. ... shows that liposomes are not capable of transporting themselves ...
... are expected to attend an INSECT EXPO at New Mexico ... February 25 at the start of the 2013 Annual Meeting ... (ESA), which will be held February 25-28 in the Ramada ... free educational event will reinforce students, science skills with hands-on ...
... P. Sloan Foundation is pleased to announce the selection ... of Sloan Research Fellowships for 2013. , Awarded ... scientists and scholars whose achievements and potential identify them ... "The Sloan Research Fellows are the best of ...
Cached Biology News:Don't trust liposomes in your beauty products 2Sloan Foundation announces 2013 Sloan Research Fellows 2
(Date:5/6/2015)...  Oxis Biotech, Inc. (OXIS), a wholly owned subsidiary ... that Cassian Yee , M.D., Professor, Department of ... University of Texas MD Anderson Cancer Center joined its ... of Immunology, Division of Cancer Medicine, and Director, Solid ... the University of Texas MD Anderson Cancer Center.  ...
(Date:5/6/2015)... The Remedy Group , the ... the specialty pharmacy industry, will be exhibiting, presenting, and ... Pharmacy Summit. The Summit will be held May 4-8, ... is the largest annual gathering for the specialty pharmacy ... pharmacy providers, pharma/biotech manufacturers, and payers, to learn more ...
(Date:5/5/2015)... 5, 2015  23andMe, Inc., the leading personal genetics ... Research Study in collaboration with Pfizer Inc. The ... erythematosus, more commonly known as lupus, into the study ... effort is also in collaboration with the Lupus Research ... May. Approximately 1.5 million people in the ...
(Date:5/5/2015)... May 5, 2015  Tikcro Technologies Ltd. (OTCQB: ... to continue trading on OTCQB  Marketplace, the market ... Marketplace allows for a continuous public market for ... have real-time quotes and market information on us ... OTCQB Marketplace includes U.S. and international companies in ...
Breaking Biology Technology:Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 2Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 3The Remedy Group presenting at the 2015 Armada Specialty Pharmacy Summit: The Pitfalls to Growth and Maintaining the Patient Experience 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 223andMe Launches the Lupus Research Study in Collaboration with Pfizer Inc. 3Tikcro Technologies Announces Approval to Continue Trading on OTCQB 2
... combines the simplicity of protein precipitation with ... removal of phospholipids and proteins from biological ... 8 Supelco, a division of Sigma-Aldrich ... leading supplier of chromatography products for analysis ...
... ImQuest Life Sciences presented their latest biological results ... molecule piperazine compound for the treatment of solid ... in Whistler, British Columbia. The presentation highlighted advances ... IQP-0304. The piperazines demonstrate potent antiproliferative activity against ...
... Upregulation by Percutaneous Administration of Gene Therapy in ... Effects of SERCA2a Enzyme Replacement Using Gene TransferSAN ... the publication of results from a Phase 1/2 ... replacement therapy for advanced heart failure, in the ...
Cached Biology Technology:HybridSPE(TM)-Precipitation Technology Wins SelectScience.net 2009 Scientists' Choice Award for Best New Separations Product in 2008 2HybridSPE(TM)-Precipitation Technology Wins SelectScience.net 2009 Scientists' Choice Award for Best New Separations Product in 2008 3ImQuest Presentation at Keystone Symposium Focuses on Advancements in Their Cancer Research and Development Program 2The Journal of Cardiac Failure Publishes Results From Celladon Corporation's First-in-Human Phase 1/2 Clinical Trial in Advanced Heart Failure 2The Journal of Cardiac Failure Publishes Results From Celladon Corporation's First-in-Human Phase 1/2 Clinical Trial in Advanced Heart Failure 3
Goat polyclonal to DDDDK tag (FITC) ( Abpromise for all tested applications)....
...
DNA fragmentation factor & Inhibitor of CAD...
Component in MasterPure™ Purification Kits...
Biology Products: