Navigation Links
HIV Therapy Greatly Extends Life of Key T Cells, Scientists Find

stigators infused 32 volunteers with a sugar solution containing a harmless chemical label, deuterium (a non-radioactive, stable isotope), for five days. Nine volunteers were HIV-positive but had never received IL-2; 15 volunteers were HIV-positive and had received between three and 28 courses of IL-2; and eight volunteers were HIV-negative.

Deuterium is incorporated into the DNA of actively dividing cells. By taking blood samples in weeks and months following the deuterium infusion and measuring the amount of deuterium remaining in the CD4+ T cell DNA at each time point, the researchers could count how many new cells were made and how long they lived.

The scientists found a marked increase in the numbers of newly made CD4+ cells in all the HIV-positive, IL-2 responsive volunteers. In two HIV-positive volunteers ?each of whom had received multiple five-day courses of IL-2 over several years ?the researchers detected CD4+ cells that lived for about three years, a result Dr. Kovacs calls “quite surprising.?/p>

Using another labeling technique, the researchers determined that IL-2 boosts the numbers of two subsets of CD4+ cells: naïve cells, those that have never encountered an infectious agent; and central memory cells, those that have encountered an infectious agent before and are primed to respond quickly if they encounter the same agent again.

The new data complement clinical observations suggesting that IL-2’s effects on HIV disease progression may become apparent only in long-term follow-up, says Dr. Kovacs. Two large, long-term efficacy trials currently underway should provide a clearer picture of the clinical impact of IL-2 on the course of HIV disease and its potential role in the management of HIV-infected patients, he adds. Information on these and other HIV clinical trials is available at www.aidsinfo.nih.gov.

Other authors on the paper include researchers from the NIH’s National Cancer Institute and the Science Applicati
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
3. Gene Therapy For Parkinsons Disease Moves Forward In Animals
4. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
5. Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy
6. Discovery Promises Simpler Therapy for Sickle Cell Disease
7. Gene Therapy Cures Inherited Liver Disease In Rats
8. Antiretroviral Therapy May Prevent HIV Transmission From Breastfeeding Mothers To Infants
9. Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy
10. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
11. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: HIV Therapy Greatly Extends Life Key Cells Scientists Find

(Date:4/15/2014)... experts who study the deadliest infectious diseases recognized the ... professors at the University of Texas Medical Branch, with ... Symposium on Filoviruses. The filoviruses include Ebola and Marburg ... of people infected. The current outbreak of Ebola virus ... deaths so far. , "This award represents the ...
(Date:4/15/2014)... loveliest in the world, but they also contain a ... become enriched in cadmium. Grasses take up this toxic ... and sheep that graze them. The problem is not ... , The concern is that if cadmium concentrations rise ... health and New Zealand,s agricultural economy could be jeopardized. ...
(Date:4/15/2014)... Netherlands Academy of Arts and Sciences (KNAW) has announced ... been awarded prestigious Heineken Prizes (one million US dollars ... Prizes for their great merits to science. , This ... Prize, awarded to the Austrian-American chemist Erwin Chargaff in ... Heineken Prizes to the following laureates: , ...
Breaking Biology News(10 mins):International research group recognizes UTMB experts 2International research group recognizes UTMB experts 3Five scientists awarded prestigious Heineken Prizes 2
... Most of what we have come to think of as ... ancestors. Over hundreds and thousands of years, humans have ... traits such as bigger, juicier, and easier-to-harvest fruits, stems, tubers, ... relatively easy to envision how such human-induced selection rapidly led ...
... Bureau of Reclamation has awarded a $3 million five-year ... integrated transponders (PIT) and related equipment to conduct on-going ... numerous river habitat restoration and endangered fish recovery programs. ... real-time, scientific knowledge about fish behavior that we rely ...
... Department of Energy (DOE),s Joint BioEnergy Institute (JBEI) have identified ... fuel for diesel engines but would be clean, green, renewable ... synthetic biology, a JBEI research team engineered strains of two ... to bisabolane, a member of the terpene class of chemical ...
Cached Biology News:Do long-lived crops differ from annual crops in their genetic response to human domestication? 2Do long-lived crops differ from annual crops in their genetic response to human domestication? 3Contract awarded for equipment to support on-going fish studies in the West 2JBEI identify new advanced biofuel as an alternative to diesel fuel 2JBEI identify new advanced biofuel as an alternative to diesel fuel 3JBEI identify new advanced biofuel as an alternative to diesel fuel 4
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Bulletin Board: DSCI), a provider of advanced wound care ... six months ended,June 30, 2008. Sales were up by ... the Company,s new First Aid Division as,well as the ... second quarter in 2008, the company reported sales of ...
... -- Michael Philen, assistant professor of aerospace and ocean ... Associated Universities (ORAU) Ralph E. Powe Junior Faculty Award. ... flexible matrix composites, which are new material and structural ... on demand. , "I believe these innovative materials ...
... At the upcoming Medical,Grade Polymers Conference, Dr. Remi ... Elastomer Gels: New Soft Adhesives for Wound,Care." The ... According to Dr. Thiria, silicones offer a ... features for wound care,scar management and transdermal drug ...
Cached Biology Technology:Derma Sciences Reports Second Quarter 2008 Results 2Derma Sciences Reports Second Quarter 2008 Results 3Derma Sciences Reports Second Quarter 2008 Results 4Derma Sciences Reports Second Quarter 2008 Results 5Bluestar Silicones Presents Adhesive Gels for Wound Care at Medical Grade Polymers Conference 2
... able to handle larger sample volumes, automate infusions, ... interface with telemetry systems. The AccuSampler LA ... pigs, and primates. The system may be ... computer can be located outside the animal room ...
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
... key to successful cell culture or fermentation ... during the process, and make rapid adjustments ... Nova BioProfile Chemistry Analyzers provide immediate analysis ... cell culture and fermentation media. BioProfile analyzers ...
... AAIPharmas Routine Testing Laboratory (RTL) ... developed over 25 years. ,,Microbial method ... used to monitor the conditions of ... quality for manufactured products,,We offer a ...
Biology Products: