Navigation Links
Gradient guides nerve growth down spinal cord

The same family of chemical signals that attracts developing sensory nerves up the spinal cord toward the brain serves to repel motor nerves, sending them in the opposite direction, down the cord and away from the brain, report researchers at the University of Chicago in the September 2005 issue of Nature Neuroscience (available online August 14). The finding may help physicians restore function to people with paralyzing spinal cord injuries.

Growing nerve cells send out axons, long narrow processes that search out and connect with other nerve cells. Axons are tipped with growth cones, bearing specific receptors, which detect chemical signals and then grow toward or away from the source.

In 2003, University of Chicago researchers reported that a gradient of biochemical signals known as the Wnt proteins acted as a guide for sensory nerves. These nerves have a receptor on the tips of their growth cones, known as Frizzled3, which responds to Wnts.

In this paper, the researchers show that the nerves growing in the opposite direction are driven down the cord, away from the brain, under the guidance of a receptor, known as Ryk, with very different tastes. Ryk sees Wnts as repulsive signals.

"This is remarkable example of the efficiency of nature," said Yimin Zou, Ph.D., assistant professor of neurobiology, pharmacology and physiology at the University of Chicago. "The nervous system is using a similar set of chemical signals to regulate axon traffic in both directions along the length of the spinal cord."

It may also prove a boon to clinicians, offering clues about how to grow new connections among neurons to repair or replace damaged nerves. Unlike many other body components, damaged axons in the adult spinal cord cannot adequately repair themselves. An estimated 250,000 people in the United States suffer from permanent spinal cord injuries, with about 11,000 new cases each year.

This study focused on corticospinal neurons,
'"/>

Source:University of Chicago Medical Center


Page: 1 2 3

Related biology news :

1. Master regulatory gene found that guides fate of blood-producing stem cells
2. Light guides flight of migratory birds
3. Wisconsin scientists grow critical nerve cells
4. Clam embryo study shows pollutant mixture adversely affects nerve cell development
5. Zebrafish may hold key to understanding human nerve cell development
6. New component of the brakes on nerve regeneration found
7. Cerebral navigation: How do nerve fibers know what direction to grow in?
8. Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
9. Diabetic nerve therapy shows striking results
10. Malfunctioning bone marrow cells sabotage nerve cells in diabetes
11. UIC researchers show protein routes messages in nerve cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gradient guides nerve growth down spinal cord

(Date:12/11/2014)... blood pressure plays a role in human health has been ... for high blood pressure – was first described as a ... used in measuring blood pressure was invented in 1896. ... its triggers and its effects. In fact, recent findings have ...
(Date:12/10/2014)... , Dec. 8, 2014 You,ve been here before: you ... remember your password, site key or the answer to your secret ... Today, Hoyos Labs , a digital infrastructure ... an end to the frustration that comes with usernames, passwords and ...
(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical Center ... its School of Medicine. Funding for this $50 million capital ... be publicly launched next summer. The medical ... R.J. Reynolds Tobacco Company complex, adjacent to 525@vine in Wake ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... , RENO, Nev. A novel treatment in development at ... common form of muscular dystrophy is advancing towards human trials ... The grant will be used to expand successful research by ... laminin-111 protein therapy prevents the onset of the devastating neuromuscular ...
... the strongest materials on Earth and are used to strengthen ... CNTs have potential uses in everything from medicine to electronics ... study by the University of Missouri and United States Geological ... The researchers urge that care be taken to prevent the ...
... AMES, Iowa Edward Yu took note of the facts ... each year, developments of multidrug-resistant, extensively drug-resistant and now totally ... to tuberculosis. Yu, an Iowa State University and Ames ... the three-part structure that allows E. coli bacteria ...
Cached Biology News:MDA supports Duchenne muscular dystrophy research by University of Nevada School of Medicine 2MDA supports Duchenne muscular dystrophy research by University of Nevada School of Medicine 3Iowa State, Ames Lab researchers study the structure of drug resistance in tuberculosis 2Iowa State, Ames Lab researchers study the structure of drug resistance in tuberculosis 3
(Date:1/22/2015)... January 22, 2015 Crystal Diagnostics (CDx) Xpress ... it has received AOAC-PTM Certifications for the six non-O157 Shiga ... O145; collectively referred to as STEC or the “Big-6”) as ... forming unit (cfu) per 325 g of raw ground beef ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a ... check the legal requirements around using controlled substances in ... , As their international operations expand and become increasingly ... built as a result of the first phase of ...
(Date:1/22/2015)... SAN DIEGO , Jan. 22, 2015   ... company, and Sequenom, Inc. (NASDAQ: SQNM ... a development agreement for next generation noninvasive prenatal ... Cypher,s genome interpretation technology, called Mantis™, to advance ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 The report ... by Product Type & Provider Type - Global Advancements, ... market with an in-depth analysis and forecasting of revenues. ... spread through 221 pages and in-depth TOC on “Service ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... State spending on information technology may soon be subject ... costing tens of millions of dollars each, have failed ... and representative Suzanne Jeskewitz, co-chairs of the Joint Audit ... developed or renovated recently are inefficient or non-functional, and ...
... citywide wireless network in Milwaukee, the surrounding communities of ... , ,Waukesha and Wauwatosa are already being pitched by ... the city of Madison. Milwaukee's network is being built ... the deals established so far, the city is essentially ...
... At $2.5 million per 30-second spot, the average 2006 ... TV advertising has never been more affordable for small ... Spot Runner , it's possible to implement a comprehensive ... at a fraction of the normal cost. You can ...
Cached Biology Technology:Local TV advertising - Super Bowl vs. super bargain 2Local TV advertising - Super Bowl vs. super bargain 3Local TV advertising - Super Bowl vs. super bargain 4
...
Full-length cDNA clone CS0DJ013YG01 of T cells (Jurkat cell line) of Homo sapiens (human). [Source:Uniprot/SPTREMBL;Acc:Q86SZ3] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
...
...
Biology Products: