Navigation Links
Federal grant funds research on novel HIV therapy

of agents called neurokinin-1 receptor antagonists, may represent a new type of anti-HIV therapy, due to its ability to block HIV replication. The new program project grant will allow researchers to explore the potential of neurokinin-1 receptor (NK-1R) antagonists in a variety of ways.

In addition to studying direct antiviral action, the researchers will also look for effects on behavior. Because NK-1R antagonists are known to have antidepressant properties, any evidence of reduced anxiety-related behavior in animals may suggest potential important benefits for human HIV patients as well.

The grant includes four separate projects. Projects 1 and 2, led by virologist Wen-Zhe Ho, M.D., of Children's Hospital, and Dr. Douglas, respectively, aim to better understand the underlying mechanisms behind anti-HIV activity of NK-1R antagonists. The basic science research will particularly examine how these agents affect HIV-infected immune cells and how they also might protect the brain. "We know that substance P plays an important role in both the immune system and the central nervous system," said Dr. Douglas, "and we are testing the hypothesis that interfering with substance P receptors may reduce neurological injury from HIV infection."

Project 3, led by Andrew A. Lackner, Ph.D., D.V.M., director of the Tulane National Primate Research Center, will test whether NK-1R antagonists are safe in animals infected with simian immunodeficiency virus (SIV), which is analogous to HIV. This study aims to provide proof of concept for human trials under Project 4.

Project 4, led by Pablo Tebas, M.D., of the Department of Medicine at the University of Pennsylvania Medical School, will be a phase 1 (safety) trial of the NK-1R antagonist aprepitant (trade name Emend) in adults with HIV infection. Aprepitant is currently used to control nausea caused by chemotherapy; this project will determine whether the antagonist may also attack HIV infection in pati
'"/>

Source:Children's Hospital of Philadelphia


Page: 1 2 3

Related biology news :

1. Federal testing for mad cow disease a failure, law review editor says
2. Researcher gets NSF grant to create mutant maize lines
3. MSU researchers receive $4 million grant to uncover gene functions
4. Virulizin granted orphan drug status in Europe
5. New NIAID grants strengthen national biodefense and emerging infectious diseases research network
6. Asian immigrants in NYC not receiving HIV education at religious institutions
7. Boston University biomedical engineers win major grant for pursuit of the $1,000 Genome
8. Scientists win grants to develop $1,000 genome sequencing technology
9. In presence of fragrant cleaning products, air purifiers that emit ozone can dirty the air
10. W.M. Keck Foundation funds study of friendly microbes
11. WHO suspends Marburg work, appeals for new funds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Federal grant funds research novel HIV therapy

(Date:10/15/2014)... VILNIUS, Lithuania , Oct. 15, 2014 /PRNewswire/ ... identification technologies, today announced the availability of the ... . VeriLook Surveillance 3.0 provides real-time biometric face ... multiple high-resolution digital surveillance cameras. The new version ... detects and differentiates people from objects while they ...
(Date:10/14/2014)... have sequenced the house fly genome for the first ... from an insect that thrives in pathogen-rich dung piles ... in the journal Genome Biology , will increase ... how flies quickly adapt to resist insecticides, which could ... (Musca domestica) carry and transmit more than 100 human ...
(Date:10/14/2014)... 2014 – Scientists from The Scripps Research Institute (TSRI) ... of Health (NIH) to lead an investigation of Lassa ... in Africa. The study aims to understand how Lassa ... while others survive the inflection. , "The ultimate ... of how Lassa fever virus causes disease and develop ...
Breaking Biology News(10 mins):VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
... seen amongst individual species within the animal kingdom evolved ... effectively serve as medical research models because humans and ... key to morphological and behavioral complexity, a growing body ... expression by a family of DNA-binding proteins called "transcription ...
... AUSTIN, Texas Researchers at The University of Texas at ... in the folic acid metabolic pathway leads to neural tube ... known for several decades that folic acid supplementation dramatically reduces ... and anencephaly, which are among the most common birth defects. ...
... press release is available in German . ... at the Max Planck Institute for Developmental Biology in ... to identify neuronal correlates of behaviour by comparing maps ... different behaviour. They compared the pharyngeal nervous systems of ...
Cached Biology News:New key to organism complexity identified 2New key to organism complexity identified 3New key to organism complexity identified 4Lack of key enzyme in the metabolism of folic acid leads to birth defects 2The neurobiological consequence of predating or grazing 2The neurobiological consequence of predating or grazing 3
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application and By ... the global market on the basis of its ... such as the key drivers, current trends and ... 81 Market Data Tables and 29 Figures spread ... Market by Application and by Geography - Trends ...
(Date:10/18/2014)... October 18, 2014 The Asian Electronic Medical ... in Asian with analysis and forecast of revenue. The electronic ... grow to $2,328.0 million by 2018, at a CAGR of ... of the Asian Electronic Medical Record (EMR) market, to get ... a glimpse of the segmentation of the market in the ...
(Date:10/18/2014)... The “Global Diagnostic Electrocardiograph (ECG) Market ... (Hospitals, Home/Ambulatory, Research Center, Physician Office, Nursing Homes), ... to 2020” provides a detailed overview of the ... and strategies impacting the global diagnostic ECG market ... revenue and share analysis. , The global diagnostic ...
(Date:10/17/2014)... DE (PRWEB) October 17, 2014 ... among top employers, as published in today’s print ... Science Careers’ annual Top Employers Survey polled employees ... determine the 20 best employers. Rankings were ... were asked to rate their companies on 23 ...
Breaking Biology Technology:1,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... ... , ... August 13, 2009 -- Inc. magazine announced on Wednesday its 2009 Inc. 5000 ranking ... solutions company and a leader in web-database solutions, healthcare intelligence and specialized job boards, ...
... in Teddington have developed imaging technology to be used in ... an impending labour shortage for UK farmers. Annual waste ... can mean up to 100,000 of lost revenue for an ... during research. Falling number of migrant labourers means that healthy ...
... , , OMAHA, Neb., Aug. 12 Transgenomic, ... June 30, 2009. The Company,s financial results are presented in the tables that ... Company reported a net loss of $730,000 or $0.01 per share for the ... per share for the second quarter of 2008. , , ...
Cached Biology Technology:Massachusetts Technology Corporation Named to Inc. 5000 List of Fastest Growing Private Companies 2UK scientists developing intelligent harvesting robot to save farms up to 100,000 a year 2Transgenomic, Inc. Reports Second Quarter 2009 Results 2Transgenomic, Inc. Reports Second Quarter 2009 Results 3Transgenomic, Inc. Reports Second Quarter 2009 Results 4Transgenomic, Inc. Reports Second Quarter 2009 Results 5Transgenomic, Inc. Reports Second Quarter 2009 Results 6Transgenomic, Inc. Reports Second Quarter 2009 Results 7Transgenomic, Inc. Reports Second Quarter 2009 Results 8
... PureLink PCR Purification Kits provide rapid ... enzymes, short-failed PCR products, and salts from ... bind/wash/elute procedure:, provides two Binding Buffer ... bp* , can be performed in either ...
... Zero Blunt TOPO PCR ... fastest and easiest method ... or equal to95%) cloning ... amplified with proofreading thermostable ...
Quartz-Halogen, 100 W, High Intensity...
... System with Gateway™ Technology is designed ... the polyhedrin promoter. The expression cassette ... (bacmid DNA) by site-specific transposition (Tn7) ... recombinant bacmid DNA is then used ...
Biology Products: