Navigation Links
Gene therapy for hereditary lung disease advances

tein," Flotte said. "That's very encouraging to us. So the next trial, which has already begun, is to use the new version of the virus and take patients through a similar range of doses, in a very similar scheme, and see if we can maintain the safety while pumping up the efficiency of the protein production."

In most people, alpha-1 antitrypsin is made in the liver and protects the lungs by counteracting inflammatory products that destroy lung tissue. But about 100,000 Americans have alpha-1 antitrypsin deficiency, according to the Miami-based Alpha-1 Foundation, a national not-for-profit organization devoted to finding a cure. In addition, medical authorities suspect less than 5 percent of affected individuals are diagnosed, often not until they are in their mid- to late-30s, after extensive lung damage occurs. Shortness of breath, wheezing, chronic cough and recurring chest colds are signs of the disease.

It is important that alpha-1 patients avoid cigarette smoke, said Mark Brantly, M.D., a professor of medicine and molecular genetics and microbiology at UF's College of Medicine who develops clinical research programs aimed at developing therapies for alpha-1 patients. Alpha-1 deficiency can in some patients lead to emphysema and cirrhosis, both progressive diseases that can be fatal.

Alpha-1 patients with symptoms of emphysema can be treated through weekly intravenous injections of alpha-1 protein derived from human plasma. The injections must continue throughout a patient's life, according to the American Lung Association. It does not cure, but it does appear to slow the progression of this disease.

Patients in the clinical trial - 10 men and two women who ranged from 42 to 69 - were asked to discontinue their replacement therapy 28 days before receiving the gene therapy.

One volunteer who had not been on protein replacement therapy exhibited low-level expression of alpha-1 antitrypsin, which was detectable 30
'"/>

Source:University of Florida


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Columbia research lifts major hurdle to gene therapy for cancer
3. Combination therapy boosts effectiveness of telomere-directed cancer cell death
4. Gene therapy converts dead bone graft to new, living tissue
5. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
8. New therapy for HIV/AIDS eliminates needles and excessive toxicity
9. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
10. Gene therapy for Parkinsons disease moves forward in animals
11. Pulsating ultrasound enhances gene therapy for tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene therapy for hereditary lung disease advances

(Date:4/13/2015)... a leading cloud-based consumer engagement platform that provides trusted ... communities around health and wellness, announced today the launching ... The ... vehicle to receive validated health information from consumers. ... will allow higi,s trusted partners, on a user opt-in ...
(Date:4/9/2015)... Calif. , April 9, 2015 Synaptics ... interface solutions, announced today that it will report financial ... Thursday, April 23, 2015, after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
(Date:4/6/2015)... Apr. 6, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... patent 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA ... NXT-ID introduces a new revolutionary method ... surrounds the use of miniature antenna modules for ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4
... Nature Communications on January 22, 2013, a team of ... Museum of Los Angeles County,s (NHM) Dinosaur Institute, has discovered ... species. Confuciusornis sanctus , a 125-million-year-old Mesozoic ... almost body length ornamental tail feathers, others had none ...
... consuming more leaves and less fruit as a result ... to invest much more time foraging for sustenance and ... analysis., The research, published today in the International ... rainforests of the Mexican state of Veracruz, which are ...
... in vivo in mice, engage molecule CD98hc, which is involved ... skin,s capacity for regeneration. The results were published in ... epidermis, the surface layer of the skin, is mainly composed ... a 21-day cycle. These cells are located on a membrane ...
Cached Biology News:Sex of early birds suggests dinosaur reproductive style 2Monkeys stressed from longer foraging times 2Monkeys stressed from longer foraging times 3The skin aging regulator 2
(Date:5/21/2015)... Veolia’s environmental monitoring technology division, Endetec, ... agreement with VWR to distribute TECTA™ B16, an ... 160 years of experience, VWR, a leading global ... production facilities, has cultivated a value proposition delivering ... enable science. Endetec’s TECTA™ B16, combines proven ...
(Date:5/20/2015)... , May 20, 2015 ... presented preliminary data demonstrating the ability of the ... fibrosis (IPF) from other interstitial lung diseases (ILDs) ... the classifier,s potential to help thousands of patients ... ambiguity in IPF diagnosis – a frequent challenge ...
(Date:5/20/2015)... This year has been one of the harshest ... Pearl’s Premium Ultra Low Maintenance Lawn Seed comes to ... coming out of record bad weather. Offering new ... concerns related to water, health, and climate change, Pearl's ... the standard, water-wasting, chemical-treated standard lawn. Many homeowners ...
(Date:5/20/2015)... 2015  Select Medical Corporation ("Select") (NYSE: ... granted early termination of the waiting period under ... as amended, applicable to the acquisition of Concentra ... venture that Select has created with Welsh, Carson, ... announced, MJ Acquisition Corporation has signed a definitive ...
Breaking Biology Technology:Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 4Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 5Breakthrough 4th Generation Low Maintenance Lawn Seed Offers Solution to California Drought 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2
... ... Premier Biodefense Company; ... Expanded Biodefense Pipeline ANNAPOLIS, Md., and TEES VALLEY, England, March ... of medical,countermeasures against biological and chemical threats, and Avecia,Biologics Limited, a ...
... Simcere,Pharmaceutical Group (NYSE: SCR ), a leading ... the patented,anti-cancer biotech product Endu in China, today announces ... of Marketing and the promotion,of Baoxing Zha and Dasheng ... Sales respectively., The company also announces that Mr. ...
... ulcers each year in the US, PRINCETON, ... Board: DSCI), provider of advanced wound care products,announced ... the clinical usage,of its newly released MEDIHONEY(TM) Wound ... the annual American Professional Wound Care,Association (APWCA) conference ...
Cached Biology Technology:PharmAthene Signs Definitive Agreement to Acquire Biodefense Vaccines Business From Avecia 2PharmAthene Signs Definitive Agreement to Acquire Biodefense Vaccines Business From Avecia 3PharmAthene Signs Definitive Agreement to Acquire Biodefense Vaccines Business From Avecia 4PharmAthene Signs Definitive Agreement to Acquire Biodefense Vaccines Business From Avecia 5PharmAthene Signs Definitive Agreement to Acquire Biodefense Vaccines Business From Avecia 6Simcere Pharmaceutical Group Announces the Appointment of New Vice President of Marketing and Two Senior Promotions 2Simcere Pharmaceutical Group Announces the Appointment of New Vice President of Marketing and Two Senior Promotions 3Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA 2Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA 3Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA 4
Applications include ELISA, immunochemistry, and Western blotting. Working Concentrations: ELISA: 0.005-0.05 U/ml, immunohisto/cytochemistry: 0.25-0.5 U/ml, Western blot: 0.1-0.25 U/ml....
...
Recombinant Ovine IFN Tau. Active on sheep, cow, human and mouse cells. Activity: 5.7 x 10 7 u/mg...
... Thermo's Wellwash AC is the easiest ... and is provided with liquid level ... bottles. The integrated orbital shaker and ... excellent washing performance. The big bottle ...
Biology Products: