Navigation Links
Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard Hughes Medical Institute predoctoral fellow at Stanford University School of Medicine.

Though multiple genetic alterations are associated with melanoma development, scientists have not been able to establish a direct causal link between these alterations and human cancer growth. Determining whether these mutations have the potential themselves to induce cancer or simply play a supporting role also has been difficult.

To determine the impact of genetic alterations associated with human melanoma, Yakov Chudnovsky; his advisor, Paul Khavari; postdoctoral fellow Amy Adams, and colleagues generated human skin tissue containing cells selectively engineered to express specific mutations found in melanoma. They report their findings in the June 12, 2005, issue of the journal Nature Genetics, offering clues to the oncogenic potency of several genes implicated in the development of melanoma.

Melanoma is the deadliest form of skin cancer, resulting from the malignant transformation of cells called melanocytes. Over the past four decades, the incidence of melanoma has risen 15-fold, a more rapid increase than that of any other cancer.

"The only current treatment is early detection and excision," Chudnovsky said. "But no treatment can substantially enhance patient survival once metastasis has occurred."

To simulate the environment in which melanoma naturally arises, the research team introduced one or more cancer-associated genes into human melanocytes, the pigment-producing cells that normally reside in the deepest layer of the skin. The genetically engineered melanocytes were then combined with keratinocytes, the cells that give skin its structure, to form a sample of human skin that was grafted onto laboratory mice. The mice were observed for
'"/>

Source:http://www.nottingham.ac.uk/


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Another Look Finds Promising Proteomics Test is Not Biologically Plausible
3. Elephants imitate truck noises, other animals
4. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
5. NJIT Presidential Award winner takes stem cell research another step
6. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
7. NASA links nanobacteria to kidney stones and other diseases
8. Anti cancer virotherapy well tolerated in first human administration, research finds
9. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
10. Report that delayed motherhood decreases life expectancy of mouse offspring
11. Rhesus monkeys can assess the visual perspective of others when competing for food
Post Your Comments:
(Date:1/22/2015)...  BellBrook Labs, a leader in high throughput screening ... a TR-FRET (time resolved Forster resonance energy transfer) ... high throughput screening assay for glycosyltransferases and other ... sensitive detection of hundreds of human and microbial ...
(Date:1/22/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a ... the recent success of the Wocket™ smart wallet at CES 2015 in ... was named as one of the "11 Hot Products at CES" in ... At CES So Far" by Newseveryday.com and "The top 10 gadgets from ...
(Date:1/22/2015)... YORK , Jan. 21, 2015  Analyst Report Issued by ... Card Brands report showed that planet-wide, transactions at merchants on ... while the total number of credit, debit, and prepaid cards ... U.S. were victims of fraudulent card usage in 2012, and ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2
... Australia, the United Kingdom and United States, including University of ... tactics, such as assisted migration, in the face of the ... policy ideas in a paper published July 18 in the ... that both the rapid rate of climate change and the ...
... as they evolve, biologists have unearthed several interesting patterns. ... members of a taxonomic group -- such as the ... elephant are often thousands or millions of times ... time two SFI researchers explain these patterns within an ...
... a close relative of the toadfish, doesn,t need good looks to ... nest for his potential partner, he calls to nearby females by ... buoyancy. The sound he makes is not a song or a ... a ballad. Female midshipman find it very alluring, and they only ...
Cached Biology News:Global warming experts recommend drastic measures to save species 2Predicting the distribution of creatures great and small 2When fish talk, scientists listen 2
(Date:1/22/2015)... Diego, California (PRWEB) January 22, 2015 ... Promotional Offer to their comprehensive portfolio of Eppendorf ... allows customers to purchase a Centrifuge 5424/5424 R and ... Bundle of either Eppendorf Research plus or Eppendorf Reference ...
(Date:1/22/2015)... Madison, WI (PRWEB) January 22, 2015 Dr. ... at the 12th annual Scripps Natural Supplements Pre-Conference seminar on ... Supplements Conference is an annual continuing education conference for health ... 15th and included the topic of probiotics in health. Dr. ...
(Date:1/22/2015)... January 22, 2015 Selexis SA, a ... Research Cell Banks (RCBs) used for drug discovery to ... Banks will include Next-Generation Sequencing (NGS) data ... de-risks biologic manufacturing by ensuring the integrity of the ...
(Date:1/22/2015)... , Nueva Jersey , 22 de enero ... for Biomedical Research abre hoy su llamada a nominaciones ... cuya investigación científica ha hecho, o tiene el potencial ... salud humana. Las nominaciones se aceptarán hasta el 15 ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... AcelRx Pharmaceuticals, Inc.,today announced positive results from ... efficacy of its lead product candidate, ARX-01, for ... replacement surgery.,The primary endpoint evaluated pain intensity (Sum ... 12-hour study period compared to baseline.,Results demonstrated that ...
... PAREXEL International Corporation,(Nasdaq: PRXL ), ... it has established an alliance with Safe Implementation,of ... network of,clinical sites with specialized capabilities in the ... from SITS, access to more than 800,investigator sites ...
... report that the small fraction of people who know ... finding has led many to assume that the public ... popular awareness grows, education expands and commercialization increases. , ... Cultural Cognition Project at Yale Law School in collaboration ...
Cached Biology Technology:AcelRx Pharmaceuticals Reports Positive Results From a Phase 2 Clinical Trial of Sublingual Sufentanil NanoTabs(TM) in Treating Post-Operative Pain 2AcelRx Pharmaceuticals Reports Positive Results From a Phase 2 Clinical Trial of Sublingual Sufentanil NanoTabs(TM) in Treating Post-Operative Pain 3PAREXEL Establishes Alliance with SITS Network of Clinical Sites Specializing in Stroke Studies 2PAREXEL Establishes Alliance with SITS Network of Clinical Sites Specializing in Stroke Studies 3PAREXEL Establishes Alliance with SITS Network of Clinical Sites Specializing in Stroke Studies 4Nanotech: To know it is not necessarily to love it 2
... phase extraction through columns is a well-known ... applications. Typical applications are in DNA/RNA extraction ... or compound purification in chemical or analytical ... on the Genesis series instruments for smaller ...
... pipetting software for life science applications on ... GENESIS WORKSTATION instruments including the Te-MO multichannel ... user the simple graphical configuration of the ... the powerful scripting language the most flexible ...
... consultation. Peptide synthesis and purification (>80% ... Conjugation to KLH. 5mg unconjugated peptide ... New Zealand white female rabbits. 70 ... production bleeds. Elisa testing Total ...
... is a comprehensive suite of advanced ... designed to reliably extract biological signals ... studies containing thousands of samples, Partek ... and will analyze large data sets ...
Biology Products: