Navigation Links
First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology

chick embryos. At this stage of development, the embryonic stem cells can make significant contributions to the developing chicken. Resulting chimeras with large contributions from the stem cells lay eggs containing milligram amounts of antibody, which is then separated from the egg white proteins generating the purified product.

"This work represents a considerable advance over past efforts to develop avian transgenes, which were limited to the insertion of only small pieces of DNA," commented Dr. Etches. "The technology described here is a general method for inserting DNA encoding proteins of essentially any size and complexity while achieving high levels of protein expression. Moreover, it is the only technology to date that restricts deposition of the therapeutic protein to egg white."

"Monoclonal antibodies have demonstrated great success as human therapeutics, with over 25 approved for human therapeutic use and an increasing number of these proteins in clinical development," continued Dr. Etches. "We expect the demand for more potent anti-cancer monoclonal antibodies and for lower production costs to increase at a rate that will tax existing cell culture production systems. The introduction of this new chicken-based production technology will be of considerable interest to an industry coping with the commercial supply of an ever increasing number of therapeutic antibodies."

"We believe the chicken system is an attractive one for therapeutic protein production compared to either plant systems or to other transgenic animal systems," said Robert Kay, Ph.D., Origen Therapeutics president and chief executive officer. "The fact that the chicken-produced anti-cancer antibodies show dramatically enhanced cell killing activity elevates the chicken system considerably relative to other non-traditional production technologies and some traditional cell culture methods as well."

"Furthermore," Dr. Kay continued, "unlike other transgenic an
'"/>

Source:emm4@pacbell.net


Page: 1 2 3

Related biology news :

1. Timing is everything: First step in protein building revealed
2. Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
5. NYCs First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention
6. First real-time view of developing neurons reveals surprises, say Stanford researchers
7. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
8. Mayo Clinic Researchers Create Obedient Virus; First Step To Use Measles Virus Against Cancer
9. First frozen egg baby born in Canada
10. Human Cells Filmed Instantly Messaging for First Time
11. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
Post Your Comments:
(Date:12/17/2014)...  HITLAB SM announced today its completion of a ... to current U.S. Food and Drug Administration (FDA) regulations. ... and smart phone application trials utilizing the highest principles ... is determined to improve global healthcare access, quality, and ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ...  report to their offering. One major ... With continuous advances in technology, it is important to ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader in performance ... a staggering demand from its licensees for highly accurate, ... is not solely coming from fitness and health sectors, ... "A wearable is only as useful as the ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... Researchers at the University of Illinois have designed a small ... type 1, the most common form of muscular dystrophy. ... tightly to its target, an abnormally elongated RNA that hijacks ... of the disease. The newly developed compound is the first ...
... neutralizing toxins produced by blue-green algae have been ... Aakash Welgama presented the group,s findings during the ... Edinburgh. Blooms of blue green algae (cyanobacteria) ... throughout the world. They produce toxins called microcystins ...
... people with type 2 diabetes that affects how the ... a new study published today in Nature Genetics ... international institutions, say the findings highlight a new target ... have identified several genetic variations in people with type ...
Cached Biology News:Small molecule inhibits pathology associated with myotonic dystrophy type 1 2Scientists discover new genetic variation that contributes to diabetes 2
(Date:12/24/2014)... GMO corn cases filed across the United ... process of being consolidated in a Kansas federal court for ... MIR 162 Corn Litigation, MDL No. 2591 in the U.S. ... the Syngenta GMO corn multidistrict litigation (MDL) has been handed ...
(Date:12/24/2014)... December 23, 2014 SoundConnect’s ... to introduce cutting edge communication technology, provide continued ... upgrades. This webinar series demonstrates online communication features ... leverage web conferencing’s most innovative and powerful tools. ...
(Date:12/24/2014)... December 23, 2014 According to Ross Selinger, ... Affiliate of ITRA Global, the national office market continues to ... This is evidenced by the third quarter’s surprising 3.9% ... Low energy costs have held inflation down and the ...
(Date:12/24/2014)... Tenn. (PRWEB) December 23, 2014 Nashville Fertility ... elected treasurer for the American Society for Reproductive Medicine (ASRM), ... in reproductive medicine. In his new role as treasurer, ... and will have a voice in furthering the mission of ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... ANN ARBOR, Mich.---By digitally photographing the tiny, hair-like blood ... look directly at how small blood vessels like those that ... New digital photos of the retina revealed that otherwise healthy ... retinal arterioles, an indication of a higher risk of heart ...
... In 2008, experiments at The Fu Foundation School ... pure graphene, a single layer of graphite only one ... This raised a question for Chris Marianetti, Assistant Professor ... Mathematics: how and why does graphene break? ...
... succeeded in creating artificial spin ice in a state ... to examine the precise configuration of this important nanomaterial. ... Department of Energy,s Brookhaven National Laboratory and the UK ... the breakthrough will allow them to study in much ...
Cached Biology Technology:Photos of tiny blood vessels in the eye link air pollution to heart disease 2Columbia engineering team discovers graphene's weakness 2Scientists create highly ordered artificial spin ice using nanotechnology 2Scientists create highly ordered artificial spin ice using nanotechnology 3
... Slide Table is designed for moving loads ... provides maximum force output while limiting overall ... of stainless steel ball bearings guided on ... self-compensating shock absorbers provide energy absorption and ...
... P5T Series Short Stroke Thrust Slide is ... where mounting envelopes are limited and substantial ... and internal bumpers provide millions of trouble-free ... Choice of composite bushings or recirculating ball ...
Hamster Serum; U.S. sourced, ideal for those who seek an uncompromising quality. Low Hemoglobin levels; U.S. sourced, ideal for those who seek an uncompromising quality. Low Hemoglobin levels....
Alkaline Phosphatase (E. coli C75), 100 units. Removes 5'-phosphates from DNA. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzymes, Alkaline Phosphatases....
Biology Products: