Navigation Links
Hirsute Or Hairless? Two Proteins May Spell The Difference

ed that reducing expression of E-cadherin—a membrane protein that forms the adhesive junctions between epidermal cells—is essential for allowing the cell remodeling required for bud formation. Here, the authors analyze the timing of external signals against the response of targeted cells to determine how targeted cells translate signals into changes in cell adhesion and remodeling, proliferation, and differentiation—the agents of most types of organogenesis.

Since Snail, a protein that impedes the transcription of a subset of genes, functions in many developmental processes requiring epithelial remodeling, the authors reasoned it might do the same in hair bud formation. Working with developing mouse embryos, they saw a spike in Snail expression on embryonic day 17.5, coinciding with hair bud formation, enhanced cell proliferation, and the down-regulation of E-cadherin. Artificially sustaining Snail expression in the skin of transgenic mice caused abnormal levels of cell proliferation in the epidermis and reduced cell adhesion.

Working with skin keratinocytes, precursors of hair fibers, Fuchs and colleagues explored several signaling proteins known to be involved in bud formation as possible activators of Snail expression. When the authors treated keratinocytes with small amounts of one stimulator, TGF-β2, they saw “rapid and transient induction of Snail.?Snail proteins were absent from 17.5-day-old knockout mice lacking TGF-β2 but not from their nonmutant littermates. Conversely, transgenic mice with elevated TGF-β2 signaling activity displayed ectopic expression of Snail. Knockout mice lacking TGF-β2 also showed higher levels of E-cadherin—normally down-regulated by Snail—than their nonmutant littermates.

Altogether, these findings suggest that TGF-β2 signaling transiently induces Snail, which in turn down-regulates E-cadherin and activates a proliferation pathway in the developing bud. Reduced E-cadherin, the authors conclude, appears to co
'"/>

Source:PLoS


Page: 1 2 3

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. Proteins stop blood-vessel and tumor growth in mice
3. Proteins spur diabetic mice models to grow blood vessels, nerves
4. Parallel evolution: Proteins do it, too
5. Proteins as parents
6. Proteins anchor memories in our brain
7. Proteins may behave differently in natural environments
8. Proteins necessary for brain development found to be critical for long-term memory
9. Proteins may predict lung transplant rejection
10. Proteins important in Alzheimers, Parkinsons disease travel in the slow lane
11. Spelling out cancer on the nanoscale
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Hirsute Hairless Two Proteins May Spell The Difference

(Date:10/29/2014)... 29, 2014, Beaverton, OR) New research presented ... International Conference in Houston, TX showed for the ... HPV infection in women using a readily available ... study, presented by Dr. Judith A. Smith, Pharm.D., ... and Reproductive Sciences at The University of Texas ...
(Date:10/29/2014)... both genetic and environmental, have been blamed for ... Some, such as a family history of schizophrenia, ... Toxoplasma gondii , a parasite transmitted by ... viewed with skepticism. , A new study by ... at the University of Pennsylvania,s School of Veterinary ...
(Date:10/29/2014)... number of chemicals from household and industrial products are ... bodies. But for most of them, scientists have yet ... taken the first step toward doing that by estimating ... new method is published in the ACS journal ... and colleagues note that the risks to human health ...
Breaking Biology News(10 mins):HPV infections in women eradicated by AHCC, Japanese mushroom extract 2Penn vet professor investigates parasite-schizophrenia connection 2Penn vet professor investigates parasite-schizophrenia connection 3
... skunk, the reaction usually is "Eww," but when they ... think "Aww." Why some animals use noxious scents ... against predators is the question that biologists Tim Caro ... of California State University, Long Beach and sought ...
... and his colleagues have found a new application for ... help solve problems in biology. Specifically, the team ... on something known as epigenetic memory -- how an ... condition, such as quality of nutrition or temperature. ...
... important in a biology lab as a gym. Shape is ... cells grown to repair or replace damaged tissue in the ... "shape up," researchers at the National Institute of Standards and ... and more importantly, classify, the shapes cells tend to take ...
Cached Biology News:Social or stinky? New study reveals how animal defenses evolve 2New application of physics tools used in biology 2Shape-sifting: NIST categorizes bio scaffolds by characteristic cell shapes 2
(Date:10/31/2014)... Jeffrey T. Manuel, assistant professor in Southern ... College of Arts and Sciences, is teaming up with ... alcohol-based fuels in Illinois. , “Farmers, researchers, ... to build Illinois’ biofuels industry for decades,” Manuel said. ... state's agricultural and business history. , “Fuel alcohol ...
(Date:10/31/2014)... Brady (NYSE:BRC), a global leader ... new video testimonial on the effectiveness of ... research technician at the BloodCenter of Wisconsin discusses the ... storing hundreds of thousands of samples, and how the ... “At Brady, we design our label materials with the ...
(Date:10/31/2014)... , Oct. 31, 2014  Atlanta-based Intellimedix could ... accompanying the onset of Ebola by suggesting a ... at Georgia Tech,s Center for Computational Systems Biology ... to find alternative uses for existing drugs through ... to aid the bout against Ebola. ...
(Date:10/30/2014)... Global polyvinyl chloride (PVC) demand registered ... during 2008-2009, especially in North America and Europe. However, ... keeping to a growing trend. , The largest chunk ... the construction segment. In 2013, the key PVC application ... and rigid film. Moreover, the PVC was consumed in ...
Breaking Biology Technology:SIUE History Prof Manuel Working on Biofuels Book with NCERC 2SIUE History Prof Manuel Working on Biofuels Book with NCERC 3Brady Debuts New Lab Label Testimonial Video 2Atlanta-Based Intellimedix May Help Solve Ebola With Computer Algorithms 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 3
... Simcere,Pharmaceutical Group (NYSE: SCR ), a ... manufacturer of the patented,anti-cancer biotech product Endu in ... one of its existing shareholders, New Good Management,Limited, ... 15,individuals, including certain senior management of Simcere Pharmaceutical,has ...
... Basis, Proprietary MicroRNAs for Research Applications ... has Access to a Full Range of ... on These MicroRNAs, REHOVOT, Israel and JERSEY CITY, ... ), a leading,developer of microRNA-based diagnostics and therapeutics, announced ...
... System Combines Clinical Benefits of Dual Wavelengths Through ... Time While Providing a Uniform, Safe and Effective ... Treatment - New Offering Signals Company,s Expansion into International Laser ... Lipolysis Market, WESTFORD, Mass., April 28 Cynosure, ...
Cached Biology Technology:Simcere Pharmaceutical Group Reports Proposed Private Sale of Ordinary Shares by Existing Shareholder 2Simcere Pharmaceutical Group Reports Proposed Private Sale of Ordinary Shares by Existing Shareholder 3Rosetta Genomics Announces Expansion of its MicroRNA Intellectual Property Estate 2Rosetta Genomics Announces Expansion of its MicroRNA Intellectual Property Estate 3Rosetta Genomics Announces Expansion of its MicroRNA Intellectual Property Estate 4Cynosure Introduces Smartlipo MPX(TM) Dual Wavelength Workstation for LaserBodySculpting(SM) 2Cynosure Introduces Smartlipo MPX(TM) Dual Wavelength Workstation for LaserBodySculpting(SM) 3Cynosure Introduces Smartlipo MPX(TM) Dual Wavelength Workstation for LaserBodySculpting(SM) 4Cynosure Introduces Smartlipo MPX(TM) Dual Wavelength Workstation for LaserBodySculpting(SM) 5
...
Request Info...
Request Info...
... purification systems provide high speed purification of ... offer increased throughput and reproducible results. The ... mL and KingFisher 96, covering sample volumes ... consists of an instrument, specially designed plastics ...
Biology Products: