Navigation Links
Gene therapy for hereditary lung disease advances

tein," Flotte said. "That's very encouraging to us. So the next trial, which has already begun, is to use the new version of the virus and take patients through a similar range of doses, in a very similar scheme, and see if we can maintain the safety while pumping up the efficiency of the protein production."

In most people, alpha-1 antitrypsin is made in the liver and protects the lungs by counteracting inflammatory products that destroy lung tissue. But about 100,000 Americans have alpha-1 antitrypsin deficiency, according to the Miami-based Alpha-1 Foundation, a national not-for-profit organization devoted to finding a cure. In addition, medical authorities suspect less than 5 percent of affected individuals are diagnosed, often not until they are in their mid- to late-30s, after extensive lung damage occurs. Shortness of breath, wheezing, chronic cough and recurring chest colds are signs of the disease.

It is important that alpha-1 patients avoid cigarette smoke, said Mark Brantly, M.D., a professor of medicine and molecular genetics and microbiology at UF's College of Medicine who develops clinical research programs aimed at developing therapies for alpha-1 patients. Alpha-1 deficiency can in some patients lead to emphysema and cirrhosis, both progressive diseases that can be fatal.

Alpha-1 patients with symptoms of emphysema can be treated through weekly intravenous injections of alpha-1 protein derived from human plasma. The injections must continue throughout a patient's life, according to the American Lung Association. It does not cure, but it does appear to slow the progression of this disease.

Patients in the clinical trial - 10 men and two women who ranged from 42 to 69 - were asked to discontinue their replacement therapy 28 days before receiving the gene therapy.

One volunteer who had not been on protein replacement therapy exhibited low-level expression of alpha-1 antitrypsin, which was detectable 30
'"/>

Source:University of Florida


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Columbia research lifts major hurdle to gene therapy for cancer
3. Combination therapy boosts effectiveness of telomere-directed cancer cell death
4. Gene therapy converts dead bone graft to new, living tissue
5. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
8. New therapy for HIV/AIDS eliminates needles and excessive toxicity
9. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
10. Gene therapy for Parkinsons disease moves forward in animals
11. Pulsating ultrasound enhances gene therapy for tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene therapy for hereditary lung disease advances

(Date:9/15/2014)... simple, mechanical solution to avoid chromosome sorting errors, ... Express. , This natural safeguard ... to infertility, miscarriage, or congenital conditions. , ... but what exactly goes wrong is often not ... Center for Cell Biology at the University of ...
(Date:9/15/2014)... When this week,s print issue of the journal ... up from New Mexico, Montana and even the Netherlands, ... more and more the norm in these connected times. ... it will produce innovations in biology, medicine, biotechnology and ... this scientist talked with that one, that one knew ...
(Date:9/15/2014)... assistant professor in the Department of Science and Technology ... Human Sciences at Virginia Tech, has won a 2014 ... study the prospects and problems of creating a global ... Japan,s Fukushima I Nuclear Power Plant in March 2011 ... viewed nuclear emergencies, Schmid said. Three of the plant,s ...
Breaking Biology News(10 mins):Cells simply avoid chromosome confusion 2Cells simply avoid chromosome confusion 3Collaboration drives achievement in protein structure research 2'Nuclear disasters don't respect national boundaries' 2
... GAINESVILLE, Fla. --- Imagine a Web site like Facebook, ... post quizzes like "What ,80s song are you?" scientists ... few mouse clicks separating them from information needed for ... $12.2 million National Center for Research Resources grant awarded ...
... , REDWOOD CITY, Calif., Oct. 20 DigitalPersona, ... solutions, today announced that WAND Corporation, a leading ... has integrated DigitalPersona technology into their NextGen POS ... now use fingerprint biometrics to boost cashier accountability ...
... a new approach to prepare ancient DNA with a ... an MU animal scientist, along with a team of ... tree" for cows and other ruminants, going back as ... allow scientists to understand the evolution of cattle, ruminants ...
Cached Biology News:UF receives $12.2 million to establish national network of scientists 2UF receives $12.2 million to establish national network of scientists 3WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 2WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 3MU research team establishes family tree for cattle, other ruminants 2
(Date:9/15/2014)... by Northeastern University has developed a novel method ... variety of nanocarbon structures in carbon nanotube arrays. ... will allow the researchers to tailor the physical ... ranging from electronic devices to CNT-reinforced composite materials ... , Their findings were published in the journal ...
(Date:9/15/2014)... The chemistry, taste, and health effects of tea ... published by the nonprofit American Botanical Council (ABC). Recent research ... its effects on the phytochemical compounds in tea ( Camellia ... Dr. Ahmed in the Yunnan province ... for the future of medicinal botanicals. Dr. Ahmed,s report ...
(Date:9/15/2014)... , Sept. 15, 2014  The second annual ... October 12-18. A joint initiative of the Plasma ... companies , IPAW is designed to: , ... Recognize the contributions of plasma donors in saving and ... protein therapies and rare diseases Member ...
(Date:9/13/2014)... September 13, 2014 Boehringer Laboratories Inc., ... is proud to announce the successful broadcast of a ... surgeons Leonardo Claros, MD, FACS, FAMBS, and Maher El ... Gastrectomy Calibration System. , This sleeve gastrectomy surgery ... of more than four hundred surgeons from around the ...
Breaking Biology Technology:Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 2International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 3Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2
... ... V™ series to its portfolio. , ... San Francisco, Calif. (PRWEB) October 2, 2009 -- Perceptum Group, ... for biotech and specialty pharma companies. The new series includes Situational Leadership V™, Situational ...
... , ... Venture Network (SCVN) announces the recipients of the 2009 Orange County Emerging Growth Awards, ... yearly revenues, have experienced significant growth over the last 12 months and that have ... ...
... the consequences can be fatal, not only for the creature ... fuselage, causing stresses in the material which can later turn ... detect such damage at an early stage and simplify maintenance ... need any cables or batteries. They draw their energy from ...
Cached Biology Technology:Perceptum Group Announces New Situational Leadership V Series 2Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 2Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 3Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 4Energy-autonomous sensors for aircraft 2
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
... Orbital Shakers combine high durability and ... power. The patented triple-counterbalanced heavy-duty ... to run with heavy out-of-balance loads. ... reduces contamination. The heavy stainless ...
... T4 Polynucleotide Kinase (PNK) catalyzes ... ATP to the 5'-hydroxyl of single- ... 3'-monophosphates. The enzyme also removes the ... and deoxyribonucleoside 3', 5'-diphosphates to form ...
The Cellject Elecroporator is suitable for all cell types including embryo, mammalian, plant, yeast and bacterial. Its has highly user-freindly programing and can be used remotely, for example in a l...
Biology Products: