Navigation Links
Imaging Lymph Nodes with Nanoparticles

A novel application involving the buzzword "nano" - cancer detection using nanoparticles and MRI (magnetic resonance imaging) : Accurate staging of cancers is one of the most important parts of the work up of patients for both prediction of prognosis and determination of the most appropriate treatment. And an essential part of this work up is assessing whether or not there has been lymphatic spread. Current methods include surgical removal of nodes for examination and various types of imaging, ranging from ultrasound to newer technologies such as magnetic resonance imaging (MRI). All these methods have problems; some are very invasive, others are very time consuming, and none are completely reliable. However in one of the more exciting crossovers from chemistry into medicine, researchers have developed nanoparticles to improve the diagnostic accuracy of MRI. The nanoparticles contain a central superparamagnetic iron oxide core and are covered by dextran, imparting long circulation times and biocompatibility. When injected intravenously, the nanoparticles localize to lymphoid tissue, and are internalized into macrophages. There is then a decrease in signal intensity on T2- and T2*-weighted images, and when metastases are present there is a recognizably abnormal pattern on MRI scans.

In a previous paper published in the New England Journal of Medicine, Ralph Weissleder and colleagues described using these nanoparticles to assess lymphoid spread in patients with prostate cancer. Now, in a paper published in this month's PLoS Medicine, they have gone further by extending the analysis to patients with different types of cancer, and producing an algorithm that allows semiautomation of the procedure. The authors developed the algorithm in a training group of 36 patients and then validated it in a group of 34 patients. The results are encouraging: the analysis showed a sensitivity of 98% (95% confidence interval, 88%?9%) and a specificity of 92% (95% confidence interval, 87%?6%). The advantages of automating this procedure are substantial, not least because it can remove the problem of different observers assessing data differently. And what is more, once the data have been collected and assessed it is possible to reconstruct a virtual picture of the patient's lymph nodes, thus potentially allowing accurate surgical removal of the nodes.
'"/>

Source:PLoS Medecine


Related biology news :

1. Special Imaging Study Shows Failing Hearts Are Energy Starved
2. Imaging study links key genetic risk for Alzheimers disease to myelin breakdown
3. Imaging techniques permit scientists to follow a day -- or four -- in the life of a cell
4. Imaging pinpoints brain regions that see the future
5. Potential Cure for Lymphoma in HIV patients
6. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
7. DNA Molecules Used To Assemble Nanoparticles
8. Probing The Promise And Perils Of Nanoparticles

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
(Date:3/30/2017)... , March 30, 2017 The research team ... for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint ... new realm of speed and accuracy for use in identification, crime ... affordable cost. ... A ...
(Date:3/24/2017)... , March 24, 2017 The Controller General ... Controller Mr. Abdulla Algeen have received the prestigious international IAIR ... Continue Reading ... ... picture) and Deputy Controller Abdulla Algeen (small picture on the right) have ...
Breaking Biology News(10 mins):
(Date:7/26/2017)... (PRWEB) , ... July 25, 2017 , ... ... 22, attendees will garner a better understanding of the considerations needed for designing ... applications. , The use of CRISPR-Cas9 to create targeted double-strand breaks in genomic ...
(Date:7/26/2017)... Iowa and REHOVOT, Israel (PRWEB) , ... July ... ... (NASDAQ, TASE: EVGN), a leading company for the improvement of crop productivity and ... entered into a multiyear collaboration. The scope of the agreement includes the research ...
(Date:7/24/2017)... ... 24, 2017 , ... Charm Sciences, Inc. is pleased to announce the Charm® ... Interstate Milk Shipments (NCIMS) Laboratory Committee and Appendix N Committee as a drug residue ... , The NCIMS voted at its annual meeting in April, 2015 to establish a ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... leading radiology and imaging centers around the U.S. that offer MR Elastography for ... alternative to needle biopsy for staging liver fibrosis assessment. , “MRE:connect was ...
Breaking Biology Technology: