The grant also includes a private sector collaborator, Seracare Bioservices, Inc., of Gaithersburg, Md., for whom the principal investigator is Janet L. Lathey, Ph.D. This core laboratory will test candidate NK-1R drugs in conjunction with existing HIV drugs, evaluating antiviral activity against HIV-infected cells. "Including a private sector partner is a way to strengthen the goal of moving our scientific studies closer to clinical application," said Dr. Douglas.
Finally, a Biostatistics and Pharmacology Core serves all other components of the project. Directed by Avital Cnaan, Ph.D., with co-director Jeffrey Barrett, Ph.D., both of Children's Hospital, this core seeks to define linkages among the basic science experiments, the animal model experiments to establish pharmacology responses and the human trials designed to assess safety and activity.
The basic science projects of this four-year grant are already providing data, building on existing investigations of NK-1R antagonists. The animal model studies and clinical trials are in their initial stages.
Source:Children's Hospital of Philadelphia