Navigation Links
Gradient guides nerve growth down spinal cord

which control voluntary movements and fine-motor skills. These are some of the longest cells in the body. The corticospinal neurons connect to groups of neurons along the length of spinal cord, some of which reach out of the spinal cord. They pass out of the cord between each pair of vertebrae and extend to different parts of the body, for example the hand or foot.

Zou and colleagues studied the guidance system used to assemble this complex network in newborn mice, where corticospinal axon growth is still underway. Before birth, axons grow out from the cell body of a nerve cell in the motor cortex. The axons follow a path back through the brain to the spinal cord.

By the time of birth, the axons are just growing into the cord. During the first week after birth they grow down the cervical and thoracic spinal cord until they reach their proper position, usually after seven to ten days.

From previous studies, Zou and colleagues knew that a gradient of various Wnt proteins, including Wnt4, formed along the spinal cord around the time of birth. Here they show that two other proteins, Wnt1 and Wnt5a are produced at high concentrations at the top of the cord and at consecutively lower levels farther down.

They also found that motor nerves are guided by Wnts through a different receptor, called Ryk, that mediates repulsion by Wnts. Antibodies that blocked the Wnt-Ryk interaction blocked the downward growth of corticospinal axons when injected into the space between the dura and spinal cord in newborn mice.

This knowledge, coupled with emerging stem cell technologies, may provide the most promising current approach to nervous system regeneration. If Wnt proteins could be used to guide transplanted nerve cells -- or someday, embryonic stem cells -- to restore the connections between the body and the brain, "it could revolutionize treatment of patients with paralyzing injuries to these nerves," Zou suggests.

"Although half the ba
'"/>

Source:University of Chicago Medical Center


Page: 1 2 3

Related biology news :

1. Master regulatory gene found that guides fate of blood-producing stem cells
2. Light guides flight of migratory birds
3. Wisconsin scientists grow critical nerve cells
4. Clam embryo study shows pollutant mixture adversely affects nerve cell development
5. Zebrafish may hold key to understanding human nerve cell development
6. New component of the brakes on nerve regeneration found
7. Cerebral navigation: How do nerve fibers know what direction to grow in?
8. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
9. Diabetic nerve therapy shows striking results
10. Malfunctioning bone marrow cells sabotage nerve cells in diabetes
11. UIC researchers show protein routes messages in nerve cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gradient guides nerve growth down spinal cord

(Date:4/27/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® Smart ... week of May, 2015 and will be fulfilling all ... Gino Pereira , Chief Executive Officer said, ... Wocket® enters the consumer market. We would like to ...
(Date:4/20/2015)... 20, 2015 The announcement comes ... Glenbeigh Records Management (GRM), Ireland,s foremost ... Bank. Having built up an impressive track record of clients ... player within the records management sector in Dubai ... is GCC staffbase and employ a further eight staff members ...
(Date:4/13/2015)... , April 13, 2015 ... TechSci Research, "Global Biometrics Market Forecast & Opportunities, 2020", ... a CAGR of around 14% till 2020. The ... for large scale implementation and review of biometric ... launch of new products with greater efficiency, are ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... machine can draw your blood, screen it for genetic mutations ... a drug tailor-made for your DNA. That hypothetical drug ... have accumulated over time that can lead to the formation ... Health has tapped Viterbi professor Andrea Armani to develop a ...
... award up to $64 million over five years to ... that have the potential for extraordinary impact. ... allows investigators to sidestep conventional stumbling blocks they often ... as the need for preliminary data or a restriction ...
... Institutes of Health (NIH) has awarded $11.5 million to ... Institute of Technology (Caltech) for the creation of a ... centercalled the Center for the X-ray Structure Determination of ... by the NIH to "solve the structures of these ...
Cached Biology News:Fighting cancers by tagging their triggers 2NIH awards $11.5 million for new Caltech-led membrane-protein center 2
(Date:5/27/2015)... , May 27, 2015 ­ Caris Life ... promise of precision medicine, today announced it has appointed ... a center of excellence site in the Caris Centers ... Levine Cancer Institute is one of the largest ... than 11,000 new cancer patients annually. Derek Raghavan ...
(Date:5/26/2015)... Regenestem Network has announced the grand opening ... Argentina. The clinic will be lead by Silvina Pastrana, ... a multidisciplinary team of medical professionals who specialize in ... office. , The new Regenestem Network members plan ... in cellular therapies, and establish Regenestem protocols to isolate ...
(Date:5/26/2015)... CA (PRWEB) May 26, 2015 ... and solutions in the human and animal health ... annual Vetericyn® Future Innovators of Agriculture College Scholarship ... school senior who exhibits a passionate commitment to ... , This year’s winners, Alexis Pedrow from ...
(Date:5/26/2015)... and HILDEN, Germany , ... N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: ... QIAGEN Clinical Insight ® (QCI™) bioinformatics content ... interpret and report on genomic variants identified in ... for the bioinformatics platform are in oncology, for ...
Breaking Biology Technology:Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 2Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 3Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 4Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 2Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 3Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 2Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 2QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 4QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 5
... -- Micromet, Inc. (Nasdaq: MITI ... the treatment of cancer, inflammation and autoimmune diseases, today ... Christian Itin, will participate in a panel discussion titled ... Markets Healthcare Conference on December 10, 2008. The ...
... based on the products of newborn fibroblasts, will be featured in ... 21st Century Breakthroughs for Biomedical Research series. , ... ... medicine company developing solutions based on the products of newborn fibroblasts, ...
... closures observed in PRECiSE 2 trial under maintenance therapy with ... , HOLLYWOOD, Fla., Dec. 5 Data ... Diseases 2008, the Crohn,s & Colitis Foundation,s Clinical & Research ... severe Crohn,s disease patients who had open fistulas at baseline ...
Cached Biology Technology:Micromet to Present at the RBC Capital Markets Healthcare Conference 2Micromet to Present at the RBC Capital Markets Healthcare Conference 3Micromet to Present at the RBC Capital Markets Healthcare Conference 4Histogen Featured on Economic Report Television Series 2New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease 2New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease 3New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease 4New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease 5New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease 6New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease 7New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease 8New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease 9
... Mouse polyclonal antibody raised against ... Immunogen: PPP4C ... a.a) partial recombinant protein with ... Accession Number: NM_002720 ...
Mouse monoclonal antibody raised against a partial recombinant CAPG. NCBI Entrez Gene ID = CAPG...
...
... array sample elements. , , ,Includes:, , , ... PBS (10X): 50 ml , INDIA HisProbe HRP: 0.2 ... 10% Tween-20: 2 x 10 ml ampules , SuperSignal ... SuperSignal West Pico Stable Peroxide: 2 x 25 ...
Biology Products: