Navigation Links
Gradient guides nerve growth down spinal cord

which control voluntary movements and fine-motor skills. These are some of the longest cells in the body. The corticospinal neurons connect to groups of neurons along the length of spinal cord, some of which reach out of the spinal cord. They pass out of the cord between each pair of vertebrae and extend to different parts of the body, for example the hand or foot.

Zou and colleagues studied the guidance system used to assemble this complex network in newborn mice, where corticospinal axon growth is still underway. Before birth, axons grow out from the cell body of a nerve cell in the motor cortex. The axons follow a path back through the brain to the spinal cord.

By the time of birth, the axons are just growing into the cord. During the first week after birth they grow down the cervical and thoracic spinal cord until they reach their proper position, usually after seven to ten days.

From previous studies, Zou and colleagues knew that a gradient of various Wnt proteins, including Wnt4, formed along the spinal cord around the time of birth. Here they show that two other proteins, Wnt1 and Wnt5a are produced at high concentrations at the top of the cord and at consecutively lower levels farther down.

They also found that motor nerves are guided by Wnts through a different receptor, called Ryk, that mediates repulsion by Wnts. Antibodies that blocked the Wnt-Ryk interaction blocked the downward growth of corticospinal axons when injected into the space between the dura and spinal cord in newborn mice.

This knowledge, coupled with emerging stem cell technologies, may provide the most promising current approach to nervous system regeneration. If Wnt proteins could be used to guide transplanted nerve cells -- or someday, embryonic stem cells -- to restore the connections between the body and the brain, "it could revolutionize treatment of patients with paralyzing injuries to these nerves," Zou suggests.

"Although half the ba
'"/>

Source:University of Chicago Medical Center


Page: 1 2 3

Related biology news :

1. Master regulatory gene found that guides fate of blood-producing stem cells
2. Light guides flight of migratory birds
3. Wisconsin scientists grow critical nerve cells
4. Clam embryo study shows pollutant mixture adversely affects nerve cell development
5. Zebrafish may hold key to understanding human nerve cell development
6. New component of the brakes on nerve regeneration found
7. Cerebral navigation: How do nerve fibers know what direction to grow in?
8. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
9. Diabetic nerve therapy shows striking results
10. Malfunctioning bone marrow cells sabotage nerve cells in diabetes
11. UIC researchers show protein routes messages in nerve cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gradient guides nerve growth down spinal cord

(Date:7/2/2015)... 25, 2015 Research ... of the "Natural Language Processing Market by ... OCR, Pattern & Image Recognition) - Worldwide Forecast ... The key vendors occupying the market are ... Microsoft Corporation, NetBase Solutions, SAS Institute Inc., Verint ...
(Date:7/2/2015)... 2, 2015 Fingerprint Cards has received ... and FPC1155 from the distributor World Peace Industrial Group (WPI), ... in Asia . Deliveries are planned to ... be used by smartphone manufacturers in Asia ... the communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
(Date:6/30/2015)... , June 30, 2015 Genisphere ... company as CEO to help further develop Genisphere,s therapeutics ... of partnering experience, having spent much of the last ... Therakine, Amgen, Baxter Bioscience, and Johnson & Johnson. Tom ... on Technology and Biotech Corporate Finance. He graduated from ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3
... water quality is good, the sport fish populations are sufficient, ... of birds. This positive trend is documented in a new ... the natural resources of Lake Mead and Lake Mohave, and ... Mead NRA. "While the Lake Mead ecosystem is generally ...
... biochemical structure in Burckhard Seelig,s lab at the University ... billions of years ago, when life on earth began ... new and improved products, from detergents to foods and ... directed evolution in the laboratory. Working with colleague Gianluigi ...
... different grape varietals can favorably balance the flavor characteristics ... of advanced biofuels might use a similar strategy, blending ... the transportation fuel they produce. A collaborative study ... Joint BioEnergy Institute (JBEI), a bioenergy research center led ...
Cached Biology News:Lake Mead aquatic-science research documents substantial improvements in ecosystem 2Lake Mead aquatic-science research documents substantial improvements in ecosystem 3U. of Minn. researchers unveil first artificial enzyme created by evolution in a test tube 2Biofuels blend right in 2Biofuels blend right in 3
(Date:7/29/2015)... , ... July 29, 2015 , ... Finding gooey or ... is quite normal. Although there are a considerable number of terms in popular use ... this post-sleep material is a mixture of mucus, blood cells, skin cells and dust, ...
(Date:7/29/2015)... ... July 29, 2015 , ... ... company is making good progress in evaluating the full range of capabilities of ... cells. Adult tissue stem cells perform the day-to-day renewal and repair of normal ...
(Date:7/28/2015)... INCLINE VILLAGE, Nev. , July 28, 2015 /PRNewswire/ ... PDLI ) today announced that the Company will release ... ended June 30, 2015, on Wednesday, August 5, 2015, ... call and webcast that day at 4:30 p.m. Eastern ... relating to the call will be available via the ...
(Date:7/28/2015)... July 21, 2015 Research and Markets ... the "Biomedical Refrigerators and Freezers Market - ... Forecast 2014 - 2022" report to their ... and freezers market has been segmented based on ... banks, and others. The others segment includes applications ...
Breaking Biology Technology:What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 4Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 2Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 3Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 4PDL BioPharma to Announce Second Quarter 2015 Financial Results on August 5, 2015 2Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 2Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 3
... have found a defense against the Black Plague, a disease ... Middle Ages and which government agencies perceive as a terrorist ... team have developed a vaccine that early research shows is ... of Health and USDA funded research appear in the August ...
... COLLEGE STATION, Sept. 24, 2008 America,s war on ... agents, and Texas A&M University chemist Dr. Frank Raushel ... that might neutralize one such chemical agent, the organophosphates. ... the 1930s but soon made their way into the ...
... (Nasdaq: SVNT ) today announced that Christopher,Clement, President ... corporate update at the upcoming Lazard Capital Markets 5th,Annual ... on Tuesday, November 18, 2008 at,9:25 a.m. ET. The ... in New,York City November 18-19, 2008., Individuals can ...
Cached Biology Technology:UCF professor develops vaccine to protect against black plague bioterror attack 2UCF professor develops vaccine to protect against black plague bioterror attack 3Researcher working on destruction of chemical weapons 2Savient Pharmaceuticals to Present at the Lazard Capital Markets 5th Annual Healthcare Conference on November 18th 2
Mouse Serpin F1/PEDF MAb (Clone 199315)...
Mouse MMP-24 (MT5-MMP) MAb (Clone 143908)...
Rabbit polyclonal to HMGB1 (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 3146 SwissProtID: P09429...
Pooled normal sreum with 0.1% sodium azide as preservative...
Biology Products: