Navigation Links
HIV Therapy Greatly Extends Life of Key T Cells, Scientists Find

stigators infused 32 volunteers with a sugar solution containing a harmless chemical label, deuterium (a non-radioactive, stable isotope), for five days. Nine volunteers were HIV-positive but had never received IL-2; 15 volunteers were HIV-positive and had received between three and 28 courses of IL-2; and eight volunteers were HIV-negative.

Deuterium is incorporated into the DNA of actively dividing cells. By taking blood samples in weeks and months following the deuterium infusion and measuring the amount of deuterium remaining in the CD4+ T cell DNA at each time point, the researchers could count how many new cells were made and how long they lived.

The scientists found a marked increase in the numbers of newly made CD4+ cells in all the HIV-positive, IL-2 responsive volunteers. In two HIV-positive volunteers ?each of whom had received multiple five-day courses of IL-2 over several years ?the researchers detected CD4+ cells that lived for about three years, a result Dr. Kovacs calls “quite surprising.?/p>

Using another labeling technique, the researchers determined that IL-2 boosts the numbers of two subsets of CD4+ cells: naïve cells, those that have never encountered an infectious agent; and central memory cells, those that have encountered an infectious agent before and are primed to respond quickly if they encounter the same agent again.

The new data complement clinical observations suggesting that IL-2’s effects on HIV disease progression may become apparent only in long-term follow-up, says Dr. Kovacs. Two large, long-term efficacy trials currently underway should provide a clearer picture of the clinical impact of IL-2 on the course of HIV disease and its potential role in the management of HIV-infected patients, he adds. Information on these and other HIV clinical trials is available at www.aidsinfo.nih.gov.

Other authors on the paper include researchers from the NIH’s National Cancer Institute and the Science Applicati
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
3. Gene Therapy For Parkinsons Disease Moves Forward In Animals
4. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
5. Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy
6. Discovery Promises Simpler Therapy for Sickle Cell Disease
7. Gene Therapy Cures Inherited Liver Disease In Rats
8. Antiretroviral Therapy May Prevent HIV Transmission From Breastfeeding Mothers To Infants
9. Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy
10. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
11. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: HIV Therapy Greatly Extends Life Key Cells Scientists Find

(Date:8/28/2015)... August 28, 2015 According to ... Market by Assessment Type (Pen & Paper Based, Hosted, ... Corporate Learning, Academic Research), Vertical and Region - Global ... Training Market to grow from USD 2.4 Billion in ... Compound Annual Growth Rate (CAGR) of 25.6% from 2015 ...
(Date:8/20/2015)... , Aug. 20, 2015 The ... consumers that are active and healthy. However, wearable ... the hospital environment to help improve diagnostic capabilities ... video from the Wearable Technologies Conference 2015 ... new applications for wearables in healthcare.    ...
(Date:8/18/2015)... DUBLIN , Aug. 17, 2015 ... the addition of the "Global Biometric Authentication ... Application - Estimation & Forecast, 2015-2020" report ... biometric authentication and identification systems market is expected ... from 2015 to 2020 and generate over $25 ...
Breaking Biology News(10 mins):Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2
... hunters are depleting lion and cougar populations as managers respond ... according to a study published in the June 17 issue ... Craig Packer, a University of Minnesota professor and renowned authority ... conservationists. The study looked at numbers of lions ...
... That,s about all that fossils ever tell paleontologists about ... new species of parrot-beaked dinosaur and its associated gizzard ... seeds. These characteristics present the first solid evidence of ... the skull to that in parrots, the descendants of ...
... This release is available in Spanish . ... marine and food research, has developed a system for ... maritime processes along our coastline. This is innovative technology ... installation of a series of cameras located at strategic ...
Cached Biology News:U of Minnesota-led study finds that hunters are depleting lion and cougar populations 2Sands of Gobi Desert yield new species of nut-cracking dinosaur 2Innovative system for monitoring coastline processes 2
(Date:9/2/2015)... 2015 Axovant Sciences Ltd. (NYSE:  AXON), a leading ... announced upcoming presentations at three investor conferences: , ... Healthcare Conference in New York at ... at 2:00 PM at the BioCentury NewsMakers Conference in ... & Conference Center , Thursday, September 17 at 9:30 ...
(Date:9/2/2015)... DUBLIN , Sept. 2, 2015 /PRNewswire/ ... has announced the addition of Jain PharmaBiotech,s ... Companies" to their offering. ... the pharmaceutical and biotechnology industries is anticipated. ... of drug development - from formulations for ...
(Date:9/2/2015)... ARBOR, Mich. and LIBERTYVILLE, Ill. (PRWEB) , ... ... ... NSF International, a leading provider of regulatory compliance, quality systems, analytical ... Avarent LLC, a consulting firm with expertise in medical device products/processes development, ...
(Date:9/2/2015)... DUBLIN , Sep. 02, 2015 ... ) has announced the addition of Jain PharmaBiotech,s ... and Companies" to their offering. ... variations, development of sequencing technologies, and their applications. ... well as companies developing them. Various applications of ...
Breaking Biology Technology:Axovant Sciences To Present At Upcoming Investor Conferences 2Axovant Sciences To Present At Upcoming Investor Conferences 3Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7Global DNA Sequencing Technologies Report 2015: Profiles of 130 Companies Involved in Sequencing and their 140 Collaborations 2
... , , SAN CARLOS, Calif., ... announce its financial results for the second quarter ended June 30, ... financial markets. Howard Robin, president and chief executive officer, will host ... Eastern Time (ET)/2:00 p.m. Pacific Time (PT). , , ...
... , RICHMOND, Va., July 31 Insmed ... announced that it will host a conference call on Thursday, ... results for the second quarter 2009. Insmed intends to ... opens on August 13(th). , , To ...
... Inc. (ERT), (Nasdaq: ERES ), a leading provider of centralized ... industries, announced today results for the second quarter and six-month period ended ... changes from the same period a year ago. ... 2009 were: , , Revenue was ...
Cached Biology Technology:Nektar to Announce Financial Results for the Second Quarter of 2009 on Tuesday, August 4, 2009, After Close of U.S.-Based Financial Markets 2Insmed to Host Second Quarter 2009 Conference Call 2ERT Reports Second Quarter 2009 Results 2ERT Reports Second Quarter 2009 Results 3ERT Reports Second Quarter 2009 Results 4ERT Reports Second Quarter 2009 Results 5ERT Reports Second Quarter 2009 Results 6ERT Reports Second Quarter 2009 Results 7ERT Reports Second Quarter 2009 Results 8ERT Reports Second Quarter 2009 Results 9ERT Reports Second Quarter 2009 Results 10ERT Reports Second Quarter 2009 Results 11ERT Reports Second Quarter 2009 Results 12
BD Primaria 35 mm Cell Culture Dish with Easy-Grip design, surface-modified polystyrene for enhanced cell culture. (20/sp, 200/ca) Packaging: 20 / sleeve, 500 / case ...
... premium quality recombinant form of Thermus aquaticus ... for a wide range of PCR applications. ... performance, each preparation is extensively tested in ... DNA Polymerase possesses an integral 5′→3′ exonuclease ...
... a direct antibiotic-based selection system for recombinant ... survival, eliminating the need for costly color ... close to 100% accuracy in recombinant selection. ... robot colony picking. This cloning kit can ...
AVOID FREEZE/THAW CYCLES. Recognizes the ~32 kDa DNase IIα chain and the ~40 kDa proenzyme. DNase II causes both DNA condensation and DNA fragmentation. ...
Biology Products: