Navigation Links
FSU biologists uncover mechanisms that shape cells for better or worse

In a landmark study, biologists at Florida State University have uncovered a specific genetic and molecular mechanism that causes cell polarity -- the asymmetric shape or composition critical to a cell's proper functioning. Their findings in fruit fly eggs may help to clarify how muscular dystrophy and some cancers develop in humans.

That's because many of the genes involved in the cell-to-cell communication that triggers the development of cell polarity in Drosophila oocytes (unfertilized fruit fly eggs) also are known players in the pathogenesis of those diseases.

The research performed by FSU Assistant Professor Wu-Min Deng and doctoral student John S. Poulton in the department of biological science could foster a better overall understanding of polarity and how it develops -- and why it doesn't, sometimes with dire consequences -- in other types of cells and organisms.

Results from the FSU study are described in the Aug. 14 online edition of the journal PNAS (Proceedings of the National Academy of Sciences).

"We have identified a novel component in the polarization of the fruit fly egg and the signals that determine the anterior-posterior positioning of its head and abdomen," said Deng.

"Such a discovery in the biological model provided by Drosophila oocytes has broad implications in humans, where, for example, neurons in the brain are designed, or polarized, to interpret information from the sense organs, and intestinal cells are polarized to take up nutrients and move them into the bloodstream," he said.

Poulton explained that in order to ensure cell polarity in the Drosophila oocyte, the cells surrounding it activate a classic signaling pathway known as the Epidermal Growth Factor Receptor (EGFR) in a process that is also essential to development in humans and a wide range of other organisms.

"Our study shows that EGFR activation in the cells surrounding the fruit fly
'"/>

Source:Florida State University


Page: 1 2

Related biology news :

1. Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
2. GeneNotes - A novel information management software for biologists
3. NYU biologists map out early stages of embryo formation
4. FSU biologists describe key role of signal-transcribing gene during cell cycle
5. High-tech tags on marine animals yield valuable data for biologists and oceanographers
6. UCSD biologists find new evidence for one-way evolution
7. UC San Diego biologists solve plant growth hormone enigma
8. NYU biologists identify gene that coordinates two cellular processes
9. MIT biologists solve vitamin puzzle
10. Yale biologists trick viruses into extinction
11. Brown cancer biologists identify major player in cell growth
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: FSU biologists uncover mechanisms that shape cells for better worse

(Date:9/30/2014)... HEIGHTS, Ill. (September 30, 2014) People who suffer ... can do to control their asthma besides properly taking ... a new article in the Annals of Allergy, ... American College of Allergy, Asthma and Immunology (ACAAI), asthma ... examining their lifestyle. The woman described in the Annals ...
(Date:9/29/2014)... 2014 -- Plants have a symbiotic relationship with ... extract nutrients and defend against invaders an ... and vegetables. Now, scientist have discovered that plants ... thus ensuring that sprouting plants are colonized from ... Notre Dame, presented their findings today at the ...
(Date:9/29/2014)... should use ventilation when cooking with a gas stove, ... new study showed an association between gas kitchen stove ... "In homes where a gas stove was used without ... than in homes where a gas stove was used ... the College of Public Health and Human Sciences at ...
Breaking Biology News(10 mins):Asthma symptoms kicking up? Check your exposure to air pollution 2Plants prepackage beneficial microbes in their seeds 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 2Childhood asthma linked to lack of ventilation for gas stoves, OSU study shows 3
... people who have a drink or two might be more ... from a University of Florida research group in the ... people 50 or older in the study metabolized alcohol similar ... tests after having moderate amounts of alcohol and did not ...
... seven new species of bamboo coral discovered on a ... Marine National Monument. Six of these species may represent ... classification a genus represents. A genus is a major ... species and below a family. Scientists expect to identify ...
... into children,s health and well-being will help solve global ... The research project, which is headed by Professor Arne ... Sciences at University of Copenhagen and will focus on ... which is based on regional food products. , Overweight ...
Cached Biology News:After a few drinks, older adults more impaired than they think 2After a few drinks, older adults more impaired than they think 3New deep-sea coral discovered on NOAA-supported mission 2Enhanced quality of 'LIFE' through Nordic food 2
(Date:9/30/2014)... Proove Biosciences , the commercial and ... a new genetic test built upon research from their ... will provide physicians with an objective way to ... are stratified between individuals. With this new test, physicians ... a genetic predisposition that will affect their pain tolerance. ...
(Date:9/30/2014)... , Sept. 30, 2014  RegeneRx Biopharmaceuticals, ... announced that it has received a Canadian Patent ... Actin-Sequestering Peptides.  This patent includes claims using thymosin ... other actin-sequestering peptides for these purposes.  The patent ... RegeneRx Biopharmaceuticals, Inc. ( www.regenerx.com ) ...
(Date:9/30/2014)... Hungary , September 30, 2014 ... and intuitive browsing of chemistry in documents ... chemistry software solutions and consulting services for life ... chemical information and generate Markush structures from documents. ... an organizations intellectual property, however generating and understanding ...
(Date:9/30/2014)... OriginOil Inc. (OTC/QB: OOIL), developer of Electro ... up large quantities of water, announced today that in ... the launch of the company's CLEAN-FRACâ„¢ industrial grade demonstrator ... STW Resources . , Immediately upon startup, the ... and achieved a 99.8% reduction in Turbidity on flowback ...
Breaking Biology Technology:Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3RegeneRx Receives Canadian Patent for Inhibition or Reversal of Skin Aging 2ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2OriginOil, Inc. Report to Shareholders: Blue Gold in West Texas 2
... DCGN ) today announced that it will host a ... Weisel Partners Healthcare,Conference 2008., The presentation will be ... / 6:30,PM British Summer Time on Wednesday, September 3 ... be accessed through the Investors page on,deCODE,s website, ...
... Abaxis, Inc.,(Nasdaq: ABAX ), a medical products ... Don Wood, Vice President,Operations, and Al Santa Ines, ... Annual West Coast Emerging Growth Institutional Investor Forum ... at the Ritz-Carlton Hotel, San,Francisco, CA., About ...
... Pharmaceuticals,Inc. (Nasdaq: ARNA ) announced today that the ... Biotech Industry Conference on September,4, 2008 at 11:00 a.m. ... Hotel in New York City. Jack Lief, Arena,s President,and ... of the,company, including its clinical development and discovery programs., ...
Cached Biology Technology:deCODE genetics to Webcast Presentation at Thomas Weisel Partners Healthcare Conference 2008 2Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference 2Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference 3
... designed to stabilize the biomolecules during ... There are neither animal proteins ... a convenient 10 times solution in ... to other traditional lyophilizing additives such ...
... benchtop incubator-shaker, has the smallest footprint of all ... 540 x 680 mm (W x D) does ... 505 x 510mm). Available in 25 mm or ... for shaking applications requiring controlled speed and temperature ...
... the smallest thermal cyclers on the market, which ... 0.5ml (20 samples) or 0.2ml microtube (25 samples) ... and cooling rate of 3.6C/sec and 2.0C/sec respectively ... Fast track programming with new quick dial facility ...
... StabilZyme HRP Conjugate Stabilizer is an ... protein and other non-toxic stabilizing chemicals in ... 6.2 6.7. This product contains ... and 20 ppm Proclin 300 (Rohm and ...
Biology Products: