Navigation Links
How IVF could be causing genetic errors in embryos

ndromes in humans, which are due to aberrant genomic imprinting, and other abnormalities in growth and development in mice have been described after culture in vitro," said Professor Rinaudo. Angelman syndrome is characterised by severe mental retardation, speech impairment, balance disorder and a happy, excitable demeanour; it occurs in about one in 10,000 to 30,000 of the population. Beckwith Wiedeman syndrome is characterised by overgrowth, with an abnormally large tongue, umbilical hernia, neonatal hypoglycaemia and a predisposition to certain tumours, in particular, Wilms tumour and hepatoblastoma; it is rare, occurring in one in 36,000 of the population.

Professor Rinaudo and his colleagues cultured mouse embryos in four media with 5% oxygen. Two of the four media were also used with 20% oxygen, making six different cultures in total. As a control, some embryos were left to mature in the mice (in vivo).

"We identified 38 imprinted genes, most of which showed no difference in expression after in vitro culture compared to the in vivo embryos. Five genes showed a statistical difference compared to the in vivo control, depending on the culture conditions," he said.

The five genes were:

  • Cd81?expresses a membrane protein with unknown function during embryogenesis. It is involved in T cell development (part of the immune system) and the hepatitis C virus binds to it to gain entry to cells.
  • H19 ?a developmentally regulated gene, thought to be a tumour suppressor and associated with Beckwith Wiedeman syndrome.
  • Slc38a4 ?plays a role in amino acid transport to cells.
  • Copg2 ?plays a role in transport of proteins within cells and is associated with Silver-Russell syndrome, a growth disorder occurring in 1 in 75,000 births (involves intrauterine growth restriction and subsequent poor growth).
  • Gnas ?plays a role in cell signalling and is associated with McCune-Albright syndrome (involves bone, hormone and skin
    '"/>


Source:European Society for Human Reproduction and Embryology


Page: 1 2 3

Related biology news :

1. Protein discovery could unlock the secret to better TB treatment
2. Tiny particles could solve billion-dollar problem
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
5. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
6. How the environment could be damaging mens reproductive health
7. Dead zone area in Gulf could be increasing, researchers say
8. Growth in biomass could put US on road to energy independence
9. Nano-bumps could help repair clogged blood vessels
10. Researchers develop assay that could be applied to drug screening
11. Currents could disrupt ocean food chain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How IVF could causing genetic errors embryos

(Date:6/30/2015)... Genisphere announced Tom Bliss ... further develop Genisphere,s therapeutics capabilities and portfolio. Mr. Bliss ... much of the last 25 years in leadership positions ... Johnson & Johnson. Tom started his career in Investment ... Finance. He graduated from Dartmouth College with a BA ...
(Date:6/25/2015)... According to a new ... Area), Technology, Material (Optical Prism, Piezoelectric, Capacitive & ... Others) & Geography - Global Forecast to 2014 ... is expected to reach $14,500.07 Million by 2020, ... Browse 76 market Tables and 109 Figures spread ...
(Date:6/24/2015)... June 24, 2015 The biologics safety testing ... drivers for the market include growth of the pharmaceutical ... drug launches. Over the years, the number of drug ... and 2010, the FDA approved 225 drug applications and ... Europe accounted for 3,822 of ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4
... and his wife, Elizabeth, have made a $5 million ... Professorships in Adult Stem Cell Research at the University ... three new endowed professorships in adult and all forms ... leadership in the field of stem cell research and ...
... The first paternity study of southern right whales has ... males, scientists say, which is good news for the overall ... local populations through in-breeding. Results of the study, by ... the New Zealand Department of Conservation, have just been published ...
... of a leaf and the tip is different from the base. ... plant superficially appears to be bilaterally symmetrical, or the same on ... there is an underlying asymmetry between the left and right sides ... it. The story begins with the mechanism by which leaves form ...
Cached Biology News:Notre Dame establishes professorships in adult stem cell research 2Notre Dame establishes professorships in adult stem cell research 3First paternity study of southern right whales finds local fathers most successful 2First paternity study of southern right whales finds local fathers most successful 3Is your leaf left-handed? 2Is your leaf left-handed? 3
(Date:7/2/2015)... ... 02, 2015 , ... Sleepless nights will become obsolete as Luzi , ... Indiegogo campaign on June 23. Sound sleepers and the sleep deprived both will love ... use, while the integration of the Bluetooth speaker, alarm clock and ability to charge ...
(Date:7/1/2015)... ... July 01, 2015 , ... It is now possible to ... single photon emission computed tomography (SPECT) according to researchers from Amen Clinics, ... over 20,000 brain scans and is believed to be the largest brain imaging study ...
(Date:7/1/2015)...   Decision Resources Group finds that ... are its oral administration, alternative mechanism of action, ... rheumatologists. Otezla was the first oral therapy specifically ... psoriatic arthritis in the United States ... conventional oral treatments including disease-modifying antirheumatic drugs (DMARDs), ...
(Date:7/1/2015)... and BANGALORE, India , July ... profiling company that uses next generation sequencing technology to ... Scott A. Storrer as chief executive officer. In ... will be responsible for all strategy, business expansion and ... who has served as Strand,s chairman and CEO since ...
Breaking Biology Technology:Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3
... of things. , ,You learn that most of them are pessimistic ... their faithfulness to the book. As a rule, you learn that ... you also learn at work among techies how they really, really ... tech environment yourself, you may have had a taste of the ...
... just put out in its March edition a list ... is primarily on the environment for formation and development ... biotechnology and medical devices and diagnostics. , ,Before I ... the key factors they used to compute their ranking. ...
... Expeditions, the kick-off for a month-long series of events ... to the public in the Engineering Centers Building ... 40 "exploration stations" and three "science spectaculars", all free, ... 4 p.m. , ,"It's a big sort of circus ...
Cached Biology Technology:How to tackle the divide between techies and non-techies at work 2How to tackle the divide between techies and non-techies at work 3How to tackle the divide between techies and non-techies at work 4Midwest states in top 10 small-tech hotspots 2UW show to give public a go at cutting-edge science 2
Peptide-affinity Purified Polyclonal Antibody to Prolactin Releasing Hormone Receptor (GPR10)...
...
...
... data entry by collecting data from any ... Collect is extremely easy to use ... data entry. An excellent solution for ... spectrophotometers, force gauges, digital calipers, bar code ...
Biology Products: