Navigation Links
FSU biologists uncover mechanisms that shape cells for better or worse

In a landmark study, biologists at Florida State University have uncovered a specific genetic and molecular mechanism that causes cell polarity -- the asymmetric shape or composition critical to a cell's proper functioning. Their findings in fruit fly eggs may help to clarify how muscular dystrophy and some cancers develop in humans.

That's because many of the genes involved in the cell-to-cell communication that triggers the development of cell polarity in Drosophila oocytes (unfertilized fruit fly eggs) also are known players in the pathogenesis of those diseases.

The research performed by FSU Assistant Professor Wu-Min Deng and doctoral student John S. Poulton in the department of biological science could foster a better overall understanding of polarity and how it develops -- and why it doesn't, sometimes with dire consequences -- in other types of cells and organisms.

Results from the FSU study are described in the Aug. 14 online edition of the journal PNAS (Proceedings of the National Academy of Sciences).

"We have identified a novel component in the polarization of the fruit fly egg and the signals that determine the anterior-posterior positioning of its head and abdomen," said Deng.

"Such a discovery in the biological model provided by Drosophila oocytes has broad implications in humans, where, for example, neurons in the brain are designed, or polarized, to interpret information from the sense organs, and intestinal cells are polarized to take up nutrients and move them into the bloodstream," he said.

Poulton explained that in order to ensure cell polarity in the Drosophila oocyte, the cells surrounding it activate a classic signaling pathway known as the Epidermal Growth Factor Receptor (EGFR) in a process that is also essential to development in humans and a wide range of other organisms.

"Our study shows that EGFR activation in the cells surrounding the fruit fly
'"/>

Source:Florida State University


Page: 1 2

Related biology news :

1. Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
2. GeneNotes - A novel information management software for biologists
3. NYU biologists map out early stages of embryo formation
4. FSU biologists describe key role of signal-transcribing gene during cell cycle
5. High-tech tags on marine animals yield valuable data for biologists and oceanographers
6. UCSD biologists find new evidence for one-way evolution
7. UC San Diego biologists solve plant growth hormone enigma
8. NYU biologists identify gene that coordinates two cellular processes
9. MIT biologists solve vitamin puzzle
10. Yale biologists trick viruses into extinction
11. Brown cancer biologists identify major player in cell growth
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: FSU biologists uncover mechanisms that shape cells for better worse

(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
(Date:10/17/2014)... This news release is available in German . ... for only a very few drugs. When treating overdoses, doctors ... Treatment is especially difficult if there is a combination of ... is playing and accidentally swallows his grandmother,s pills? ETH professor ... Zurich wanted to find an answer to this question. "The ...
(Date:10/16/2014)... they are anything but sustainable: environmental damage to ... becoming increasingly evident. Despite their disadvantages, however, monocultures ... as the sole possibility of achieving higher yields ... Schmid, an ecology professor at the University of ... and forestry. After all, a new study carried ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... the University of Leicester approaches the 25th anniversary of ... interested in a particular type of DNA are receiving ... Chimpanzees at Twycross Zoo in Leicestershire have been trained ... cheek swabs. Dr Richard Badge, of the University,s ...
... Louis, Sept. 6, 2009 An international team of ... Alzheimer,s disease. The findings are reported in the online ... The group, led by investigators from the School of ... scientists from Washington University School of Medicine in St. ...
... know often comes at the price of learning about more ... many, but not for those with conditions such as Alzheimer,s ... Using brain scans in monkeys, Duke University Medical ... switch from exploiting a known resource to exploring their options. ...
Cached Biology News:Zoo volunteers help explain mysteries of the genome 2Zoo volunteers help explain mysteries of the genome 3Researchers find 2 more genetic risk factors for Alzheimer's disease 2Monkey brains signal the desire to explore 2
(Date:10/18/2014)... The “Human Insulin Market- by Product Type, ... Human Insulin (Rapid Acting, Long Acting, Premixed)], by ... - Forecast to 2018” provides a detailed overview ... market trends, and strategies impacting the global human ... of the revenue and share analysis. , The ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 The Asia-Pacific ... concerned market in Asia-Pacific with analysis and forecast of ... and is expected to reach $51,362.6 million by 2018, ... , Browse through the TOC of the Asia-Pacific hardware ... in-depth analysis provided. This also provides a glimpse of ...
(Date:10/18/2014)... 18, 2014 According to a new ... Well Type - Global Trends & Forecasts up till ... billion in 2011. This value is expected to increase ... 2017, with 10% CAGR during the same period. North ... production market in terms of hydraulic horse power supplied ...
(Date:10/17/2014)... through the looking-glass to Wonderland, mirrors in the real ... including a new class of mirror that works like ... Optical Society,s (OSA) new high-impact journal Optica ... a new type of mirror that forgoes a familiar ... using an unusual magnetic property of a non-metallic metamaterial. ...
Breaking Biology Technology:Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4Magnetic mirrors enable new technologies by reflecting light in uncanny ways 2Magnetic mirrors enable new technologies by reflecting light in uncanny ways 3Magnetic mirrors enable new technologies by reflecting light in uncanny ways 4
... SAN CARLOS, Calif., Jan. 8 Millions of ... some good news: the agency that,regulates Medicare and Medicaid ... treatment of sleep apnea., On December 14, 2007, ... policy memo proposing to allow coverage of Continuous,Positive Airway ...
... News briefs concerning the,economic and business growth ... Bay,Partnership:, Dental Supplier Announces Expansion of Tampa ... recently announced that it will merge two of ... and 144,employees in Manatee County, and Raintree, which ...
... N.J., Jan. 7 Quest Diagnostics,Incorporated (NYSE: ... information and services, announced that it is scheduled ... on Tuesday, January 8,2008, at the Westin St. ... is scheduled to begin at 11:00 a.m. Eastern ...
Cached Biology Technology:Medicare Coverage Recommended for In-Home Sleep Testing 2Highlights of Economic and Business Growth in the Tampa Bay Region 2Highlights of Economic and Business Growth in the Tampa Bay Region 3Highlights of Economic and Business Growth in the Tampa Bay Region 4Quest Diagnostics to Speak at the 26th Annual JPMorgan Healthcare Conference 2