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Hirsute Or Hairless? Two Proteins May Spell The Difference

ntribute to Snail-mediated enhanced proliferation by allowing proteins normally sequestered at the membrane to operate in a proliferation pathway after the number of cellular junctions diminishes. By identifying which molecules are active in specific cell types at specific developmental stages, this study lays the foundation for dissecting the mechanisms that connect two key processes—intercellular remodeling and proliferation—in epithelial development. And since the consequences of TGF-β2 activity seen here in the hair bud more closely resemble certain types of skin cancer progression than skin development, a mechanistic understanding of hair follicle development promises to shed light on how skin cancer develops as well.


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Source:PLoS


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