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How IVF could be causing genetic errors in embryos

abnormalities), pseudohypoparathyroidism Ib (involves inadequate levels of calcium and excessive levels of phosphates in the blood), and GH-secreting adenomas (type of tumour).

Of these, the greatest changes in gene expression were seen in Cd81 (consistently over-expressed in all media) and H19 (consistently under-expressed in all media), but Professor Rinaudo said the significance of these findings was unclear at present.

"The next stage of our research is to examine further the effects of IVF and ICSI on the genetic make-up and the form and function of cells from mouse embryos. We want to understand why these techniques appear to be affecting the imprinting of these genes. We hope this understanding will enable the scientific community to make better culture media for IVF in humans."


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Source:European Society for Human Reproduction and Embryology


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