Navigation Links
Imaging Lymph Nodes with Nanoparticles

A novel application involving the buzzword "nano" - cancer detection using nanoparticles and MRI (magnetic resonance imaging) : Accurate staging of cancers is one of the most important parts of the work up of patients for both prediction of prognosis and determination of the most appropriate treatment. And an essential part of this work up is assessing whether or not there has been lymphatic spread. Current methods include surgical removal of nodes for examination and various types of imaging, ranging from ultrasound to newer technologies such as magnetic resonance imaging (MRI). All these methods have problems; some are very invasive, others are very time consuming, and none are completely reliable. However in one of the more exciting crossovers from chemistry into medicine, researchers have developed nanoparticles to improve the diagnostic accuracy of MRI. The nanoparticles contain a central superparamagnetic iron oxide core and are covered by dextran, imparting long circulation times and biocompatibility. When injected intravenously, the nanoparticles localize to lymphoid tissue, and are internalized into macrophages. There is then a decrease in signal intensity on T2- and T2*-weighted images, and when metastases are present there is a recognizably abnormal pattern on MRI scans.

In a previous paper published in the New England Journal of Medicine, Ralph Weissleder and colleagues described using these nanoparticles to assess lymphoid spread in patients with prostate cancer. Now, in a paper published in this month's PLoS Medicine, they have gone further by extending the analysis to patients with different types of cancer, and producing an algorithm that allows semiautomation of the procedure. The authors developed the algorithm in a training group of 36 patients and then validated it in a group of 34 patients. The results are encouraging: the analysis showed a sensitivity of 98% (95% confidence interval, 88%?9%) and
'"/>

Source:PLoS Medecine


Page: 1 2

Related biology news :

1. Special Imaging Study Shows Failing Hearts Are Energy Starved
2. Imaging study links key genetic risk for Alzheimers disease to myelin breakdown
3. Imaging techniques permit scientists to follow a day -- or four -- in the life of a cell
4. Imaging pinpoints brain regions that see the future
5. Potential Cure for Lymphoma in HIV patients
6. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
7. DNA Molecules Used To Assemble Nanoparticles
8. Probing The Promise And Perils Of Nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Imaging Lymph Nodes with Nanoparticles

(Date:10/19/2014)... India over the last 30 years contributed only ... during that time, according to a new study ... ., "Energy access is fundamental to development: it ... education, communication, and health," says IIASA researcher Shonali ... energy access is widely agreed to be an ...
(Date:10/18/2014)... undiagnosed, suspected genetic conditions, a certain type of exome ... yield than traditional molecular diagnostic methods, according to a ... being released to coincide with the American Society of ... the protein­coding region of the genome (the complete set ... or organism), has been rapidly applied in research settings ...
(Date:10/17/2014)... University of Copenhagen have shown for the first time ... Cystic fibrosis patients, giving them the opportunity to get ... infections. , The study also discovered the bacterial growth ... was halted or slowed down by the immune cells. ... oxygen and helped "suffocate" the bacteria, forcing the bacteria ...
Breaking Biology News(10 mins):Improved electricity access has little impact on climate change 2Study examines type of exome sequencing and molecular diagnostic yield 2Study examines type of exome sequencing and molecular diagnostic yield 3Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2
... This release is available in Spanish . ... ozone levels above 50 parts per billion (ppb) along the ... costing more than $1 billion in lost crop production, according ... a 5-year study led by the National Aeronautics and Space ...
... ITHACA, N.Y. Losing weight without a grumbling stomach or ... lighter lunch, finds a new Cornell University study to be ... . Participants who ate portion-controlled lunches did not compensate ... to believe the human body does not possess the mechanisms ...
... higher-protein, lower-carbohydrate energy-restricted diet has a major positive impact ... muscle, particularly when the proteins come from dairy products. ... the Journal of Nutrition, compared three groups ... Each consumed either low, medium or high amounts ...
Cached Biology News:Monitoring ground-level ozone from space 2Foods rich in protein, dairy products help dieters preserve muscle and lose belly fat: study 2
(Date:10/20/2014)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced four new ... and provides a good start to Q4.  The orders are for ... and one in the Middle East . ... Peter Bruijns , President & CEO. "Total bidding activity and ... have been for any complete year since the company has tracked ...
(Date:10/20/2014)... 2014 OncLive® is ... Center at Thomas Jefferson University has joined its ... Strategic Alliance Partnership program, the Sidney Kimmel Cancer ... raise awareness of the Center’s cutting-edge research programs, ... Clinicians and other health care professionals from the ...
(Date:10/19/2014)... OCTOBER 20-22, 2014: The 9th Annual ... take place at the Congress Center Basel, ... now available at http://www.abim.ch . ... from all over the globe will exchange ... products and developments on the world market. ...
(Date:10/19/2014)... October 19, 2014 The Asia-Pacific Speech ... market in Asia-Pacific with analysis and forecast of revenue. ... in 2014 to $208 million by 2019, at a ... to 2019. , Browse through the TOC of the ... of the in-depth analysis provided. It also provides a ...
Breaking Biology Technology:Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4
... and ALACHUA, Fla., Sept. 4 ,Zimmer Holdings, Inc. ... in the orthopaedics,industry, and Tutogen Medical, Inc., a ... human (allograft) and animal,(xenograft) tissue, today announced the ... wholly owned subsidiary of Zimmer Holdings,Inc., into Europe, ...
... Ind., Sept. 4 ,Tutogen Medical, Inc. (Amex: ... products made from human (allograft) and animal,(xenograft) tissue, ... a leader,in the orthopaedics industry, today announced the ... wholly owned subsidiary of Zimmer,Holdings, Inc., into Europe, ...
... to Present at BioCentury,s Newsmakers in the Biotech,Industry, Bank of America ... ... Conferences, SEATTLE, Sept. 4 Trubion Pharmaceuticals,Inc. ... executive officer, and chairman of Trubion, will present an overview,of the ...
Cached Biology Technology:Zimmer and Tutogen Announce Agreement for International Distribution of Biological Products 2Zimmer and Tutogen Announce Agreement for International Distribution of Biological Products 3Zimmer and Tutogen Announce Agreement for International Distribution of Biological Products 4Zimmer and Tutogen Announce Agreement for International Distribution of Biological Products 5Tutogen Medical, Inc. and Zimmer Holdings, Inc. Announce Agreement for International Distribution of Biological Products 2Tutogen Medical, Inc. and Zimmer Holdings, Inc. Announce Agreement for International Distribution of Biological Products 3Tutogen Medical, Inc. and Zimmer Holdings, Inc. Announce Agreement for International Distribution of Biological Products 4Tutogen Medical, Inc. and Zimmer Holdings, Inc. Announce Agreement for International Distribution of Biological Products 5Trubion Pharmaceuticals to Present at Upcoming Investor Conferences 2
... a tetramethylrhodamine-conjugated jetSI-ENDO (excitation at ... nm), the powerful siRNA transfection ... to determine the transfection efficiency ... and trafficking of siRNAs. More ...
... movement counts, similar to an infrared beam break ... subjects at once, in two frames of reference, ... experimental group at once, and allow social interaction ... a variety of other spatial behavior situations, including ...
... a score of movement counts, similar to an ... up to 6 subjects at once, in two ... Can outpt a sync pulse to coordinate with ... animal location and timing information to control arena ...
... features of Tracker, plus software to note when ... of the arena, and trigger a penaltyThe Spatial ... built around a video camera, frame grabber, and ... fields at once and up to 6 moving ...
Biology Products: