Navigation Links
Hormone helps mice 'hibernate,' survive starvation

A key hormone enables starving mice to alter their metabolism and “hibernate” to conserve energy, revealing a novel molecular target for drugs to treat human obesity and metabolic disorders, UT Southwestern Medical Center researchers have found.

The starvation-fighting effects of the hormone, called fibroblast growth factor 21 (FGF21), are described for the first time in a study appearing online today in Cell Metabolism.

FGF21, triggered in starving mice by a specific cellular receptor that controls the use of fat as energy, spurs a metabolic shift to burning stored fats instead of carbohydrates and induces a hibernation-like state of decreased body temperature and physical activity, all geared to promote survival.

“This hormone changes the metabolism and behavior of mice in the face of inadequate nutrition,” said Dr. Steven Kliewer, professor of molecular biology and pharmacology at UT Southwestern and the study’s senior author. “We hope to manipulate this hormone-receptor signaling pathway to craft the next generation of drugs to combat human obesity and other conditions.”

Mammals on the brink of starvation normally shift their main fuel source from carbohydrates to stored fats, promoting survival during foodless periods. Some mammals also enter a hibernation-like state of regulated hypothermia, known as torpor, which conserves energy.

The molecular driver behind this reaction to starvation, however, had been unknown.

To find an answer, UT Southwestern researchers and other scientists examined potential molecular cues and cellular interactions at play during starvation and fasting.

They focused on a nuclear receptor – a protein that turns genes on and off in the body – called peroxisome proliferator-activated receptor alpha, or PPAR-alpha, which is known to control the use of fat as energy. Starving mice without PPAR-alpha become hypoglycemic and quickly die.

In analyzing th
'"/>

Source:UT Southwestern Medical Center


Page: 1 2

Related biology news :

1. Hormones and growth: The control of body size and developmental growth rate in fruit flies
2. Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy
3. Hormone linked to brains cravings for food and other energy sources
4. Jumping gene helps explain immune systems abilities
5. Protein helps regulate the genes of embryonic stem cells
6. Scientists reveal the shape of a protein that helps retroviruses break into cells
7. Thai spice helps cut blood sugar swings
8. Chemists synthesize molecule that helps body battle cancers, malaria
9. Ancient DNA helps clarify the origins of two extinct New World horse species
10. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
11. Study: Well-known protein helps stem cells become secretory cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Hormone helps mice hibernate survive starvation

(Date:9/15/2014)... that a single group of microorganisms may be responsible ... the oceans, with implications for the global carbon cycle ... essential molecule required by most life on this planet, ... of microorganisms because it is so large and complex. ... maintaining the brain and nervous systems, as well as ...
(Date:9/15/2014)... coral reef ecologists fears that reef biodiversity may not ... we once thought. , In an international study published ... Excellence for Coral Reef Studies (Coral CoE) says we ... within reef ecosystems. , In coral reefs, just as ... keep the ecosystem safe and functioning. , Professor ...
(Date:9/15/2014)... lifeplants and animalsto thrive in the oceans, there ... In certain coastal areas, extreme oxygen-starvation produces "dead ... web structure. As dissolved oxygen levels decline, energy ... microbial community metabolism resulting in impacts on the ... the past 50 years, oxygen minimum zones (OMZs) ...
Breaking Biology News(10 mins):Researchers discover new producer of crucial vitamin 2Specialized species critical for reefs 2Decoding virus-host interactions in the oxygen-starved ocean 2Decoding virus-host interactions in the oxygen-starved ocean 3Decoding virus-host interactions in the oxygen-starved ocean 4Decoding virus-host interactions in the oxygen-starved ocean 5
... Nile virus alarmed Americans when it made its first ... has since spread from coast to coast, sickened more ... the virus spread, medical investigators hastened research to develop ... a newly published paper by researchers at Washington University ...
... of Health in Angola has reported 266 cases of Marburg ... Province, which remains the epicentre of the outbreak, 253 cases, ... 21 April. , Assessment of the outbreak , The international ... on 22 March. The features of Marburg haemorrhagic fever, and ...
... biological network - can get you lost - quick. Tons of ... even more being unknown, tons of database with tons of information... ... a biologically meaningfull way. Applications are being developped to make it ... of them; I didn't have time to try it yet, but ...
Cached Biology News:Promising new West Nile therapy cures disease in mice 2Marburg haemorrhagic fever in Angola update 2Marburg haemorrhagic fever in Angola update 3GeneNotes - A novel information management software for biologists 2
(Date:9/15/2014)... go downhill fast when a patient has sepsis, a ... a patient,s blood -- often too fast for antibiotics ... spleen and developed by a team at Harvard,s Wyss ... way doctors treat sepsis. , "Even with the ... care units at least 30 percent of the time," ...
(Date:9/15/2014)... MORRISVILLE, NC (PRWEB) September 15, 2014 ... newly developed deep imaging OCT system for the optical ... , The EnvisuTM S4410 SDOCT for Contact ... measurements for standard and high complexity contact lens, IOL ... allows imaging of a complete contact lens immersed in ...
(Date:9/15/2014)... DUBLIN , Sept. 15, 2014 Research ... "Whole Exome Sequencing Market by Product, by Services, by Technology, ... their offering. Whole Exome Sequencing (WES) is ... the genome, i.e. the exon. The exome, which is the ... of the total genome and is actually converted into proteins ...
(Date:9/15/2014)... ANNAPOLIS, Maryland , 15. September 2014 /PRNewswire/ ... Week (IPAW) wird vom 12. bis 18. ... der Plasma Protein Therapeutics Association (PPTA) ... Ziele: , Das globale Bewusstsein für ... Den Beitrag von Plasmaspendern beim Retten und Verbessern ...
Breaking Biology Technology:Blood-cleansing biospleen device developed for sepsis therapy 2Blood-cleansing biospleen device developed for sepsis therapy 3Blood-cleansing biospleen device developed for sepsis therapy 4Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology 2Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 2Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 3International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 2International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 3
... ... based on the Altera Stratix® IV 820 devices. These contain the largest FPGA on ... , ... 16, 2010 -- IRIS Technologies Inc. ( www.iris-technologies.net ) has released two new ...
... , ... Writers Association Recognizes Buckley/Swartz , ... Boston, MA (PRWEB) June 16, 2010 -- The American Medical Writers Association ... recipient of two Will Solimene Awards for Excellence in Medical Communication. She received the ...
... This release is avaiable in French ... range of high-tech products such as computer displays or ... ordered chemical composition as inorganic materials, preventing scientists from ... team of researchers led by McGill,s Dr. Dmitrii Perepichka ...
Cached Biology Technology:IRIS Technologies Inc. Launches Two New Stratix IV FPGA-Based Boards 2IRIS Technologies Inc. Launches Two New Stratix IV FPGA-Based Boards 3Medical Writer Rita Buckley Wins Awards for Excellence in Medical Communication 2Medical Writer Rita Buckley Wins Awards for Excellence in Medical Communication 3Organic nanoelectronics a step closer 2
... to rapidly and reliably amplify unknown genomic ... APAgene provides hassle-free, ready-to use components, at ... are provided in each kit. The Genome ... filling, localized cloning of genomic DNA, isolating ...
Rabbit polyclonal to Quinaldic Acid ( Abpromise for all tested applications). Antigen: Synthetic peptide Quinaldic Acid conjugated to a protein carrier....
Mol wt: average mol wt16,951.27 Da by calculation...
A set of five peptides which can be used to calibrate a Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or Electrospray Ionization (ESI) mass spectrometer....
Biology Products: