Navigation Links
Imaging Lymph Nodes with Nanoparticles

A novel application involving the buzzword "nano" - cancer detection using nanoparticles and MRI (magnetic resonance imaging) : Accurate staging of cancers is one of the most important parts of the work up of patients for both prediction of prognosis and determination of the most appropriate treatment. And an essential part of this work up is assessing whether or not there has been lymphatic spread. Current methods include surgical removal of nodes for examination and various types of imaging, ranging from ultrasound to newer technologies such as magnetic resonance imaging (MRI). All these methods have problems; some are very invasive, others are very time consuming, and none are completely reliable. However in one of the more exciting crossovers from chemistry into medicine, researchers have developed nanoparticles to improve the diagnostic accuracy of MRI. The nanoparticles contain a central superparamagnetic iron oxide core and are covered by dextran, imparting long circulation times and biocompatibility. When injected intravenously, the nanoparticles localize to lymphoid tissue, and are internalized into macrophages. There is then a decrease in signal intensity on T2- and T2*-weighted images, and when metastases are present there is a recognizably abnormal pattern on MRI scans.

In a previous paper published in the New England Journal of Medicine, Ralph Weissleder and colleagues described using these nanoparticles to assess lymphoid spread in patients with prostate cancer. Now, in a paper published in this month's PLoS Medicine, they have gone further by extending the analysis to patients with different types of cancer, and producing an algorithm that allows semiautomation of the procedure. The authors developed the algorithm in a training group of 36 patients and then validated it in a group of 34 patients. The results are encouraging: the analysis showed a sensitivity of 98% (95% confidence interval, 88%?9%) and a specificity of 92% (95% confidence interval, 87%?6%). The advantages of automating this procedure are substantial, not least because it can remove the problem of different observers assessing data differently. And what is more, once the data have been collected and assessed it is possible to reconstruct a virtual picture of the patient's lymph nodes, thus potentially allowing accurate surgical removal of the nodes.
'"/>

Source:PLoS Medecine


Related biology news :

1. Special Imaging Study Shows Failing Hearts Are Energy Starved
2. Imaging study links key genetic risk for Alzheimers disease to myelin breakdown
3. Imaging techniques permit scientists to follow a day -- or four -- in the life of a cell
4. Imaging pinpoints brain regions that see the future
5. Potential Cure for Lymphoma in HIV patients
6. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
7. DNA Molecules Used To Assemble Nanoparticles
8. Probing The Promise And Perils Of Nanoparticles

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/6/2017)... , March 6, 2017 Mintigo ... technology, today announced Predictive Sales Coach TM , ... actionable sales intelligence into Salesforce. This unique AI ... their sales organizations with deep knowledge of their ... for intelligent engagement. Predictive Sales Coach extends Mintigo,s ...
(Date:3/2/2017)... , March 2, 2017 Australian stem cell ... (ASX: CYP), has signed an agreement with the Monash ... Monash Biomedicine Discovery Institute and Department of Pharmacology at ... a further preclinical study to support the use of ... asthma.  Asthma is a chronic, long ...
(Date:2/28/2017)... Spanien, 27. Februar 2017  EyeLock LLC, ein marktführendes ... seine erstklassige biometrische Lösung zur Iris-Erkennung auf ... X16 LTE auf dem Mobile World Congress ... Qualcomm-Stand in Halle 3, Stand 3E10, vorstellen. ... Sicherheitsplattform Qualcomm Haven™ – eine Kombination aus ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... Biotech Ltd. ("Sinovac" or the "Company") (NASDAQ: SVA), a leading provider ... that its board of directors has amended its shareholder rights plan. The ... 2017 to March 27, 2018. The amendment was not in response to ... ... Ltd. is a China -based biopharmaceutical company that ...
(Date:3/24/2017)... 24, 2017 Agenus Inc. (NASDAQ: AGEN), an ... and cancer vaccines, today announced participation at the following ... William Blair and Maidstone Life Sciences conference "Cancer Immunotherapy ... New York, NY . Agenus will ... at 9:40 am: Robert B. Stein , M.D., ...
(Date:3/23/2017)... 2017 Research and Markets has announced ... report to their offering. ... The Global Market for Bioproducts Should ... at a CAGR of 8.9%, This research ... into seven major product segments: bio-derived chemicals, biofuels, pharmaceuticals (biodrugs ...
(Date:3/23/2017)... March 23, 2017  GlobeImmune, Inc. today announced it ... sale of 12,835,490 shares of its common stock to ... companies. In connection with the sale of its common stock, ... and issue to GlobeImmune 200,000 shares, an estimated $2.0 ... "We are pleased to enter into this strategic ...
Breaking Biology Technology: