Navigation Links
How the neuron sprouts its branches

Neurobiologists have gained new insights into how neurons control growth of the intricate tracery of branches called dendrites that enable them to connect with their neighbors. Dendritic connections are the basic receiving stations by which neurons form the signaling networks that constitute the brain's circuitry.

Such basic insights into neuronal growth will help researchers better understand brain development in children, as well as aid efforts to restore neuronal connections lost to injury, stroke or neurodegenerative disease, said the researchers.

In a paper published in the Dec. 8, 2005, issue of Neuron, Howard Hughes Medical Institute investigator Michael Ehlers and his colleagues reported that structures called "Golgi outposts" play a central role as distribution points for proteins that form the building blocks of the growing dendrites.

Besides Ehlers, who is at Duke University Medical Center, other co-authors were April Horton in Ehlers' laboratory; Richard Weinberg of the University of North Carolina at Chapel Hill.; Bence Rácz in Weinberg's laboratory; and Eric Monson and Anna Lin of Duke's Department of Physics. The research was sponsored by The National Institutes of Health.

The Golgi apparatus is a cellular warehouse responsible for receiving, sorting and shipping cargoes of newly synthesized molecules needed for cell growth and function. Until the new findings, researchers believed that only a central Golgi apparatus played a role in such distribution, said Ehlers.

"In most mammalian cells, the Golgi has a very stereotyped structure, a stacked system that resides near the cell nucleus in the middle of the cell," he said. "But mammalian neurons in the brain are huge, with a surface area about ten thousand times that of the average cell. So, it was an entirely open question where all the membrane components came from to generate the complex surface of growing dendrites. And we thought these remote structures we had
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. New research questions basic tenet of neuron function
2. First real-time view of developing neurons reveals surprises, say Stanford researchers
3. One gene links newborn neurons with those that die in diseases such as Alzheimers
4. Researchers make surprise discovery that some neurons can transmit three signals at once
5. Mapping neuron connections in the brain
6. Speak up: Louder neurons form more connections
7. Eating, body weight regulated by specific neurons
8. MIT researcher finds neuron growth in adult brain
9. New neurons take baby steps in the adult brain
10. Algal protein in worm neurons allows remote control of behavior by light
11. Scientists crack code for motor neuron wiring
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How the neuron sprouts its branches

(Date:1/22/2015)... , Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading source ... launch of its new website design. "When we ... infancy", says Peter O,Neill , founder and CEO of ... industry needs involvement from the key players on a very ...
(Date:1/22/2015)... 2015 Technology Showcase, Hall E -   EyeLock Inc. ... announced it will showcase its EyeLock ID technology integrated in ... of Energy,s Oak Ridge National Laboratory (ORNL) at ... iris identity authentication technology is being used to validate the ...
(Date:1/22/2015)...  A man-made form of insulin delivered by nasal spray ... adults with mild cognitive impairment and Alzheimer,s disease dementia, ... Wake Forest Baptist Medical Center. The study,s ... impairment (MCI) or mild to moderate Alzheimer,s dementia (AD). ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3
... Spanish . , Sugars give rise to ... functions they carry out: they act as an energy storage ... systems; they form part of DNA and of ribonucleic acid ... Recently interest in sugars has also been increasingly attracting the ...
... Resolving the world,s major challenges whether climate change, ... scarcity requires a sweeping shift in our approach ... leading scientists told European policy makers today during ... and Societal Challenges for our Unstable Earth" (RESCUE). ...
... Dr. Zsuzsanna Izsvk, research group leader at the Max ... named recipient of a European Research Council (ERC Advanced) ... "jumping genes" (transposons). With the aid of the ERC ... on investigating how mobile DNA elements (transposons) influence the ...
Cached Biology News:The quest for sugars involved in origin of life 2Europe needs a 'RESCUE' revolution 2Europe needs a 'RESCUE' revolution 3MDC researcher Zsuzsanna Izsvák receives advanced European research grant 2
(Date:3/5/2015)... , March 5, 2015   HX360 today ... in the HX360 Innovation Challenge competition. These ... compete to be chosen as one of four finalists ... senior health system executives and venture capitalists during the ... Challenge takes place at the 2015 HIMSS Annual Conference ...
(Date:3/5/2015)... Park, NC (PRWEB) March 05, 2015 ... announced that Pierre Noel, M.D., Professor of Medicine, ... to the Company’s Board of Directors. ... “We are extremely fortunate to have Dr. Noel, ... country’s leading healthcare organization, join Entegrion’s Board. His ...
(Date:3/5/2015)... March 05, 2015 e2b teknologies ... Partner located in Northeast Ohio, today announced a leading ... to support its upgrade to the latest version of ... independent group practice of its kind in the region, ... volume of transactions, so efficiency and data accessibility are ...
(Date:3/4/2015)... March 4, 2015 The UPMC Center for ... Fellows in the Emerging Leaders in Biosecurity Initiative (ELBI). ... in the field of biosecurity, UPMC has selected 28 ... wide array of backgrounds, including biological science, medicine, policy, ... "With the vision and support of the ...
Breaking Biology Technology:HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 2HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 3HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 4Entegrion Announces Appointment of Pierre Noel, MD, to Its Board of Directors 2Physician Group Practice Chooses e2b teknologies to Support Its Upgrade to Sage 100 ERP 2014 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3
... HEIGHTS, N.J., Feb. 16, 2011 Zymes LLC is ... two-year $476,000 grant from the Michael J. Fox Foundation,s ... titled, "Evaluation of the Neuroprotectivity Ability of Zymes, ... disease): Preclinical Validation and Dose Optimizations for Clinical Study" ...
... Pa., Feb. 16, 2011 Tengion, Inc. (Nasdaq: ... it has been engaged in negotiations with a publicly traded ... merger.  As a result of the recent increases in the ... acquirer has terminated merger negotiations. As has ...
... An important milestone toward the realization of a large-scale quantum ... quantum control of light, were accomplished by a team of ... The study, published in the Feb. 7 issue of ... Zhejiang University, China, and NEC Corporation, Japan. The experimental effort ...
Cached Biology Technology:Michael J. Fox Foundation Awards Grant to Zymes LLC 2Tengion Addresses Recent Trading Activity in its Common Stock 2International team of scientists says it's high 'NOON' for microwave photons 2
Request Info...
Request Info...
Request Info...
Epi-Grids™ Colony Grid Templates are easy-to-use griding templates that allow rapid organization of colonies from initial screening plates and for preparing precise master plates....
Biology Products: