Navigation Links
Findings have implications for tracking disease, drugs at the molecular level

Researchers in the laboratory of Boston College Chemistry Professor John T. Fourkas have demonstrated that gold particles comparable in size to a molecule can be induced to emit light so strongly that it is readily possible to observe a single nanoparticle. Fourkas, in collaboration with postdoctoral researcher Richard Farrer and BC undergraduates Francis Butterfield and Vincent Chen, coaxed the particles into strong emission of visible light using a technique called multiphoton absorption induced luminescence (MAIL).

The most efficient gold nanoparticles could be observed at laser intensities lower than those commonly used for multiphoton imaging, in which specific tissues or cells -- cancer cells, for example -- are fluorescently-labeled using special stains that enable them to be studied.

"One of the most exciting aspects of this technique is that it paves the way for being able to observe behavior in living tissues at the single molecule level," said Fourkas. "The fluorescent molecules commonly used in multiphoton imaging give out only a limited amount of light, 'burn out' quickly under continuous observation, and are prone to blinking on and off.

"The gold particles, however, do not blink or burn out, even after hours of observation, and the brightest ones emit much more light than do molecules," he said. "We now have the ability to see single nanoparticles under conditions where people usually look at thousands or millions of stain molecules. This could allow us, for instance, to track a single molecule of a drug in a cell or other biological sample."

Other advantages of the technique are that the gold particles can be prepared easily, have very low toxicity, and can readily be attached to molecules of biological interest, said Fourkas. In addition, the laser light used to visualize the particles is at a wavelength range that causes only minimal damage to most biological tissue.

The findings will be published in the June
'"/>

Source:Eurekalert


Page: 1 2

Related biology news :

1. Findings advance use of adult stem cells for replacement bone
2. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
3. Science study holds implications for gene therapy and stem cell biology
4. Muscle repair: Making a good system better, faster; implications for aging, disease
5. New classification of eukaryotes has implications for AIDS treatment, agriculture and beyond
6. Inside rocks, implications for finding life on Mars
7. How mammals fuel milk production may have implications for cancer
8. Radio-tracking associated with dramatic shift in water vole sex ratio
9. UQ researcher tracking key to healing the brain
10. Concern over fast tracking of new drugs
11. How satellite tracking revealed the migratory mysteries of endangered Atlantic loggerhead turtles
Post Your Comments:
(Date:11/12/2014)... GARDENS, Fla. , Nov. 12, 2014 ... announced today that its U.are.U ® fingerprint readers ... bakery chain in Central Mexico . ... June 2014 to eliminate payroll issues caused by employees ... to installing the U.are.U fingerprint readers, Montparnasse relied on ...
(Date:11/7/2014)... Debra Auguste, associate professor, biomedical engineering, in the ... of New York, have identified a molecule that ... the most aggressive forms of breast cancer. , ... mortality rate owing to aggressive proliferation and metastasis ... Professor Auguste,s team, discovered the overexpression of intercellular ...
(Date:11/6/2014)... A groundbreaking paper from a team of Florida State ... how plants could adapt to and survive environmental swings ... in the latest issue of the journal The ... complex of DNA and proteins) is organized in a ... some genes are turned on and others are turned ...
Breaking Biology News(10 mins):Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Maize analysis yields whole new world of genetic science 2
... of vertebrates sometimes assist a more dominant pair by ... has been shown to occur among subordinate female cichlids. ... ONE , Dik Heg and colleagues at the University ... that rather than engaging in an act of reciprocal ...
... Norman Ellstrand , a professor of genetics in UC ... been elected as one of this year,s four Botanical ... The BSA Merit Award is the society,s highest honor, ... scientists in plant biology. Some past Merit Award recipients have ...
... Princeton University,s third Art of Science competition will go live ... allows members of the public to choose their favorite 2009 ... time. The juried show features 48 works chosen from ... found here: www.princeton.edu/artofscience/2009 The theme of ...
Cached Biology News:The importance of being helpful -- Cooperative cichlids boost their own reproductive success 2UC Riverside geneticist receives highest honor from Botanical Society of America 2Exhibition showcases the 'art of science' 2Exhibition showcases the 'art of science' 3
(Date:11/26/2014)... (PRWEB) November 26, 2014 On January, ... the Baltimore and Washington D.C. science community to the ... The event, sponsored by the Protein Society, will take ... University Center, Room 312. Through discussion, presentations and ... structural importance of proteins, their role in the industry ...
(Date:11/26/2014)... Silicon Valley Electronic Data Capture (EDC) provider ... , provider of clinical research and data management services ... to its CRO Partnership Program, Clinovo expands ClinCapture ... , “We have found Clinovo’s ClinCapture to exceed ... which is both user friendly and easy to deploy. ...
(Date:11/26/2014)... November 26, 2014 SoundConnect , ... is proud to announce that Darren Suders has joined ... Darren will drive the partner program ... experience. , Darren brings more than 10-years ... key roles in channel operations, from policy development, to ...
(Date:11/26/2014)... , 25 novembre 2014 /PRNewswrie/ -- Theravalues Corporation annuncia ... mercato europeo in occasione di Hi Europe 2014 (dal ... Si tratta della curcumina con la maggiore ... (senza cristalli) e ingredienti approvati dalle norme europee. ... spezia della pianta curcumina ( Curcuma longa ) che ...
Breaking Biology Technology:RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2SoundConnect Appoints Director of Channel Development & Sales 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3
... ("Dyadic") (OTC Pink: DYAI), a global biotechnology company focused ... and protein products for the industrial enzyme, bioenergy, and ... FibreZyme® G5000, a next generation, high performance ... quality and improve the economics of various pulp and ...
... N.Y., March 13, 2012   Health Care Compliance ... Christi Health System of Wichita, Kansas has realized ... just two months after selecting and implementing COI-SMART, ... disclosure process. (Logo: http://photos.prnewswire.com/prnh/20061010/NYTU194LOGO ...
... 8, 2012 - Researchers in applied physics have cleared ... called metamaterials, that bend light in unusual ways. ... Harvard team has used extremely short and powerful laser ... within a material. Those suspended metal dots are essential ...
Cached Biology Technology:Dyadic International Launches FibreZyme® G5000 High Performance Powder Pulp and Paper Enzyme in Booth #1065 at Tissue World Americas Conference 2Dyadic International Launches FibreZyme® G5000 High Performance Powder Pulp and Paper Enzyme in Booth #1065 at Tissue World Americas Conference 3Conflict of Interest Management System Selected by Via Christi Health 2Conflict of Interest Management System Selected by Via Christi Health 3Metamaterials may advance with new femtosecond laser technique 2
The SmartSpec printer paper is used to record data generated by the SmartSpec Plus spectrophotometer. Supplied as 5 packs....
... arrays have been developed for affinity ... A variety of ProteinChip chemical surfaces ... to their unique biochemical properties. Each ... side-by-side sample comparison, and the chips ...
... Leu-CMK FLISP Assay with SR-101 Labeled ... nm) • Accurately measure serine protease ... permeabilization • B-Bridge's FLISP Kits utilize ... proteases (FLISPs) to measure chymotrypsin-like activity ...
... Spacer Leu-CMK FLISP Assay with FAM-Labeled ... nm) • Accurately measure serine protease ... permeabilization • B-Bridge's FLISP Kits utilize ... proteases (FLISPs) to measure chymotrypsin-like activity ...
Biology Products: