Navigation Links
Imaging Lymph Nodes with Nanoparticles

A novel application involving the buzzword "nano" - cancer detection using nanoparticles and MRI (magnetic resonance imaging) : Accurate staging of cancers is one of the most important parts of the work up of patients for both prediction of prognosis and determination of the most appropriate treatment. And an essential part of this work up is assessing whether or not there has been lymphatic spread. Current methods include surgical removal of nodes for examination and various types of imaging, ranging from ultrasound to newer technologies such as magnetic resonance imaging (MRI). All these methods have problems; some are very invasive, others are very time consuming, and none are completely reliable. However in one of the more exciting crossovers from chemistry into medicine, researchers have developed nanoparticles to improve the diagnostic accuracy of MRI. The nanoparticles contain a central superparamagnetic iron oxide core and are covered by dextran, imparting long circulation times and biocompatibility. When injected intravenously, the nanoparticles localize to lymphoid tissue, and are internalized into macrophages. There is then a decrease in signal intensity on T2- and T2*-weighted images, and when metastases are present there is a recognizably abnormal pattern on MRI scans.

In a previous paper published in the New England Journal of Medicine, Ralph Weissleder and colleagues described using these nanoparticles to assess lymphoid spread in patients with prostate cancer. Now, in a paper published in this month's PLoS Medicine, they have gone further by extending the analysis to patients with different types of cancer, and producing an algorithm that allows semiautomation of the procedure. The authors developed the algorithm in a training group of 36 patients and then validated it in a group of 34 patients. The results are encouraging: the analysis showed a sensitivity of 98% (95% confidence interval, 88%?9%) and
'"/>

Source:PLoS Medecine


Page: 1 2

Related biology news :

1. Special Imaging Study Shows Failing Hearts Are Energy Starved
2. Imaging study links key genetic risk for Alzheimers disease to myelin breakdown
3. Imaging techniques permit scientists to follow a day -- or four -- in the life of a cell
4. Imaging pinpoints brain regions that see the future
5. Potential Cure for Lymphoma in HIV patients
6. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
7. DNA Molecules Used To Assemble Nanoparticles
8. Probing The Promise And Perils Of Nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Imaging Lymph Nodes with Nanoparticles

(Date:5/22/2015)... -- According to a new market research ... Emotion, Forensic), by Software (Middleware, Databases), by Hardware (Cameras, Integrated ... Home) - Global Forecast to 2020", published by MarketsandMarkets, ... 2015 to $6.19 Billion by 2020, at a CAGR ... Tables and   43 Figures spread through 140 Pages ...
(Date:5/20/2015)... 2015 Research ... the addition of the  "5-year Opportunity ... Market"  report to their offering.  ,     ... analyses trends in the iris recognition ... sectors, globally. Despite hardware pricing and ...
(Date:5/19/2015)...  Technology is rapidly advancing, outpacing enterprises, ability to ... Passwords and their management are soon to be rendered ... such as those developed by the FIDO Alliance™. With ... for BYOD, COPE, IoT, and mobile payments, the interconnected ... In response to the call for seamless, ...
Breaking Biology News(10 mins):Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3
... to wonder how a fruit fly is able to locate ... summer evening, especially since its flight path seems to be ... Andy Reynolds at Rothamsted Research in the United Kingdom have ... their environment using a series of straight flight paths punctuated ...
... unique protein from jellyfish that could be inserted into ... them to radiate a brilliant green color. This green ... new discoveries regarding how living cells function. But one ... plants harbor tough cell walls and enormous subcellular ...
... the University of East Anglia have discovered exactly what makes ... The age-old mystery was unlocked thanks to some novel bacteria ... Johnston and his team at UEA isolated this microbe from ... single gene responsible for the emission of the strong-smelling gas, ...
Cached Biology News:Flies don't buzz about aimlessly! 2Cloning the smell of the seaside 2
(Date:5/27/2015)... The Medical Innovation Impact Index (MI3), a ... medical innovation, has been developed at the Initiative ... University’s ( FDU ) Rothman Institute of Innovation and ... new FDA (Food & Drug Administration) draft guidance documents ... certain medical devices. , “The main impediment to ...
(Date:5/26/2015)... May 26, 2015 Innovacyn, a ... in the human and animal health industries, announced ... Future Innovators of Agriculture College Scholarship Award. The ... who exhibits a passionate commitment to the agriculture ... This year’s winners, Alexis Pedrow from Anderson County ...
(Date:5/26/2015)... 26, 2015  Alere Inc. (NYSE: ALR ) (the ... to timely file its Quarterly Report on Form 10-Q for ... it has received a notice from the New York Stock ... with the NYSE,s continued listing requirements under the timely filing ... Manual. The reason for the delay relates ...
(Date:5/26/2015)...  A simple blood test developed at the University ... Alzheimer,s disease is a step closer to being used ... that are needed before a blood test could be ... & Dementia . The guidelines establish protocols and reflect ... includes UNT Health Science Center. "If we ...
Breaking Biology Technology:Medical Innovation Impact Index Launched at Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) under the Rothman Institute 2Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 2Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 3Guidelines bring UNT Health Science Center's blood test for Alzheimer's one step closer 2
... 1 Sidec announces the first,Protein Tomography(TM) ... This Award,is set up to enable research ... yet collaborated with Sidec on a Protein ... technology successfully used in,cancer drug research., ...
... Highlights 140 Doctors Changing the Face of ... ... of BLACK ENTERPRISE (BE),unveils its 2008 report on the best and brightest ... millions of lives through the revolutionary treatment of,diseases, from cancer and diabetes ...
... CryoLife, Inc., (NYSE: CRY ) a,biomaterials, ... Harvey Morgan has been elected to the Company,s ... Managing Director at Bentley,Associates L.P., an investment banking ... years of investment banking experience with,significant expertise in ...
Cached Biology Technology:Sidec Announces the First Protein Tomography(TM) Award at Sidec's Executive Forum at PEGS 2Black Enterprise Unveils America's Leading Doctors 2Black Enterprise Unveils America's Leading Doctors 3Harvey Morgan Joins CryoLife Board of Directors 2
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed...
Protein 3D structure prediction, via threading. Easy to use....
... (3 per pack), 1. One ... processing.Automated staining of Coomassie Blue or ... acid analysis.Prepares blots for high sensitivity ... of protocol, solution, volume, and processing ...
DITHIOTHREITOL, 150UMOL, 1 EA. Dithiothreitol (DTT), 0.1 M Solution:, *0.1 M solution of DTT in high purity dH2O., *0.2 m filtered., *Storage: -20C. Category: SEQUENASE....
Biology Products: