Navigation Links
Federal grant funds research on novel HIV therapy

An immunology researcher at The Children's Hospital of Philadelphia leads a multi-center $6.7 million program project grant recently awarded by the National Institute of Mental Health (NIMH) to explore a novel approach to HIV treatment.

Encompassing basic science research, animal studies and clinical trials in adult patients, the new grant focuses on a potential Achilles' heel in the human immunodeficiency virus: sites on immune cells known as neurokinin-1 receptors. In focusing on those sites, researchers hope to achieve a triple benefit: fighting HIV by blocking the virus from immune cells, improving innate immune function and reducing symptoms of depression that are associated with the disease.

Steven D. Douglas, M.D., professor of Pediatrics, chief of the Section of Immunology and director of Clinical Immunology Laboratories at The Children's Hospital of Philadelphia, is the principal investigator and program director of the new Integrated Preclinical/Clinical Program grant. Dr. Douglas oversees projects led by collaborators at four sites: Children's Hospital, the University of Pennsylvania, Tulane National Primate Research Center, and Seracare Bioservices, Inc.

The program project is entitled, "Neurokinin-1R (SP Receptor) Antagonists for HIV Therapy." NIMH, a member institute of the National Institutes of Health, issued the four-year, $6.7 million grant award this fall.

The grant builds on more than a decade of investigation by Dr. Douglas into substance P, a neurotransmitter long known to be active in the brain and nervous system. Dr. Douglas and colleagues discovered in 1997 that immune cells produce substance P and its receptor, neurokinin-1, and later showed that incubation with substance P raised HIV levels in immune cell cultures. They subsequently found that a compound that binds to the substance P receptor in immune cells inhibits HIV from entering its hiding place within immune cells.

That compound, from a class
'"/>

Source:Children's Hospital of Philadelphia


Page: 1 2 3

Related biology news :

1. Federal testing for mad cow disease a failure, law review editor says
2. Researcher gets NSF grant to create mutant maize lines
3. MSU researchers receive $4 million grant to uncover gene functions
4. Virulizin granted orphan drug status in Europe
5. New NIAID grants strengthen national biodefense and emerging infectious diseases research network
6. Asian immigrants in NYC not receiving HIV education at religious institutions
7. Boston University biomedical engineers win major grant for pursuit of the $1,000 Genome
8. Scientists win grants to develop $1,000 genome sequencing technology
9. In presence of fragrant cleaning products, air purifiers that emit ozone can dirty the air
10. W.M. Keck Foundation funds study of friendly microbes
11. WHO suspends Marburg work, appeals for new funds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Federal grant funds research novel HIV therapy

(Date:4/22/2014)... Inspired by the fist-like club of a ... of California, Riverside, in collaboration with University of Southern ... for composite materials that is more impact resistant and ... more we study the club of this tiny crustacean, ... many things we use every day," said David Kisailus, ...
(Date:4/22/2014)... Scientists at the University of Massachusetts Amherst and ... this week report that they have discovered a new ... of the Negro River in the Amazonia State of ... with Adlia Nogueira and Jos Antnio Alves-Gomes of INPA, ... of the journal Proceedings of the Natural Sciences ...
(Date:4/22/2014)... for Experimental Biology (FASEB) has released updated factsheets ... from the National Institutes of Health (NIH) benefits each ... is pleased to make these factsheets available to help ... their state," said FASEB President, Margaret K. Offermann, MD, ... research funding, investing $29.2 billion in FY 2013 ...
Breaking Biology News(10 mins):Mantis shrimp stronger than airplanes 2Mantis shrimp stronger than airplanes 3New electric fish genus and species discovered in Brazil's Rio Negro 2
... COMO, ITALY -- Traditionally addressed through hand-weeding and/or herbicide ... in nursery production. Increased labor costs have made hand-weeding ... although herbicides may be effective and less expensive, non-target ... can harm the environment. To address the economic and ...
... is pleased to announce a mobile-optimized web interface for ... Journal of Experimental Biology and Disease Models & Mechanisms. ... Biology Open , will also be available as a ... increasing number of our readers want to access journal ...
... Li Qian, PhD, has won the Louis N. and ... Investigators from the American Heart Association (AHA), marking the ... Gladstone Institutes researcher has been the recipient. ... a leading and independent biomedical-research organization -- and a ...
Cached Biology News:Biodegradable mulches successfully control weeds in container-grown arborvitae 2Gladstone scientist receives American Heart Association's Katz prize for cardiovascular research 2
(Date:1/15/2014)... January 15, 2014 The Pittcon Organizing Committee ... Food Safety Tech , an e-Journal and producer of ... agreement for the second year for the co-location of Food ... The partnership provides that the registration fee to attend the ...
(Date:1/15/2014)... and SAN JOSE, California , January ... company developing antibody-drug conjugates for cancer, today announced the appointment ... Directors. Dr Reynolds has over 20 years, development experience gained ... at Seattle Genetics. "I am delighted to welcome ...
(Date:1/15/2014)... 15, 2014 More than 5 million ... 1 in 3 seniors will die with Alzheimer’s or ... jaw-dropping figures have shocked many Americans into looking for ... prevent these tragic age-related cognitive disorders. Jonathan Weisman, president ...
(Date:1/15/2014)... 15, 2014 2013 was a banner ... State Technologies®. They saw continued independent research led by ... were awarded a $1 million grant from the Susanne ... and Behavior” a peer reviewed journal, Amy Grant highlighted ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... important parameters for optimizing electroporation., , , , , , , ... Pulse length , , ... Adjustment , of the electroporation buffer , ... , of temperature , Influence , ...
... and the Brinkmann Bottletop Buret , ... , Bottletop dispensers are used in the lab for dispensing ... or stainless steel containers. These dispensers , have to ... substances which may disturb trace analysis, have cytotoxic properties, , ...
... , Sample Preparation: , ... washed and pelleted cultured cells, add 200 , l 4 ... Sodium Citrate, pH 7.0, 1 M b-Mercaptoethanol) , to 0.5 ... To directly extract RNA from cultured cells growing in monolayer, , ...
Cached Biology Technology:Optimizing electroporation parameters 2Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 2Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 3Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 4Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 5Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 6Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 7Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 8Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 9Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 10Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 11Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 12Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 13Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 14Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 15Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 16Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 17Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 18Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 19Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 20Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 21Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 22Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 23Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 24Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 25Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 26Total RNA Isolation Protocol 1,2,3 2Total RNA Isolation Protocol 1,2,3 3
Mouse monoclonal [6911] to E. coli K99 pilus ( Abpromise for all tested applications)....
...
... the first fully genetically encoded fluorescent sensor ... hydrogen peroxide (H2O2), one of the main ... basis of yellow fluorescent protein inserted into ... OxyR (OxyR-RD), HyPer demonstrates submicromolar affinity to ...
Alexa Fluor 647 anti-mouse Qa-2...
Biology Products: