Navigation Links
Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard Hughes Medical Institute predoctoral fellow at Stanford University School of Medicine.

Though multiple genetic alterations are associated with melanoma development, scientists have not been able to establish a direct causal link between these alterations and human cancer growth. Determining whether these mutations have the potential themselves to induce cancer or simply play a supporting role also has been difficult.

To determine the impact of genetic alterations associated with human melanoma, Yakov Chudnovsky; his advisor, Paul Khavari; postdoctoral fellow Amy Adams, and colleagues generated human skin tissue containing cells selectively engineered to express specific mutations found in melanoma. They report their findings in the June 12, 2005, issue of the journal Nature Genetics, offering clues to the oncogenic potency of several genes implicated in the development of melanoma.

Melanoma is the deadliest form of skin cancer, resulting from the malignant transformation of cells called melanocytes. Over the past four decades, the incidence of melanoma has risen 15-fold, a more rapid increase than that of any other cancer.

"The only current treatment is early detection and excision," Chudnovsky said. "But no treatment can substantially enhance patient survival once metastasis has occurred."

To simulate the environment in which melanoma naturally arises, the research team introduced one or more cancer-associated genes into human melanocytes, the pigment-producing cells that normally reside in the deepest layer of the skin. The genetically engineered melanocytes were then combined with keratinocytes, the cells that give skin its structure, to form a sample of human skin that was grafted onto laboratory mice. The mice were observed for
'"/>

Source:http://www.nottingham.ac.uk/


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Another Look Finds Promising Proteomics Test is Not Biologically Plausible
3. Elephants imitate truck noises, other animals
4. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
5. NJIT Presidential Award winner takes stem cell research another step
6. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
7. NASA links nanobacteria to kidney stones and other diseases
8. Anti cancer virotherapy well tolerated in first human administration, research finds
9. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
10. Report that delayed motherhood decreases life expectancy of mouse offspring
11. Rhesus monkeys can assess the visual perspective of others when competing for food
Post Your Comments:
(Date:7/24/2014)... out of York University shows a surprisingly effective way ... fungus: moose saliva (yes moose saliva). , Published ... inhibits a grassendophyte mutualism" shows that moose and reindeer ... a fungus called epichlo festucae that produces the toxin ... , "Plants have evolved defense mechanisms to protect themselves, ...
(Date:7/24/2014)... have similar counterparts in humans, affect the connections between ... into the hippocampus, an area of the brain that ... creation of memories. The results of the study have ... Brain function depends on the active communication between nerve ... woven together into a dense network where they constantly ...
(Date:7/24/2014)... funded by the New Jersey Recovery Fund and conducted ... Planning and Public Policy at Rutgers University has found ... about the likelihood of community-based rebuilding solutions. Of the ... they were "pessimistic" or "very pessimistic" that the parts ... rebuilt better than they were before the storm; another ...
Breaking Biology News(10 mins):Moose drool inhibits growth of toxic fungus: York U research 2A protein couple controls flow of information into the brain's memory center 2A protein couple controls flow of information into the brain's memory center 3A protein couple controls flow of information into the brain's memory center 4Rutgers study explores attitudes, preferences toward post-Sandy rebuilding 2
... molecular and protein signatures that predict rapid onset of ... transplant. The markers appeared soon after transplant and ... Such early detection of susceptibility to hepatitis C virus-induced ... treatment options after a transplant. Also, because the ...
... charcoal preserved in deeply buried sediments in Egypt,s Nile ... a huge drought 4,200 years ago associated with the ... the pyramid-building time. "Humans have a long history ... Bernhardt, a researcher with the U.S. Geological Survey. "Along ...
... NC Leukemia and lymphoma patients who receive life-saving ... side effects that significantly decrease quality of life, can ... In chronic Graft vs. Host Disease ... and the recipient,s body often cause these immune cells ...
Cached Biology News:Molecular and protein markers discovered for liver transplant failure from hepatitis C 2Molecular and protein markers discovered for liver transplant failure from hepatitis C 3Molecular and protein markers discovered for liver transplant failure from hepatitis C 4Climate and drought lessons from ancient Egypt 2B cell survival holds key to chronic graft vs. host disease 2
(Date:7/24/2014)... 1000 balances – 4 steps – One Recommendation: the ... expertly narrows down the mass of product choices to ... , First, select the working environment, then enter ... and define the accuracy – it’s really that simple. ... list to models that fit best with the customer’s ...
(Date:7/24/2014)... NJ (PRWEB) July 24, 2014 As ... manage numerous projects in the MENA region during 2014 ... have a preferred provider agreement with DZS to manage ... MENA region,” said Global VP of R&D and President ... has developed excellent operational practices with a focus on ...
(Date:7/23/2014)... in saving China,s endangered national treasure, the giant panda. ... reserves that have been established and three large breeding ... in the wild. , Breeding programs in conservation ... improving genetic diversity, avoid inbreeding and ultimately, introduce pandas ... programs doing so far? , In a new study ...
(Date:7/23/2014)... 2014 Shimadzu Scientific Instruments has ... analysis system developed jointly with Ajinomoto Co. Inc. ... analyze 38 amino acids in nine minutes, drastically ... high-speed analysis utilizing a fast application-specific column and ... analytical results even under conditions with difficult samples ...
Breaking Biology Technology:SBI Pharmaceuticals Co. Ltd. Enters into Preferred Provider Agreement with DZS Clinical Services 2Shimadzu's New UF-Amino Station Provides High-Speed, Multi-Component Analysis of Amino Acids in Food & Beverage and Pharmaceutical Testing 2
... United States Department of Energy will invest up to ... Centers, including $125 million for a center led by the ... cellulosic ethanol. , ,The Madison bioenergy research facility , ... Center, will operate in collaboration with Michigan State University ...
... In the age of digital everything, print still captures the ... of everything Internet. , ,There's no clearer example than ... when the company was no more than a brief ... on a windy afternoon and Eileen unwound a vision for ...
... Adelante, Atras!* (For a translation, scroll to the end). The ... buyers alike modifying their steps as the Internet changes everything. ... us have adopted at least some of these changes (both ... information, communicate, interact with each other, or buy and sell ...
Cached Biology Technology:UW-Madison to receive $125M for bioenergy research center 2UW-Madison to receive $125M for bioenergy research center 3Blurb shows that print still captures imaginations 2Blurb shows that print still captures imaginations 3Online retailing "tango" is adding some steps 2Online retailing "tango" is adding some steps 3Online retailing "tango" is adding some steps 4Online retailing "tango" is adding some steps 5Online retailing "tango" is adding some steps 6
... neurons in vesicles called synaptosomes. ... bouton. Synaptosomes may be centrifuged ... cellular debris. Abnormalites in neurotransmitter release ... condtions. Conditions of release may ...
... Detection Systems allow non-radioactive detection of ... systems, biotinylated lysine residues are incorporated ... the need for labeling with [35-S]methionine ... biotinylated lysine is added to the ...
... Series Hybridization chambers with forced convection ... ambient up to 99.9 C / 212 F ... and reproducible results DS controller Timer ... with an accuracy of a tenth of a ...
... microarray data using Asuragens bioinformatics expertise. We ... to extensive data analysis using the most ... in combination with the Gene Expression Profiling ... ,Normalization and basic statistical analysis including publication ...
Biology Products: