Navigation Links
Hirsute Or Hairless? Two Proteins May Spell The Difference

If you're a cat fancier, you're well aware that hair follicles are expendable. The product of a spontaneous mutation that caught a cat breeder's eye, le chat nu, would quickly succumb in the wild—its winter coat consists of little more than a ridge of fur down the midback and tail—and needs special care to thrive as a pet. Hairless animals in the lab, on the other hand, can be very instructive. Understanding how hair develops sheds light on the fundamental processes that generate a wide range of tissues and organs, including the lungs, cornea, and mammary glands.

How complex, three-dimensional structures emerge from single sheets of cells is a fundamental question in developmental biology. The dispensability of hair follicles makes them the perfect model system for studying this question—specifically, how structures and organs develop from buds. In a new study, Elaine Fuchs and colleagues use a three-pronged approach—involving gene expression analysis, transgenic mice, and cell cultures—to study how epithelial buds, the precursors of hair follicles, form. Their experiments point to two key actors in a signaling pathway that molds a targeted cluster of cells into a hair bud.

During the budding process, overlapping signaling pathways from two adjacent embryonic cell layers—the epithelium and the mesenchyme—direct morphogenesis. The mesenchymal cells initiate the cell-to-cell “crosstalk?that controls bud formation by first directing a small cluster of epithelial cells to form a placode, the pouch that forms hair plugs. The placode in turn directs underlying mesenchymal cells to form the base of the hair follicle, called the dermal papilla, and both structures contribute to the mature hair follicle. During development, cells are constantly bombarded with external signals. The trick is figuring out which signals trigger the transcriptional and behavioral properties in cells that spur bud formation.

In previous experiments, Fuchs and colleagues show
'"/>

Source:PLoS


Page: 1 2 3

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. Proteins stop blood-vessel and tumor growth in mice
3. Proteins spur diabetic mice models to grow blood vessels, nerves
4. Parallel evolution: Proteins do it, too
5. Proteins as parents
6. Proteins anchor memories in our brain
7. Proteins may behave differently in natural environments
8. Proteins necessary for brain development found to be critical for long-term memory
9. Proteins may predict lung transplant rejection
10. Proteins important in Alzheimers, Parkinsons disease travel in the slow lane
11. Spelling out cancer on the nanoscale
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Hirsute Hairless Two Proteins May Spell The Difference

(Date:10/16/2014)... Northridge, Calif. (October 16, 2014) – Post-menopausal women ... effect on hormone levels or genital bleeding, after ... of an investigational fermented soy germ-based nutritional supplement ... according to a new peer-reviewed pilot study reported ... Society (NAMS) annual scientific meeting. , "These ...
(Date:10/15/2014)... The book ,Models of Life, is a non-traditional biophysics ... itself. The book is a journey of discovery into ... of life and biological regulation. It is about how ... strategic communication between the billions of cells in an ... the relationships between principles, which can be found on ...
(Date:10/15/2014)... Conn. , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce market releases ... MarketSite in Times Square on Monday October 13 th . ... CTO David Tunnel and angel investor Mr. Chad ... Pereira , CEO of NXT-ID thanked his investors and employees "for ...
Breaking Biology News(10 mins):S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2New book about life as seen from physics 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
... of Michigan,s first human embryonic stem cell line will be ... the cells available for federally-funded research. It is the first ... Michigan to be placed on the registry. The line, ... October 2010 from a cluster of about 30 cells removed ...
... in Salt Lake City is part of a select ... clinical guidelines used by physicians worldwide for the diagnosis ... common cardiovascular diseases in the United States. Scott ... Intermountain Medical Center, says the new guidelines are critically-needed ...
... Economic Forum,s Global Agenda Council on Emerging Technologies has ... change the world in the years ahead. The list ... state of the world in the near future and ... science, businesses, and public policy. The technologies are expected ...
Cached Biology News:U-M human embryonic stem cell line placed on national registry 2U-M human embryonic stem cell line placed on national registry 3New guidelines developed for improved DVT diagnosis 2Important Emerging Technologies for the 21st Century 2Important Emerging Technologies for the 21st Century 3
(Date:10/19/2014)... The report "Unmanned Ground Vehicle Market ... Payload, Type & by Geography - Forecasts & ... ground vehicle market into various sub segments with ... The report also identifies the factors driving this ... with the adoption trends. , The unmanned ground ...
(Date:10/18/2014)... October 18, 2014 The Asia-Pacific ... and segments the bio-based advanced phase change material ... revenue. , Browse through the TOC of the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bio-based advanced phase change ...
(Date:10/18/2014)... October 18, 2014 The Asia-Pacific hardware ... market in Asia-Pacific with analysis and forecast of revenue. ... is expected to reach $51,362.6 million by 2018, at ... Browse through the TOC of the Asia-Pacific hardware encryption ... analysis provided. This also provides a glimpse of the ...
(Date:10/18/2014)... October 18, 2014 The Biomass ... in the five years to 2014. The industry's expansion ... energy tax credits that encouraged the use of biomass ... portfolio standards (RPSs), which require local utilities to generate ... total energy portfolio. Increased campaigning for green technology also ...
Breaking Biology Technology:Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 4The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3
... 26 Oxygen Biotherapeutics, Inc. (OTC Bulletin Board: OXBO) today ... the addition of two new members. Appointed to the company,s ... Chatfield. With their addition, the company board now has eight ... of the U. S. Selective Service System from November of ...
... Pa., Oct. 26 Cadient Group , ... today announced that it has been recognized as one of ... the Greater Philadelphia region for the second consecutive year. ... during the five year period from 2004-2008. Cadient Group ...
... , ... blue dye test alternative using innovative laser technology has been installed at ... processes. Bayer China has acquired Sepha ’s ‘BlisterScan’ machines for non-destructive leak testing ... ...
Cached Biology Technology:Oxygen Biotherapeutics, Inc. Expands Board of Directors 2Cadient Group Ranks as Deloitte Fast 50 Company for Greater Philadelphia Region for Second Consecutive Year 2Blue Dye Test Alternative Installed at Bayer China for Packaging Quality Assurance Process 2Blue Dye Test Alternative Installed at Bayer China for Packaging Quality Assurance Process 3
... • Dog serum is collected from fasted mixed ... age Available Anticoagulants: N-02: ... K2EDTA N-08: Potassium Oxalate ... N-05: ACD N-07: CPD ...
Ready-to-use; 40mg/ml X-Gal and 32mg/ml IPTG...
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
Designed for flow cytometric applications intended to identify...
Biology Products: