Navigation Links
HIV Therapy Greatly Extends Life of Key T Cells, Scientists Find

Interleukin-2 (IL-2), an immune-boosting drug used experimentally in HIV therapy, greatly increases the lifespan of certain subsets of immune system T cells in some HIV-positive people who respond to this therapy, discovered researchers from the National Institutes of Health (NIH) Clinical Center and the National Institute of Allergy and Infectious Diseases (NIAID), part of the NIH. A report describing the study, led by the Clinical Center’s Joseph A. Kovacs, M.D., appears online today in The Journal of Clinical Investigation.

A hallmark of HIV infection is the progressive loss of CD4+ T cells (a key type of white blood cell) and the subsequent decline in the infected person’s ability to fend off disease. NIH clinical investigators pioneered the experimental use of IL-2 in HIV therapy to help boost the immune systems of people with HIV infection. Produced naturally by T cells, IL-2 is a powerful immune system regulator. While its use in HIV therapy is experimental and can be associated with various side effects, IL-2 is licensed to treat certain cancers.

NIH researchers have long observed that in responsive patients, intermittent cycles of IL-2 therapy lead to substantial increases in the number of circulating CD4+ cells. The mechanisms driving this increase as well as its potential clinical significance, however, have remained unclear, note the scientists.

Using two relatively new techniques for labeling cells, the team demonstrated that IL-2 therapy can lead to greatly increased numbers of new CD4+ cells. “More remarkable than the proliferation of these cells was how long they lived,?says Dr. Kovacs. The average lifespan of CD4+ cells in healthy individuals as measured with this technique is about four weeks, according to Dr. Kovacs. In contrast, the average lifespan of CD4+ cells in 15 HIV-positive volunteers who had received three or more courses of IL-2 was 37.6 weeks, about nine times longer.

In the first set of experiments, inve
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
3. Gene Therapy For Parkinsons Disease Moves Forward In Animals
4. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
5. Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy
6. Discovery Promises Simpler Therapy for Sickle Cell Disease
7. Gene Therapy Cures Inherited Liver Disease In Rats
8. Antiretroviral Therapy May Prevent HIV Transmission From Breastfeeding Mothers To Infants
9. Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy
10. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
11. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: HIV Therapy Greatly Extends Life Key Cells Scientists Find

(Date:9/2/2014)... Bavaria, the Tithonian Konservat-Lagersttte of lithographic limestone is ... of emblematic fossils from that area (for example, ... found fossil insects in the French equivalent of ... species representing the oldest known water treader. , ... Bavarian outcrops, fewer fossils have been obtained from ...
(Date:9/1/2014)... making us fat? An increasing amount of research shows ... and a more sedentary lifestyle. Now, a new Cornell ... alike. Some TV programs might lead people to eat ... if you,re watching an action movie while snacking your ... Ph.D. lead author on the new article just published ...
(Date:9/1/2014)... that corals whose calcium-carbonate skeletons form the ... that rely entirely on ocean currents to deliver ... now scientists at MIT and the Weizmann Institute ... they are far from passive, engineering their environment ... enhance their ability to exchange nutrients and dissolved ...
Breaking Biology News(10 mins):Exceptionally well preserved insect fossils from the Rhône Valley 2Can action movies make you fat? 2Nature's tiny engineers 2Nature's tiny engineers 3
... of olive ridley sea turtles off the coast of ... be inadequate to safeguard turtles from fishing nets, according ... Wildlife Conservation Society, the University of Exeter, and others. ... an international marine park that spans the waters of ...
... Germs survive for several days in wind ... a pilot study published in the International Journal ... Stuart Levy, MD, of Tufts University School of Medicine, ... a need for additional research to determine the conditions ...
... DALLAS May 12, 2011 UT Southwestern Medical ... development and eventually might lead to a treatment to keep ... that the Ras interacting protein 1 (Rasip1) is so specific ... new blood vessels simply cannot form, said Dr. Ondine Cleaver, ...
Cached Biology News:Africa's sea turtles need passports for protection 2Africa's sea turtles need passports for protection 3Sharing musical instruments means sharing germs 2UT Southwestern researchers find protein that might be key to cutting cancer cells' blood supply 2
(Date:9/2/2014)... 2, 2014 /PRNewswire/ - Oncothyreon Inc. (Nasdaq: ONTY ) ... Chief Executive Officer, will present at the Rodman & Renshaw ... New York on Tuesday, Sept. 9, 2014 at ... webcast of the presentation will be accessible by visiting the ... section. About Oncothyreon Oncothyreon ...
(Date:9/2/2014)... 2, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... orders consist of three large odour control systems for waste ... "These orders are consistent with the market resurgence in ... , President and CEO. "After a difficult period of restraint ... beginning to see sales growth. Our lower cost structure, technology ...
(Date:9/2/2014)... , Sept. 2, 2014  Spherix Incorporated (SPEX) -- an ... monetization of intellectual property, today announced that the United ... to the Company in the month of August that ... The issued patents are: ... U.S.RE45,081 issued August 19, 2014; and , U.S.RE45,095 ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 The inventors ... cure for chronic tinnitus are seeking support for development ... the Indiegogo platform ( http://igg.me/at/tinaway ), was launched on ... a therapeutic ‘mHealth’ app and is based on ten ... a team of biomedical and software engineers, Dr. Ian ...
Breaking Biology Technology:United States Patent & Trademark Office Issues Three New Standard Essential Patents to Spherix 2tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 2tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 3tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 4tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 5
... it; you brought Bill Gates to his tender knees. Oh, yes, ... you worm writer, you!" It echoed among the buildings, all but ... beneath the whimpers you could almost hear Billy saying it: "I ... fix my software."* , ,Wow, if only the U.S. ...
... electricity-usage growth rate, we wont have enough power in 15 ... company. With a 2.5 percent growth rate, if we dont ... keep the lights on in 15 years, especially in this ... ,Paul Wilson, Ph.D, assistant professor of engineering physics at the ...
... consultants and executives are reporting that there are early ... half of 2003, which provides the necessary first steps ... ,Steve Haroldson, chief technology officer for CUNA Mutual Group ... talk regularly with technology vendors, and over the last ...
Cached Biology Technology:Open Letter: Blasted Worm 2Open Letter: Blasted Worm 3Software Company Tackles Energy Shortage Issues 2IT Spending to Increase in Second Half of 2003 2IT Spending to Increase in Second Half of 2003 3IT Spending to Increase in Second Half of 2003 4IT Spending to Increase in Second Half of 2003 5