Navigation Links
First real-time view of developing neurons reveals surprises, say Stanford researchers

Scientists have believed that neurons need a long period of fine-tuning and training with other neurons before they take on their adult role. But after using new technology for the first time to watch these cells develop, a team of researchers at the Stanford University School of Medicine found that neurons come into this world with a good idea about what they'll become as adults.

The work, which is detailed in a paper in the March 24 issue of Neuron, took place in the brain of a small see-through fish called a zebra fish. Stephen Smith, PhD, professor of molecular and cellular physiology, and graduate student Christopher Niell immobilized a young fish at an age when the nerves first grow from the eye to reach the brain. Then, with the aid of a 6-foot-long laser and some fancy microscopy, the researchers were able to watch individual neurons as they matured in real time.

The pair specifically monitored hundreds of neurons in the region of the brain that respond to images. Niell set up a tiny LCD screen showing squares the size of the fish's favorite planktonic food moving up and down or left and right.

They expected to find that young neurons fire in response to a variety of different images, then refine their role over time so that in the adult fish the neurons only respond to images moving in a certain direction or near the left or right side of the visual field.

What they found was a surprise. As soon as the neurons were old enough to respond to the LCD screen, they specifically fired when they sensed only one type of movement. When the tiny square moved left to right, a distinct population of neurons turned fluorescent colors to indicate their activity. Moving the square the reverse direction triggered a different population of neurons to light up.

"At first we felt like we let some air out of our own tires with this finding," said Smith. His previous work had supported the prevailing idea that neurons need a period of fine
'"/>

Source:Stanford University Medical Center


Page: 1 2

Related biology news :

1. Timing is everything: First step in protein building revealed
2. Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
5. NYCs First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention
6. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
7. Mayo Clinic Researchers Create Obedient Virus; First Step To Use Measles Virus Against Cancer
8. First frozen egg baby born in Canada
9. Human Cells Filmed Instantly Messaging for First Time
10. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
11. First technology to remove prions that cause vCJD from blood launched
Post Your Comments:
(Date:7/23/2014)... are disappearing, and though conservationists are examining several possible ... rain and light pollution, a key piece of the ... once they leave their breeding sites, and what threats ... answer this question, a team of researchers out of ... map produced for a songbird, using tracking from both ...
(Date:7/23/2014)... 780 million people around the world have no access ... Organization (WHO), 3.4 million people die from water-related diseases ... goal of making a contribution to solving this problem. ... Stark, head of the Functional Materials Laboratory, the 23-year-old ... a prototype. , "What makes our DrinkPure filter unique ...
(Date:7/23/2014)... This news release is available in German . ... shape and stability to cells, drive metabolic processes and ... into complex three-dimensional shapes. Scientists at the Max Planck ... that proteins can be constructed of similar amino acid ... suggests that the proteins that exist today arose from ...
Breaking Biology News(10 mins):York University researchers use bird 'backpacks' to put wood thrushes migration on the map 2ETH student develops filter for clean water around the world 2Protein evolution follows a modular principle 2
... of our hearts and blood vessels. Conventional treatment attempts ... in the blood plasma. The opposite approach, which involves ... acid, has proven unpopular among patients up to now. ... acid has an unpleasant but harmless side-effect: the ...
... November, the Malaspina expedition 2010 will set sail from ... the Spanish National Research Council (CSIC) aims to evaluate ... to survey their biodiversity. The expedition has the backing ... and takes its name from mariner Alessandro Malaspina, the ...
... MADISON, WI, July 26th, 2010 NASA scientists ... and ground-based observations of precipitation. The NASA data ... to monitor non-point pollution and improve water quality. ... of Science Systems and Applications, Inc., incorporated two ...
Cached Biology News:Preventing heart problems while keeping a cool head 2Preventing heart problems while keeping a cool head 3Malaspina expedition 2010 2NASA satellite improves pollution monitoring 2
(Date:7/23/2014)... Sergei Filippov (MIPT and Russian Quantum Center at ... Czech Republic, and the Institute of Physics in ... quantum entanglement of particles passing through an amplifier ... distances. Details are provided in an article published ... (see preprint). , Quantum entangled particles are considered ...
(Date:7/23/2014)... Last year, Formedix celebrated its partnership with ... data management solutions for clinical trials. The company launched ... data capture (EDC) and clinical data management. Formedix, a ... added TrialMaster to its Transform for EDC product line. ... TrialMaster, is being released this week, in response to ...
(Date:7/23/2014)... DuPont Pioneer announced today that Neal Gutterson, ... Agricultural Biotechnology (ABT), effective July 21, 2014. Gutterson joins ... as president, chief executive officer and board member. , ... seed and crop protection industry to this integral role ... president of DuPont Pioneer. “I am looking forward to ...
(Date:7/23/2014)... 2014  Sofinnova Ventures, a Menlo Park ... of Sofinnova Venture Partners IX, L.P. at the hard ... initial fund target of $425 million. Sofinnova ... Consistent with recent funds, SVP IX will provide capital ... along with select investments in earlier stage opportunities. Investments ...
Breaking Biology Technology:Scientists find way to maintain quantum entanglement in amplified signals 2Scientists find way to maintain quantum entanglement in amplified signals 3Scientists find way to maintain quantum entanglement in amplified signals 4Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Sofinnova Raises $500 Million Biotech Venture Fund 2
... executives, mostly in denial, are shunning the subject. Smart ones ... general broadcasts. This is a revolution, and the entire model ... , Device Explosion , ,The receptacles to receive the ... but rather handheld devices or the hundreds of gadgets and ...
... Read Part 1 . Winslow Sargeants combination of ... the world of entrepreneurship and risk. His memories of growing ... tenacity is essential. , , Winslow Sargeant ... a child. In June, 1974, U.S. District Court Judge W. ...
... MadCity Murder Mystery game Madison, Wis. ... the UW-Madison School of Education, hopes to bring a ... games, which combine aspects of physical activity, traditional reading ... through the UW System and the Academic ADL ...
Cached Biology Technology:When TV surrenders to Web... 2When TV surrenders to Web... 3Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 2Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 3Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 4Augmented reality brings a new dimension to learning 2Augmented reality brings a new dimension to learning 3
... greater incorporation of Br-dUTP results in a ... using a fluorescein-labeled anti-BrdU antibody. Propidium ... kit to counterstain the total DNA. Features ... in improved detection than found by using ...
... cytoplasmic expression of an N-terminal FLAG® fusion ... selection marker from bicistronic mRNA. Two ... MCS2 for transcription of a single message ... useful for protein-protein interaction studies, multi-subunit proteins, ...
...
Mouse monoclonal antibody raised against a partial recombinant SCARB2. NCBI Entrez Gene ID = SCARB2...
Biology Products: