Navigation Links
Imaging Lymph Nodes with Nanoparticles

A novel application involving the buzzword "nano" - cancer detection using nanoparticles and MRI (magnetic resonance imaging) : Accurate staging of cancers is one of the most important parts of the work up of patients for both prediction of prognosis and determination of the most appropriate treatment. And an essential part of this work up is assessing whether or not there has been lymphatic spread. Current methods include surgical removal of nodes for examination and various types of imaging, ranging from ultrasound to newer technologies such as magnetic resonance imaging (MRI). All these methods have problems; some are very invasive, others are very time consuming, and none are completely reliable. However in one of the more exciting crossovers from chemistry into medicine, researchers have developed nanoparticles to improve the diagnostic accuracy of MRI. The nanoparticles contain a central superparamagnetic iron oxide core and are covered by dextran, imparting long circulation times and biocompatibility. When injected intravenously, the nanoparticles localize to lymphoid tissue, and are internalized into macrophages. There is then a decrease in signal intensity on T2- and T2*-weighted images, and when metastases are present there is a recognizably abnormal pattern on MRI scans.

In a previous paper published in the New England Journal of Medicine, Ralph Weissleder and colleagues described using these nanoparticles to assess lymphoid spread in patients with prostate cancer. Now, in a paper published in this month's PLoS Medicine, they have gone further by extending the analysis to patients with different types of cancer, and producing an algorithm that allows semiautomation of the procedure. The authors developed the algorithm in a training group of 36 patients and then validated it in a group of 34 patients. The results are encouraging: the analysis showed a sensitivity of 98% (95% confidence interval, 88%?9%) and
'"/>

Source:PLoS Medecine


Page: 1 2

Related biology news :

1. Special Imaging Study Shows Failing Hearts Are Energy Starved
2. Imaging study links key genetic risk for Alzheimers disease to myelin breakdown
3. Imaging techniques permit scientists to follow a day -- or four -- in the life of a cell
4. Imaging pinpoints brain regions that see the future
5. Potential Cure for Lymphoma in HIV patients
6. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
7. DNA Molecules Used To Assemble Nanoparticles
8. Probing The Promise And Perils Of Nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Imaging Lymph Nodes with Nanoparticles

(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ... its team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ... and robust – with the clinical data to back ...
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition ... Region 2015-2019"  report to their offering. ... is advances in technology. With continuous advances in ... to the latest standard that meets the needs ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... , The bottled water, soda pop, or micro brew-beer that ... cities contains a natural chemical imprint related to geographic location. ... imprint in your hair that could be used to track ... believed to be the first concerted effort to describe the ...
... looking for new antibiotics: A new research published in the ... ( http://www.fasebj.org ) explains for the first time how honey ... protein that they add to the honey, called defensin-1, which ... infections and to develop new drugs that could combat antibiotic-resistant ...
... WEST LAFAYETTE, Ind. - Fast-food restaurants can supersize French ... to supersize a type of apple. Peter Hirst, a ... in some Gala apple trees causes some apples to grow ... reported in the current issue of the Journal of ...
Cached Biology News:Beverages leave 'geographic signatures' that can track people's movements 2Honey as an antibiotic: Scientists identify a secret ingredient in honey that kills bacteria 2Apples grow larger when cells don't divide, study shows 2
(Date:12/19/2014)... (PRWEB) December 18, 2014 iLab Solutions, ... the appointment of Siri Bryant as the new Director ... Director of Core Implementations. These two new leadership positions ... customer service by ensuring that iLab continues to meet ... the last four years, iLab has been deployed at ...
(Date:12/19/2014)... San Diego, CA (PRWEB) December 18, 2014 ... announces a limited time special on Sartorius Biohit ... 1 Free on mLINE pipettes, Picus Electronic Pipette Trade-in ... recommended by Health and Safety officers around the world. ... repetitive manual pipetting. Other features include:, , ...
(Date:12/19/2014)... Dec. 18, 2014   ISN has released ... Performance Indicators publication series. With data aggregated ... reported in 2013 within its online contractor management platform, ... key performance indicator (KPI) statistics. The ... publication is available in two industry specific ...
(Date:12/17/2014)... Based on the revenues gained from ... is dominated by four major players contributing to ... players include GE Healthcare (U.K.), Siemens AG (Germany), ... Full Report Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html , ... attributed to its strong product portfolio, which includes ...
Breaking Biology Technology:iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... June 2, 2011 Morphotek®, Inc., a subsidiary of ... multi-center, phase II study of MORAb-004 for the treatment ... potentially first-in-class monoclonal antibody that specifically binds to endosialin/tumor ... its safety and therapeutic activity at two dosages. ...
... Calif., June 2, 2011 Life Technologies Corporation ... performed in cooperation with the University Hospital Muenster, Germany, on ... bacterium at the root of the deadly outbreak in Germany ... strains. The data obtained from the DNA ...
... electrodes have been coated with a drug-loaded polymer in ... a number of neurological symptoms, such as those associated ... In a study published today, 2 June 2011, ... researchers have developed a novel technology to precisely modulate ...
Cached Biology Technology:Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 2Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 3DNA Sequencing Data Reveals New Hybrid E. coli Strain is Cause of German Outbreak 2DNA Sequencing Data Reveals New Hybrid E. coli Strain is Cause of German Outbreak 3DNA Sequencing Data Reveals New Hybrid E. coli Strain is Cause of German Outbreak 4New technology could inspire brain implant for detecting and treating seizures 2
... Kit is based on quantification of the ... and free orthophosphate. The rapid color formation ... on a spectrophotometer (600-660 nm) or on ... kits have been optimized to offer superior ...
... Chemicon Select Tissue Arrays are intended ... individual tissues were fixed in neutral buffered ... identification and diagnosis was performed by certified ... their paraffin blocks and relocated into a ...
... The desk-top XCAT 50 X-Ray System from KUBTEC ... to provide two and three dimensional representation of ... provides volumetric reconstruction of specimen X-ray images, the ... provide high level of detail in standard 2D ...
... BTX, the leader in electroporation products and ... innovative product line for experiment optimization and ... is a breakthrough in Molecular Delivery. The ... procedures that typically limited the number of ...
Biology Products: