Navigation Links
Hirsute Or Hairless? Two Proteins May Spell The Difference

If you're a cat fancier, you're well aware that hair follicles are expendable. The product of a spontaneous mutation that caught a cat breeder's eye, le chat nu, would quickly succumb in the wild—its winter coat consists of little more than a ridge of fur down the midback and tail—and needs special care to thrive as a pet. Hairless animals in the lab, on the other hand, can be very instructive. Understanding how hair develops sheds light on the fundamental processes that generate a wide range of tissues and organs, including the lungs, cornea, and mammary glands.

How complex, three-dimensional structures emerge from single sheets of cells is a fundamental question in developmental biology. The dispensability of hair follicles makes them the perfect model system for studying this question—specifically, how structures and organs develop from buds. In a new study, Elaine Fuchs and colleagues use a three-pronged approach—involving gene expression analysis, transgenic mice, and cell cultures—to study how epithelial buds, the precursors of hair follicles, form. Their experiments point to two key actors in a signaling pathway that molds a targeted cluster of cells into a hair bud.

During the budding process, overlapping signaling pathways from two adjacent embryonic cell layers—the epithelium and the mesenchyme—direct morphogenesis. The mesenchymal cells initiate the cell-to-cell “crosstalk?that controls bud formation by first directing a small cluster of epithelial cells to form a placode, the pouch that forms hair plugs. The placode in turn directs underlying mesenchymal cells to form the base of the hair follicle, called the dermal papilla, and both structures contribute to the mature hair follicle. During development, cells are constantly bombarded with external signals. The trick is figuring out which signals trigger the transcriptional and behavioral properties in cells that spur bud formation.

In previous experiments, Fuchs and colleagues show
'"/>

Source:PLoS


Page: 1 2 3

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. Proteins stop blood-vessel and tumor growth in mice
3. Proteins spur diabetic mice models to grow blood vessels, nerves
4. Parallel evolution: Proteins do it, too
5. Proteins as parents
6. Proteins anchor memories in our brain
7. Proteins may behave differently in natural environments
8. Proteins necessary for brain development found to be critical for long-term memory
9. Proteins may predict lung transplant rejection
10. Proteins important in Alzheimers, Parkinsons disease travel in the slow lane
11. Spelling out cancer on the nanoscale
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Hirsute Hairless Two Proteins May Spell The Difference

(Date:9/30/2014)... conducted by the Ocean Health Index rates the ... overall health. In addition, for the first time, ... ocean regions beyond national jurisdiction (high-seas areas) ... safeguarding biodiversity and providing sustainable food sources. , ... a partnership led by scientists from UC Santa ...
(Date:9/30/2014)... Ecker, a Salk professor and Howard Hughes Medical ... have been named recipients in the 2014 round ... (NIH) through the BRAIN (Brain Research through Advancing ... The grant, announced September 30, provides more than ... over three years. , The BRAIN Initiative, launched ...
(Date:9/30/2014)... almost any aquatic environment on Earth, but when the ... pushed to the limit. The amount of time needed ... how different species cope in the future, reveals a ... published in the scientific journal Proceedings of the ... thanks to increasing levels of greenhouse gases in the ...
Breaking Biology News(10 mins):Rating the planet's oceans 2Rating the planet's oceans 3Salk scientists receive $3 million for BRAIN Initiative grant 2Shape up quickly -- applies to fish, too! 2
... When neurons started dying in Clive Svendsen,s lab dishes, ... cells the same type lost in patients with ... that the University of Wisconsin-Madison stem cell biologist had ... lab, using stem cells derived from a patient. ...
... left Africa over 60,000 years ago in a migration that ... population that exist outside Africa today. Now, researchers ... that exodus. By tracing variations in the X chromosome and ... probably outnumbered women in that migration. The scientists expect that ...
... Deep inside the Frasassi cave system in Italy and more ... ropes of microbes growing in the cold water, according to ... microbiology paradise. Many different types of organisms live in the ... professor of geosciences. "We are trying to map which organisms ...
Cached Biology News:Patient-derived induced stem cells retain disease traits 2Patient-derived induced stem cells retain disease traits 3Unusual microbial ropes grow slowly in cave lake 2
(Date:9/30/2014)... 30, 2014 FemCap Inc., www.femcap.com  an ... receipt of a patent No: US, 8,795,248 B2 dated ... received FDA clearance in the U.S., 510(K) K121857, medical ... Europe. This patent is related to its menstrual cup with ... company is releasing FemmyCycle Teen, a third menstrual cup ...
(Date:9/30/2014)... SoundConnect, an award ... dedicated to supporting business communication solutions, including business ... a carrier services specialist has joined ... connected and productive at all times. This growth ... businesses to cloud communications services. On a ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Back in the ... 500 square feet. per employee, which included space for circulation ... then.” says Jeff Howell, partner at Nidea Corporate Real ... in Toronto. “By the year 2000, however, 250 square ... seeing that number come down to 175 to 225 square ...
(Date:9/29/2014)... 2014  Ten of the most highly-respected physicians ... regeneration, allograft reconstruction and research and development, as ... to discuss the future of cartilage regeneration at ... symposium, Cartilage Regeneration: State of the Art ... Minced Juvenile Allograft, and State of the Art ...
Breaking Biology Technology:The FemmyCycle 2SoundConnect Expands Carrier Services Division 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3World Renowned Experts Discuss Future Of Cartilage Regeneration 2World Renowned Experts Discuss Future Of Cartilage Regeneration 3
... DIEGO, Aug. 8 Halozyme Therapeutics, Inc.,(Nasdaq: ... targeting the extracellular matrix, today reported financial,results for ... 2008., "As we,ve previously stated, we continue ... programs that target large markets. Now we are,beginning ...
... -- China Sky One,Medical, Inc. ("China Sky One ... a,manufacturer, marketer and distributor of pharmaceutical, medicinal and,diagnostic ... conduct a,conference call at 10:00 a.m. Eastern Time ... 2008 financial results., Joining Mr. Yan-qing Liu, ...
... 8 Insmed Inc. (Nasdaq:,INSM), a developer of follow-on biologics and ... 30, 2008., Recent Company Highlights, -- Follow-on Biologics ... bioequivalence of INS-19, the ... factor (G-CSF), to Neupogen(R), an FDA-approved G-CSF product for ...
Cached Biology Technology:Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 2Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 3Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 4Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 5Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 6Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 7Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 8Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 9China Sky One Medical, Inc. Announces Conference Call to Discuss Second Quarter 2008 Results 2China Sky One Medical, Inc. Announces Conference Call to Discuss Second Quarter 2008 Results 3Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 2Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 3Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 4Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 5Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 6Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 7Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 8Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 9Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 10
...
... is the research-grade spectrofluorometer with a minimum ... S/N ratio 200 or greater for the ... especially designed to keep in mind in ... kinetics, stopped-flow, titration, or anisotropic measurements. ,The ...
... Microarrays designed for genome-wide microRNA expression ... and powerful Paraflo microfluidic on-chip synthesis ... part of our comprehensive microRNA Expression ... The Arabidopsis microRNA Microarray contains ...
... Microarrays designed for genome-wide microRNA expression profiling ... Paraflo microfluidic on-chip synthesis platform. These microarrays ... microRNA Expression Profiling Service. Probe ... all known cow microRNAs (108 unique mature ...
Biology Products: